Serotonin

Periodicum Biologorum

Volumn 113, Issue 1, 2011, Pages 29-41

  Mück Šeler, Dorotea ^a   Pivac, Nela ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); GENE PRODUCT; NEUROTRANSMITTER; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 2;

ALCOHOLISM; ALZHEIMER DISEASE; APPETITE; ARTICLE; ATTENTION DEFICIT DISORDER; AUTOPSY; BEHAVIOR; BLOOD BRAIN BARRIER; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; COGNITION; DEPRESSION; DISEASE ASSOCIATION; DNA POLYMORPHISM; DNA SEQUENCE; ENTEROCHROMAFFIN CELL; EPILEPSY; GASTROINTESTINAL TRACT; GENE LOCUS; GENETIC ASSOCIATION; HOMEOSTASIS; HORMONE SYNTHESIS; HUMAN; HYDROXYLATION; IMPULSIVENESS; IN VIVO STUDY; INTRON; LEARNING; MEMORY; MIGRAINE; NEUROPSYCHIATRY; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; SCHIZOPHRENIA; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; SEXUALITY; SLEEP; THROMBOCYTE; VOMITING;

ANIMALIA;

EID: 79957538833     PISSN: 00315362     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (133)

1. ERSPAMER V, ASERO B 1952 Identification of enteramine, specific hormone of enterochromaffine cell, as 5-hydroxytryptamine. Nature 169: 800-801
2. MARC D J, AILTS J W, AILTS CAMPEAU D C, BULL M J, OLSON K L 2010 Neurotransmitters excreted in the urine as biomarkers of nervous system activity: Validity and clinical applicability. Neurosci Biobehav Rev doi:10.1016/j.neurobiorev.2010.07.007
3. SAVELIEVA K V, ZHAO S, POGORELOV VM, RAJAN I, YANG Q, CULLINAN E, THOMAS H, LANTHORN TH 2008 Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behaviour in models sensitive to antidepressants. PLoSONE3(10): e3301, doi:10.1371/journal.pone.0003301
4. Q, Q, SUN W, P,W, X-Q, Z,YUW, B, R, V, M, E, R, E, PLATT, K, A, D, A, B, Z-C 2008 Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J Pharmacol Exp Therapy 325: 47-55
5. HOYER D, HANNON J P, MARTIN G R 2002 Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71: 533-554
6. JACOBS B L, AZMITIA E C 1992 Structure and function of the brain serotonin system. Physiol Review 72: 165-229
7. D'SOUZA UM, CRAIG IW 2006 Functional polymorphisms in dopamine and serotonin pathway genes. Human Mutation 27: 1-13
8. LUCKI I 1998 The spectrum of behaviours influenced by serotonin. Biol Psychiatry 44: 151-162
9. RICCIO D, POTTER G, WALZER C, VALLET P, SZABO G, VUTSKITS L, KISS J Z, DAYER A G 2009 Express of serotonin affects embryonic of the serotonin receptor 6. Mol Psychiatry 14: 280-290
10. DIKSIC M, NAGAHIRO S, SOURKES T L, YAMAMOTO Y L 1990 A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J Cereb Blood Flow Metab 10: 1-12
11. WATTS S W 2005 5-HT in systemic hypertenstion: Foe, friend or fantasy. Clin Chem 108: 399-412
12. STAHL S M 1985 Platelets as pharmacological models for the receptors and biochemistry of monoaminergic neurons. In: Longenecker G L (ed) Platelets: Physiology and Pharmacology., Academic Press, New York, p 307-340
13. ANDRES A H, RAO M A, OSTROWITZKI S, ENZIAN W 1993 Human brain cortex and platelet serotonin2 receptor binding properties and their regulation by endogenous serotonin. Life Sci 52: 313-321
14. MENDELSON SC 2000 The current status of the platelet 5-HT2A receptor in depression. J Affect Disord 57: 13-24
15. PILETZ J E, SCUBERT D S P, HALARIS A 1986 Evaluation of studies on platelet alpha2-adrenoreceptors in depressive illness. Life Sci 39: 1589-1616
16. MUCK-SELER D, PIVAC N, MUSTAPIC ́ M, CRNČEVIĆ Ž, JAKOVLJEVIC ́ M, ŠAGUD M 2004 Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women. Psychiatry Res 127: 217-226
17. MUCK-SELER, D, JAKOVLJEVIC M, PIVAC N 1996 Platelet 5-HT concentrations and suicidal behaviour in recurrent major depression. J Affect Disord 39: 73-80
18. SAGUD M, PIVAC N, MUSTAPIC M, NEDIC G, MIHALJEVIC-PELES A, KRAMARIC M, JAKOVLJEVIC M, MUCK-SELER D 2008 The influence of lamotrigine on platelet serotonin concentration in patients with bipolar depression. Psychopharmacology 197: 683-685
19. MUCK-SELER D, JAKOVLJEVIC M, DEANOVIC Z 1991 Platelet serotonin in subtypes of schizophrenia and unipolar depression. Psychiatry Res 38: 105-113
20. MUCK-SELER D, PIVAC N, JAKOVLJEVIC M 1999 Sex differences, season of birth and platelet 5-HT levels in schizophrenic patients. J Neural Transm 106: 337-347
21. MUCK-SELER D, PIVAC N, JAKOVLJEVIĆ M, BRZOVIĆ Z 1999 Platelet 5-HT, plasma cortisol and dexamethasone suppression test in schizophrenic patients. Biol Psychiatry 45: 1433-1439
22. MAURER-SPUREJ E, PITTENDREIGH C, MISRI S 2006 Platelet serotonin levels support depression scores for women with postpartum depression. J Psychiatry Neurosci 32: 23-29
23. MUCK-SELER D, PIVAC N, JAKOVLJEVIĆ M, ŠAGUD M, MIHALJEVIĆ-PELEŠ A 2003 Platelet 5-HT concentration and comorbid depression in war veterans with or without posttraumatic stress disorder. J Affect Disord 75: 171-179
24. PIVAC N, KOZARIC-KOVACIC D, MUSTAPIC M, DEZELJIN M, BOROVECKI A, GRUBISIC-ILIC M, MUCK-SELER D 2006 Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms. J Affect Disord 93: 223-227
25. MUCK-ŠELER D, MUSTAPIC M, NENADIC-ŠVIGLIN K, KOZARIC-KOVACIC D 2004 Platelet serotonin concentration in alcoholic subjects. Life Sci 76: 521-531
26. HERCIGONJA-NOVKOVIC V, RUDAN V, PIVAC N, NEDIC G, MUCK-SELER D 2009 Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder. Neuropsychobiology 59: 17-22
27. MUCK-SELER D, DEANOVIC Z, DUPELJ M 1979 Platelet serotonin (5-HT) releasing factor in plasma of migrainous patients. Headache 19: 14-17
28. KUMAR A M, SEVUSH S, KUMAR M, RUIZ J, EISDORFER C 1995 Peripheral serotonin in Alzheimer's disease. Neuropsychobiology 32: 9-12
29. MUCK-SELER D, PRESECKI P, MIMICA N, MUSTAPIC M, PIVAC N, BABIC A, NEDIC G, FOLNEGOVIC SMALC V 2009 Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer's disease. Progr Neuro-Psychopharmacol Biol Psychiatry 33: 1226-1231
30. NESTLER E J, BARROT M, DILEONE R J, EISCH A J, GOLD S J, MONTEGGIA L M 2002 Neuro Depression Rev Neuron 34: 13-25
31. COPPEN A 1967 The biochemistry of affective disorders. Br J Psychiatry 113: 1237-1264
32. ASBERG M, TRASKMAN L, THOREN P 1976 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33: 1193-1197
33. PLACIDI GP, OQUENDO MA, MALONE KM, HUANG YY, ELLIS SP, MANN JJ 2001 Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels. Biol Psychiatry 50: 783-791
34. BARTON D A, ESLER M D, DAWOOD T, LAMBERT E A, HAIKERWA LD, BRENCHLEY C, SOCRATOUS F, HASTINGS J, GUO L, WIESNER G, KAYE DM, BAYLES R, SCHLAICHM P, LAMBER GW 2008 Elevated brain serotonin turnover in patients with depression effect of genotype and therapy. Arch Gen Psychiatry 65: 38-46
35. OXENKRUG G F 1979 The content and uptake of 5-HT by blood platelets in depressive patients. J Neural Transm 45: 285-289
