메뉴 건너뛰기




Volumn 69, Issue 1, 2007, Pages 1-9

Immune regulation by mesenchymal stem cells: Two sides to the coin

Author keywords

Adult stem cells; Antigen presenting cells; Immune suppression; Mesenchymal stem cells

Indexed keywords

BIOLOGICAL MARKER; CELL ADHESION MOLECULE; CELL RECEPTOR; CHEMOKINE RECEPTOR; CYTOKINE RECEPTOR; GAMMA INTERFERON; GROWTH FACTOR RECEPTOR; LIGAND; MEMBRANE ANTIGEN; TOLL LIKE RECEPTOR;

EID: 33845885144     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2006.00739.x     Document Type: Review
Times cited : (158)

References (62)
  • 1
    • 0017119380 scopus 로고
    • Fibroblast precursors in normal and irradiated mouse hematopoietic organs
    • Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 1976: 4: 267-74.
    • (1976) Exp Hematol , vol.4 , pp. 267-274
    • Friedenstein, A.J.1    Gorskaja, J.F.2    Kulagina, N.N.3
  • 2
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999: 284: 143-7.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 3
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002: 418: 41-9.
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 4
    • 0037728761 scopus 로고    scopus 로고
    • Al-Khaldi A, Eliopoulos N, Martineau Det al. Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neo-angiogenic response in vivo. Gene Ther 2003: 10: 621-9.
    • Al-Khaldi A, Eliopoulos N, Martineau Det al. Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neo-angiogenic response in vivo. Gene Ther 2003: 10: 621-9.
  • 5
    • 19944427214 scopus 로고    scopus 로고
    • Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: Potential therapy for cystic fibrosis
    • Wang G, Bunnell BA, Painter RG et al. Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis. Proc Natl Acad Sci USA 2005: 102: 186-91.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 186-191
    • Wang, G.1    Bunnell, B.A.2    Painter, R.G.3
  • 6
    • 0034934262 scopus 로고    scopus 로고
    • Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells
    • Colter DC, Sekiya I, Prockop DJ. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc Natl Acad Sci USA 2001: 98: 7841-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7841-7845
    • Colter, D.C.1    Sekiya, I.2    Prockop, D.J.3
  • 7
    • 27944435821 scopus 로고    scopus 로고
    • Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
    • Horwitz EM, Le Blanc K, Dominici M et al. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005: 7: 393-5.
    • (2005) Cytotherapy , vol.7 , pp. 393-395
    • Horwitz, E.M.1    Le Blanc, K.2    Dominici, M.3
  • 8
    • 0033824164 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Biology and potential clinical uses
    • Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 2000: 28: 875-84.
    • (2000) Exp Hematol , vol.28 , pp. 875-884
    • Deans, R.J.1    Moseley, A.B.2
  • 10
    • 0020997754 scopus 로고
    • Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells
    • Kannagi R, Cochran NA, Ishigami F et al. Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells. EMBO J 1983: 2: 2355-61.
    • (1983) EMBO J , vol.2 , pp. 2355-2361
    • Kannagi, R.1    Cochran, N.A.2    Ishigami, F.3
  • 11
    • 26444585020 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in stem cells and cancer
    • Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science 2005: 310: 68-71.
    • (2005) Science , vol.310 , pp. 68-71
    • Mishra, L.1    Derynck, R.2    Mishra, B.3
  • 12
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997: 11: 3286-305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 13
    • 33645007189 scopus 로고    scopus 로고
    • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells
    • Jian H, Shen X, Liu I, Semenov M, He X, Wang XF. Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev 2006: 20: 666-74.
    • (2006) Genes Dev , vol.20 , pp. 666-674
    • Jian, H.1    Shen, X.2    Liu, I.3    Semenov, M.4    He, X.5    Wang, X.F.6
  • 14
    • 12544253854 scopus 로고    scopus 로고
    • Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow
    • Gregory CA, Perry AS, Reyes E, Conley A, Gunn WG, Prockop DJ. Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow. J Biol Chem 2005: 280: 2309-23.
    • (2005) J Biol Chem , vol.280 , pp. 2309-2323
    • Gregory, C.A.1    Perry, A.S.2    Reyes, E.3    Conley, A.4    Gunn, W.G.5    Prockop, D.J.6
  • 15
    • 0042204967 scopus 로고    scopus 로고
    • Transcriptional mechanisms in osteoblast differentiation and bone formation
    • Nakashima K, de Crombrugghe B. Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 2003: 19: 458-66.
    • (2003) Trends Genet , vol.19 , pp. 458-466
    • Nakashima, K.1    de Crombrugghe, B.2
  • 17
    • 23644431709 scopus 로고    scopus 로고
    • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
    • Hong JH, Hwang ES, McManus MT et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 2005: 309: 1074-8.
    • (2005) Science , vol.309 , pp. 1074-1078
    • Hong, J.H.1    Hwang, E.S.2    McManus, M.T.3
  • 18
    • 33845277598 scopus 로고    scopus 로고
    • Mesenchymal stem cells (MSCs) display coordinated rolling and adhesion behavior on endothelial cells
    • Ruster B, Gottig S, Ludwig RJ et al. Mesenchymal stem cells (MSCs) display coordinated rolling and adhesion behavior on endothelial cells. Blood 2006: 108: 3938-44.
    • (2006) Blood , vol.108 , pp. 3938-3944
    • Ruster, B.1    Gottig, S.2    Ludwig, R.J.3
  • 19
    • 33745489036 scopus 로고    scopus 로고
    • Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors
    • Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells 2006: 24: 1030-41.
    • (2006) Stem Cells , vol.24 , pp. 1030-1041
    • Honczarenko, M.1    Le, Y.2    Swierkowski, M.3    Ghiran, I.4    Glodek, A.M.5    Silberstein, L.E.6
  • 20
    • 32644438233 scopus 로고    scopus 로고
    • Mesenchymal stem cell-natural killer cell interactions: Evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation
    • Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 2006: 107: 1484-90.
    • (2006) Blood , vol.107 , pp. 1484-1490
    • Spaggiari, G.M.1    Capobianco, A.2    Becchetti, S.3    Mingari, M.C.4    Moretta, L.5
  • 21
    • 10644253717 scopus 로고    scopus 로고
    • Activation of NK cell cytotoxicity
    • Smyth MJ, Cretney E, Kelly JM et al. Activation of NK cell cytotoxicity. Mol Immunol 2005: 42: 501-10.
    • (2005) Mol Immunol , vol.42 , pp. 501-510
    • Smyth, M.J.1    Cretney, E.2    Kelly, J.M.3
  • 22
    • 33845881810 scopus 로고    scopus 로고
    • Toll-like receptors and their ligands control mesenchymal stem cell functions
    • Epub ahead of print
    • Pevsner-Fischer M, Morad V, Cohen-Sfady M et al. Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood 2006: [Epub ahead of print].
    • (2006) Blood
    • Pevsner-Fischer, M.1    Morad, V.2    Cohen-Sfady, M.3
  • 23
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation
    • Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003: 75: 389-97.
    • (2003) Transplantation , vol.75 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3    Egalka, M.C.4    Guinan, E.C.5
  • 24
    • 0242410394 scopus 로고    scopus 로고
    • Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
    • Djouad F, Plence P, Bony C et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 2003: 102: 3837-44.
    • (2003) Blood , vol.102 , pp. 3837-3844
    • Djouad, F.1    Plence, P.2    Bony, C.3
  • 25
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005: 105: 1815-22.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 26
    • 14944339174 scopus 로고    scopus 로고
    • Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness
    • Beyth S, Borovsky Z, Mevorach D et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005: 105: 2214-19.
    • (2005) Blood , vol.105 , pp. 2214-2219
    • Beyth, S.1    Borovsky, Z.2    Mevorach, D.3
  • 27
    • 33845898303 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T cell proliferation by mesenchymal stem cells
    • Epub ahead of print
    • Sato K, Ozaki K, Oh I et al. Nitric oxide plays a critical role in suppression of T cell proliferation by mesenchymal stem cells. Blood 2006: [Epub ahead of print].
    • (2006) Blood
    • Sato, K.1    Ozaki, K.2    Oh, I.3
  • 28
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    • Krampera M, Glennie S, Dyson J et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003: 101: 3722-9.
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3
  • 29
    • 18844404360 scopus 로고    scopus 로고
    • Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
    • Augello A, Tasso R, Negrini SM et al. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol 2005: 35: 1482-90.
    • (2005) Eur J Immunol , vol.35 , pp. 1482-1490
    • Augello, A.1    Tasso, R.2    Negrini, S.M.3
  • 30
    • 15044348816 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
    • Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res 2005: 305: 33-41.
    • (2005) Exp Cell Res , vol.305 , pp. 33-41
    • Rasmusson, I.1    Ringden, O.2    Sundberg, B.3    Le Blanc, K.4
  • 31
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • Krampera M, Cosmi L, Angeli R et al. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006: 24: 386-98.
    • (2006) Stem Cells , vol.24 , pp. 386-398
    • Krampera, M.1    Cosmi, L.2    Angeli, R.3
  • 32
    • 33745076513 scopus 로고    scopus 로고
    • Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-{gamma}
    • Chan JL, Tang KC, Patel AP et al. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-{gamma}. Blood 2006: 107: 4817-24.
    • (2006) Blood , vol.107 , pp. 4817-4824
    • Chan, J.L.1    Tang, K.C.2    Patel, A.P.3
  • 33
    • 33644799418 scopus 로고    scopus 로고
    • Interferon-gamma-stimulated marrow stromal cells: A new type of nonhematopoietic antigen-presenting cell
    • Stagg J, Pommey S, Eliopoulos N, Galipeau J. Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood 2006: 107: 2570-7.
    • (2006) Blood , vol.107 , pp. 2570-2577
    • Stagg, J.1    Pommey, S.2    Eliopoulos, N.3    Galipeau, J.4
  • 34
    • 0141484485 scopus 로고    scopus 로고
    • HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
    • Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringden O. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003: 10: 890-6.
    • (2003) Exp Hematol , vol.10 , pp. 890-896
    • Le Blanc, K.1    Tammik, C.2    Rosendahl, K.3    Zetterberg, E.4    Ringden, O.5
  • 35
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002: 99: 3838-43.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 36
    • 15944376184 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells
    • Glennie S, Soeiro I, Dyson PJ, Lam EW, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood 2005: 105: 2821-7.
    • (2005) Blood , vol.105 , pp. 2821-2827
    • Glennie, S.1    Soeiro, I.2    Dyson, P.J.3    Lam, E.W.4    Dazzi, F.5
  • 37
    • 30144440925 scopus 로고    scopus 로고
    • Humanmesenchymal stem cells modulate B-cell functions
    • Corcione A, Benvenuto F, Ferretti E et al. Humanmesenchymal stem cells modulate B-cell functions. Blood 2006: 107: 367-72.
    • (2006) Blood , vol.107 , pp. 367-372
    • Corcione, A.1    Benvenuto, F.2    Ferretti, E.3
  • 38
    • 18544371666 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    • Jiang XX, Zhang Y, Liu B et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005: 105: 4120-6.
    • (2005) Blood , vol.105 , pp. 4120-4126
    • Jiang, X.X.1    Zhang, Y.2    Liu, B.3
  • 39
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004: 363: 1439-41.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 40
    • 33744917000 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice
    • Sudres M, Norol F, Trenado A et al. Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice. J Immunol 2006: 176: 7761-7.
    • (2006) J Immunol , vol.176 , pp. 7761-7767
    • Sudres, M.1    Norol, F.2    Trenado, A.3
  • 41
    • 33746514768 scopus 로고    scopus 로고
    • Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a non-myeloablative setting
    • Nauta AJ, Westerhuis G, Kruisselbrink AB, Lurvink EG, Willemze R, Fibbe WE. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a non-myeloablative setting. Blood 2006: 108: 2114-20.
    • (2006) Blood , vol.108 , pp. 2114-2120
    • Nauta, A.J.1    Westerhuis, G.2    Kruisselbrink, A.B.3    Lurvink, E.G.4    Willemze, R.5    Fibbe, W.E.6
  • 42
    • 28844483809 scopus 로고    scopus 로고
    • Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice
    • Eliopoulos N, Stagg J, Lejeune L, Pommey S, Galipeau J. Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice. Blood 2005: 106: 4057-65.
    • (2005) Blood , vol.106 , pp. 4057-4065
    • Eliopoulos, N.1    Stagg, J.2    Lejeune, L.3    Pommey, S.4    Galipeau, J.5
  • 43
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • Zappia E, Casazza S, Pedemonte E et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005: 106: 1755-61.
    • (2005) Blood , vol.106 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3
  • 44
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • Gunn WG, Conley A, Deininger L, Olson SD, Prockop DJ, Gregory CA. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells 2006: 24: 986-91.
    • (2006) Stem Cells , vol.24 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3    Olson, S.D.4    Prockop, D.J.5    Gregory, C.A.6
  • 45
    • 0037173116 scopus 로고    scopus 로고
    • Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
    • Horwitz EM, Gordon PL, Koo WK et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA 2002: 99: 8932-7.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8932-8937
    • Horwitz, E.M.1    Gordon, P.L.2    Koo, W.K.3
  • 46
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006: 98: 1076-84.
    • (2006) J Cell Biochem , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 47
    • 0141483047 scopus 로고    scopus 로고
    • One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues
    • Prockop DJ, Gregory CA, Spees JL. One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci USA 2003: 100(Suppl 1): 11917-23.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.SUPPL. 1 , pp. 11917-11923
    • Prockop, D.J.1    Gregory, C.A.2    Spees, J.L.3
