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Volumn 13, Issue 6, 2011, Pages 369-376

Clinical implications of DNA methylation in hepatocellular carcinoma

Author keywords

Epigenetics; Hepatocellular carcinoma; Methylation

Indexed keywords

DNA;

EID: 79957580468     PISSN: 1365182X     EISSN: 14772574     Source Type: Journal    
DOI: 10.1111/j.1477-2574.2011.00303.x     Document Type: Review
Times cited : (57)

References (63)
  • 1
    • 60249083789 scopus 로고    scopus 로고
    • Evolving molecular classification by genomic and proteomic biomarkers in colorectal cancer: Potential implications for the surgical oncologist
    • Soreide K, Nedrebo BS, Knapp JC, Glomsaker TB, Soreide JA, Korner H. (2009) Evolving molecular classification by genomic and proteomic biomarkers in colorectal cancer: potential implications for the surgical oncologist. Surg Oncol 18:31-50.
    • (2009) Surg Oncol , vol.18 , pp. 31-50
    • Soreide, K.1    Nedrebo, B.S.2    Knapp, J.C.3    Glomsaker, T.B.4    Soreide, J.A.5    Korner, H.6
  • 2
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 4
    • 0031416750 scopus 로고    scopus 로고
    • Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis
    • Zingg JM, Jones PA. (1997) Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 18:869-882.
    • (1997) Carcinogenesis , vol.18 , pp. 869-882
    • Zingg, J.M.1    Jones, P.A.2
  • 8
    • 66149100139 scopus 로고    scopus 로고
    • DNA methylation inhibits p53-mediated survivin repression
    • Nabilsi NH, Broaddus RR, Loose DS. (2009) DNA methylation inhibits p53-mediated survivin repression. Oncogene 28:2046-2050.
    • (2009) Oncogene , vol.28 , pp. 2046-2050
    • Nabilsi, N.H.1    Broaddus, R.R.2    Loose, D.S.3
  • 9
    • 0031442751 scopus 로고    scopus 로고
    • Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis
    • Sun L, Hui AM, Kanai Y, Sakamoto M, Hirohashi S. (1997) Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis. Jpn J Cancer Res 88:1165-1170. (Pubitemid 28048263)
    • (1997) Japanese Journal of Cancer Research , vol.88 , Issue.12 , pp. 1165-1170
    • Sun, L.1    Hui, A.-M.2    Kanai, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 10
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 11
    • 55949083674 scopus 로고    scopus 로고
    • Age-related methylation in normal colon mucosa differs between the proximal and distal colon in patients who underwent colonoscopy
    • Horii J, Hiraoka S, Kato J, Harada K, Kuwaki K, Fujita H et al. (2008) Age-related methylation in normal colon mucosa differs between the proximal and distal colon in patients who underwent colonoscopy. Clin Biochem 41:1440-1448.
    • (2008) Clin Biochem , vol.41 , pp. 1440-1448
    • Horii, J.1    Hiraoka, S.2    Kato, J.3    Harada, K.4    Kuwaki, K.5    Fujita, H.6
  • 12
    • 0029919109 scopus 로고    scopus 로고
    • Hereditary cancer: Two hits revisited
    • Knudson AG. (1996) Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 122:135-140.
    • (1996) J Cancer Res Clin Oncol , vol.122 , pp. 135-140
    • Knudson, A.G.1
  • 13
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • DOI 10.1038/nrg1748
    • Feinberg AP, Ohlsson R, Henikoff S. (2006) The epigenetic progenitor origin of human cancer. Nat Rev Genet 7:21-33. (Pubitemid 41828945)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.1 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 14
    • 0031966161 scopus 로고    scopus 로고
    • A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
    • DOI 10.1016/S0025-5564(97)10007-4, PII S0025556497100074
    • Kopp-Schneider A, Portier C, Bannasch P. (1998) A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events. Math Biosci 148:181-204. (Pubitemid 28224431)
    • (1998) Mathematical Biosciences , vol.148 , Issue.2 , pp. 181-204
    • Kopp-Schneider, A.1    Portier, C.2    Bannasch, P.3
  • 15
    • 34047190317 scopus 로고    scopus 로고
    • Epigenetic field for cancerization
    • Ushijima T. (2007) Epigenetic field for cancerization. J Biochem Mol Biol 40:142-150.
