Iron Metabolism and Its Disorders

Clinical Biochemistry of Domestic Animals, Sixth Edition

Volumn , Issue , 2008, Pages 259-285

  Harvey, John W ^a  

^a University of Florida   (United States)

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EID: 79955952380     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-370491-7.00009-X     Document Type: Chapter

References (223)

1. K.K. Adamama-Moraitou, M.N. Saridomichelakis, Z. Polizopoulou, M. Kritsepi, A. Tsompanakou and A.F. Koutinas (2005) Short-term exogenous glucocorticosteroidal effect on iron and copper status in canine leishmaniasis (Leishmania infantum). Can. J. Vet. Res. 69 287-292.
2. G.J. Anderson and D.M. Frazer (2005) Hepatic iron metabolism. Semin. Liver Dis. 25 420-432.
3. R.R. Anderson (1992) Comparison of trace elements in milk of four species. J. Dairy Sci. 75 3050-3055.
4. G.A. Andrews, P.S. Chavey and J.E. Smith (1994) Enzyme-linked immunosorbent assay to measure serum ferritin and the relationship between serum ferritin and nonheme iron stores in cats. Vet. Pathol. 31 674-678.
5. G.A. Andrews and J.E. Smith (2000) Iron metabolism. B.F. Feldman, J.G. Zinkl, N.C. Jain (Eds) Schalm's Veterinary Hematology Philadelphia: Lippincott Williams and Wilkins 129-139.
6. J. Arnbjerg (1981) Poisoning in animals due to oral application of iron: with description of a case in a horse. Nord. Vet. Med. 33 71-76.
7. P. Arosio and S. Levi (2002) Ferritin, iron homeostasis, and oxidative damage. Free Radic. Biol. Med. 33 457-463.
8. S. Auclair, C. Feillet-Coudray, C. Coudray, S. Schneider, M.U. Muckenthaler and A. Mazur (2006) Mild copper deficiency alters gene expression of proteins involved in iron metabolism. Blood Cells Mol. Dis. 36 15-20.
9. E. Beutler (1995) Hereditary and acquired sideroblastic anemias. E. Beutler, M.A. Lichtman, B.S. Coller, T.J. Kipps (Eds) Williams Hematology New York: McGraw-Hill 747-750.
10. E. Beutler (2006) Anemia resulting from other nutritional deficiencies. M.A. Lichtman, E. Beutler, T.J. Kipps, U. Seligsohn, K. Kaushansky, J.T. Prchal (Eds) Williams Hematology New York: McGraw-Hill 555-559.
11. E. Beutler (2006) Disorders of iron metabolism. M.A. Lichtman, E. Beutler, T.J. Kipps, U. Seligsohn, K. Kaushansky, J.T. Prchal (Eds) Williams Hematology New York: McGraw-Hill 511-553.
12. J.T. Blue, T.W. French and J.S. Kranz (1988) Non-lymphoid hematopoietic neoplasia in cats: a retrospective study of 60 cases. Cornell Vet. 78 21-42.
13. J.W. Blum and U. Zuber (1975) Iron stores of liver, spleen and bone marrow, and serum iron concentrations in female dairy cattle in relationship to age. Res. Vet. Sci. 18 294-298.
14. A.S. Borges, T.J. Divers, T. Stokol and O.H. Mohammed (2007) Serum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horses. J. Vet. Intern. Med. 21 489-494.
15. S.S. Bottomley (2004) Sideroblastic anemias. J.P. Greer, J. Foerster, J.N. Lukens, G.M. Rogers, F. Paraskevas (Eds) Wintrobe's Clinical Hematology Philadelphia: Lippincott Williams and Willkin 1011-1033.
16. S.S. Bottomley (2006) Congenital sideroblastic anemias. Curr. Hematol. Rep. 5 41-49.
17. N.R. Brewer (1987) Comparative metabolism of copper. J. Am. Vet. Med. Assoc. 190 654-658.
18. C. Brugnara (2003) Iron deficiency and erythropoiesis: new diagnostic approaches. Clin. Chem. 49 1573-1578.
19. C. Brugnara, L.A. Chambers, E. Malynn, M.A. Goldberg and M.S. Kruskall (1993) Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects. Blood 81 956-964.
20. C. Brugnara, B. Schiller and J. Moran (2006) Reticulocyte hemoglobin equivalent (Ret He) and assessment of iron-deficient states. Clin. Lab. Haematol. 28 303-308.
21. S.E. Bunch, H.L. Jordan, R.K. Sellon, J.M. Cullen and J.E. Smith (1995) Characterization of iron status in young dogs with portosystemic shunt. Am. J. Vet. Res. 56 853-858.
22. C. Camaschella, A. Campanella, F.L. De, L. Boschetto, R. Merlini, L. Silvestri, S. Levi and A. Iolascon (2007) Blood 110 1353-1358.
23. P.J. Canfield, A.D.J. Watson and R.C.C. Ratcliffe (1987) Dyserythropoiesis, sideroblasts/siderocytes and hemoglobin crystallization in a dog. Vet. Clin. Pathol. 16(1), 21-28.
24. G.E. Cartwright and A. Deiss (1975) Sideroblasts, siderocytes, and sideroblastic anemia. N. Engl. J. Med. 292 185-193.
25. S.A. Center and M.L. Magne (1990) Historical, physical examination, and clinicopathologic features of portosystemic vascular anomalies in the dog and cat. Sem. Vet. Med. Surg. Small Anim. 5 83-93.
26. J.J. Ceron, P.D. Eckersall and S. Martynez-Subiela (2005) Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet. Clin. Pathol. 34 85-99.
27. D.G. Chausow and G.L. Czarnecki-Maulden (1987) Estimation of the dietary iron requirement for the weanling puppy and kitten. J. Nutr. 117 928-932.
