Alveolar epithelial ion and fluid transport: Recent progress

American Journal of Respiratory Cell and Molecular Biology

Volumn 35, Issue 1, 2006, Pages 10-19

  Folkesson, Hans C ^b   Matthay, Michael A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUMETANIDE; CATECHOLAMINE; GLIBENCLAMIDE; ISOPRENALINE; SODIUM CHANNEL;

FLUID TRANSPORT; HUMAN; HYDROSTATIC PRESSURE; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG CLEARANCE; LUNG EDEMA; LUNG FLUID; LUNG INJURY; NONHUMAN; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; BODY FLUIDS; EPITHELIUM; HUMANS; LUNG; PULMONARY ALVEOLI; SODIUM CHANNELS;

EID: 33745623165     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2006-0080SF     Document Type: Review

References (132)

1. Matthay MA, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelium in the adult lung. Am J Physiol Lung Cell Mol Physiol 1996;270:L487-L503.
2. Crandall ED, Matthay MA. Alveolar epithelial transport: basic science to clinical medicine. Am J Respir Crit Care Med 2001;163:1021-1029.
3. Matthay MA, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 2002;82:569-600.
4. Matalon S, Lazrak A, Jain L, Eaton DC. Biophysical properties of sodium channels in lung alveolar epithelial cells. J Appl Physiol 2002;93:1852-1859.
5. +-ATPase. J Appl Physiol 2002;93:1860-1866.
6. + channels in lung alveolar type II epithelial cells. Proc Am Thorac Soc 2004;1:10-16.
7. Matalon S, O'Brodovich H. Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance. Annu Rev Physiol 1999;61:627-661.
8. Mutlu GM, Sznajder JI. Mechanisms of pulmonary edema clearance. Am J Physiol Lung Cell Mol Physiol 2005;289:L685-L695.
9. Olver RE, Walters DV, Wilson SM. Developmental regulation of lung liquid transport. Annu Rev Physiol 2004;66:77-101.
10. Saumon G, Basset G. Electrolyte and fluid transport across the mature alveolar epithelium. J Appl Physiol 1993;74:1-15.
11. Schneeberger EE, Lynch RD. Structure, function, and regulation of cellular tight junctions. Am J Physiol Lung Cell Mol Physiol 1992;262:L647-L661.
12. Clements JA, Hustead RF, Johnson RP, Gribetz I. Pulmonary surface tension and alveolar stability. J Appl Physiol 1961;16:444-450.
13. + channel is made of three homologous subunits. Nature 1994;367:463-467. (see comments).
14. + channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc Natl Acad Sci USA 1994;91:247-251.
15. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 2002;119:199-208.
16. Fang X, Song Y, Hirsch J, Galietta LJV, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol 2006;290:L242-L249.
17. - channel activation and transport function in cultures with an apical air interface. J Membr Biol 2001;181:195-204.
18. - channel activation is necessary for stimulation of Na transport in adult alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000;278:L239-L244.
19. Ridge KM, Rutschman DH, Factor P, Katz AI, Bertorello AM, Sznajder JL. Differential expression of Na-K-ATPase isoforms in rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 1997;273:L246-L255.
20. 2 adrenergic receptors are expressed in alveolar type I cells. Am J Respir Crit Care Med 2001;163:A570. (Abstract).
21. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim K-J, Crandall ED. Alveolar epithelial ion and fluid transport: Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol 2002;282:L599-L608.
22. Johnson MD, Widdicombe JH, Allen L, Barbry P, Dobbs LG. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci USA 2002;99:1966-1971.
23. Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS. Highly water permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci USA 1998;95:2991-2996.
24. 2Na,K-ATPase, which contributes to lung liquid clearance. Circ Res 2003;92:453-460.
25. 2- subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol 2005;289:L104-L110.
26. Johnson MD, Bao HF, Helms MN, Chen XJ, Tigue Z, Jain L, Dobbs LG, Eaton DC. Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport. Proc Natl Acad Sci USA 2006;103:4964-4969.
27. 2-ARS) in the alveolar septum of the rat [abstract]. FASEB J 2000; 14:A129.