    • (2007) J Biochem Mol Biol , vol.40 , pp. 142-150
    • Ushijima, T.1
  • 16
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on eight CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. (2000) Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on eight CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 32:970-979.
    • (2000) Hepatology , vol.32 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3    Mizokami, M.4    Ueda, R.5    Hirohashi, S.6
  • 19
    • 58449135983 scopus 로고    scopus 로고
    • Stem cells in liver regeneration, fibrosis and cancer: The good, the bad and the ugly
    • Alison MR, Islam S, Lim S. (2009) Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly. J Pathol 217:282-298.
    • (2009) J Pathol , vol.217 , pp. 282-298
    • Alison, M.R.1    Islam, S.2    Lim, S.3
  • 20
    • 77951728697 scopus 로고    scopus 로고
    • Characterization of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver
    • Lorenzini S, Bird TG, Boulter L, Bellamy C, Samuel K, Aucott R et al. (2010) Characterization of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut 59:645-654.
    • (2010) Gut , vol.59 , pp. 645-654
    • Lorenzini, S.1    Bird, T.G.2    Boulter, L.3    Bellamy, C.4    Samuel, K.5    Aucott, R.6
  • 21
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM positive hepatocellular carcinoma cells are tumor initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY et al. (2009) EpCAM positive hepatocellular carcinoma cells are tumor initiating cells with stem/progenitor cell features. Gastroenterology 136:1012-1024.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3    Forgues, M.4    Yang, W.5    Wang, H.Y.6
  • 22
    • 77955852219 scopus 로고    scopus 로고
    • Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implications
    • Marquardt JU, Factor VM, Thorgeirsson SS. (2010) Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications. J Hepatol 53:568-577.
    • (2010) J Hepatol , vol.53 , pp. 568-577
    • Marquardt, J.U.1    Factor, V.M.2    Thorgeirsson, S.S.3
  • 23
    • 77954030910 scopus 로고    scopus 로고
    • Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma
    • Lingala S, Cui YY, Chen X, Ruebner BH, Qian XF, Zern MA et al. (2010) Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma. Exp Mol Pathol 89:27-35.
    • (2010) Exp Mol Pathol , vol.89 , pp. 27-35
    • Lingala, S.1    Cui, Y.Y.2    Chen, X.3    Ruebner, B.H.4    Qian, X.F.5    Zern, M.A.6
  • 24
    • 77957327502 scopus 로고    scopus 로고
    • Transgelin promotes migration and invasion of cancer stem cells
    • Lee EK, Han GY, Park HW, Song YJ, Kim CW. (2010) Transgelin promotes migration and invasion of cancer stem cells. J Proteome Res 9:5108-5117.