28. Q. Chen and R.E. Hirsch (2006) A direct and simultaneous detection of zinc protoporphyrin IX, free protoporphyrin IX, and fluorescent heme degradation product in red blood cell hemolysates. Free Radic. Res. 40 285-294.
29. J.L.L.M. Coenen, M.P. Van Dieijen-Visser, J. Van Pelt, C.T.B.M. Van Deursen, M.M.F. Fickers, J.W.J. Van Wersch and P.J. Brombacher (1991) Measurements of serum ferritin used to predict concentrations of iron in bone marrow in anemia of chronic disease. Clin. Chem. 37 560-563.
30. M.E. Conrad, J.N. Umbreit, E.G. Moore, L.N. Hainsworth, M. Porubcin, M.J. Simovich, M.T. Nakada, K. Dolan and M.D. Garrick (2000) Separate pathways for cellular uptake of ferric and ferrous iron. Am. J. Physiol. Gastrointest. Liver Physiol. 279 G767-gG774.
31. L.D. Cowgill, K.M. James, J.K. Levy, J.K. Browne, A. Miller, R.T. Lobingier and J.C. Egrie (1998) Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure. J. Am. Vet. Med. Assoc. 212 521-528.
32. C.M. Craven, J. Alexander, M. Eldridge, J.P. Kushner, S. Bernstein and J. Kaplan (1987) Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis. Proc. Natl. Acad. Sci. USA 84 3457-3461.
33. A. Deiss, D. Kurth, G.E. Cartwright and M.M. Wintrobe (1966) Experimental production of siderocytes. J. Clin. Invest. 45 353-364.
34. R.C. Doberneck, D.G. Kline, A.S. Morse and A. Berman (1963) Relationship of hemosiderosis to portocaval shunting. Surgery 54 912-921.
35. G. Doong, C.L. Keen, Q.R. Rogers, J.G. Morris and R.B. Rucker (1983) Selected features of copper metabolism in the cat. J. Nutr. 113 1963-1971.
36. V.F. Fairbanks and E. Beutler (1995) Iron deficiency. E. Beutler, M.A. Lichtman, B.S. Coller, T.J. Kipps (Eds) Williams Hematology New York: McGraw-Hill 490-511.
37. B.F. Feldman, J.J. Kaneko and T.B. Farver (1981) Anemia of inflammatory disease in the dog: clinical characterization. Am. J. Vet. Res. 42 1109-1113.
38. B.F. Feldman, J.J. Kaneko and T.B. Farver (1981) Anemia of inflammatory disease in the dog: ferrokinetics of adjuvant-induced anemia. Am. J. Vet. Res. 42 583-585.
39. B.F. Feldman, C.L. Keen, J.J. Kaneko and T.B. Farver (1981) Anemia of inflammatory disease in the dog: measurement of hepatic superoxide dismutase, hepatic nonheme iron, copper, zinc, and ceruloplasmin and serum iron, copper, and zinc. Am. J. Vet. Res. 42 1114-1117.
40. B.J. Ferguson, B.S. Skikne, K.M. Simpson, R.D. Baynes and J.D. Cook (1992) Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J. Lab. Clin. Med. 119 385-390.
41. G. Fillet, J.D. Cook and C.A. Finch (1974) Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport. J. Clin. Invest. 53 1527-1533.
42. C.A. Finch, H.A. Ragan, I.A. Dyer and J.D. Cook (1978) Body iron loss in animals. Proc. Soc. Exp. Biol. Med. 159 335-338.
43. R.E. Fleming, R.S. Britton, A. Waheed, W.S. Sly and B.R. Bacon (2005) Pathophysiology of hereditary hemochromatosis. Semin. Liver Dis. 25 411-419.
44. G.J. Fosmire (1990) Zinc toxicity. Am. J. Clin. Nutr. 51 225-227.
45. P. Franken, T. Wensing and A.J. Schotman (1981) The concentration of iron in the liver, spleen and plasma, and the amount of iron in bone marrow of horses. Zentralbl. Veterinarmed. A 28 381-389.
46. D.M. Frazer and G.J. Anderson (2005) Iron imports. I. Intestinal iron absorption and its regulation. Am. J. Physiol. Gastrointest. Liver Physiol. 289 G631-gG635.
47. T.W. French, L.E. Fox, J.F. Randolph and W.J. Dodds (1987) A bleeding disorder (von Willebrand's disease) in a Himalayan cat. J. Am. Vet. Med. Assoc. 190 437-439.
48. R. Fresco (1981) Electron microscopy in the diagnosis of the bone marrow disorders of the erythroid series. Semin. Hematol. 18 279-292.
49. J.S. Friedman, M.F. Lopez, M.D. Fleming, A. Rivera, F.M. Martin, M.L. Welsh, A. Boyd, S.R. Doctrow and S.J. Burakoff (2004) SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood 104 2565-2573.
50. M.M. Fry and C.A. Kirk (2006) Reticulocyte indices in a canine model of nutritional iron deficiency. Vet. Clin. Pathol. 35 172-181.
51. M.M. Fry, J.L. Liggett and S.J. Baek (2004) Molecular cloning and expression of canine hepcidin. Vet. Clin. Pathol. 33 223-227.
52. R. Fulton, M.G. Weiser, J.L. Freshman, P.W. Gasper and M.J. Fettman (1988) Electronic and morphologic characterization of erythrocytes of an adult cat with iron deficiency anemia. Vet. Pathol. 25 521-523.
53. K. Furugouri (1972) Plasma iron and total iron-binding capacity in piglets in anemia and iron administration. J. Anim. Sci. 34 421-426.
54. A.K. Ganti, N. Moazzam, S. Laroia, K. Tendulkar, A. Potti and S.A. Mehdi (2003) Predictive value of absent bone marrow iron stores in the clinical diagnosis of iron deficiency anemia. In Vivo 17 389-392.
