Loss of p21 Waf1/Cip1/Sdl1 enhances intestinal stem cell survival following radiation injury

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 2, 2009, Pages

  George, Robert J ^c   Sturmoski, Mark A ^d   May, Randal ^a,f   Sureban, Sripathi M ^a,f   Dieckgraefe, Brian K ^c,f   Anant, Shrikant ^a,b,e   Houchen, Courtney W ^a,e,f,g  

^a Health Sciences Center   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c Division of Gastroenterology   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e OU Cancer Institute   (United States)

^f Medical Center   (United States)

^g UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Crypt survival; Gamma irradiation; Musashi 1; Survivin

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; MESSENGER RNA; NERVE PROTEIN; PROTEIN MUSASHI 1; SURVIVIN; UNCLASSIFIED DRUG; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MICROTUBULE ASSOCIATED PROTEIN; MSI1H PROTEIN, MOUSE; RNA BINDING PROTEIN; SURVIVIN PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FATE; CELL SURVIVAL; CONTROLLED STUDY; CRYPT CELL; INTESTINE CELL; INTESTINE CRYPT; LASER CAPTURE MICRODISSECTION; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIATION INJURY; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; STEM CELL; ANIMAL; C57BL MOUSE; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; RADIATION EXPOSURE; SMALL INTESTINE; TIME; WHOLE BODY RADIATION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; INTESTINE, SMALL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; NERVE TISSUE PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; STEM CELLS; TIME FACTORS; WHOLE-BODY IRRADIATION;

EID: 59449098969     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00021.2008     Document Type: Article

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