36. MANN J J, McBRIDGE P A, ANDERSON G M, MIECZKOWSKI T A 1992 Platelet and whole blood serotonin content in depressed inpatinets: correltions with acute and life-time psychopathology. Biol Psychiatry 32: 243-257
37. SHELINE Y I, BARDGETT ME, JACKON J L, NEWCOMER J W, CSERNANSKY JG 1995 Platelet serotonin markers and depressive symptomatology. Biol Psychiatry 37: 442-447
38. TAMMINGA C A, NEMEROFF C B, BLAKELY R D, BRADY L, CARTER C S, DAVIS K L, DINGLEDINE R, GORMAN J M, GRIGORIADIS D E, HENDERSON D C, INNIS R B, KILLEN J, LAUGHREN T P, MCDONALD W M, MURPHY G M JR, PAUL SM, RUDORFER MV, SAUSVILLE E, SCHATZBERG A F, SCOLNICK EM, SUPPEST2002 Developing novel treatments for mood disorders: accelerating discovery. Biol Psychiatry 52: 589-609
39. ABI-DARGHAM A, LARUELLE M, AGHAJANIAN GK, CHARNEY D, KRYSTAL J 1997 The role of serotonin in the pathophysiology and treatment of schizophrenia. J Neuropsychiat Clin Neurosci 9: 1-17
40. WONGAH C, VAN TOL H H M 2003 Schizophrenia: from phenomenology to neurobiology. Neurosci BiobehavlReviews 27: 269-306
41. MUCK-SELER D, JAKOVLJEVIC M, DEANOVIC Z 1988 Time course of schizophrenia and platelet 5-HT level. Biol Psychiatry 23: 243-251
42. PIVAC N, MUCK-SELER D, JAKOVLJEVIĆ M 1997 Platelet 5-HT levels and hypothalamic-pituitary-adrenal axis activity in schizophrenic patients with positive and negative symptoms. Neuropsychobiology 36: 19-21
43. DELISI L E, NECKERS LM, WEINBERGER D R, WYATT R J 1981 Increased whole blood serotonin concentrations in chronic schizophrenic patients. Arch Gen Psychiatry 38: 647-650
44. FINK G 2011 Stress controversies: Post-traumatic stress disorder, hippocampal volume, gastroduodenal ulceration. J Neuroendocrinol 23: 107-117
45. HEIM C, NEMEROFF C B 2009 Neurobiology of posttraumatic stress disorder. CNS Spectrums 14 (Suppl. 1): 13-24
46. GOVEAS J S, CSERNANSKY J G, COCCARO E F 2004 Platelet serotonin content correlates inversely with life history of aggression in personality-disordered subjects. Psychiatry Res 126: 23-32
47. BONNE O, BAIN E, NEUMEISTER A, NUGENT A C, VYTHILINGAM M, CARSONR E, LUCKDNBAUGH DA, ECKELMAN W, HERSCOCITCH P, DREVETS W C, CHARNEY DS 2005 No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder. Am J Psychiatry 162: 383-385
48. MELLMAN TA, KUMARA M 1994 Platelet serotonin measures in posttraumatic stress disorder. Psychiatry Res 53: 99-101
49. JOHNSON B A 2004 Role of the serotonergic system in the neurobiology of alcoholism - Implications for treatment. CNS Drugs 18: 1105-1118
50. CHEN H-T, CASANOVA MF, KLEINMAN JE, ZITO M, GOLDMAN D, LINNOILA M 1991 3H-Paroxetine binding in brains of alcoholics. Psychiat Research 38: 293-299
51. STORVIK M, TIIHONEN J, HAUKIJÄRVI T, TUPALA E 2006 Lower serotonin ransporter binding in caudate in alcoholics. Synapse 144-151
52. DILLON K A, GROSS-ISSEROFF R, ISRAELI M, BIEGON A 1991 Autoradiographic analysis of serotonin 5-HT1A receptor binding in the human brain post mortem: effects of age and alcohol. Brain Res 554: 56-64
53. HEINZ A, MANN K, WEINBERGER D R, GOLDMAN D 2001 Serotonergic dysfunction, negative mood states, and response to alcohol. Alcohol: Clini Exp Res 25: 487-495
54. FILS-AIME ML, ECKARDT MJ, GEORGE DT, BEOWN DL, MEFFORD I, LINNOILA M 1996 Early onset alcoholics have lower cerebrospinal fluid 5HIAA levels than late onset alcoholics. Arch Gen Psychiatry 53: 211-216
