Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation

Leukemia

Volumn 25, Issue 5, 2011, Pages 770-780

  Gandillet, A ^a   Park, S ^a   Lassailly, F ^a   Griessinger, E ^a   Vargaftig, J ^a   Filby, A ^a   Lister, T A ^b   Bonnet, D ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

acute myeloid leukemia; leukemic culture initiating cells; Leukemic stem cell; whole body imaging; Wnt catenin; xenotransplantation

Indexed keywords

BETA CATENIN; CD34 ANTIBODY; LENTIVIRUS VECTOR; RETINOIC ACID; SHORT HAIRPIN RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CLINICAL ARTICLE; ENGRAFTMENT; ENZYME INDUCTION; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; KARYOTYPE; LEUKOCYTE COUNT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL; STROMA; WESTERN BLOTTING; XENOTRANSPLANTATION;

EID: 79955811282     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.17     Document Type: Article

References (37)

1. Gilliland DG, Jordan CT, Felix CA. The molecular basis of leukemia. Hematol Am Soc Hematol Educ Program 2004; 1: 80-97.
2. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367: 645-648. (Pubitemid 24067706)
3. Bonnet D, DickJE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-737. (Pubitemid 27298715)
4. Ailles LE, Gerhard B, Kawagoe H, Hogge DE. Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice. Blood 1999; 94: 1761-1772. (Pubitemid 29411327)
5. Ailles LE, Humphries RK, Thomas TE, Hogge DE. Retroviral marking of acute myelogenous leukemia progenitors that initiate long-term culture and growth in immunodeficient mice. Exp Hematol 1999; 27: 1609-1620. (Pubitemid 29526745)
6. Feuring-Buske M, Gerhard B, CashmanJ, Humphries RK, Eaves CJ, Hogge DE. Improved engraftment of human acute myeloid leukemia progenitor cells in fi 2-microglobulin-deficient NOD/ SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 2003; 17: 760-763. (Pubitemid 36519373)
7. Rizo A, Dontje B, Vellenga E, de Haan G, Schuringa JJ. Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1. Blood 2008; 111: 2621-2630.
8. Sengupta A, Banerjee D, Chandra S, Banerji SK, Ghosh R, Roy R et al. Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression. Leukemia 2007; 21: 949-955. (Pubitemid 46672071)
9. Dash AB, Williams IR, Kutok JL, Tomasson MH, Anastasiadou E, Lindahl K et al. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci USA 2002; 99: 7622-7627. (Pubitemid 34568741)
10. Bansal D, Scholl C, Frohling S, McDowell E, Lee BH, Dohner K et al. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci USA2006; 103: 16924-16929.
11. Nusse R. The Wnt Homepage. http://www.stanford.edu/group/ nusselab/cgi-bin/wnt/.
12. Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K et al. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 2003; 423: 409-414. (Pubitemid 36626987)
13. Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C. The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. Leukemia 2007; 21: 1638-1647. (Pubitemid 47086754)
14. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003; 423: 448-452. (Pubitemid 36626997)
15. Baba Y, Yokota T, Spits H, Garrett KP, Hayashi S, Kincade PW. Constitutively active 3-catenin promotes expansion of multi-potent hematopoietic progenitors in culture. J Immunol 2006; 177: 2294-2303. (Pubitemid 44200989)
16. Kirstetter P, Anderson K, Porse BT, Jacobsen SE, Nerlov C. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 2006; 7: 1048-1056. (Pubitemid 44420649)
17. SchellerM, HuelskenJ, Rosenbauer F, Taketo MM, BirchmeierW, Tenen DG et al. Hematopoietic stem cell and multilineage defects generated by constitutive 3-catenin activation. Nat Immunol 2006; 7: 1037-1047. (Pubitemid 44420648)
18. Zhao C, Blum J, Chen A, Kwon HY, JungSH, CookJM et al. Loss of 3-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 2007; 12: 528-541. (Pubitemid 350199070)
19. Sloma I, Jiang X, Eaves AC, Eaves CJ. Insights into the stem cells of chronic myeloid leukemia. Leukemia 2010; 24: 1823-1833.
20. Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N EnglJ Med2004; 351: 657-667. (Pubitemid 39063268)
21. Abrahamsson AE, Geron I, Gotlib J, Dao KH, Barroga CF, Newton IG et al. Glycogen synthase kinase 3fi missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci USA 2009; 106: 3925-3929.
22. Brandts CH, Sargin B, RodeM, Biermann C, Lindtner B, SchwableJ et al. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res 2005; 65: 9643-9650. (Pubitemid 41541439)
23. Tickenbrock L, Schwable J, Wiedehage M, Steffen B, Sargin B, Choudhary C et al. Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction. Blood 2005; 105: 3699-3706. (Pubitemid 40628219)
24. Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol 2004; 24: 2890-2904. (Pubitemid 38381278)
25. Roman-Gomez J, Cordeu L, Agirre X, Jimenez-Velasco A, San Jose-Eneriz E, Garate L et al. Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. Blood 2007; 109: 3462-3469. (Pubitemid 46572536)
26. Valencia A, Roman-Gomez J, Cervera J, Such E, Barragan E, Bolufer P et al. Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia 2009; 23: 1658-1666.
27. Ysebaert L, Chicanne G, Demur C, De Toni F, Prade-Houdellier N, Ruidavets JB et al. Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia 2006; 20: 1211-1216. (Pubitemid 43905823)
28. Majeti R, Becker MW, Tian Q, Lee TL, Yan X, Liu R et al. Dysregulated gene expression networks in human acute myelo-genous leukemia stem cells. Proc Natl Acad Sci USA 2009; 106: 3396-3401.
29. Yeung J, Esposito MT, Gandillet A, Zeisig BB, Griessinger E, Bonnet D et al. catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 2010; 18: 606-618.
30. Siapati EK, Papadaki M, Kozaou Z, Rouka E, Michali E, Savvidou I et al. Proliferation and bone marrow engraftment of AML blasts is dependent on b-catenin signalling. Br J Haematol 2011; 152: 164-174.
31. Taussig DC, Miraki-Moud F, Anjos-Afonso F, Pearce DJ, Allen K, Ridler C et al. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood 2008; 112: 568-575.
32. Taussig DC, Vargaftig J, Miraki-Moud F, Griessinger E, Sharrock K, Luke T et al. Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction. Blood 2010; 115: 1976-1984.
33. Ortyn WE, Hall BE, George TC, Frost K, Basiji DA, Perry DJ et al. Sensitivity measurement and compensation in spectral imaging. Cytometry A 2006; 69: 852-862. (Pubitemid 44469997)
34. Schuringa JJ, Schepers H. Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells. Methods Mol Biol 2009; 538: 287-300.
35. Matkovic K, Brugnoli F, Bertagnolo V, Banfic H, Visnjic D. The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells. Leukemia 2006; 20: 941-951. (Pubitemid 43797283)
36. Wang X, Rosol M, Ge S, Peterson D, McNamara G, Pollack H et al. Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood 2003; 102: 3478-3482. (Pubitemid 37409362)
37. Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009; 136: 823-837.