Prevalence of high serotonin uptake in lymphocytes of abstinent alcoholics

Biochemical Pharmacology

Volumn 53, Issue 1, 1997, Pages 53-57

  Faraj, Bahjat A ^a   Olkowski, Zbigniew L ^a   Jackson, Richard T ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

alcoholism; human lymphocyte; impulsive violence; lymphocyte 5 HT transporter cDNA; serotonin; serotonin uptake activity

Indexed keywords

RADIOISOTOPE; SEROTONIN; SEROTONIN TRANSPORTER;

ABSTINENCE; ADULT; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEREDITY; HUMAN; HUMAN CELL; MALE; PERIPHERAL LYMPHOCYTE; PREVALENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONIN UPTAKE; SEROTONINERGIC TRANSMISSION;

ADULT; ALCOHOLICS ANONYMOUS; ALCOHOLISM; CARRIER PROTEINS; FEMALE; HUMANS; HYDROXYINDOLEACETIC ACID; LYMPHOCYTES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0031060654     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00726-5     Document Type: Article

References (34)

1. Zhou FC, Bledsoe S, Lumeng L and Li T-K, Reduced serotonergic immunoreactive fibers in the forebrain of alcohol-preferring rats. Alcohol Clin Exp Res 18: 571-579, 1994.
2. Balldin J, Berggren U, Engel J and Ericksson M, Neuroendocrine evidence for reduced serotonergic neurotransmission during heavy drinking. Alcohol Clin Exp Res 18: 822-834, 1994.
3. Le Marquard D, Pihl RO and Benkelfat C, Serotonin and alcohol intake, abuse and dependence: Findings of animal studies. Biol Psychiatry 36: 395-421, 1994.
4. Murphy JM, McBride W, Lumeng L and Li T-K, Regional levels of monoamines in alcohol-preferring and non-preferring lines of rats. Pharmacol Biochem Behav 16: 145-149, 1982.
5. Murphy JM, McBride WJ, Lumeng L and Li T-K, Alcohol preference and regional brain monoamine content of N/NIh heterogeneous stode rats. Alcohol Drug Res 7: 33-39, 1986.
6. Gongwer MA, Murphy JM, McBride WJ, Lumeng L and Li T-K, Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high-and low-alcohol drinking lines of rats. Alcohol 6: 317-320, 1989.
7. Sevensson L, Fahlke C, Hard E and Engel JA, Involvement of the serotonergic system in ethanol intake in the rat. Alcohol 10: 219-224, 1993.
8. McBride WJ, Murphy JM, Lumeng L and Li T-K, Serotonin and ethanol preference. Recent Dev Alcohol 7: 187-209, 1989.
9. McBride WJ, Murphy JM, Lumeng L and Li T-K, Serotonin, dopamine and GABA involvement in alcohol-drinking of selectively bred rats. Alcohol 7: 199-205, 1990.
10. McBride WJ, Murphy JM, Gatto GT, Levy AD, Lumeng L and Li T-K, Serotonin and dopamine system regulating alcohol intake. Alcohol (Suppl 1): 411-416, 1991.
11. Engel JA, Enerback C, Fahlke C, Hulthe P, Hard E, Johannessen K, Sevensson L and Soderpalm B, Serotonin involvement in ethanol intake. In: Novel Pharmacological Interventions for Alcoholism (Eds. Narango CA and Sellers EM), pp. 68-82. Springer, New York, 1992.
12. Sellers EM, Higgins GA and Sobel MB, 5-HT and alcohol abuse. Trends Pharmacol Sci 13: 69-75, 1992.
13. Amit Z, Brown A, Sutherland G, Rockman K, Gill K and Selvaggi N, Reduction in alcohol intake in humans as a function of treatment with zimelidine: Implications for treatment. In: Research Advances In New Psychopharmacological Treatments for Alcoholism (Eds. Naranjo CA and Sellers EM), pp. 189-198. Elsevier Science Publishers B.V. (Biomedical Division), New York, 1985.