55. BALLENGER J, GOODWIN F, MAJOR L 1979 Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry 36: 224-227
56. VIRKKUNEN M, GOLDMAN D, NIELSEN DA, LINNOILA M 1995 Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence. J Psychiatry Neurosci 20: 271-275
57. KENT TA, CAMPBELL J L, PAZDERNIK T L, HUNTER R, GUNN WH, GOODWIN DW 1985 Blood platelet uptake of serotonin in men alcoholics. J Stud Alcohol 46: 357-359
58. FARAJ B A, OLKOWSKI L, JACKSON R T 1997 Prevalence of high serotonin uptake in lymphocytes of abstinent alcoholics. Biochem Pharmacol 53: 53-57
59. JAVORS M, TIOURIRINE M, PRIHODA T 2000 Platelet serotonin uptake is higher in early-onset than in late-onset alcoholics. Alcohol Alcoholism 35: 390-393
60. KOZARIC-KOVACIC D, MUSTAPIC M, DEZELJIN M, NENADIC-SVIGLIN K, MUCK-SELER D 2008 Peripheral biological markers in alcoholism, In: Pivac N (ed). Nova Science Publishers, New York, p 1-93
61. KRYSTAL J H, WEBB E, COONEY N L, KRANZLER H R, CHARNEY D S 1994 Specificity of ethanol-like effects elicited by serotonergic and noradrenergic mechanisms. Arch Gen Psychiatry 51: 898-911
62. BIEDERMAN J 2005 Attention-Deficit/Hyperactivity Disorder: A Selective Overview. Biol Psychiatry 57: 1215-1220
63. OADES R D 2002 Dopamine may be »hyper« with respect to noradrenaline metabolism, but »hypo« with respect to serotonin metabolism in children with attention deficit hyperactivity disorder. Behav Brain Res 130: 97-102
64. COMINGS DE 1993 Serotonin and the biochemical genetics of alcoholism: lessons from studies of attention deficit hyperactivity disorder (ADHD) and Tourette syndrome.: 237-241
65. MANUCK S B, FLORY JD, MCCAFFERY JM, MATTHEWS K A, MANN J J, MULDOON M F 1998 Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. 19: 287-299
66. FLORY J D, NEWCORN J H, MILLER C, HARTY S, HALPERIN J M 2007 Serotonergic function in children with attention-deficit hyperactivity disorder: Relationship to later antisocial personality disorder. Br J Psychiatry 190: 410-414
67. HALPERIN J M, SHARMA V, SIEVER L J, SCHWARTZ S T, MATIER K, WORNELL G, NEWCORN J H 1994 Serotonergic function in aggressive and nonaggressive boys with attention-deficit hyperactivity disorder. Am J Psychiatry 151: 243-248
68. KEPE V, BARRIO J R, HUANG, S-C, ERCOLI L, SIDDARTH P, SHOGHI-JADID K, COLE G M, SATYAMURTHY N, CUMMINGS J L, SMALL GW, PHELPS ME 2006 Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Nat. Acad Sci USA 103: 702-707
69. BLIN J, BARON J C, DUBOIS B, CROUZE L C, FIORELLI M, ATTAR-LEVY D, PILLON B, FOURNIER D, VIDALHET M, AGID Y 1993 Loss of brain 5-HT2 receptors in Alzheimer's disease. Brain 116: 497-510
70. PRITCHARD A L, HARRIS J, PRITCHARD C W, COATES J, HAQUE S, HOLDER R, BENTHAM P, LENDON CL 2008 Role of 5-HT2A and 5-HT2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease. Neurobiol Aging 29: 341-347
71. TOHGI H, ABE T, TAKAHASHI S, KIMURA M, TAKAHASHI J, KIKUCHI T 1992 Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia. Neurosci Lett 141: 9-12
72. M, GIL-BEA F, DIEZ-ARIZA M, CHEN-CPL H, FRANCIS P T, LASHERAS B, RAMIREZ M J 2005 Cholinergic-serotonergic imbalance contributes to cognitive and behavioural symptoms in Alzheimer's disease. Neuropsychologia 43: 442-449