55. T. Ganz and E. Nemeth (2006) Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am. J. Physiol. Gastrointest. Liver Physiol. 290 G199-gG203.
56. J.W. George and J.R. Duncan (1981) Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves. Am. J. Vet. Res. 42 1630-1637.
57. S. Ghosh, S. Hevi and S.L. Chuck (2004) Regulated secretion of glycosylated human ferritin from hepatocytes. Blood 103 2369-2376.
58. D.B. Gillis and R.A. Mitchell (1974) Erythrokinetics in normal cats. Am. J. Vet. Res. 35 31-33.
59. J.L. Gookin, S.E. Bunch, L.J. Rush and C.B. Grindem (1998) Evaluation of microcytosis in 18 Shibas. J. Am. Vet. Med. Assoc. 212 1258-1259.
60. J.H. Graversen, M. Madsen and S.K. Moestrup (2002) CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. Int. J. Biochem. Cell. Biol. 34 309-314.
61. X.T. Gregg, V. Reddy and J.T. Prchal (2002) Copper deficiency masquerading as myelodysplastic syndrome. Blood 100 1493-1495.
62. E.J. Gyorffy and H. Chan (1992) Copper deficiency and microcytic anemia resulting from prolonged ingestion of over-the-counter zinc. Am. J. Gastroenterol. 87 1054-1055.
63. K. Halvorsen and S. Halvorsen (1973) The "early anaemia"; its relation to postnatal growth rate, milk feeding, and iron availability. Experimental study in rabbits. Arch. Dis. Child. 48 842-849.
64. E. Hammond, A. Deiss, W.H. Carnes and G.E. Cartwright (1969) Ultrastructural characteristics of siderocytes in swine. Lab. Invest. 21 292-297.
65. J.W. Harvey (1981) Myeloproliferative disorders in dogs and cats. Veterinary Clinics of North America, Small Animal Practice 11 349-381.
66. J.W. Harvey (2000) Microcytic anemias. B.F. Feldman, J.G. Zinkl, N.C. Jain (Eds) Schalm's Veterinary Hematology Philadelphia: Lippincott Williams and Wilkins 200-204.
67. J.W. Harvey (2001) Atlas of Veterinary Hematology. Blood and Bone Marrow of Domestic Animals. Philadelphia: Saunders
68. J.W. Harvey (2006) Pathogenesis, laboratory diagnosis, and clinical implications of erythrocyte enzyme deficiencies in dogs, cats, and horses. Vet. Clin. Pathol. 35 144-156.
69. J.W. Harvey, R.L. Asquith, W.A. Sussman and J. Kivipelto (1987) Serum ferritin, serum iron, and erythrocyte values in foals. Am. J. Vet. Res. 48 1348-1352.
70. J.W. Harvey, W.L. Clapp, Y. Yao and G.D. Efremov (2007) Microcytic hypochromic erythrocytes containing siderotic inclusions, Heinz bodies, and hemoglobin crystals in a dog (abstract). Vet. Clin. Pathol. 36 313-314.
71. J.W. Harvey, T.W. French and D.J. Meyer (1982) Chronic iron deficiency anemia in dogs. J. Am. Anim. Hosp. Assoc. 18 946-960.
72. J.W. Harvey, D. Levin and C.L. Chen (1987) Potential effects of glucocorticoids on serum iron concentrations in dogs. Vet. Clin. Pathol. 16 46-50.
73. J.W. Harvey and J.E. Smith (1994) Haematology and clinical chemistry of English springer spaniel dogs with phosphofructokinase deficiency. Comp. Haematol. Int. 4 70-74.
74. J.W. Harvey and C.L. West (1987) Prednisone-induced increases in serum alpha-2-globulin and haptoglobin concentrations in dogs. Vet. Pathol. 24 90-92.
75. J.W. Harvey, K.J. Wolfsheimer, C.F. Simpson and T.W. French (1985) Pathologic sideroblasts and siderocytes associated with chloramphenicol therapy in a dog. Vet. Clin. Pathol. 14(1), 36-42.
76. J. Hastka, J.-J. Lasserre, A. Schwarzbeck and R. Hehlmann (1994) Central role of zinc protoporphyrin in staging iron deficiency. Clin. Chem. 40 768-773.
77. C.G. Hawke, J.E. Maddison, V. Poulos and A.D.J. Watson (1992) Erythrocyte protoporphyrin concentrations in clinically normal cats and cats with lead toxicity. Res. Vet. Sci. 53 260-263.
78. N.E. Hellman and J.D. Gitlin (2002) Ceruloplasmin metabolism and function. Annu. Rev. Nutr. 22 439-458.
79. H. Higuchi, N. Katoh, T. Miyamoto, E. Uchida, A. Yuasa and K. Takahashi (1994) Dexamethasone-induced haptoglobin release by calf liver parenchymal cells. Am. J. Vet. Res. 55 1080-1085.
80. C.T. Holland, P.J. Canfield, A.D.J. Watson and G.S. Allan (1991) Dyserythropoiesis, polymyopathy, and cardiac disease in three related English springer spaniels. J. Vet. Intern. Med. 5 151-159.
81. J.K. House, B.P. Smith, V.M. Lane, B.C. Anderson, T.W. Graham and M.V. Pino (1994) Hemochromatosis in Salers cattle. J. Vet. Intern. Med. 8 105-111.
82. H. Huebers, E. Csiba, E. Huebers and C.A. Finch (1985) Molecular advantage of diferric transferrin in delivering iron to reticulocytes: a comparative study. Proc. Natl. Acad. Sci. USA 179 222-226.
83. H.A. Huebers, B. Josephson, E. Huebers, E. Csiba and C.A. Finch (1984) Occupancy of the iron binding sites of human transferrin. Proc. Natl. Acad. Sci. USA 81 4326-4330.
84. D.A. Hughes, S.E. Stuart-Smith and B.J. Bain (2004) How should stainable iron in bone marrow films be assessed? J. Clin. Pathol. 57 1038-1040.
85. V. Hvidberg, M.B. Maniecki, C. Jacobsen, P. Hojrup, H.J. Moller and S.K. Moestrup (2005) Identification of the receptor scavenging hemopexin-heme complexes. Blood 106 2572-2579.
86. S. Hyyppa, M. Hoyhtya, M. Nevalainen and A.R. Poso (2002) Effect of exercise on plasma ferritin concentrations: implications for the measurement of iron status. Equine Vet. J. Suppl. 34 186-190.
87. G. Kadikoylu, I. Yavasoglu, Z. Bolaman and T. Senturk (2006) Platelet parameters in women with iron deficiency anemia. J. Natl. Med. Assoc. 98 398-402.
88. J.J. Kaneko (1964) Iron metabolism in canine anemia. Gaines Vet. Symp. 13 2-5.
89. J.J. Kaneko and D.R. Mattheeuws (1966) Iron metabolism in normal and porphyric calves. Am. J. Vet. Res. 27 923-929.
90. C.L. Keen, B. Lonnerdal and G.L. Fisher (1981) Age-related variations in hepatic iron, copper, zinc, and selenium concentrations in beagles. Am. J. Vet. Res. 42 1884-1887.
91. E. Kemna, P. Pickkers, E. Nemeth, H. van der Hoeven and D. Swinkels (2005) Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106 1864-1866.
92. D.S. Kempe, P.A. Lang, C. Duranton, A. Akel, K.S. Lang, S.M. Huber, T. Wieder and F. Lang (2006) Enhanced programmed cell death of iron-deficient erythrocytes. FASEB J. 20 368-370.
93. E. Kolb (1963) The metabolism of iron in farm animals under normal and pathologic conditions. Adv. Vet. Sci. Comp. Med. 19 49-114.
94. G.J. Kontoghiorghes and E.D. Weinberg (1995) Iron: mammalian defense systems, mechanisms of disease, and chelation therapy approaches. Blood Rev. 9 33-45.
95. M.J. Koury and P. Ponka (2004) New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu. Rev. Nutr. 24 105-131.
96. D.F. Kowalczyk, J.M. Naylor and D. Gunson (1981) The value of zinc protoporphyrin in equine lead poisoning: a case report. Vet. Hum. Toxicol. 23 12-15.
97. R.F. Labbe, H.J. Vreman and D.K. Stevenson (1999) Zinc protoporphyrin: a metabolite with a mission. Clin. Chem. 45 2060-2072.
98. D.P. Laflamme, E.A. Mahaffey, S.W. Allen, D.C. Twedt, K.W. Prasse and T.L. Huber (1994) Microcytosis and iron status in dogs with surgically induced portosystemic shunts. J. Vet. Intern. Med. 8 212-216.
99. M.E. Lahey, C.J. Gubler, M.S. Chase, G.E. Cartwright and M.M. Wintrobe (1952) Studies on copper metabolism. II. Hematologic manifestations of copper deficiency in swine. Blood 7 1053-1074.
100. A.A. Lamola and T. Yamane (1974) Zinc protoporphyrin in the erythrocytes of patients with lead intoxication and iron deficiency anemia. Science 186 936-938.
101. R.D. Lange, J.B. Jones, C. Chambers, Y. Quirin and J.C. Sparks (1976) Erythropoiesis and erythrocytic survival in dogs with cyclic hematopoiesis. Am. J. Vet. Res. 37 331-334.
102. G.O. Latunde-Dada, A.T. McKie and R.J. Simpson (2006) Animal models with enhanced erythropoiesis and iron absorption. Biochim. Biophys. Acta. 1762 414-423.
103. G.O. Latunde-Dada, R.J. Simpson and A.T. McKie (2006) Recent advances in mammalian haem transport. Trends Biochem. Sci. 31 182-188.
104. J.P. Lavoie and E. Teuscher (1993) Massive iron overload and liver fibrosis resembling haemochromatosis in a racing pony. Equine Vet. J. 25 552-554.
105. G.R. Lee, G.E. Cartwright and M.M. Wintrobe (1968) Heme biosynthesis in copper deficient swine. Proc. Soc. Exp. Biol. Med. 127 977-981.
106. G.R. Lee, S. Nacht, J.N. Lukens and G.E. Cartwright (1968) Iron metabolism in copper-deficient swine. J. Clin. Invest. 47 2058-2069.
107. P. Lee, H. Peng, T. Gelbart, L. Wang and E. Beutler (2005) Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc. Natl. Acad. Sci. USA 102 1906-1910.
108. S. Levi, P. Santambrogio, A. Cozzi, E. Rovida, B. Corsi, E. Tamborini, S. Spada, A. Albertini and P. Arosio (1994) The role of the L-chain in ferritin iron incorporation. Studies of homo and heteropolymers. J. Mol. Biol. 238 649-654.
109. J.K. Levy, S.E. Bunch and J. Komtebedde (1995) Feline portosystemic vascular shunts. J.D. Bondagura (Eds) Kirk's Current Veterinary Therapy XII. Small Animal Practice Philadelphia: Saunders 743-749.
110. R. Lill, R. Dutkiewicz, H.P. Elsasser, A. Hausmann, D.J. Netz, A.J. Pierik, O. Stehling, E. Urzica and U. Muhlenhoff (2006) Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes. Biochim. Biophys. Acta 1763 652-667.
111. P.E. Lisboa (1971) Experimental hepatic cirrhosis in dogs caused by chronic massive iron overload. Gut 12 363-368.
112. M. Loo and Y. Beguin (1999) The effect of recombinant human erythropoietin on platelet counts is strongly modulated by the adequacy of iron supply. Blood 93 3286-3293.
113. L.J. Lowenstine and L. Munson (1999) Iron overload in the animal kingdom. M.E. Fowler, R.E. Miller (Eds) Zoo and Wild Animal Medicine: Current Therapy 4 Philadelphia: Saunders 260-268.
114. M.D. Lucroy, M.M. Christopher, S.A. Kraegel, E.R. Simonson and B.R. Madewell (1998) Anaemia associated with canine lymphoma. Comp. Haematol. Int. 8 1-6.
115. J.E. Lund and P.K. Brown (1997) Hypersegmented megakaryocytes and megakaryocytes with multiple separate nuclei in dogs treated with PNU-100592, an oxazolidinone antibiotic. Toxicol. Pathol. 25 339-343.
116. B. Mackenzie and M.D. Garrick (2005) Iron imports. II. Iron uptake at the apical membrane in the intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 289 G981-gG986.
117. J.M. Maddux, W.E. Moore, K.S. Keeton and R.M. Shull (1988) Dexamethasone-induced serum biochemical changes in goats. Am. J. Vet. Res. 49 1937-1940.
118. E.A. Mahaffey and J.E. Smith (1978) Depression anemia in cats. Feline Pract. 8 19-22.
119. C.J. Martin, C.L. Werntz III and A.M. Ducatman (2004) The interpretation of zinc protoporphyrin changes in lead intoxication: a case report and review of the literature. Occup. Med. (Lond) 54 587-591.
120. M. Melamed-Frank, O. Lache, B.I. Enav, T. Szafranek, N.S. Levy, R.M. Ricklis and A.P. Levy (2001) Structure-function analysis of the antioxidant properties of haptoglobin. Blood 98 3693-3698.
121. A. Mete, G.M. Dorrestein, J.J.M. Marx, A.G. Lemmens and A.C. Beynen (2001) A comparative study of iron retention in mynahs, doves, and rats. Avian Pathol. 30 479-486.
122. A. Mete, H.G. Hendriks, P.H. Klaren, G.M. Dorrestein, J.E. Van Dijk and J.J. Marx (2003) Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis. Avian Pathol. 32 625-632.
123. A. Mete, R. Jalving, B.A. van Oost, J.E. Van Dijk and J.J. Marx (2005) Intestinal over-expression of iron transporters induces iron overload in birds in captivity. Blood Cells Mol. Dis. 34 151-156.
124. G. Metzgeroth, V. Adelberger, A. Dorn-Beineke, C. Kuhn, M. Schatz, O. Maywald, T. Bertsch, H. Wisser, R. Hehlmann and J. Hastka (2005) Soluble transferrin receptor and zinc protoporphyrin: competitors or efficient partners? Eur. J. Haematol. 75 309-317.
125. D.J. Meyer and J.W. Harvey (1994) Hematologic changes associated with serum and hepatic iron alterations in dogs with congenital portosystemic vascular abnormalities. J. Vet. Intern. Med. 8 55-56.
126. G.A. Miltenburg, T. Wensing, F.J. Smulders and H.J. Breukink (1992) Relationship between blood hemoglobin, plasma and tissue iron, muscle heme pigment, and carcass color of veal. J. Anim. Sci. 70 2766-2772.
127. G.A. Miltenburg, T. Wensing, J. van de Broek, D.J. Mevius and H.J. Breukink (1992) Effects of different iron contents in the milk replacer on the development of iron deficiency anaemia in veal calves. Vet. Q. 14 18-21.
128. L. Mollerberg, L. Ekman and S.O. Jacobsson (1975) Ferrokinetic studies in normal and iron deficiency anemic calves. Acta Vet. Scand. 16 205-217.
129. A. Montaser, C. Tetreault and M. Linder (1992) Comparison of copper binding components in dog serum with those in other species. Proc. Soc. Exp. Biol. Med. 200 321-329.
130. C.V. Moore, R. Dubach, V. Minnich and H.K. Roberts (1944) Absorption of ferrous and ferric radioactive iron by human subjects and by dogs. J. Clin. Invest. 23 755-767.
131. D.E. Morin, F.B. Garry and M.G. Weiser (1993) Hematologic responses in llamas with experimentally-induced iron deficiency anemia. Vet. Clin. Pathol. 22 81-85.
132. T.P. Mullaney and C.M. Brown (1988) Iron toxicity in neonatal foals. Equine Vet. J. 20 119-124.
133. O. Nakajima, S. Okano, H. Harada, T. Kusaka, X. Gao, T. Hosoya, N. Suzuki, S. Takahashi and M. Yamamoto (2006) Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes. Genes Cells 11 685-700.
134. I. Napier, P. Ponka and D.R. Richardson (2005) Iron trafficking in the mitochondrion: novel pathways revealed by disease. Blood 105 1867-1874.
135. M.H. Nathanson, A. Muir and G.D. McLaren (1985) Iron absorption in normal and iron-deficient beagle dogs: mucosal iron kinetics. Am. J. Physiol. 249 G439-gG448.
136. R. Navone, L. Azzoni and G. Valente (1988) Immunohistochemical assessment of ferritin in bone marrow trephine biopsies: correlation with marrow hemosiderin. Acta Haematol. (Basel) 80 194-198.
137. E. Nemeth, S. Rivera, V. Gabayan, C. Keller, S. Taudorf, B.K. Pedersen and T. Ganz (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113 1271-1276.
138. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, D.M. Ward, T. Ganz and J. Kaplan (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 2090-2093.
139. S. Neumann (2003) Serum iron level as an indicator for inflammation in dogs and cats. Comp. Clin. Path. 12 90-94.
140. C.E. Newlands, D.M. Houston and D.Y. Vasconcelos (1994) Hyperferritinemia associated with malignant histiocytosis in a dog. J. Am. Vet. Med. Assoc. 205 849-851.
141. R.W. Norrdin, K.J. Hoopes and D. O'Toole (2004) Skeletal changes in hemochromatosis of Salers cattle. Vet. Pathol. 41 612-623.
