Serotonergic dysfunction, negative mood states, and response to alcohol

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 4, 2001, Pages 487-495

  Heinz, Andreas ^a,c,d   Mann, Karl ^a   Weinberger, Daniel R ^b   Goldman, David ^c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Impulsivity; Negative Mood States; Serotonin Transporters; SLC6A4 Level of Response to Alcohol

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ALCOHOL; SEROTONIN; SEROTONIN TRANSPORTER;

AFFECTIVE NEUROSIS; AGGRESSION; ALCOHOL CONSUMPTION; ALCOHOLISM; ANTISOCIAL BEHAVIOR; DISEASE ASSOCIATION; HUMAN; NEUROTRANSMISSION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SEDATION; SEROTONINERGIC NERVE CELL;

PRIMATES;

EID: 0035044801     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02240.x     Document Type: Review

References (104)

1. Pindolol, 5-hydroxytryptamine, and antidepressant augmentation
2. Neuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism
3. Tryptophan depletion in patients with obsessive-compulsive disorder who respond to serotonin reuptake inhibitors
4. Psychopharmacology of central serotonergic systems
5. Anatomy of central serotoninergic projection systems
6. Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder
7. 5-Hydroxytryptophol in human cerebrospinal fluid: Conjugation, concentration gradient, relationship to 5-hydroxyindoleacetic acid, and influence of hereditary factors
8. Predisposition to criminality: Swedish adoption studies in retrospect
9. Predisposition to petty criminality in Swedish adoptees: I. Genetic and environmental heterogeneity
10. Genetic perspectives on crime
11. 3 antagonist on drug-induced stimulation of dopamine release
12. Family and genetic epidemiology of aggressive and antisocial behavior
13. Rearing experiments and biogenic amine activity in infant rhesus monkeys
14. Inheritance of alcohol abuse: Cross-fostering analysis of adopted men
15. Neurogenetic adaptive mechanisms in alcoholism
16. A systematic method for clinical description and classification of personality variants: A proposal
17. Serotonergic studies in patients with affective and personality disorders
18. 1B serotonin receptors
19. Serotonin function and the mechanisms of antidepressant action: Reversal of antidepressant induced remission by rapid depletion of plasma tryptophan
20. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
21. Ethanol as a neurochemical surrogate of conventional reinforcers: The dopamine-opioid link
22. Rewarding and aversive effects of ethanol: Interplay of GABA, glutamate and dopamine
23. Cerebral glucose metabolism, CSF 5-HIAA levels, and aggressive behavior in rhesus monkeys
24. A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence
25. Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics
26. Serotonin transporter protein (SCL6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American populations and alcohol-dependent subjects
27. Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area
28. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
29. The neuroanatomy of 5-HT dysregulation and panic disorder
30. The collaborative alcohol-related longitudinal project: A meta-analysis of depressive symptomatology and alcohol consumption over time
31. Neurobiological and anthropological aspects of compulsions and rituals
32. Serotonergic dysfunction after social isolation
33. Psychopathological and behavioral correlates of dopaminergic sensitivity in alcohol-dependent patients
34. In vivo observation of an association between serotonin transporters and sensitivity to alcohol intoxication
35. Reduced serotonin transporters in alcoholism
36. Tourette's syndrome: Serotonin transporters predict severity of vocal tics
37. Disinhibition of subcortical dopaminergic neurotransmission in rhesus monkeys with neonatal mesial temporal lesions
38. Serotonin transporter genotype interacts with in vivo protein expression and alcohol neurotoxicity
39. Wenn der Körper mit der Seele spricht: Ansätze zu einer Neuroimmunopsychologie
40. CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys
41. A non-human primate model of type II excessive alcohol consumption: 1 and 2
42. Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta)
43. Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymetamphetamine (MDMA, "ecstasy") and its congeners
44. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol
45. Clinical importance of age of onset in type 1 and type 2 primary alcoholics
46. Subtypes of alcohol-dependent men: A typology based on relative genetic and environmental loading
47. Depletion-restoration studies reveal the impact of endogenous dopamine and serotonin on [I-123]β-CIT SPECT imaging in primate brain
48. Dopaminergic and serotonergic function following isolation rearing in rats: Study of behavioral responses and postmortem and in vivo neurochemistry
49. Heritability of monoaminergic metabolites measured in the cerebrospinal fluid of baboons
50. Effects of fluoxetine on play dominance in juvenile rats
51. Early central serotonin damage increases "anxious" behaviors in juvenile rats
52. Selective alteration of personality and social behavior by serotonergic intervention
53. Interactions of pharmacological agents which alter biogenic amine metabolism and depression
54. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo
55. Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents
56. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations
57. Serotonin and alcohol intake, abuse, and dependence: Findings in animal studies
58. Serotonin and alcohol intake, abuse, and dependence: Clinical evidence
59. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
60. Serotonin uptake blockers influence serotonin autoreceptors by increasing the biophase concentration of serotonin and not through a "molecular link"
61. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non-impulsive violent behavior
62. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
63. Alcohol sensitivity and smoking history in men and women
64. 123I]-2β-carboxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography
65. Attempted suicide characteristics and cerebrospinal fluid metabolites in depressed inpatients
66. Altered dopamine transporter densities in alcohol-preferring vervet monkeys
67. Role of the serotonin transporter promoter polymorphism in anxiety-related traits
68. Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents
69. Neurotransmitter actions in the thalamus and cerebral cortex
70. The biological basis of refractory depression
71. Influence of fluoxetine on regional serotonin synthesis in the rat brain
72. Alcohol challenge with sons of alcoholics: A critical review and analysis
73. Passive avoidance learning in psychopathic and nonpsychopathic offenders
74. Passive avoidance in psychopaths: The effects of reward
75. A tryptophan hydroxylase gene marker for suicidality and alcoholism
76. Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter
77. Concentrations of monoamine metabolism in the cerebrospinal fluid of twins and unrelated individuals: A genetic study
78. Reflectivity and learning from aversive events: Toward a psychological mechanism for the syndromes of disinhibition
79. Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics
80. Behavioral and cognitive effects of altered tryptophan and tyrosine supply
81. Bidirectional relationship between tryptophan and social behavior in vervet monkeys
82. Does psychomotor sensitivity predict subsequent alcohol use?
83. Adaptive changes of dopamine-D2 receptors in rat brain following ethanol withdrawal: A quantitative autoradiographic investigation
84. Individual differences in subjective response to alcohol challenge: Data from studies of twins
85. Role of serotonin transporter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder
86. Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder
87. 1B receptor
88. An evaluation of type A and B alcoholics
89. An 8-year follow-up of 450 sons of alcoholics and control subjects
90. 6 receptors and the serotonin transporter in the level of response to alcohol: A pilot study
91. Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain
92. 1B agonists on ethanol self-administration
93. CSF monoamine metabolites of depressed patients during illness and after recovery
94. High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene
95. Significance of biochemical parameters in the diagnosis, treatment and prevention of depressive disorders
96. Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers
97. The electroencephalogram after alcohol administration in high-risk men and the development of alcohol use disorders 10 years later: Preliminary findings
98. Prediction of resumption of drinking in posttreatment alcoholics
99. Role of serotonin in alcohol abuse
100. The neurobiology of craving: Implications for the understanding of addiction
101. Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder