The effect of lamotrigine on platelet serotonin concentration in patients with bipolar depression

Psychopharmacology

Volumn 197, Issue 4, 2008, Pages 683-685

  Sagud, Marina ^a   Pivac, Nela ^b   Mustapic, Maja ^b   Nedic, Gordana ^b   Peles, Alma Mihaljevic ^a   Kramaric, Milivoj ^a   Jakovljevic, Miro ^a   Muck Seler, Dorotea ^b  

^a KBC Zagreb   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPAM; LAMOTRIGINE; LITHIUM; OLANZAPINE; PAROXETINE; QUETIAPINE; RISPERIDONE; SEROTONIN;

BIPOLAR DEPRESSION; BIPOLAR I DISORDER; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; HUMAN; LETTER; LOW DRUG DOSE; MAJOR DEPRESSION; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RASH; SEROTONIN BLOOD LEVEL; THROMBOCYTE; UNSPECIFIED SIDE EFFECT; WOMEN'S HEALTH;

ADULT; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; BLOOD PLATELETS; DEPRESSIVE DISORDER, MAJOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LITHIUM COMPOUNDS; MIDDLE AGED; PAROXETINE; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN; TRIAZINES;

EID: 41849104203     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1074-2     Document Type: Letter

References (16)

1. Ahmad S, Fowler LJ, Whitton PS (2005) Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids. Epilepsy Res 63:141-149
2. American Pychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric, Washington, DC
3. Barbosa L, Berk M, Vorster M (2003) A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry 64:403-407
4. Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 60:79-88
5. Calabrese JR, Bowden CL, Sachs G, Yatham LN, Behnke K, Mehtonen OP, Montgomery P, Ascher J, Paska W, Earl N, DeVeaugh-Geiss J, Lamictal 605 Study Group (2003) A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 64:1013-1024
6. Camacho A, Dimsdale JE (2000) Platelets and psychiatry: lessons learned from old and new studies. Psychosom Med 62:326-336
7. Consoni FT, Vital MABF, Andreatini R (2006) Dual monoamine modulation for the antidepressant-like effect of lamotrigine in the modified forced swimming test. Eur Neuropsychopharmacol 16:451-458
8. First MB, Spitzer RL, Gibbon M, Williams JBW (1995) Structured clinical interview for DSM-IV patient edition (SCID-I/P, Version 2.0). Biometrics Research Department, New York State Psychiatric Institute, New York, NY
9. Goldsmith DR, Wagstaff AJ, Ibbotson T, Perry CM (2003) Lamotrigine. A review of its use in bipolar disorder. Drugs 63:2029-2050
10. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62
11. Muck-Seler D, Jakovljevic M, Pivac N (1996) Platelet 5-HT concentrations and suicidal behavior in recurrent major depression. J Affect Disord 39:73-80
12. Muck-Seler D, Pivac N, Sagud M, Jakovljevic M, Mihaljević-Peles A (2002) The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression. Progress Neuro-Psychopharmacol Biol Psychiatry 26:1235-1243
13. Muck Seler D, Pivac N, Sagud M, Mustapic M, Jakovljevic M (2005) The effects of serotonin uptake inhibitors on platelet serotonin: From basic to clinical research. In: Shirley AC (ed) Trends in serotonin uptake inhibitors research. Nova Science, New York, pp 29-53
14. Normann C, Hummel B, Schärer LO, Hörn M, Grunze H, Walden J (2002) Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study. J Clin Psychiatry 63:337-344
15. Southam E, Kirkby D, Higgins GA, Hagan RM (1998) Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. Eur J Pharmacol 358:19-24
16. Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429-435