142. D. O'Toole, E.J. Kelly, M.M. McAllister, A.W. Layton, R.W. Norrdin, W.C. Russell, K. Saeb-Parsy and A.P. Walker (2001) Hepatic failure and hemochromatosis of Salers and Salers-cross cattle. Vet. Pathol. 38 372-389.
143. R.S. Ohgami, D.R. Campagna, E.L. Greer, B. Antiochos, A. McDonald, J. Chen, J.J. Sharp, Y. Fujiwara, J.E. Barker and M.D. Fleming (2005) Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat. Genet. 37 1264-1269.
144. J. Okabe, S. Tajima, O. Yamato, M. Inaba, S. Hagiwara and Y. Maede (1996) Hemoglobin types, erythrocyte membrane skeleton and plasma iron concentration in calves with poikilocytosis. J. Vet. Med. Sci. 58 629-634.
145. M. Okumura, T. Fujinaga, K. Yamashita, N. Tsunoda and S. Mizuno (1991) Isolation, characterization, and quantitative analysis of ceruloplasmin from horses. Am. J. Vet. Res. 52 1979-1985.
146. K. Orino, T. Miura, S. Muto and K. Watanabe (2005) Sequence analysis of canine and equine ferritin H and L subunit cDNAs. DNA Seq. 16 58-64.
147. S. Osaki, D.A. Johnson and E. Frieden (1971) The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, I. J. Biol. Chem. 246 3018-3023.
148. M. Ottenjann, C. Weingart, G. Arndt and B. Kohn (2006) Characterization of the anemia of inflammatory disease in cats with abscesses, pyothorax, or fat necrosis. J. Vet. Intern. Med. 20 1143-1150.
149. D.E. Paglia, D.E. Kenny, E.S. Dierenfeld and I.H. Tsu (2001) Role of excessive maternal iron in the pathogenesis of congenital leukoencephalomalacia in captive black rhinoceroses (Diceros bicornis). Am. J. Vet. Res. 62 343-349.
150. M. Pak, M.A. Lopez, V. Gabayan, T. Ganz and S. Rivera (2006) Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108 3730-3735.
151. C.H. Park, E.V. Valore, A.J. Waring and T. Ganz (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276 7806-7810.
152. E.G. Pearson, O.R. Hedstrom and R.H. Poppenga (1994) Hepatic cirrhosis and hemochromatosis in three horses. J. Am. Vet. Med. Assoc. 204 1053-1056.
153. P. Ponka, C. Beaumont and D.R. Richardson (1998) Function and regulation of transferrin and ferritin. Semin. Hematol. 35 35-54.
154. P. Ponka and D.R. Richardson (1997) Can ferritin provide iron for hemoglobin synthesis? Blood 89 2611-2612.
155. R.J. Porra and O.T.G. Jones (1963) Studies on ferrochelatase. I. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract. Biochem. J. 87 181-185.
156. G.C. Pritchard, G. Lewis, G.A. Wells and A. Stopforth (1985) Zinc toxicity, copper deficiency and anaemia in swill-fed pigs. Vet. Rec. 117 545-548.
157. J.G. Quigley, Z. Yang, M.T. Worthington, J.D. Phillips, K.M. Sabo, D.E. Sabath, C.L. Berg, S. Sassa, B.L. Wood and J.L. Abkowitz (2004) Identification of a human heme exporter that is essential for erythropoiesis. Cell 118 757-766.
158. G.A. Ramm and R.G. Ruddell (2005) Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. Semin. Liver Dis. 25 433-449.
159. P.G. Reeves, L.C. Demars, W.T. Johnson and H.C. Lukaski (2005) Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. J. Nutr. 135 92-98.
160. S. Rivera, E. Nemeth, V. Gabayan, M.A. Lopez, D. Farshidi and T. Ganz (2005) Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 106 2196-2199.
161. H.P. Roeser, G.R. Lee, S. Nacht and G.E. Cartwright (1970) The role of ceruloplasmin in iron metabolism. J. Clin. Invest. 49 2408-2417.
162. V. Rosen (2006) BMP and BMP inhibitors in bone. Ann. NY Acad. Sci. 1068 19-25.
163. R.J. Rothman, A. Serroni and J.L. Farber (1992) Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury. Mol. Pharmacol. 42 703-710.
164. L.P. Ruhr, S.S. Nicholson, A.W. Confer and B.W. Blakewood (1983) Acute intoxication from a hematinic in calves. J. Am. Vet. Med. Assoc. 182 616-618.
165. T.P. Ryan and S.D. Aust (1992) The role of iron in oxygen-mediated toxicities. Crit. Rev. Toxicol. 22 119-141.
166. P.C. Schultheiss, C.L. Bedwell, D.W. Hamar and M.J. Fettman (2002) Canine liver iron, copper, and zinc concentrations and association with histologic lesions. J. Vet. Diagn. Invest. 14 396-402.
167. G.P. Searcy, J.B. Tasker and D.R. Miller (1979) Animal model: pyruvate kinase deficiency in dogs. Am. J. Physiol. 94 689-692.
168. G.C. Shaw, J.J. Cope, L. Li, K. Corson, C. Hersey, G.E. Ackermann, B. Gwynn, A.J. Lambert, R.A. Wingert, D. Traver, N.S. Trede, B.A. Barut, Y. Zhou, E. Minet, A. Donovan, A. Brownlie, R. Balzan, M.J. Weiss, L.L. Peters, J. Kaplan, L.I. Zon and B.H. Paw (2006) Mitoferrin is essential for erythroid iron assimilation. Nature 440 96-100.
169. M. Shayeghi, G.O. Latunde-Dada, J.S. Oakhill, A.H. Laftah, K. Takeuchi, N. Halliday, Y. Khan, A. Warley, F.E. McCann, R.C. Hider, D.M. Frazer, G.J. Anderson, C.D. Vulpe, R.J. Simpson and A.T. McKie (2005) Identification of an intestinal heme transporter. Cell 122 789-801.
