Improved formulations of antisense oligodeoxynucleotides using wrapped liposomes

Journal of Controlled Release

Volumn 114, Issue 2, 2006, Pages 268-275

  Yamauchi, Masahiro ^a   Kusano, Hiroko ^a   Saito, Etsuko ^a   Iwata, Takeshi ^a   Nakakura, Masashi ^a   Kato, Yasuki ^a   Uochi, Takaaki ^a   Akinaga, Shiro ^a   Aoki, Noboru ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Cationic lipids; Delivery; DOTAP; Liposome; Oligonucleotides; PEG

Indexed keywords

COMPLEXATION; DRUG PRODUCTS; LIPIDS; POLYETHYLENE GLYCOLS; POLYSACCHARIDES; POSITIVE IONS; PROTEINS; TUMORS;

CATIONIC LIPIDS; DOTAP; OLIGONUCLEOTIDES; WRAPPED LIPOSOMES (WL);

NUCLEIC ACIDS;

1,2 DISTEAROYL SN GLYCERO 3 PHOSPHOETHANOLAMINE N METHOXY(POLYETHYLENE GLYCOL) 2000; ANTISENSE OLIGODEOXYNUCLEOTIDE; LIPID; LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHOROTHIOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; ENCAPSULATION; HUMAN; IN VITRO STUDY; INOCULATION; KIDNEY; MALE; METHODOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL; TUMOR XENOGRAFT;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ETHANOL; FLUORESCEIN-5-ISOTHIOCYANATE; INJECTIONS, INTRAVENOUS; KIDNEY NEOPLASMS; LIPOSOMES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDES, ANTISENSE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SOLUBILITY; SOLVENTS; VEHICLES;

EID: 33747891997     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.05.025     Document Type: Article

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