28. Newman GR, Campbell L, von Ruhland C, Jasani B, Gumbleton M. Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar epithelial type I cell function. Cell Tissue Res 1999;295:111-120.
29. Willumsen NJ, Boucher RC. Sodium transport and intracellular sodium activity in cultured human nasal epithelium. Am J Physiol Cell Physiol 1991;261:C319-C331.
30. Ballard ST, Schepens SM, Falcone JC, Meininger GA, Taylor AE. Regional bioelectric properties of porcine airway epithelium. J Appl Physiol 1992;73:2021-2027.
31. Al-Bazzaz FJ. Regulation of Na and Cl transport in sheep distal airways. Am J Physiol Lung Cell Mol Physiol 1994;267:L193-L198.
32. Sakuma T, Pittet JF, Jayr C, Matthay MA. Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep. J Appl Physiol 1993;74:176-185.
33. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA. Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med 1994;150:305-310.
34. Li T, Folkesson HG. RNA interference for α-ENaC inhibits rat lung fluid absorption in vivo. Am J Physiol Lung Cell Mol Physiol 2006; 290:L649-L660.
35. O'Brodovich H, Hannam V, Seear M, Mullen JB. Amiloride impairs lung water clearance in newborn guinea pigs. J Appl Physiol 1990; 68:1758-1762.
36. Yue G, Matalon S. Mechanisms and sequelae of increased alveolar fluid clearance in hyperoxic rats. Am J Physiol Lung Cell Mol Physiol 1997; 272:L407-L412.
37. Canessa CM, Merillat AM, Rossier BC. Membrane topology of the epithelial sodium channel in intact cells. Am J Physiol Cell Physiol 1994; 267:C1682-C1690.
38. Snyder PM, McDonald FJ, Stokes JB, Welsh MJ. Membrane topology of the amiloride-sensitive epithelial sodium channel. J Biol Chem 1994; 269:24379-24383.
39. + channel in colon, lung and kidney. Pflügers Arch Eur J Physiol 1995;430:299-307.
40. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC. Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice. Nat Genet 1996;12:325-328.
41. Matsushita K, McCray PB Jr, Sigmund RD, Welsh MJ, Stokes JB. Localization of epithelial sodium channel subunit mRNAs in adult rat lung by in situ hybridization. Am J Physiol Lung Cell Mol Physiol 1996; 271:L332-L339.
42. Dagenais A, Kothary R, Berthiaume Y. The α subunit of the epithelial sodium channel in the mouse: Developmental regulation of its expression. Pediatr Res 1997;42:327-334.
43. Talbot CL, Bosworth DG, Briley EL, Fenstermacher DA, Boucher RC, Gabriel SE, Barker PM. Quantitation and localization of ENaC subunit expression in fetal, newborn, and adult mouse lung. Am J Respir Cell Mol Biol 1999;20:398-406.
44. Barker PM, Nguyen MS, Gatzy JT, Grubb B, Norman H, Hummler E, Rossier B, Boucher RC, Koller B. Role of γENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism. J Clin Invest 1998;102:1634-1640.
45. + channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proc Natl Acad Sci USA 1999;96:1727-1731.
46. Kerem E, Bistritzer T, Hanukoglu A, Hofmann T, Zhou Z, Bennett W, MacLaughlin E, Barker P, Nash M, Quittel L, et al. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N Engl J Med 1999;341:156-162.
47. Otulakowski G, Freywald T, Wen Y, O'Brodovich H. Translational activation and repression by distinct elements within the 5′-UTR of ENaC α-subunit mRNA. Am J Physiol Lung Cell Mol Physiol 2001;281: L1219-L1231.
48. Rotin D, Kanelis V, Schild L. Trafficking and cell surface stability of ENaC. Am J Physiol Renal Physiol 2001;281:F391-F399.
49. Planès C, Leyvraz C, Uchida T, Apostolova Angelova M, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B. In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases. Am J Physiol Lung Cell Mol Physiol 2005;288:L1099-L1109.