    • (2010) J Proteome Res , vol.9 , pp. 5108-5117
    • Lee, E.K.1    Han, G.Y.2    Park, H.W.3    Song, Y.J.4    Kim, C.W.5
  • 25
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller M, Corn PG, Baylin SB, Herman JG. (2001) A gene hypermethylation profile of human cancer. Cancer Res 61:3225-3229. (Pubitemid 32695003)
    • (2001) Cancer Research , vol.61 , Issue.8 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3    Herman, J.G.4
  • 26
    • 0038339107 scopus 로고    scopus 로고
    • Age-related methylation of tumor suppressor and tumor-related genes: An analysis of autopsy samples
    • DOI 10.1038/sj.onc.1206651
    • Waki T, Tamura G, Sato M, Motoyama T. (2003) Age-related methylation of tumour suppressor and tumour-related genes: an analysis of autopsy samples. Oncogene 22:4128-4133. (Pubitemid 36819653)
    • (2003) Oncogene , vol.22 , Issue.26 , pp. 4128-4133
    • Waki, T.1    Tamura, G.2    Sato, M.3    Motoyama, T.4
  • 27
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • DOI 10.1038/nrc1934, PII NRC1934
    • Farazi PA, DePinho RA. (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6:674-687. (Pubitemid 44286000)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 28
    • 27744483159 scopus 로고    scopus 로고
    • Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells
    • DOI 10.1159/000089288
    • Maeta Y, Shiota G, Okano J, Murawaki Y. (2005) Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells. Tumour Biol 26:300-305. (Pubitemid 41619460)
    • (2005) Tumor Biology , vol.26 , Issue.6 , pp. 300-305
    • Maeta, Y.1    Shiota, G.2    Okano, J.-I.3    Murawaki, Y.4
  • 31
    • 0037455979 scopus 로고    scopus 로고
    • P16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis
    • DOI 10.1016/S0304-3835(02)00613-4
    • Shim YH, Yoon GS, Choi HJ, Chung YH, Yu E. (2003) p16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis. Cancer Lett 190:213-219. (Pubitemid 36136020)
    • (2003) Cancer Letters , vol.190 , Issue.2 , pp. 213-219
    • Shim, Y.-H.1    Yoon, G.-S.2    Choi, H.-J.3    Chung, Y.H.4    Yu, E.5
  • 32
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • DOI 10.1002/hep.22110
    • Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. (2008) Aberrant methylation of multiple tumour suppressor genes in ageing liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 47: 908-918. (Pubitemid 351449682)
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 908-918
    • Nishida, N.1    Nagasaka, T.2    Nishimura, T.3    Ikai, I.4    Boland, C.R.5    Goel, A.6
  • 33
    • 0032924622 scopus 로고    scopus 로고
    • P16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
    • DOI 10.1016/S0016-5085(99)70137-X
    • Matsuda Y, Ichida T, Matsuzawa J, Sugimura K, Asakura H. (1999) p16(INK4A) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 116:394-400. (Pubitemid 29055363)
    • (1999) Gastroenterology , vol.116 , Issue.2 , pp. 394-400
    • Matsuda, Y.1    Ichida, T.2    Matsuzawa, J.3    Sugimura, K.4    Asakura, H.5
  • 35
    • 0033818628 scopus 로고    scopus 로고
    • Frequent p15 promoter methylation in tumour and peripheral blood from hepatocellular carcinoma patients
    • Wong IH, Lo YM, Yeo W, Lau WY, Johnson PJ. (2000) Frequent p15 promoter methylation in tumour and peripheral blood from hepatocellular carcinoma patients. Clin Cancer Res 6:3516-3521.
    • (2000) Clin Cancer Res , vol.6 , pp. 3516-3521
    • Wong, I.H.1    Lo, Y.M.2    Yeo, W.3    Lau, W.Y.4    Johnson, P.J.5
  • 36
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • DOI 10.1038/88225
    • Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE et al. (2001) SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 28:29-35. (Pubitemid 32405812)
    • (2001) Nature Genetics , vol.28 , Issue.1 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.-S.3    Jackson, P.4    Groopman, J.D.5    Manning, J.E.6    Harris, C.C.7    Herman, J.G.8
  • 37
    • 0035890771 scopus 로고    scopus 로고
    • Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily
    • Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S. (2001) Hypermethylation in human cancers of the RIZ1 tumour suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res 61:8094-8099. (Pubitemid 33091596)
    • (2001) Cancer Research , vol.61 , Issue.22 , pp. 8094-8099
    • Du, Y.1    Carling, T.2    Fang, W.3    Piao, Z.4    Sheu, J.-C.5    Huang, S.6
  • 38
    • 77949877704 scopus 로고    scopus 로고
    • High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma
    • Archer KJ, Mas VR, Maluf DG, Fisher RA. (2010) High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma. Mol Genet Genomics 283:341-349.