73. WIDNER B, LEBLHUBER F, WALLI J, TILZ G P, DEMEL U, FUCHS D 2000 Tryptophan degradation and immune activator in Alzheimer's disease. J Neural Transm 107: 343-353
74. FEKKES D, VAN DER CAMMON TJM, VAN LOON CMP, VERSCHOOR C, VAN HARSKAMP F, DE KONING I, SCHUDELWJ, PEPPLINKHUIZEN L 1998 Abnormal amino acid metabolism in patients with early stage Alzheimer dementia. J Neural Transm 105: 287-294
75. FONTEH A N, HARRINGTON R J, TSAI A, LIAO P, HARRINGTON MG 2007 Free amino acid and peptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids 32: 213-224
76. RUDDICK J P, EVANS A K, NUTT D J, LIGHTMAN S L, ROOK G A W, LOWRY C A 2006 Tryptophan metabolism in the central nervous system: medical implications. Expert Rev Mol Med 8: 1-27
77. PARK S B, COULL J T, MCSHANE R H, YOUNG A H, SAHAKIAN B J, ROBBINS T W, COWEN P J, 1994 Tryptophan depletion in normal volunteers produces selective impairments in learning and memory. Neuropharmacology 33: 575-588
78. NEWHOUSE P, TATRO A, NAYLOR M, QUEALEY K, DELGADO P 2002 Alzheimer's disease, serotonin systems and tryptophan depletion. Am. J. Geriatr Psychiatry 10: 483-484
79. GOTTFRIES C G 1990 Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia. J Neural Transm 30(Suppl): 33-43
80. CASH C D 1998 Why tryptophan hydroxylase is difficult to purify: A reactive oxygen-derived species-mediated phenomenon that may be implicated in human pathology. Gen Pharmacol 30: 569-574
81. ARORA R C, EMERY OB, MELTZER HY 1991 Serotonin uptake in the blood platelets of Alzheimer's disease patients. Neurology 41: 1307-1309
82. WALTHER D J, BADER M 2003 A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 66: 1673-1680
83. ZHANG X, GAINETDINOV R R, BEAULIEU J M, SOTNIKOVA T D, BURCH L H, WILLIAMS R B, SCHWARTZ D A, RANGA K, KRISHNAN R, CARON MG 2005 Loss-of-Function mutation in meport tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45: 11-16
84. DELORME R, DURAND C M, BETANCUR C, WAGNER M, RUHRMANN S, GRABE H-J, NYGREN G, GILLBERG C, LEBOYER M, BOURGERON T, COURTET P JOLLANT F, BURESI C, AUBRY J-M, BAUD P, BONDOLFI G, BERTSCHY G, PERROUD N, MALAFOSSE A 2006 No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. Biol Psychiatry 60: 202-203
85. XUE K X, FAN C H, LI X L 2009 No association between tryptophan hydroxylase-2 gene G1463A polymorphism and unipolar depression in a Southern Chinese Han population. Hong Kong J Psychiatry 1: 1-5
86. CAMPOS S B, MARQUES MIRANDA D, SOUZA B R, FERNANDO SILVA NEVES P A P, BICALHO M A C, CASADEI MELILLO PH, TRAMONTINA J, KAPCZINSKI F, ROMANO-SILVA MA, CORREA H 2010 Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behaviour. J Psychiat Res 44: 271-274
87. CHOI K-Y, YOON H-K, KIM Y-K 2010 Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population. Psychiat Invest 7: 60-67
88. JOHANSSON S, HALMØY A, MAVROCONSTANTI T, JACOBSEN K K, ELISABETH T, LANDAAS K K, REIF A, JACOB C, BOREATTI-HÜMMER A, KREIKER S, LESCHK L, KANC C, SANDRA-KOOIJ S J J, KIEMENEY L A, BUITELAAR J K, FRANKE B, RIBASÉS M, BOSCH R, BAYÉS M, CASAS M,RAMOS-QUIROGA J A, CORMAND B, KNAPPSKOG P, HAAVIK J 2010 Common variants in the TPH1 and TPH2 regions are not associated with persistentADHDin a combined sample of 1,636adult cases and 1,923 controls from four European populations.AmJ Mol Genetics Part B: Neuropsychiatric Genetics DOI: 10.1002/ajmg.b.31067.