50. Vuagniaux G, Vallet V, Jaeger NF, Pfister C, Bens M, Farman N, Courtois-Coutry N, Vandewalle A, Rossier BC, Hummler E. Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line. J Am Soc Nephrol 2000;11:828-834.
51. Adachi M, Kitamura K, Miyoshi T, Narikiyo T, Iwashita K, Shiraishi N, Nonoguchi H, Tomita K. Activation of epithelial sodium channels by prostasin in xenopus oocytes. J Am Soc Nephrol 2001;12:1114-1121.
52. Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, Gabriel SE. Regulation of the epithelial sodium channel by serine proteases in human airways. J Biol Chem 2002;277:8338-8345.
53. Guipponi M, Vuagniaux G, Watterhofer M, Shibuya K, Vazquez M, Dougherty L, Scamuffa N, Guida E, Okui M, Rossier C, et al. The transmembrane serine protease (TMPRSS3) mutated in deafness DFN8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum Mol Genet 2002;11:2829-2836.
54. Vuagniaux G, Vallet V, Fowler Jaeger N, Hummler E, Rossier BC. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucose-regulated kinase (Sgk1) in Xenopus oocytes. J Gen Physiol 2002;120:191-201.
55. + transport. Am J Physiol Renal Physiol 2002;283: F377-F387.
56. + channel through convergent phosphorylation of Nedd4-2. J Biol Chem 2004;279:45753-45758.
57. Fabisiak JP, Vesell ES, Rannels DE. Interactions of beta adrenergic antagonists with isolated rat alveolar type II pneumocytes. I. Analysis, characterization and regulation of specific beta adrenergic receptors. J Pharmacol Exp Ther 1987;241:722-727.
58. Barnes PJ. Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 1995;152:838-860.
59. Matthay MA, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis 1990;142:1250-1257.
60. Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Am J Respir Crit Care Med 1997;155:506-512.
61. Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson HG, et al. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med 2006;34:676-681.
62. + channels in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 1996;271:L1-L22.
63. - in fetal rat alveolar epithelium. J Physiol 1999; 515:669-683.
64. Blanco G, Sanchez G, Mercer RW. Differential regulation of Na,K-ATPase isozymes by protein kinases and arachidonic acid. Arch Biochem Biophys 1998;359:139-150.
65. + channel to the cell surface. J Clin Invest 2000;105:45-53.
66. Shimkets RA, Lifton R, Canessa CM. In vivo phosphorylation of the epithelial sodium channel. Proc Natl Acad Sci USA 1998;95:3301-3305.
67. + channel. J Gen Physiol 1996;108:49-65.
68. Maron MB, Folkesson HG, Stader SM, Walro JM. PKA delivery to the distal lung airspaces increases alveolar liquid clearance after isoproterenol-induced alveolar epithelial PKA desensitization. Am J Physiol Lung Cell Mol Physiol 2005;289:L349-L354.
69. Berdiev BK, Prat AG, Cantiello HF, Ausiello DA, Fuller CM, Jovov B, Benos DJ, Ismailov II. Regulation of epithelial sodium channels by short actin filaments. J Biol Chem 1996;271:17704-17710.
70. + channels. Am J Physiol Cell Physiol 2004; 287:C1569-C1576.
71. Butterworth MB, Frizzell RA, Johnson JP, Peters KW, Edinger RS. PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin. Am J Physiol Renal Physiol 2005;289:F969-F977.
72. +-ATPaSe activity by membrane insertion of α-subunits in lung alveolar cells. Am J Physiol Lung Cell Mol Physiol 1999;276:L20-L27.
73. + transport. Circ Res 2005;96:999-1005.
74. - channel in adult alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2004;287:L382-L392.
75. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC. CFTR as a cAMP-dependent regulator of sodium channels. Science 1995;269:847-850. (see comments).
76. - channel function. Nature 1999; 402:301-304.
77. Ye X, Norlin A, Folkesson HG. Stimulation of distal airspace fluid clearance in guinea pigs involves bumetanide-sensitive ion transport. Am J Obstet Gynecol 2004;191:340-345.
78. - secretion across rat fetal distal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2002;282:L650-L658.
79. 2- adrenergic receptors to type II cells increases alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol 2001;281:L895-L903.