    • (2010) Mol Genet Genomics , vol.283 , pp. 341-349
    • Archer, K.J.1    Mas, V.R.2    Maluf, D.G.3    Fisher, R.A.4
  • 40
    • 39749198581 scopus 로고    scopus 로고
    • Epigenetic Inhibition of Nuclear Receptor Small Heterodimer Partner Is Associated with and Regulates Hepatocellular Carcinoma Growth
    • DOI 10.1053/j.gastro.2008.01.006, PII S0016508508000334
    • He N, Park K, Zhang Y, Huang J, Lu S, Wang L. (2008) Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. Gastroenterology 134:793-802. (Pubitemid 351312736)
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 793-802
    • He, N.1    Park, K.2    Zhang, Y.3    Huang, J.4    Lu, S.5    Wang, L.6
  • 41
    • 77954663598 scopus 로고    scopus 로고
    • DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC)
    • Arasaradnam RP, Khoo KT, Bradburn M, Mathers JC, Kelly SB. (2010) DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC). Epigenetics 5:422-426.
    • (2010) Epigenetics , vol.5 , pp. 422-426
    • Arasaradnam, R.P.1    Khoo, K.T.2    Bradburn, M.3    Mathers, J.C.4    Kelly, S.B.5
  • 42
    • 66249114998 scopus 로고    scopus 로고
    • A multicentre, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's oesophagus
    • Jin Z, Cheng Y, Gu W, Zheng Y, Sato F, Mori Y et al. (2009) A multicentre, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's oesophagus. Cancer Res 69:4112-4115.
    • (2009) Cancer Res , vol.69 , pp. 4112-4115
    • Jin, Z.1    Cheng, Y.2    Gu, W.3    Zheng, Y.4    Sato, F.5    Mori, Y.6
  • 44
    • 35148873511 scopus 로고    scopus 로고
    • Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B
    • Liu H, Zhou Y, Boggs SE, Belinsky SA, Liu J. (2007) Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B. Oncogene 26:5900-5910.
    • (2007) Oncogene , vol.26 , pp. 5900-5910
    • Liu, H.1    Zhou, Y.2    Boggs, S.E.3    Belinsky, S.A.4    Liu, J.5
  • 45
    • 68949217876 scopus 로고    scopus 로고
    • Potential of DNMT and its epigenetic regulation for lung cancer therapy
    • Tang M, Xu W, Wang Q, Xiao W, Xu R. (2009) Potential of DNMT and its epigenetic regulation for lung cancer therapy. Curr Genomics 10:336-352.
    • (2009) Curr Genomics , vol.10 , pp. 336-352
    • Tang, M.1    Xu, W.2    Wang, Q.3    Xiao, W.4    Xu, R.5
  • 46
    • 74749090903 scopus 로고    scopus 로고
    • Correlation of CpG island methylator phenotype with poor prognosis in hepatocellular carcinoma
    • Cheng Y, Zhang C, Zhao J, Wang C, Xu Y, Han Z et al. (2010) Correlation of CpG island methylator phenotype with poor prognosis in hepatocellular carcinoma. Exp Mol Pathol 88:112-117.
    • (2010) Exp Mol Pathol , vol.88 , pp. 112-117
    • Cheng, Y.1    Zhang, C.2    Zhao, J.3    Wang, C.4    Xu, Y.5    Han, Z.6
  • 47
    • 77950299830 scopus 로고    scopus 로고
    • Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer
    • Sakamoto J, Fujiya M, Okamoto K, Nata T, Inaba Y, Moriichi K et al. (2010) Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer. Cancer Epidemiol 34:194-199.
    • (2010) Cancer Epidemiol , vol.34 , pp. 194-199
    • Sakamoto, J.1    Fujiya, M.2    Okamoto, K.3    Nata, T.4    Inaba, Y.5    Moriichi, K.6
  • 48
    • 66349102768 scopus 로고    scopus 로고
    • Methylation of TFPI2 in stool DNA: A potential novel biomarker for the detection of colorectal cancer
    • Glockner SC, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J et al. (2009) Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer. Cancer Res 69:4691-4699.
    • (2009) Cancer Res , vol.69 , pp. 4691-4699
    • Glockner, S.C.1    Dhir, M.2    Yi, J.M.3    McGarvey, K.E.4    Van Neste, L.5    Louwagie, J.6
  • 49
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • Ehrlich M. (2002) DNA methylation in cancer: too much, but also too little. Oncogene 21:5400-5413.
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 50
    • 58149330690 scopus 로고    scopus 로고
    • Methylation of Tip30 promoter is associated with poor prognosis in human hepatocellular carcinoma
    • Lu B, Ma Y, Wu G, Tong X, Guo H, Liang A et al. (2008) Methylation of Tip30 promoter is associated with poor prognosis in human hepatocellular carcinoma. Clin Cancer Res 14:7405-7412.
    • (2008) Clin Cancer Res , vol.14 , pp. 7405-7412
    • Lu, B.1    Ma, Y.2    Wu, G.3    Tong, X.4    Guo, H.5    Liang, A.6
  • 52
    • 33745922882 scopus 로고    scopus 로고
    • TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU
    • DOI 10.1002/hep.21213
    • Zhao J, Zhang X, Shi M, Xu H, Jin J, Ni H et al. (2006) TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU. Hepatology 44:205-215. (Pubitemid 44049153)
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 205-215
    • Zhao, J.1    Zhang, X.2    Shi, M.3    Xu, H.4    Jin, J.5    Ni, H.6    Yang, S.7    Dai, J.8    Wu, M.9    Guo, Y.10
  • 54
    • 0033737604 scopus 로고    scopus 로고
    • Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumours
    • Zheng S, Chen P, McMillan A, Lafuente A, Lafuente MJ, Ballesta A et al. (2000) Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumours. Carcinogenesis 21:2057-2064.
    • (2000) Carcinogenesis , vol.21 , pp. 2057-2064
    • Zheng, S.1    Chen, P.2    McMillan, A.3    Lafuente, A.4    Lafuente, M.J.5    Ballesta, A.6
  • 55
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1in human cancers
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC et al. (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1in human cancers. Nat Med 1:686-692.
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6
  • 57
    • 77149160616 scopus 로고    scopus 로고
    • Race, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United States
    • Artinyan A, Mailey B, Sanchez-Luege N, Khalili J, Sun CL, Bhatia S et al. (2010) Race, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United States. Cancer 116:1367-1377.
    • (2010) Cancer , vol.116 , pp. 1367-1377
    • Artinyan, A.1    Mailey, B.2    Sanchez-Luege, N.3    Khalili, J.4    Sun, C.L.5    Bhatia, S.6
  • 58
    • 68749097208 scopus 로고    scopus 로고
    • MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer
    • Ng EK, Tsang WP, Ng SS, Jin HC, Yu J, Li JJ et al. (2009) MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br J Cancer 101:699-706.
    • (2009) Br J Cancer , vol.101 , pp. 699-706
    • Ng, E.K.1    Tsang, W.P.2    Ng, S.S.3    Jin, H.C.4    Yu, J.5    Li, J.J.6
  • 59
    • 0037598752 scopus 로고    scopus 로고
    • Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
    • DOI 10.1002/ijc.11127
    • Saito Y, Kanai Y, Nakagawa T, Sakamoto M, Saito H, Ishii H et al. (2003) Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer 105:527-532. (Pubitemid 36578558)
    • (2003) International Journal of Cancer , vol.105 , Issue.4 , pp. 527-532
    • Saito, Y.1    Kanai, Y.2    Nakagawa, T.3    Sakamoto, M.4    Saito, H.5    Ishi, H.6    Hirohashi, S.7
  • 60
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • DOI 10.1002/hep.20933
    • Bruix J, Sherman M. (2005) Management of hepatocellular carcinoma. Hepatology 42:1208-1236. (Pubitemid 43112690)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 63
    • 48549101423 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) in cancer: Causes and implications
    • Teodoridis JM, Hardie C, Brown R. (2008) CpG island methylator phenotype (CIMP) in cancer: causes and implications. Cancer Lett 268: 177-186.
    • (2008) Cancer Lett , vol.268 , pp. 177-186
    • Teodoridis, J.M.1    Hardie, C.2    Brown, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.