89. CLONINGER C R, SVRAKIC D M, PRZYBECK T R 1993 A psychobiological model of temperament and character. Arch Gen Psychiatry 50: 975-990
90. LESCHK P, GUTKNECHT L 2005 Pharmacogenetics of the serotonin transporter. Progr Neuro-Psychopharmacol Biol Psychiatry 29: 1062-1073
91. SCHLOSS P, WILLIAMS D C 1998 The serotonin transporter: a primary target for antidepressant drugs. J Psychopharmacol 12: 15-21
92. LESCH KP, MOSSNER R 1998 Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry 44: 179-192
93. NAKAMURA M, UENO S, SANO A, TANABE H 2000 The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 5: 32-38
94. GREENBERG B D, TOLLIVER T J, HUANG S J, LI Q, BENGEL D, MURPHY D L 1999 Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genetics 88: 83-87
95. PEZAWAS L, MEYER-LINDENBERG A, DRABANT EM, VERCHINSKI B A, MUNOZ K E, KOLACHANA B S, EGAN M F, MATTAY V S, HARIRI A R, WEINBERGER D 2005 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 8: 828-834
96. LESCH KP, BALLING U, GROSS J, STRAUSS K, WOLOZINB L, MURPHY D L, RIEDERER P 1994 Organization of the human serotonin transporter gene. J Neural Transm 95: 157-162
97. MACKENZIE A, QUINN J P 1999 A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele dependent differential enhancer-like properties in the mouse embryo. Proc Nat Acad Sci USA 96: 15251-15255
98. FISKERSTRAND C E, LOVEJOY E A, QUINN J P 1999 An intronic polymorphic domain often associated with susceptibility toaffective disorders has allele dependent enhancer activity in embryonic stem cells. FEBS Letters 458: 171-174
99. LEVINSON D F 2006 The genetics of depression: A review. Biol Psychiatry 60: 84-92
100. COOK E H, COURCHESNE R, LORD C, COX N J, YAN S, LINCOLN A, HAAS R, COURCHESNE E, LEVENTHAL B L 1997 Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiary 2: 247-250
101. MENDLEWICZ J, MASSAT I, SOUERY D, DEL-FAVERO J, ORUC L, NOTHEN M M, BLACKWOOD D, MUIR W, BATTERSBY S, LERER B, SEGMAN R H, KANEVA R, SERRETTI A, LILLI R, LORENZI C, JAKOVLJEVIC M, IVEZIC S, RIETSCHEL M, MILANOVA V, VANBROECKHOVEN C 2004 Serotonin transporter 5-HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. EurJ Hum Genetics 12: 377-382
102. CASPI A, SUGDEN K, MOFFITT TE, TAYLOR AW, CRAIG I, HARRINGTON L, MCCLAY J, MILL J, MARTIN J, BRAITHWAITE A,POULTONR 2003 Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301: 386-389
103. RISCH N, HERRELL R, LEHNER T, LIANG K Y, EAVES L, HOH J, GRIEM A, KOVACS M, OTT J, RIES MERIKANGAS K 2009 Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression. A Meta-analysis. J Am Med Association 301: 2462-2471
104. NOSKOVA T, PIVAC N, NEDIC G, KAZANTSEVA A, GAYSINA D, FASKHUTDINOVA G, GAREEVA A, KHALILOVA Z, KHUSNUTDINOVA E, KOZARIC KOVACIC D, KOVACIC Z, JOKIC M, MUCK SELER D 2008 Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations. Prog Neuro-Psychopharmacol Biol Psychiatry 32: 1735-1739