170. A.D. Sheftel, A.S. Zhang, C. Brown, O.S. Shirihai and P. Ponka (2007) Direct interorganellar transfer of iron from endosome to mitochondrion. Blood 110 125-132.
171. K.W. Simpson, D.J. Meyer, A. Boswood, R.N. White and I.E. Maskell (1997) Iron status and erythrocyte volume in dogs with congenital portosystemic vascular anomalies. J. Vet. Intern. Med. 11 14-19.
172. J.E. Smith (1992) Iron metabolism in dogs and cats. Comp. Cont. Ed. Pract. Vet. 14 39-43.
173. J.E. Smith (1997) Iron metabolism and its disorders. J.J. Kaneko, J.W. Harvey, M.L. Bruss (Eds) Clinical Biochemistry of Domestic Animals San Diego, CA: Academic Press 223-238.
174. J.E. Smith and J.E. Cipriano (1987) Inflammation-induced changes in serum iron analytes and ceruloplasmin of Shetland ponies. Vet. Pathol. 24 354-356.
175. J.E. Smith, J.E. Cipriano, R. DeBowes and K. Moore (1986) Iron deficiency and pseudo-iron deficiency in hospitalized horses. J. Am. Vet. Med. Assoc. 188 285-287.
176. J.E. Smith, R.M. DeBowes and J.E. Cipriano (1986) Exogenous corticosteroids increase serum iron concentrations in mature horses and ponies. J. Am. Vet. Med. Assoc. 188 1296-1298.
177. J.E. Smith, K. Moore, D. Boyington, D.S. Pollmann and D. Schoneweis (1984) Serum ferritin and total iron-binding capacity to estimate iron storage in pigs. Vet. Pathol. 21 597-600.
178. J.E. Smith, K. Moore, J.E. Cipriano and P.G. Morris (1984) Serum ferritin as a measure of stored iron in horses. J. Nutr. 114 677-681.
179. N. Soubasis, T.S. Rallis, J. Vlemmas, K.K. Adamama-Moraitou, N. Roubies, N.N. Prassinos and G. Brellou (2006) J. Gastroenterol. Hepatol. 21 599-604.
180. W.S. Sprague, T.B. Hackett, J.S. Johnson and C.J. Swardson-Olver (2003) Hemochromatosis secondary to repeated blood transfusions in a dog. Vet. Pathol. 40 334-337.
181. R.R. Starzynski, M.A. Gralak, E. Smuda and P. Lipinski (2004) A characterization of the activities of iron regulatory protein 1 in various farm animal species. Cell. Mol. Biol. Lett. 9 651-664.
182. T.M. Steele, D.M. Frazer and G.J. Anderson (2005) Systemic regulation of intestinal iron absorption. IUBMB Life 57 499-503.
183. D.J. Steffen, G.S. Elliott, H.W. Leipold and J.E. Smith (1992) Congenital dyserythropoiesis and progressive alopecia in Polled Hereford calves: hematologic, biochemical, bone marrow cytologic, electrophoretic, and flow cytometric findings. J. Vet. Diagn. Invest. 4 31-37.
184. J.D. Steinberg and C.S. Olver (2005) Hematologic and biochemical abnormalities indicating iron deficiency are associated with decreased reticulocyte hemoglobin content (CHr) and reticulocyte volume (rMCV) in dogs. Vet. Clin. Pathol. 34 23-27.
185. W.B. Stewart, P.S. Vassar and R.S. Stone (1953) Iron absorption in dogs during anemia due to acetylphenylhydrazine. J. Clin. Invest. 32 1225-1228.
186. F. Stohlman, A. Howard and A. Beland (1963) Humoral regulation of erythropoiesis. XII. Effect of erythropoietin and iron on cell size in iron deficiency anemia. Proc. Soc. Exp. Biol. Med. 113 986-988.
187. T. Stokol and J.T. Blue (1999) Pure red cell aplasia in cats: 9 cases (1989–1997). J. Am. Vet. Med. Assoc. 214 75-79.
188. T. Stokol, J.T. Blue and T.W. French (2000) Idiopathic pure red cell aplasia and nonregenerative immune-mediated anemia in dogs: 43 cases (1988–1999). J. Am. Vet. Med. Assoc. 216 1429-1436.
189. I. Theurl, V. Mattle, M. Seifert, M. Mariani, C. Marth and G. Weiss (2006) Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood 107 4142-4148.
190. F.M. Torti and S.V. Torti (2002) Regulation of ferritin genes and protein. Blood 99 3505-3516.
191. J. Truksa, H. Peng, P. Lee and E. Beutler (2006) Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc. Natl. Acad. Sci. USA 103 10289-10293.
192. E.J. Underwood (1977) Trace Elements in Human and Animal Nutrition. New York: Academic Press
193. A.S. van Miert, C.T. van Duin and T. Wensing (1986) The effects of ACTH, prednisolone and Escherichia coli endotoxin on some clinical haematological and blood biochemical parameters in dwarf goats. Vet. Q. 8 195-203.
194. A.S. van Miert, C.T. van Duin and T. Wensing (1990) Fever and changes in plasma zinc and iron concentrations in the goat: the effects of interferon inducers and recombinant IFN-alpha 2a. J. Comp. Pathol. 103 289-300.
195. S. Vaulont, D.Q. Lou, L. Viatte and A. Kahn (2005) Of mice and men: the iron age. J. Clin. Invest. 115 2079-2082.
196. M.V. Verga Falzacappa and M.U. Muckenthaler (2005) Hepcidin: iron-hormone and anti-microbial peptide. Gene 364 37-44.
