Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence

Molecular Psychiatry

Volumn 4, Issue 1, 1999, Pages 85-88

  Nakamura, T ^a   Matsushita, S ^a   Nishiguchi, N ^a   Kimura, M ^a   Yoshino, A ^b   Higuchi, S ^a  

^a KURIHAMA NATIONAL HOSPITAL   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

5HT2A receptor gene; Alcohol dependence; Aldehyde dehydrogenase 2; Polymorphism

Indexed keywords

ALDEHYDE DEHYDROGENASE; SEROTONIN 2A RECEPTOR;

ADULT; ALCOHOLISM; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE;

EID: 0033009323     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000474     Document Type: Article

References (33)

1. 1 Higuchi S, Matsushita S, Imazeki H, Kinoshita T, Takagi S, Kono H. Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 1994; 343: 741-742.
2. 2 Harada S, Agarwal DP, Goedde HW, Takagi S, Ishikawa B. Possible protective role against alcoholism for aldehyde dehydrogenase deficiency in Japan. Lancet 1982; 2: 827.
3. 3 Collier DA, Arranz MJ, Li T, Mupita D, Brown N, Treasure J. Association between 5HT2A gene promoter polymorphism and anorexia norvosa. Lancet 1997; 350: 412.
4. 4 Hinney A, Ziegler A, Nothen MM, Remschmidt H, Hebebrand J. 5-HT2A receptor gene polymorphisms, anorexia nervosa and obesity. Lancet 1997; 350: 1324-1325.
5. 5 Sellers EM, Higgins GA, Sobell MB. 5HT and alcohol abuse. TIPS 1992; 13: 69-75.
6. 6 LeMarquand D, Pihl RO, Benkelfat C. Serotonin and alcobol intake, abuse, and dependence: clinical evidence. Biol Psychiatry 1994; 36: 326-337.
7. 7 LeMarquand D, Pihl RO, Benkelfat C. Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol Psychiatry 1994; 36: 395-421.
8. 8 Higuchi S, Suzuki K, Yamada K, Parrish KM, Kono H. Alcoholics with eating disorders: prevalence and clinical course: a study from Japan. Br J Psychiatry 1993; 162: 403-406.
9. 9 Crabb DW, Edenberg HJ, Bosron WF, Li T-K. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity: the inactive ALDH22 allele is dominant. J Clin Invest 1988; 83: 314-316.
10. 10 Higuchi S, Matsushita S, Murayama M, Takagi S, Hayashida M. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatry 1996; 152: 1219-1221.
11. 11 Yamamoto K, Ueno Y, Mizoi Y, Tatsuno Y. Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism. Jpn J Alcohol Drug Depend 1993; 28: 13-25.
12. 12 Takeshita T, Morimoto K, Mao X-Q, Hashimoto T, Furuyama J. Charactirization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population. Hum Genet 1994; 94: 217-223.
13. 13 Maezawa Y, Yamauchi M, Toda G, Suzuki H, Sakurai S. Alcohol metabolizing enzyme polymorphisms and alcoholism in Japan. Alcohol Clin Exp Res 1995; 19: 951-954.
14. 14 Kirkwood BR. Essentials of Medical Statistics. Blackwell Scientific Publications: London, 1990, pp 94-105.
15. 15 Naranjo CA, Sellers EM, Lawrin MO. Modulation of ethanol intake by serotonin uptake inhibitors. J Clin Psychiatry 1986; 47 (suppl 4): 16-22.
16. 16 Gorelick DA. Serotonin uptake blockers and the treatment of alcoholism. In: Galanter M (ed). Recent Developments in Alcoholism, vol 7. Plenum Press: New York, 1989. pp 267-281.
17. 17 Naranjo CA, Sellers EM. Serotonin uptake inhibitors attenuate ethanol intake in problem drinkers. In: Galanter M (ed). Recent Developments in Alcoholism, vol 7. Plenum Press: New York, 1989, pp 255-265.
18. 18 Pandey SC, Davis JM, Pandey GN. Phosphoinositide systemlinked scrotonin receptor subtypes and their pharmacological properties and clinical correlates. J Psychiatr Neurosci 1995; 20: 215-225.
19. 19 Myers RD, Lankford MF. Suppression of alcohol preference in high alcohol drinking rats: efficacy of amperozide versus naltrexone. Neuropsychopharmacology 1996; 14: 139-149.
20. 2A promoter polymorphism in anorexia nervosa. Lancet 1998; 351: 1785.
21. 2A promoter polymorphism - 1438 G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet 1998; 351: 1785-1786.
22. 22 Hatsukami DK, Eckert ED, Mitchell JE, Pyle RL. Affective disorder and substance abuse among women with bulimia. Psychol Med 1984; 14: 701-704.
23. 23 Beary MD, Lacey JH, Merry J. Alcoholism and eating disorders in women of fertile age. Br J Addict 1986; 81: 685-689.
24. 24 Zhu QS, Chen K, Shih JC. Characterization of the human 5HT2A receptor gene promoter. J Neurosci 1995; 15: 4885-4895.
25. 25 Spurlock G, Heils A, Holmans P, Williams J, D'Souza UM, Cardno A et al. A family-based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol Psychiatry 1998; 3: 42-49.
26. 2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum Genet 1996; 97: 614-619.
27. 27 Ozaki N, Rosenthal NE, Pesonen U, Lappalainen J, Feldman-Naim S, Schwartz. PJ et al. Two naturally occurring amino acid substitutions of the 5HT2A receptor: similar prevalence in patients with seasonal affective disorder and controls. Biol Psychiatry 1996; 40: 1267-1272.
28. 28 Ono H, Nishiguchi N, Yoh J, Nishimura A, Nushida H, Tatsuno Y et al. Serotonin 2A receptor gene polymorphism in suicide victims. Abstracts of the 20th Conference of the Japanese Society for Biological Psychiatry, Kitakyushu, 1998, p 213.
29. 29 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 3rd rev edn. American Psychiatric Association: Washington DC. 1987.
30. 30 Spitzer RL, Williams JW, Gibbon M, First MB. Structured Clinical Interview for DSMA-III-R (SCID) User's Guide. American Psychiatric Press: Washington DC, 1990.
31. 31 Higuchi S. Muramatsu T, Shigemori K, Saito M, Kono H, Dufour MC et al. The relationship between low Km aldehyde dehydrogenase phenolype and drinking behavior in Japanese. J Stud Alcohol 1992; 53: 170-175.
32. 32 Saito S, Ikegami N. KAST (Kurihama Alcoholism Screening Test) and its applications, Jpn J Alcohol Drug Depend 1978; 13: 229-235.
33. 33 Harada S, Zhang S. New strategy for detection of ALDH2 mutant. Alcohol Alcohol 1993; 28: 11-13.