105. SERRETTI A, CALATI R, MANDELLI L, DE RONCHI D 2006 Serotonin transporter gene variants and behavior: A comprehensive review. Curr Drug Targ 7:1659-1669
106. GREENBERG B D, TOLLIVER T J, HUANG S J, LI Q, BENGEL D, MURPHY D L 1999 Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88: 83-87
107. PIVAC N, NEDIĆ G, MUSTAPIĆ M, BABIĆ A, STIPČEVIĆ T, BOROVEČKI F, HAJNŠEK S, MUCK-ŠELER D 2009The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects. Neurosci Lett 462: 45-48
108. ZILL P, PADBERG F, DE JONGE S, HAMPEL H, BURGER K, STUBNER S, BOETSCH T, JURGEN MOLLER H, ACKENHEILM, BONDY B 2000 Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients. Neurosci Lett 284: 113-115
109. SUKONICK D L, POLLOCK B G, SWEET R A, MULSANT B H, ROSEN J, KLUNK W E, KASTANGO K B, DEKOSKY S T, FERRELL R E 2001 The 5-HTTPR*S/*L polymorphism and aggressive hebavior in Alzheimer's disease. Arch Neurol 58: 1425-1428
110. PAZOS A, PALACIOS J M 1985 Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 346: 205-230
111. LE FRANCOIS B, CZESAK M, STEUBL D, ALBERT P R 2008 Transcriptional regulation at a HTR1A polymorphism associated with mental illness. Neuropharmacol 55: 977-985
112. WHITAKER-AZMITIA P M, DRUSE M,WALKER P, LAUDER J M 1996 Serotonin as a developmental signal. Behav Brain Res 73: 19-29
113. DRAGO A, DE RONCHI D, SERRETTI A 2008 5-HT1A genevariants and psychiatric disorders: a review of current literature and selection of SNPs for future studies. Int J Neuropsychopharmacol 11: 701-721
114. LÓPEZ-FIGUEROA A L, NORTON C S, LÓPEZ-FIGUEROA M O, BURKE S, MEADOR-WOODRUFF J H, L LÓPEZ J F, WATSON S J 2004 Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder and schizophrenia. Biol Psychiatry 55: 225-233
115. STOCKMEIER C A, SHAPIROLA, DILLEY G E, KOLLI T N, FRIEDMAN L, RAJKOWSKA G 1998 Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci 18: 7394-7401
116. LOWTHER S, DE PAERMENTIER F, CHEETHAM SC, CROMPTON MR, KATONA C L, HORTON RW 1997 5-HT1A receptor binding sites in post-mortem brain samples from depressed suicide and controls. J Affect Disord 42: 199-207
117. LEMONDE S, TURECKI G, BAKISH D, DU L, HRDINA P D, BOWN C D, SEQUEIRA A, KUSHWAHA N, MORRIS S J, BASAK A, OU X-M, ALBERT P R 2003 Impaired expression at a 5-Hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23: 8788-8799
118. SZEWCZYKB, ALBERT P R, BURNS AM, CZESAK M, OVERHOLSER J C, JURJUS G J, MELTZER H Y, KONICK L C, DIETER L, HERBST N, MAY W, RAJKOWSKA G, STOCKMEIER C A, AUSTIN M C 2009 Gender-specific decrease in NUDRand 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int J Neuropsychopharmacol 12: 155-168
119. 18F]MPPF binding potential in healthy subjects: a PET study. Behav Brain Functions 6: 37-46
