Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression

Circulation Research

Volumn 89, Issue 6, 2001, Pages 477-479

  Kim, Injune ^a   Moon, Sang Ok ^a   Sung, Kwang Park ^a   Soo, Wan Chae ^a   Gou, Young Koh ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Adhesion; Angiopoietin; Inflammation; Vascular endothelial growth factor

Indexed keywords

ANGIOPOIETIN 1; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

EID: 0035860845     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1801.097034     Document Type: Article

References (8)

1. Vascular-specific growth factors and blood vessel formation
2. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
3. Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization
4. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
5. VEGF stimulates expression of ICAM-1, VCAM-1 and E-selectin through nuclear factor-κB activation in endothelial cells
6. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
7. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
8. Angiopoietin-1 is an antiperme ability and anti-inflammatory agent in vitro and targets cell junctions