  • 48
    • 0037041427 scopus 로고    scopus 로고
    • Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
    • Terada N, Hamazaki T, Oka M et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002: 416: 542-5.
    • (2002) Nature , vol.416 , pp. 542-545
    • Terada, N.1    Hamazaki, T.2    Oka, M.3
  • 49
    • 0037418179 scopus 로고    scopus 로고
    • Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma
    • Spees JL, Olson SD, Ylostalo J et al. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci USA 2003: 100: 2397-402.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2397-2402
    • Spees, J.L.1    Olson, S.D.2    Ylostalo, J.3
  • 50
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006: 126: 677-89.
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 51
    • 20244389882 scopus 로고    scopus 로고
    • Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
    • Gnecchi M, He H, Liang OD et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005: 11: 367-8.
    • (2005) Nat Med , vol.11 , pp. 367-368
    • Gnecchi, M.1    He, H.2    Liang, O.D.3
  • 52
    • 33646252939 scopus 로고    scopus 로고
    • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
    • Gnecchi M, He H, Noiseux N et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 2006: 20: 661-9
    • (2006) FASEB J , vol.20 , pp. 661-669
    • Gnecchi, M.1    He, H.2    Noiseux, N.3
  • 53
    • 33744959141 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1
    • Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J Biol Chem 2006: 281: 15554-63.
    • (2006) J Biol Chem , vol.281 , pp. 15554-15563
    • Okuyama, H.1    Krishnamachary, B.2    Zhou, Y.F.3    Nagasawa, H.4    Bosch-Marce, M.5    Semenza, G.L.6
  • 54
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003: 349: 2483-94.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 55
    • 33845914432 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor- induced bone resorption and multiple myeloma growth in- vivo
    • Epub ahead of print
    • Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD Jr. Antibody-based inhibition of DKK1 suppresses tumor- induced bone resorption and multiple myeloma growth in- vivo. Blood 2006: [Epub ahead of print].
    • (2006) Blood
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy Jr., J.D.6
  • 56
    • 0036644833 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors
    • Studeny M, Marini FC, Champlin RE et al. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002: 62:3603-8.
    • (2002) Cancer Res , vol.62 , pp. 3603-3608
    • Studeny, M.1    Marini, F.C.2    Champlin, R.E.3
  • 57
    • 33845869398 scopus 로고    scopus 로고
    • Nakamizo A, Marini F, Amano T et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005: 65: 3307-18. Erratum in: Cancer Res 2006: 66: 5975.
    • Nakamizo A, Marini F, Amano T et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005: 65: 3307-18. Erratum in: Cancer Res 2006: 66: 5975.
  • 58
    • 16544369419 scopus 로고    scopus 로고
    • Marrow stromal cells for interleukin-2 delivery in cancer immunotherapy
    • Stagg J, Lejeune L, Paquin A, Galipeau J. Marrow stromal cells for interleukin-2 delivery in cancer immunotherapy. Hum Gene Ther 2004: 15: 597-608.
    • (2004) Hum Gene Ther , vol.15 , pp. 597-608
    • Stagg, J.1    Lejeune, L.2    Paquin, A.3    Galipeau, J.4
  • 59
    • 33646690027 scopus 로고    scopus 로고
    • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    • Khakoo AY, Pati S, Anderson SA et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 2006: 203: 1235-47.
    • (2006) J Exp Med , vol.203 , pp. 1235-1247
    • Khakoo, A.Y.1    Pati, S.2    Anderson, S.A.3
  • 60
    • 17144363265 scopus 로고    scopus 로고
    • Spontaneous human adult stem cell transformation
    • Rubio D, Garcia-Castro J, Martin MC et al. Spontaneous human adult stem cell transformation. Cancer Res 2005: 65: 3035-9.
    • (2005) Cancer Res , vol.65 , pp. 3035-3039
    • Rubio, D.1    Garcia-Castro, J.2    Martin, M.C.3
  • 61
    • 9444265320 scopus 로고    scopus 로고
    • Gastric cancer originating from bone marrow-derived cells
    • Houghton J, Stoicov C, Nomura S et al. Gastric cancer originating from bone marrow-derived cells. Science 2004: 306: 1568-71.
    • (2004) Science , vol.306 , pp. 1568-1571
    • Houghton, J.1    Stoicov, C.2    Nomura, S.3
  • 62
    • 0141796315 scopus 로고    scopus 로고
    • Bone marrow as a priming site for T-cell responses to blood-borne antigen
    • Feuerer M, Beckhove P, Garbi N et al. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Med 2003: 9: 1151-7.
    • (2003) Nat Med , vol.9 , pp. 1151-1157
    • Feuerer, M.1    Beckhove, P.2    Garbi, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.