197. J.H. Verheijden, A.S. van Miert, A.J. Schotman and C.T. van Duin (1982) Plasma zinc and iron concentrations as measurements for evaluating the influence of endotoxin-neutralizing agents in Escherichia coli endotoxin-induced mastitis. Am. J. Vet. Res. 43 724-728.
198. M. Vokurka, J. Krijt, K. Sulc and E. Necas (2006) Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol. Res. 55 667-674.
199. D.F. Wallace, L. Summerville, P.E. Lusby and V.N. Subramaniam (2005) Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes. J. Hepatol. 43 720-728.
200. K. Watanabe, K. Hayashi, T. Miyamoto, M. Tanaka, S. Okano and S. Yamamoto (2000) Characterization of ferritin and ferritin-binding proteins in canine serum. Biometals 13 57-63.
201. K. Watanabe, M. Ozawa, H. Ochiai, H. Kamohara, N. Iijima, H. Negita, K. Orino and S. Yamamoto (1998) Changes in iron and ferritin in anemic calves infected with Theileria sergenti. J. Vet. Med. Sci. 60 943-947.
202. B.R. Weeks, J.E. Smith, R.M. DeBowes and J.M. Smith (1989) Decreased serum iron and zinc concentrations in cattle receiving intravenous dexamethasone. Vet. Pathol. 26 345-346.
203. B.R. Weeks, J.E. Smith and J.K. Northrop (1989) Relationship of serum ferritin and iron concentrations and serum total iron-binding capacity to nonheme iron stores in dogs. Am. J. Vet. Res. 50 198-200.
204. B.R. Weeks, J.E. Smith and R.M. Phillips (1988) Enzyme-linked immunosorbent assay for canine serum ferritin, using monoclonal anti-canine ferritin immunoglobulin G. Am. J. Vet. Res. 49 1193-1196.
205. B.R. Weeks, J.E. Smith and C.K. Stadler (1990) Effect of dietary iron content on hematologic and other measures of iron adequacy in dogs. J. Am. Vet. Med. Assoc. 196 749-753.
206. P.L. Weiden, R.C. Hackman, J. Deeg, C. Graham, E.D. Thomas and R. Strob (1981) Long-term survival and reversal of iron overload after marrow transplantation in dogs with congenital hemolytic anemia. Blood 57 66-70.
207. G. Weiser and M. O'Grady (1983) Erythrocyte volume distribution analysis and hematologic changes in dogs with iron deficiency anemia. Vet. Pathol. 20 230-241.
208. M.G. Weiser and G.J. Kociba (1983) Sequential changes in erythrocyte volume distribution and microcytosis associated with iron deficiency in kittens. Vet. Pathol. 20 1-12.
209. D.J. Weiss (2005) Sideroblastic anemia in 7 dogs (1996–2002). J. Vet. Intern. Med. 19 325-328.
210. D.J. Weiss, B. Aird and M.P. Murtaugh (1992) Neutrophil-induced immunoglobulin binding to erythrocytes involves proteolytic and oxidative injury. J. Leuk. Biol. 51 19-23.
211. D.J. Weiss and J.S. Klausner (1988) Neutrophil-induced erythrocyte injury: a potential cause of erythrocyte destruction in the anemia associated with inflammatory disease. Vet. Pathol. 25 450-455.
212. D.J. Weiss and J.D. Krehbiel (1983) Studies of the pathogenesis of anemia of inflammation: erythrocyte survival. Am. J. Vet. Res. 44 1830-1831.
213. D.J. Weiss, J.D. Krehbiel and J.E. Lund (1983) Studies of the pathogenesis of anemia of inflammation: mechanisms of impaired erythropoiesis. Am. J. Vet. Res. 44 1832-1835.
214. D.J. Weiss and J. Lulich (1999) Myelodysplastic syndrome with sideroblastic differentiation in a dog. Vet. Clin. Pathol. 28 59-63.
215. G. Weiss and L.T. Goodnough (2005) Anemia of chronic disease. N. Engl. J. Med. 352 1011-1023.
216. S. Welch (1990) A comparison of the structure and properties of serum transferrin from 17 animal species. Comp. Biochem. Physiol. B 97 417-427.
217. M. Wessling-Resnick (2006) Iron imports. III. Transfer of iron from the mucosa into circulation. Am. J. Physiol. Gastrointest. Liver Physiol. 290 G1-gG6.
218. M.S. Wheby and D.A. Spyker (1981) Hemoglobin iron absorption kinetics in the iron-deficient dog. Am. J. Clin. Nutr. 34 1686-1693.
219. S.J. Wilkins, D.M. Frazer, K.N. Millard, G.D. McLaren and G.J. Anderson (2006) Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood 107 1659-1664.
220. D.M. Williams, D. Loukopoulos, G.R. Lee and G.E. Cartwright (1976) Role of copper in mitochondrial iron metabolism. Blood 48 77-85.
221. R.A. Wingert, J.L. Galloway, B. Barut, H. Foott, P. Fraenkel, J.L. Axe, G.J. Weber, K. Dooley, A.J. Davidson, B. Schmid, B.H. Paw, G.C. Shaw, P. Kingsley, J. Palis, H. Schubert, O. Chen, J. Kaplan and L.I. Zon (2005) Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature 436 1035-1039.
222. K. Yoshino, N. Katoh, K. Takahashi and A. Yuasa (1993) Possible involvement of protein kinase C with induction of haptoglobin in cows by treatment with dexamethasone and by starvation. Am. J. Vet. Res. 54 689-694.
223. J.A. Zaucha, C. Yu, C.D.J. Lothrop, R.A. Nash, G. Sale, G. Georges, H.P. Kiem, G.P. Niemeyer, M. Dufresne, Q. Cao and R. Storb (2001) Severe canine hereditary hemolytic anemia treated by nonmyeloablative marrow transplantation. Biol. Blood Marrow Transplant. 7 14-24.