Changes in dietary folate intake differentially affect oxidised lipid and mitochondrial DNA damage in various brain regions of rats in the absence/presence of intracerebroventricularly injected amyloid β-peptide challenge

British Journal of Nutrition

Volumn 105, Issue 9, 2011, Pages 1294-1302

  Chen, Ta Fu ^a   Chiu, Ming Jang ^a,b   Huang, Chou Tz ^c   Tang, Ming Chi ^c   Wang, Sue Jane ^c   Wang, Chia Chuan ^c   Syu Huang, Rwei Fen ^c  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

A (25 35) peptide; Dietary folate intake; Lipid peroxidation; Mitochondrial DNA large deletion; Neuronal death

Indexed keywords

AMYLOID BETA PROTEIN; FOLIC ACID; MITOCHONDRIAL DNA; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; BRAIN REGION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; FOLIC ACID DEFICIENCY; FRONTAL CORTEX; GENE DELETION; GENOTOXICITY; HIPPOCAMPUS; LIPID OXIDATION; MALE; MEDULLA OBLONGATA; NERVE CELL NECROSIS; NONHUMAN; RAT; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

AMYLOID BETA-PEPTIDES; ANIMAL FEED; ANIMALS; BRAIN; CELL DEATH; DIET; DNA DAMAGE; DNA, MITOCHONDRIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLIC ACID; INFUSIONS, INTRAVENTRICULAR; LIPID PEROXIDATION; MALE; NEURONS; RATS;

RATTUS; RATTUS NORVEGICUS;

EID: 79956052515     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510005052     Document Type: Article

References (50)