80. 2-adrenergic receptor overexpression increases alveolar fluid clearance by upregulating solute transport proteins on both sides of the cell membrane. Am J Respir Crit Care Med 2001;163:A570.
81. 2-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circ Res 2001;89:907-914.
82. Morgan EE, Stader SM, Hodnichak CM, Mavrich KE, Folkesson HG, Maron MB. Postreceptor defects in alveolar epithelial β-adrenergic signaling after prolonged isoproterenol infusion. Am J Physiol Lung Cell Mol Physiol 2003;285:L578-L583.
83. Maron MB, Folkesson HG, Stader SM, Hodnichak CM. Impaired alveolar liquid clearance after 48 h isoproterenol infusion recovers spontaneously by 96 h of continuous infusion. Am J Physiol Lung Cell Mol Physiol 2006; (In press).
84. Norlin A, Baines DL, Folkesson HG. Role of endogenous cortisol in basal liquid clearance from distal air spaces in adult guinea-pigs. J Physiol 1999;519:261-272.
85. Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA. Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. J Appl Physiol 2000;88:416-424.
86. + channels by dexamethasone. Am J Physiol Cell Physiol 2000;279:C762-C770.
87. +-ATPase by cAMP and dexamethasone in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2001;281: L217-L230.
88. Noda M, Suzuki S, Tsubochi H, Sugita M, Maeda S, Kobayashi S, Kubo H, Kondo T. Single dexamethasone injection increases alveolar fluid clearance in adult rats. Crit Care Med 2003;31:1183-1189.
89. Folkesson HG, Pittet J-F, Nitenberg G, Matthay MA. Transforming growth factor-α increases alveolar liquid clearance in anesthetized ventilated rats. Am J Physiol Lung Cell Mol Physiol 1996;271:L236-L244.
90. Borok Z, Lubman RL, Danto SI, Zhang X-L, Zabski SM, King LS, Lee DM, Agre P, Crandall ED. Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5. Am J Respir Cell Mol Biol 1998;18:554-561.
91. Danto SI, Borok Z, Zhang X-L, Lopez MZ, Patel P, Crandall ED, Lubman RL. Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells. Am J Physiol Cell Physiol 1998; 275:C82-C92.
92. Sznajder JI, Ridge KM, Yeates DB, Ilekis J, Olivera W. Epidermal growth factor increases lung liquid clearance in rat lungs. J Appl Physiol 1998;85:1004-1010.
93. Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and β-agonist therapy. J Appl Physiol 1999;87:1852-1860.
94. Barnard ML, Olivera WG, Rutschman DM, Bertorello AM, Katz AI, Sznajder JI. Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium. Am J Respir Crit Care Med 1997;156:709-714.
95. Lecuona E, Garcia A, Sznajder JI. A novel role for protein phosphatase 2A in the dopaminergic regulation of Na,K-ATPase. FEBS Lett 2000;481:217-220.
96. Guerrero C, Lecuona E, Pesce L, Ridge KM, Sznajder JI. Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol 2001;281: L79-L85.
97. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. J Clin Invest 1997;99:325-335.
98. Börjesson A, Norlin A, Wang X, Andersson R, Folkesson HG. TNFα stimulates alveolar liquid clearance during intestinal ischemia-reperfusion in rats. Am J Physiol Lung Cell Mol Physiol 2000;278:L3-L12.
99. Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay MA. Mechanisms of TNF-α stimulation of amiloride-sensitive sodium transport across alveolar epithelium. Am J Physiol Lung Cell Mol Physiol 2001;280:L1258-L1265.
100. Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, Rossier BC. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 1997;389:607-610.
101. Gutkowska J, Nemer M, Sole MJ, Drouin J, Sirois P. Lung is an important source of atrial natriuretic factor in experimental cardiomyopathy. J Clin Invest 1989;83:1500-1504.
102. Rambotti MG, Spreca A. Ultrastructural demonstration of guanylate cyclase in rat lung after activation by ANF. Cell Mol Biol 1991;37:455-462.
103. Tharaux P-L, Dussaule J-C, Coulette S, Clerici C. Evidence for functional ANP receptors in cultured alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 1998;274:L244-L251.
104. Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA. Alveolar fluid clearance persists in the presence of moderate left atrial hypertension in sheep. J Appl Physiol 1999;86:139-151.
105. Olivera W, Ridge K, Wood LD, Sznajder JI. ANF decreases active sodium transport and increases alveolar epithelial permeability in rats. J Appl Physiol 1993;75:1581-1586.
106. Planes C, Escoubet B, Blot-Chabaud M, Friedlander G, Farman N, Clerici C. Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am J Respir Cell Mol Biol 1997;17:508-518.
107. Mairbäurl H, Mayer K, Kim K-J, Borok Z, Bärtsch P, Crandall ED. Alveolar epithelial ion and fluid transport: Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol 2002;282:L659-L665.
108. Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI. Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ. J Clin Invest 2003;111:1057-1064.
109. Vivona ML, Matthay MA, Chabaud MB, Friedlander G, Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by β-adrenergic agonist treatment. Am J Respir Cell Mol Biol 2001;25:554-561.
110. + channels in A6 cells. Am J Physiol Renal Physiol 1994;266:F506-F511.
111. Verghese GM, Ware LB, Matthay BA, Matthay MA. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. J Appl Physiol 1999;87:1301-1312.
112. Ware LB, Golden JA, Finkbeiner WE, Matthay MA. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med 1999;159:980-988.
113. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;163:1376-1383.
114. Frank JA, Wang Y, Osorio O, Matthay MA. β-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol 2000;89:1255-1265.
115. Saldías FJ, Azzam ZS, Ridge KM, Yeldandi A, Rutschman DH, Schraufnagel D, Sznajder JI. Alveolar fluid reabsorption is impaired by increased left atrial pressures in rats. Am J Physiol Lung Cell Mol Physiol 2001;281:L591-L597.
116. Brigham KL, Meyrick B. Endotoxin and lung injury. State of art. Am Rev Respir Dis 1986;133:913-927.
117. Wiener-Kronish JP, Albertine KH, Matthay MA. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest 1991;88:864-875.
118. Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA. Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. J Appl Physiol 1993;75:1661-1669.
119. Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR, Wiener-Kronish JP. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest 1999;104:743-750.
120. Su X, Robriquet L, Folkesson HG, Matthay MA. Protective effect of endogenous β-adrenoceptor tone on lung fluid balance in acute bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol 2006;290:L769-L776.
121. +-ATPase. Am J Respir Cell Mol Biol 2005;33:343-354.
122. Ware LB. Modulation of alveolar fluid clearance by acute inflammation: the plot thickens (Editorial). Am J Respir Crit Care Med 2004;169: 332-333.
123. 1 decreases expression of the epithelial sodium channel αENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem 2003;278:43939-43950.
124. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. Interleukin-1β decreases expression of the epithelial sodium channel α-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem 2005;280: 18579-18589.
125. + channels in respiratory epithelia. Proc Natl Acad Sci USA 2000;97:10282-10287.
126. Guggino WB, Guggino SE. Amiloride-sensitive sodium channels con tribute to the woes of the flu. Proc Natl Acad Sci USA 2000;97:9827-9829.
127. Chen X-J, Seth S, Yue G, Kamat P, Compans RW, Guidot D, Brown LA, Eaton DC, Jain L. Influenza virus inhibits ENaC and lung fluid clearance. Am J Physiol Lung Cell Mol Physiol 2004;287:L366-L373.
128. Hickman-Davis JM, McNicholas-Bevensee C, Davis IC, Ma H-P, Davis GC, Bosworth CA, Matalon S. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care. Med 2006;173:334-344.
129. Perkins GD, McAuley DF, Thickett DR, Gao F. The β-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 2006;173:281-287.
130. Matthay MA, Abraham E. β-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med 2006;173: 254-255.
131. McAuley DF, Matthay MA. Is there a role for β-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome? Treat Respir Med 2005;4:297-307.
132. Norlin A, Finley N, Abedinpour P, Folkesson HG. Alveolar liquid clearance in the anesthetized ventilated guinea pig. Am J Physiol Lung Cell Mol Physiol 1998;274:L235-L243.