Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics

Archives of General Psychiatry

Volumn 53, Issue 3, 1996, Pages 211-216

  Fils Aime, Marie Lourdes ^a   Eckardt, Michael J ^a   George, David T ^a   Brown, Gerald L ^a   Mefford, Ivan ^b   Linnoila, Markku ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID;

ADULT; AFFECTIVE NEUROSIS; ALCOHOLISM; ARTICLE; CEREBROSPINAL FLUID LEVEL; DISEASE ASSOCIATION; DRINKING BEHAVIOR; FAMILY HISTORY; FEMALE; HUMAN; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; RISK FACTOR; SCHIZOPHRENIA;

ADULT; AGE OF ONSET; ALCOHOL DRINKING; ALCOHOLISM; COMORBIDITY; FAMILY; FEMALE; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; MALE; MENTAL DISORDERS; METHOXYHYDROXYPHENYLGLYCOL; PREVALENCE; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN;

EID: 0029868373     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.1996.01830030029006     Document Type: Article

References (36)

1. Robins LN, Heizer JE, Weissman MM, Orvaschel H, Gruenberg E, Burke JD, Regier DA. Lifetime prevalence of specific psychiatric disorders in three sites Arch Gen Psychiatry. 1984;41:949-958.
2. Cloninger R, Bohman M, Sigvardsson S Inheritance of alcohol abuse: cross fostering analysis of adopted men. Arch Gen Psychiatry. 1981;38:861-868.
3. Irwin M, Schuckit M, Smith T. Clinical importance of age of onset in type 1 and type 2 primary alcoholics. Arch Gen Psychiatry. 1990;47:320-324
4. Lamparski DM, Roy A, Nutt DJ, Linnoila M. The criteria of Cloninger et at. and von Knorring et al. for subgrouping of alcoholics: a comparison in a clinical population. Acta Psychiatr Scand. 1991;84:497-502.
5. von Knorring AL, Bohman M, von Knorring L, Oreland L. Platelet MAO activity as a biological marker in subgroups of alcoholism. Actaa Psychiatr Scand 1985; 72:51-58.
6. von Knorring L, Oreland L, von Knorring AL. Personality traits and platelet MAO activity in alcohol and drug abusing teenage boys Acta Psychiatr Scand. 1987;75:307-314.
7. Benkelfat C, Murphy DL, Hill JL, George DT, Nutt D, Linnoila M. Ethanollike properties of the serofonergic partial agonist m-chlorophenylpiperazine in chronic alcoholic patients Arch Gen Psychiatry. 1991;48:383.
8. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior Life Sci 1983;33:2609-2614.
9. Virkkunen M, Nuutila A, Goodwin FK, Linnoila M. Cerebrospinal fluid monoamine metabolites in male arsonists Arch Gen Psychiatry. 1987;44:241-247.
10. Roy A, Virkkunen M, Linnoila M. Reduced centrai serotomn turnover in a subgroup of alcoholics? Proy Neuropsychopharmacol Biol Psychiatry. 1987;11: 173-177.
11. Spitzer R, Endicott J, Robins E. Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry. 1978;35:773-782
12. Muscettola G, Wehr T, Goodwin FK. Effect of diet on urinary MHPG excretion in depressed patients and normal control subjects. Am J Psychiatry. 1977; 134:914-916
13. Scheinm M, Chang W, Kirk K, Linnoila M. Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid with high performance liquid chromatography using electrochemical detection. Anal Biochem. 1983;131:246-253
14. Endicott J, Spitzer R. A diagnostic interview the Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry. 1978;35:837-844
15. Selzer ML. The Michigan Alcoholism Screening Test: the quest for a new diagnostic instrument Am J Psychiatry. 1971;127:1653-1658.
16. Mayfield DG, McLeod G, Hall P. The CAGE questionnaire, validation of a new alcoholism screening instrument. Am J Psychiatry. 1974;131:1121-1123.
17. Eckardt MJ, Parker ES, Noble EP, Feldman DJ, Gottschalk LA. Relationship between neuropsychological performance and alcohol consumption in alcoholies. Biol Psychiatry. 1978;13:551-564.
18. Dixon WJ BMDP Statistical Software Manual. Berkeley, Calif: University of California Press; 1990.
19. Cloninger R. Neurogenetic mechanisms in alcoholism. Science. 1987;236:410-416.
20. Roy A, DeJong J, Lamparski D, Adinoff B, George T, Moore V, Garnett D, Kerich M, Linnoila M. Mental disorders among alcoholics. Arch Gen Psychiatry. 1991; 48:423-427.
21. Ballenger J, Goodwin F, Major L, Brown G. Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry. 1979;36:224-227.
22. Banki C. Factors influencing monoamine metabolites and tryptophan in pa tients with alcohol dependence. J Neural Transm. 1981;50:98-101.
23. Takahashi S, Yamane H, Kondo H, Tani M. CSF monoamine metabolites in alcoholism, a comparative study with depression. Folia Psychiatr Neurol Jpn. 1974;28:347-354.
24. Andreasen NC, Rice J, Endicott J, Reich T, Coryell W. The family history approach to diagnosis: how useful is it? Arch Gen Psychiatry. 1986;43:421-429.
25. Roy M-A, Walsh D, Prescott CA, Kendler K. Biases in the diagnosis of alcoholism by the family history method. Alcohol Clin Exp Res. 1994,18:845-851.
26. Agren H. Mefford IN, Rudorter MV, Linnoila M, Potter WZ. Interacting neurotransmitter systems: a non-experimental approach to the 5HIAA-HVA correlation in human CSF. Psychiatry Res. 1986;20:175-193.
27. Cutler NR, Kay AD, Agren H, Linnoila M, Potter WZ. Cerebrospinal fluid monoamine metabolites in 32 healthy men aged 19-77 years. Brain Dysfunct 1988; 1:192-196
28. Fernstrom JD, Wurtman RJ. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science. 1972;178:414-416.
29. Virkkunen M, Narvanen S Plasma insulin, tryptophan and serotonin levels during the glucose tolerance test among habitually violent and impulsive offenders. Neuropsychobiology. 1987;17:19-23.
30. Nielsen D, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M Suicidality and 5-hydroxymdoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism Arch Gen Psychiatry. 1994;51:34-38.
31. Schuckit M. The clinical implications of primary diagnostic groups among alcoholics. Arch Gen Psychiatry. 1985;42-1043-1049.
32. Hesselbrock M, Meyer R, Keener J. Psychopathology in hosprtalized alcoholics. Arch Gen Psychiatry. 1985;42:1050-1055.
33. Linnoila M, DeJong J, Virkkunen M. Family history of alcoholism in violent offenders and impulsive fire setters. Arch Gen Psychiatry. 1989;46:613-616.
34. Virkkunen M, DeJong J, Bartko J, Linnoila M. Psychobiological concomitants of a history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry. 1989;42:604-606.
35. Roy A, Lamparski D, DeJong J, Moore V, Linnoila M Characteristics of alcoholics who attempt suicide. Am J Psychiatry. 1990;147:761-765.
36. Rosenthal M, Davenport Y, Cowdry R, Webster M, Goodwin F. Monoamine metabolites in cerebrospinal fluid of depressive subgroups. Psychiatry Res. 1980;2:113-119.