Double intratracheal instillation of keratinocyte growth factor prevents bleomycin-induced lung fibrosis in rats

Journal of Pathology

Volumn 186, Issue 1, 1998, Pages 90-98

  Sugahara, Kazuhiro ^a   Iyama, Ken Ichi ^a   Kuroda, Marcelo J ^a   Sano, Kimihiko ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Alveolar type II cells; Keratinocyte growth factor; Pulmonary fibrosis

Indexed keywords

BLEOMYCIN; KERATINOCYTE GROWTH FACTOR;

ANIMAL EXPERIMENT; ARTICLE; COLLAGEN METABOLISM; EPITHELIZATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOTAL LUNG CAPACITY;

ANIMALS; BLEOMYCIN; BLOTTING, NORTHERN; BODY WEIGHT; COLLAGEN; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GROWTH SUBSTANCES; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; MALE; ORGAN SIZE; PROCOLLAGEN; PROTEOLIPIDS; PULMONARY FIBROSIS; PULMONARY SURFACTANTS; RATS; RATS, INBRED F344; RNA, MESSENGER; TOTAL LUNG CAPACITY;

EID: 0031681160     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199809)186:1<90::AID-PATH137>3.0.CO;2-X     Document Type: Article

References (28)

1. Adamson IYR, Bowden DH. Deviation of type 1 epithelium from type 2 cells in the developing rat lung. Lab Invest 1975; 32: 736-745.
2. 2. Am J Pathol 1975; 22: 142-150.
3. Crouch E. Pathobiology of pulmonary fibrosis. Am J Physiol 1990; 259: L159-L184.
4. Sugahara K, Iyama K, Sano K, Kuroki Y, Akino T, Matsumoto M. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury. Lab Invest 1996; 74: 209-220.
5. Sugahara K, Rubin JS, Mason RJ, Aronsen EL, Shannon JM. Keratinocyte growth factor increases mRNAs for SP-A and SP-B in adult rat alveolar type II cells in culture. Am J Physiol 1995; 269: L344-L350.
6. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson PA. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 1989; 86: 802-806.
7. Panos RJ, Rubin JS, Aarsonson SA, Mason RJ. Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest 1993; 92: 969-977.
8. Ulich TE, Yi ES, Longmuir K, et al. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest 1994; 93: 1298-1306.
9. Panos RJ, Bak PM, Simonet WS, Rubin JS, Smith LJ. Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. J Clin Invest 1995; 96: 2026-2033.
10. Mason IJ, Fuller-Pace F, Smith R, Dickson C. FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisaton and epithelial-mesenchymal interactions. Mech Dev 1994; 45: 15-30.
11. Urtreger AO. Development localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol 1993; 158: 475-486.
12. Peters K, Werner S, Liao X, Wert S, Whitsett J, William L. Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. EMBO J 1994; 13: 3296-3301.
13. Simonet WS, DeRose ML, Bucay N, et al. Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. Proc Natl Acad Sci USA 1995; 92: 12 461-12 465.
14. Werner S, Smola H, Liao X, et al. The function of KGF on morphogenesis of epithelium and reepithelialization of wounds. Science 1994; 266: 819-822.
15. Staiano-Coico L, Krueger JG, Rubin JS, et al. Human keratinocyte growth factor effects in a porcine model of epidermal wound healing. J Exp Med 1993; 178: 865-878.
16. Shen AS, Haslett C, Feldsien DC, Henson PM, Cherniak RM. The intensity of chronic lung inflammation and fibrosis after bleomycin is directly related to the severity of acute injury. Am Rev Respir Dis 1988; 137: 564-571.
17. Hay J, Shahzeidi S, Laurent G. Mechanisms of bleomycin-induced lung damage. Arch Toxicol 1991; 65: 81-94
18. Sugahara K, Iyama K, Sakanashi Y, Sano K. Keratinocyte growth factor (KGF) prevents bleomycin-induced lung fibrosis in rats. Mol Biol Cell 1995; 6: 203a.
19. McBride JT. Postpneumonectomy airway growth in the ferret. J Appl Physiol 1985; 53: 1010-1014.
20. Kitaoka M, Iyama K, Ushijima T, et al. Differential expressions of collagen types IV, III and I during the development of invasive trophoblasts in rats and platelet aggregating activities by these collagens. Dev Dyn 1997; 207: 319-331.
21. Emrie PA, Shannon JM, Mason RJ, Fisher H. cDNA and deduced amino acid sequence for the rat hydrophobic pulmonary surfactant-associated protein, SP-B. Biochim Biophys Acta 1989; 994: 215-221.
22. Fisher JH, Shannon JM, Hoffman T, Mason RJ. Nucleotide and deduced amino acid sequence of the hydrophobic surfactant protein SP-C for the rat; expression in alveolar type II cells and homology with SP-C from other species. Biochim Biophys Acta 1989; 995: 225-230.
23. Sano K, Fisher J, Mason RJ, et al. Isolation and sequence of a cDNA clone for the rat pulmonary surfactant-associated protein (PSP-A). Biochem Biophys Res Commun 1987; 144: 367-374.
24. Iyama K, Ninomiya K, Olsen BR, Linsenmayer TF, Trelstad RL, Hayashi M. Spatiotemporal pattern of type X collagen gene expression and collagen deposition in embryonic chick vertebrae undergoing endochondral ossification. Anat Rec 1991; 229: 462-472.
25. Sugahara K, Iyama K, Sano K, Monoka T. Differential expressions of surfactant protein SP-A, SP-B and SP-C mRNAs in rats with streptozotocin-induced diabetes demonstrated by in situ hybridization. Am J Respir Cell Mol Biol 1994; 11: 397-404.
26. Kuroki Y, Mason RJ, Voelker DR. Pulmonary surfactant apoprotein A structure and modulation of surfactant secretion by rat alveolar type II cells. J Biol Chem 1988; 263: 3388-3394.
27. Guery B, deBoisblanc BP, Nelson S, et al. Keratinocyte growth factor protects against mechanical ventilation lung injury. Am J Respir Crit Care Med 1996; 153: A393.
28. Yi ES, William ST, Lee H, et al. Keratinocyte growth factor ameliorates radiation-and bleomycin-induced lung injury and mortality. Am J Pathol 1996; 149: 1963-1970.