1. Reynolds E (2006) Vitamin B12, folic acid, and the nervous system. Lancet Neurol 5, 949-960. (Pubitemid 44556551)
2. Engelborghs S, Vloeberghs E, Maertens K, et al. (2004) Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia. Int J Geriatr Psychiatry 19, 365-370. (Pubitemid 38461076)
3. Reynolds EH (2002) Folic acid, ageing, depression, and dementia. BMJ 324, 1512-1515. (Pubitemid 34666626)
4. Ramos MI, Allen LH, Mungas DM, et al. (2005) Low folate status is associated with impaired cognitive function and dementia in the Sacramento area Latino study on aging. Am J Clin Nutr 82, 1346-1352. (Pubitemid 43779735)
5. Luchsinger JA, Tang MX, Miller J, et al. (2007) Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 64, 86-92. (Pubitemid 46072428)
6. Fioravanti M, Ferrario E, Massaia M, et al. (1998) Low folate levels in the cognitive decline of elderly patients and the effi- cacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatr 26, 1-13. (Pubitemid 27511030)
7. Bryan J, Calvaresi E & Hughes D (2002) Short-term folate, vitamin B12 or vitamin B6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr 132, 1345-1356. (Pubitemid 34606475)
8. Durga J, van Boxtel MP, Schouten EG, et al. (2007) Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomized, double blind, controlled trial. Lancet 369, 208-216. (Pubitemid 46107683)
9. Sommer BR, Hoff AL & Costa M (2003) Folic acid supplementation in dementia: a preliminary report. J Geriatr Psychiatry Neurol 16, 156-159. (Pubitemid 37409025)
10. Morris MC, Evans DA, Bienias JL, et al. (2005) Dietary folate and vitamin B12 intake and cognitive decline among community- dwelling older persons. Arch Neurol 62, 641-645. (Pubitemid 40489899)
11. Duyckaerts C (2004) Looking for the link between plaques and tangles. Neurobiol Aging 25, 735-739. (Pubitemid 38698246)
12. Thal DR, Rüb U, Orantes M, et al. (2002) Phases of A betadeposition in the human brain and its relevance for the development of AD. Neurology 58, 1791-1800. (Pubitemid 34663580)
13. Velliquete RA, O'Connor T & Vassar R (2005) Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. J Neurosci 25, 10874-10883. (Pubitemid 41692617)
14. Behl C & Moosmann B (2002) Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. Free Radic Biol Med 33, 182-191. (Pubitemid 34775190)
15. Chinnery PF, Samuels DC, Elson J, et al. (2002) Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism? Lancet 360, 1323-1325. (Pubitemid 35284628)
16. Ravagnan L, Roumier T & Kroemer G (2002) Mitochondria, the killer organelles and their weapons. J Cell Physiol 192, 131-137. (Pubitemid 34747781)
17. Reddy PH & Beal MF (2005) Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res Rev 49, 618-632. (Pubitemid 41546661)
18. Maruszak A, Gaweda-Walerych G, Soltyszewski I, et al. (2006) Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases. Acta Neurobiol Exp 66, 153-176. (Pubitemid 44124955)
19. Bosetti F, Brizzi F, Barogi S, et al. (2002) Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging 23, 371-376. (Pubitemid 34312019)
20. Mancuso M, Filosto M, Bosetti F, et al. (2003) Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease. Exp Neurol 182, 421-426. (Pubitemid 36937094)
21. Wang J, Xiong S, Xie C, et al. (2005) Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J Neurochem 93, 953-962. (Pubitemid 40695754)
22. Markesbery WR & Lovell MA (2006) DNA oxidation in Alzheimer's disease. Antioxid Redox Signal 8, 2039-2045. (Pubitemid 46489629)
23. Branda RF, Brooks EM, Chen Z, et al. (2002) Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats. Mutat Res 501, 29-36. (Pubitemid 34270648)
24. Crott JW, Choi SW, Branda RF, et al. (2005) Accumulation of mitochondrial DNA deletions is age, tissue and folatedependent in rats. Mutat Res 570, 63-70. (Pubitemid 40179268)
25. Chou YF, Yu CC & Huang RFS (2007) Changes in mitochondrial DNA deletion, content, and biogenesis in folatedeficient tissues of young rats depend on mitochondrial folate and oxidative DNA injuries. J Nutr 137, 2036-2042.
26. Cortopassi GA, Shibata DD, Soong NW, et al. (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 89, 7370-7374.
27. Wei YH (1992) Mitochondrial DNA alterations as ageingassociated molecular events. Mutat Res 275, 145-155.
28. Lee HC, Pang CY, Hsu HS, et al. (1994) Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys Acta 1226, 37-43.
29. Lee HC & Wei YH (2007) Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp Biol Med 232, 592-606.
30. Sun MK & Alkon DL (2002) Impairment of hippocampal CA1 heterosynaptic transformation and spatial memory by betaamyloid25 - 35. J Neurophysiol 87, 2441-2449. (Pubitemid 34670715)
31. Walzem RL & Clifford AJ (1988) Folate deficiency in rats fed diets containing free amino acid or intact proteins. J Nutr 118, 1089-1096.
32. Wilkinson B, Koenigsknecht-Talboo J, Grommes C, et al. (2006) Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia. J Biol Chem 281, 20842-20850. (Pubitemid 44115425)
33. Stepanichev MY, Moiseeva YV, Lazareva NA, et al. (2003) Single intracerebroventricular administration of amyloidbeta( 25 - 35) peptide induces impairment in short-term rather than long-term memory in rats. Brain Res Bull 61, 197-205. (Pubitemid 36794278)
34. Varela-Moreiras G & Selhub J (1992) Long-term folate deficiency alters folate content and distribution differentially in rat tissues. J Nutr 122, 986-991.
35. Horne DW & Patterson D (1988) Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. Clin Chem 34, 2357-2359. (Pubitemid 19001275)
36. Fraga CG, Leibovitz BE & Tappel AL (1988) Lipid peroxidation measured as thiobarbituric-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radic Biol Med 4, 155-161. (Pubitemid 18052530)
37. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.
38. Tocco G, Musleh W, Sakhi S, et al. (1997) Complement and glutamate neurotoxicity: genotypic influences of C5 in a mouse model of hippocampal neurodegeneration. Mol Chem Neuropathol 31, 1-12.
39. Joshi R, Adhikari S, Patro BS, et al. (2001) Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radic Biol Med 30, 1390-1399. (Pubitemid 32522954)
40. Doshi SN, McDowell IFW, Moat SJ, et al. (2001) Folate improves endothelial function in coronary artery disease. An effect mediated by reduction of intracellular superoxide? Arterioscler Thromb Vasc Biol 21, 1196-1202. (Pubitemid 34215150)
41. Chen YH, Huang RFS, Wei JS, et al. (2001) Folate deficiencymediated down regulation of intracellular glutathione and antioxidant enzymes increases susceptibility of human hepatoma HepG2 cells to various oxidant stress-induced cytotoxicity. J Biomed Lab Sci 13, 52-57.
42. Chern CL, Huang RFS, Chen YH, et al. (2001) Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhances activation of NF-kB in human HepG2 cells. Biomed Pharmacother 55, 434-442.
43. Huang RFS, Hsu YC, Lin HL, et al. (2001) Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J Nutr 131, 33-38.
44. Ho PI, Ashline D, Dhitavat S, et al. (2003) Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis 14, 32-42. (Pubitemid 37103177)
45. Kruman II, Kumaravel TS, Lohani A, et al. (2002) Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 22, 1752-1762. (Pubitemid 35386293)
46. Chang CM, Yu CC, Lu HT, et al. (2007) Folate deprivation promotes mitochondrial oxidative decay: DNA large deletions, cytochrome c oxidase dysfunction, membrane depolarization and superoxide overproduction in rat liver. Br J Nutr 97, 855-863.
47. Suematsu N, Tsutsui H, Wen J, et al. (2003) Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation 107, 1418-1423. (Pubitemid 36350742)
48. Bagnyukovaa TV, Powell CL, Oleksandra Pavliv O, et al. (2008) Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet. Brain Res 1237, 44-51.
49. Huang RFS, Yaong HC, Chen SC, et al. (2004) In vitro folate supplementation alleviates oxidative stress, mitochondriaassociated death signalling and apoptosis induced by 7-ketocholesterol. Br J Nutr 92, 887-894.
50. Ye YL, Chan YT, Liu HC, et al. (2010) Depleted folate pool and dysfunctional mitochondria associated with defective mitochondrial folate proteins sensitize Chinese ovary cell mutants to tert-butyl hydroperoxide- induced oxidative stress and apoptosis. J Nutr Biochem 21, 793-800.