Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA

Journal of Controlled Release

Volumn 151, Issue 2, 2011, Pages 149-154

  Tagami, Tatsuaki ^a,b   Uehara, Yumi ^a   Moriyoshi, Naoto ^a   Ishida, Tatsuhiro ^a   Kiwada, Hiroshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

2 O methyl uridine modified siRNA (2 OMe siRNA); Accelerated blood clearance (ABC) phenomenon; Anti PEG IgM; Polyethylene glycol (PEG); Small interfering RNA (siRNA)

Indexed keywords

ACCELERATED BLOOD CLEARANCES; ANTI-PEG IGM; CATIONIC LIPOSOMES; CYTOKINES; EFFECT OF ENCAPSULATION; IMMUNE REACTION; LIPID NANOCARRIER; LIPOPLEXES; PEGYLATED LIPIDS; SMALL INTERFERING RNA (SIRNA); THERAPEUTIC APPLICATION;

BLOOD; GLYCOLS; IMMUNOLOGY; LIPOSOMES; PHOSPHOLIPIDS; POLYETHYLENE OXIDES; RNA;

POLYETHYLENE GLYCOLS;

IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 6; LIPOPLEX; SMALL INTERFERING RNA; SOLID LIPID NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOSTIMULATION; MALE; MOUSE; NANOENCAPSULATION; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RNA SEQUENCE;

ANIMALS; BASE SEQUENCE; DRUG CARRIERS; IMMUNOGLOBULIN M; LIPOSOMES; MALE; MICE; NANOCAPSULES; NANOPARTICLES; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING;

EID: 79956071882     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.12.013     Document Type: Article

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