Association between serotonin-related polymorphisms in 5HT2A,TPHI,TPH2 genes and bipolar disorder in Korean population

Psychiatry Investigation

Volumn 7, Issue 1, 2010, Pages 60-67

  Choi, Kwang Yeon ^a   Yoon, Ho Kyoung ^a   Kim, Yong Ku ^a,b  

^a Korea University College of Medicine   (South Korea)

^b Korea University   (South Korea)

Author keywords

Bipolar disorder; Mania; Polymorphism; Serotonin

Indexed keywords

ALANINE; CYSTEINE; GLYCINE; SEROTONIN; THREONINE; TRYPTOPHAN HYDROXYLASE;

ADULT; ARTICLE; BIPOLAR DISORDER; BRIEF PSYCHIATRIC RATING SCALE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; KOREA; MAJOR CLINICAL STUDY; MANIA; YOUNG MANIA RATING SCALE;

EID: 77950805342     PISSN: 17383684     EISSN: None     Source Type: Journal    
DOI: 10.4306/pi.2010.7.1.60     Document Type: Article

References (35)

1. Merikangas KR, Akiskal HS, Angst J, Greenberg PE, Hirschfeld RM, Petukhova M, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007; 64: 543-552.
2. McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 2003; 60: 497-502.
3. Arranz MJ, Munro J, Owen MI, Spurlock G, Sham PC, Zhao J, et al. Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine. Mol Psychiatry 1998; 3: 61-66. (Pubitemid 28045186)
4. Parsons MI, D'Souza UM, Arranz MJ, Kerwin RW, Makoff AJ. The-1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry 2004; 56: 406-410.
5. Chee IS, Lee SW, Kim JL, Wang SK, Shin YO, Shin SC, et al. 5-HT2A receptor gene promoter polymorphism-1438A/G and bipolar disorder. Psychiatr Genet 2001; 11: 111-114.
6. Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y. 5-HT2A receptor gene promoter polymorphism-1438G/A and mood disorders. Neuroreport 1998; 9: 1139-1141.
7. Etain B, Rousseva A, Roy I, Henry C, Malafosse A, Buresi C, et al. Lack of association between 5-HT2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample. Am J Med Genet B Neuropsychiatr Genet 2004; 129B: 29-33.
8. Zhang HY, Ishigaki T, Tani K, Chen K, Shih JC, Miyasato K, et al. Serotonin2A receptor gene polymorphism in mood disorders. Biol Psychiatry 1997; 41: 768-773.
9. Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A. Further studies on tryptophan hydroxylase in rat brainstem and beef pineal. Biochem Pharmacol 1969; 18: 1071-1081.
10. Patel PD, Pontrello C, Burke S. Robust and tissue-specific expression of TPH2 versus TPH 1 in rat raphe and pineal gland. Biol Psychiatry 2004; 55: 428-433.
11. Walther DJ, Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 2003; 66: 1673-1680.
12. Bellivier F, Leboyer M, Courtet P, Buresi C, Beaufils B, Samolyk D, et al. Association between the tryptophan hydroxylase gene and manic-depressive illness. Arch Gen Psychiatry 1998; 55: 33-37. (Pubitemid 28069037)
13. Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long IC, et al. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 1998; 55: 593-602.
14. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 1999; 45: 603-614.
15. Yoon HK, Kim YK. Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1293-1297.
16. Lalovic A, Turecki G. Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. Am I Med Genet 2002; 114: 533-540.
17. Lai TJ, Wu CY, Tsai HW, Lin YM, Sun HS. Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan. BMC Med Genet 2005; 6: 14.
18. Chen C, Glatt SJ, Tsuang MT. The tryptophan hydroxylase gene influences risk for bipolar disorder but not major depressive disorder: results of meta-analyses. Bipolar Disord 2008; 10: 816-821.
19. Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003; 299: 76.
20. Yoon HK, Kim YK. TPH2-703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 403-409.
21. Lopez VA, Detera-Wadleigh S, Cardona I, Kassem L, McMahon FJ. Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biol Psychiatry 2007; 61: 181-186.
22. Grigoroiu-Serbanescu M, Diaconu CC, Herms S, Bleotu C, Vollmer J, Muhleisen TW, et al. Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population. Psychiatr Genet 2008; 18: 240-247.
23. De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. Psychopharmacology (Berl) 2005; 183: 378-382.
24. APA (American Psychological Association). Diagnostic and statistical manual of mental disorders, 4th edition. Washington DC: American Psychiatric Press; 1994.
25. First M, Spitzer RL, Gibbon M, William JB. Structured clinical Interview for DSM-IV Axis I Disorder-Patient Edition (SCID-I/NP, version 2.0), New York: Biometrics Research Department, New York State Psychiatric Institute; 1998.
26. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429-435.
27. Bech P, Larsen JK, Andersen J. The BRPS: psychometric developments. Psychopharmacol Bull 1988; 24: 118-121.
28. Stahl SM. Sahl's essential psychopharmacology, neuroscientific basis and practical applications. 3rd edition. New York: Cambridge U. P. 2008, p. 359-361.
29. Glenthoj BY, Mackeprang T, Svarer C, Rasmussen H, Pinborg LH, Friberg L, et al. Frontal dopamine D{2/3) receptor binding in drugnaive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender. Biol Psychiatry 2006; 60: 621-629.
30. Gouzoulis-Mayfrank E, Heekeren K, Neukirch A, Stoll M, Stock C, Daumann I, et al. Inhibition of return in the human 5HT2A agonist and NMDA antagonist model of psychosis. Neuropsychopharmacology 2006; 31: 431-441.
31. Spurlock G, Heils A, Holmans P, Williams J, D'Souza UM, Cardno A, et al. A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol Psychiatry 1998; 3: 42-49.
32. Myers RL, Airey DC, Manier DH, Shelton RC, Sanders-Bush E. Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression. Biol Psychiatry 2007; 61: 167-173.
33. Stahl SM. Stahl's essential psychopharmacology-neuroscientific basis and practical application. 3rd edition. Cambridge. 2008, p. 484.
34. Lin YM, Chao SC, Chen TM, Lai TJ, Chen JS, Sun HS. Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Arch Gen Psychiatry 2007; 64: 1015-1024.
35. Oh SY, Chee IS, Lee YH. Association between 5-HT2A receptor gene promoter-1438A/G polymorphism and bipolar disorder in a Korean population Korean Neuropsychiatric Association 2001; 40: 81-86.