120. SVENNINGSSON P, CHERGUI K, RACHLEFF I, FLAJOLET M, ZHANG X, EL YACOUBI M, VAUGEOIS J.-M, NOMIKOS G G, GREENGARD P 2006 Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311: 77-80
121. P, AISSI F, BATEL P, ADES J, COHEN SALMON C, HAMON M, BONI C, LANFURMEY L 2002 Reappraisal of the serotonin 5HT(1B) receptor gene in alcoholism: of mice and men. Brain Res Bull 57: 103-107
122. SOYKA M, PREUSS U W, KOLLER G, ZILL P, BONDY B 2004 Association of 5-HT1B receptor gene and antisocial behaviour in alcoholism. J Neural Transm 111: 101-109
123. STOCKMEIER C A, SHAPIROLA, DILLEY G E, KOLLI T N, FRIEDMAN L, RAJKOWSKA GR, CAO Q, TAYLOR J, LEVIN T, BADNER J A, CRAVCHIK A, COMERON JM, NARUYA S, DEL ROSARIO A, SALVI D, WALCZYK K, MOWRY B, LEVINSON DF, CROWE R R, SILVERMAN J M, GEJMAN P V 2001). Genetic diversity of the human serotonin receptor 1B (HTR1B) gene. Genomics 72: 1-14
124. SMOLLER JW, BIEDERMAN J, ARBEITMAN L, DOYLE A E, FAGERNESS J, PERLIS JH, SKLAR P, FARAONE S V 2006 Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD. Biol Psychiat 59: 460-467
125. SPARKES R S, LAN N, KLISAK I, MOHANDAS T, DIEP A, KOJIS T, HEINZMANN C, SHIH JC 1991 Assignment of a serotonin 5HT-2 receptor gene (HTR2) to human chromosome 13q14-q21 and mouse chromosome 14. Genomics 9: 461-465
126. CHEN K, YANG W, GRIMSBY J, SHIH JC 1992 The human 5-HT2 receptor is encoded by a multiple intron-exon gene. BrainRes Mol Brain Res 14: 20-26
127. ABDOLMALEKY HM, FARAONE SV, GLATTS J, TSUANGM T 2004 Meta-analysis of association between the T102C polymorphism of the 5-HT2a receptor gene and schizophrenia. Schizophr Res 67: 53-62
128. VIDETIC A, PUNGERCIC G, ZUPANIC PAJNIC I, ZUPANC T, BALAZIC J, TOMORI M, KOMEL R 2006 Association study of seven polymorphisms in four serotonin receptor genes on suicide victims. Am J Med Genetics Part B (Neuropsychiatric Genetics) 141B: 669-672
129. NAKAMURA T, MATSUSHITA S, NISHIGUCHI N, KIMURA M, YOSHINO A, HIGUCHI S 1999 Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence. Mol Psychiatry 4: 85-88
130. NACMIAS B, TEDDE A, FORLEO P 2001 Association between 5-HT2A receptor polymorphism and psychotic symptoms in Alzheimer's disease. Biol Psychiatry 50: 472-475
131. YAMANOUCHI Y, IWATAN, SUZUKI T, KITAJAMA T, IKEDA M, OZAKI N 2003 Effect of DRD2, 5-HT2A and COMT genes on antipsychotic response to risperidone. Pharmacogenomic J 3: 356-361
132. HARVEY L, REID R E, MA C, KNIGHT P J K, PFEIFER T A, GRIGLIATTI T A 2003 Human genetic variations in the 5-HT2A receptor: a single nucleotide polymorphism identified with altered response to clozapine. Pharmacogenetics 13: 107-118
133. MCMAHON F J, BUERVENICH S, CHARNEY D, LIPSKY R, RUSH A J, WILSON A F, SORANT A J M, PAPANICOLAOU G J, LAJE G, FAVA M, TRIVEDI M H, WISNIEWSKI S R, MANJI H 2006 Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.Am J Hum Genetics 78: 804-814