Depleted folate pool and dysfunctional mitochondria associated with defective mitochondrial folate proteins sensitize Chinese ovary cell mutants to tert-butylhydroperoxide-induced oxidative stress and apoptosis

Journal of Nutritional Biochemistry

Volumn 21, Issue 9, 2010, Pages 793-800

  Ye, Yi Ling ^a   Chan, Ya Tsun ^a   Liu, Hsiu Chuan ^a   Lu, Hsin Te ^a   Huang, Rwei Fen S ^a  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Chinese hamster ovary cell mutants; Folate metabolism; Oxidative stress; Respiratory dysfunction

Indexed keywords

CYTOCHROME C OXIDASE; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; MITOCHONDRIAL DNA; PROCASPASE 3; PROCASPASE 9; PROTEIN BAX; SUPEROXIDE; TERT BUTYL HYDROPEROXIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL MUTANT; CHINESE HAMSTER; CONTROLLED STUDY; CYTOSOL; DIET SUPPLEMENTATION; ENZYME ACTIVATION; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OVARY CELL; OXIDATIVE STRESS; PHENOTYPE; PROTEIN TRANSPORT; REGULATORY MECHANISM; RESPIRATORY FUNCTION;

ANIMALS; APOPTOSIS; CHO CELLS; CRICETINAE; CRICETULUS; FOLIC ACID; FOLIC ACID TRANSPORTERS; GLYCINE HYDROXYMETHYLTRANSFERASE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; OXIDATIVE STRESS; TERT-BUTYLHYDROPEROXIDE;

CRICETULUS GRISEUS; MAMMALIA;

EID: 77955844910     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.05.005     Document Type: Article

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