14. Gorelick DA and Paredes A, Effect of fluoxetine on alcohol consumption in male alcoholics. Alcohol Clin Exp Res 16: 261-265, 1992.
15. Balldin J, Berggren U, Bokstrom K, Eriksson M, Gottfries CG, Karlsson I and Walinder J, Six months open trial with zimelidine in alcohol-dependent patients: Reduction in days of alcohol intake. Drug Alcohol Depend 35: 245-248, 1994.
16. Faraj BA, Olkowski ZL and Jackson RT, Expression of a high-affinity serotonin transporter in human lymphocytes, Int J Immunopharmacol 16: 561-567, 1994.
17. Hendley ED, Neurotransmitter uptake. In: Handbook of Neurochemistry (Ed. Lajtha A), Vol. 6, pp. 411-429. Plenum Press, New York, 1984.
18. American Psychiatric Association, DSM-III-R: Statistical Manual of Mental Disorders, 3rd Edn, revised. APA, Washington, DC, 1987.
19. Von Knorring A-L, Bohman M, von Knorring L and Oreland L, Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatr Scand 72: 51-58, 1985.
20. Boismare F, Lhuintre JP, Daoust M, Moore N, Salignaut C and Hillemand B, Platelet affinity for serotonin is increased in alcoholics and former alcoholics: A biological marker for dependence. Alcohol Alcohol 2: 155-159, 1987.
21. Ernouf D, Campagnon P, Lothion P, Narcisse G, Bénard JY and Daoust M, Platelets 3H 5-HT uptake in descendants from alcoholic patients: A potential risk factor for alcohol dependence. Life Sci 52: 989-995, 1993.
22. Rausch JF, Monteiro MG and Schuckit MA, Platelet serotonin uptake in men with family histories of alcoholism. Neuropsychopharmacology 4: 83-86, 1991.
23. Pletscher A, The 5-hydroxytryptamine system of blood platelets: Physiology and pathophysiology. Int J Cardiol 14: 177-188, 1987.
24. Zabik JE, Use of serotonin-active drugs in alcohol preference studies. Recent Dev Alcohol 7: 211-223, 1989.
25. Cool DR, Leibach FH, Bhalla VK, Mahesh V and Ganapathy V, Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). J Biol Chem 266: 15750-15757, 1991.
26. Villinger F, Faraj BA, Olkowski ZL, Jackson RT and Ansari AA, Functional expression of a serotonin transporter in human peripheral lymphocytes. FASEB J 8: A108, 1994.
27. Lesch KP, Wolozin BL, Estler HC, Murphy DL and Reiderer P, Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm 91: 67-73, 1993.
28. Higley JD, Mehlman PT, Taub DM, Higley SB, Suomi SJ, Vickers JH and Linnoila M, Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 49: 436-441, 1992.
29. Salomon RM, Mazure CM, Delgado PL, Mendia P and Charney DS, Serotonin function in aggression: The effect of acute plasma tryptophan depletion in aggressive patients. Biol Psychiatry 35: 570-572, 1994.
30. Cloninger CR, Sigvardsson S, von Knorring A-L and Bohman M, The Swedish studies of adopted children of alcoholics: A reply to Littrell J. J Stud Alcohol 49: 500-509, 1988.
31. Buydens-Branchey L, Branchey MH, Noumair D and Lieber CS, Age of alcoholism onset. II. Relation to susceptibility to serotonin precursor availability. Arch Gen Psychiatry 46: 231-236, 1989.
32. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R and Goodwin FK, Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non-impulsive violent behavior. Life Sci 33: 2609-2614, 1983.
33. Virkkunen M and Linnoila M, Brain serotonin, type II alcoholism and impulsive violence. J Stud Alcohol (Suppl 11): 163-169, 1993.
34. Linnoila M, De Jong J and Virkkunen M, Family history of alcoholism in violent offenders and impulsive fire setters. Arch Gen Psychiatry 46: 613-616, 1989.