The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells

Leukemia

Volumn 20, Issue 6, 2006, Pages 941-951

  Matkovic, K ^a   Brugnoli, F ^b   Bertagnolo, V ^b   Banfic, H ^a   Visnjic, D ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Akt; Akt inhibitor; All trans retinoic acid; HL 60 cells; NB4 cells; Nuclei

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 DEOXY 2 O METHYL MYOINOSITOL 2 METHOXY 3 (OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE; 6 HYDROXYMETHYL CHIROINOSITOL 2 O METHYL 3 O OCTADECYLCARBONATE; CD11B ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE INHIBITOR; RETINOIC ACID; SH 5; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL LYSATE; CELL NUCLEUS; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; WESTERN BLOTTING;

EID: 33744468497     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404204     Document Type: Article

References (39)

1. Datta SR, Brunet A, Greenberg ME. Cellular survival: A play in three Akts. Genes Dev 1999; 13: 2905-2927.
2. Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/ AKT-a major therapeutic target. Biochim Biophys Acta 2004; 1697: 3-16.
3. Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P et al. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 2000; 10: 439-448.
4. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101.
5. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241.
6. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-1321.
7. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 2001; 21: 893-901.
8. Biggs III WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 1999; 96: 7421-7426.
9. Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/ PKB. J Biol Chem 1998; 273: 32377-32379.
10. Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 2002; 8: 1145-1152.
11. Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002; 14: 381-395.
12. Neri LM, Marchisio M, Colamussi ML, Bertagnolo V. Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms. Biochem Biophys Res Commun 1999; 259: 314-320.
13. Visnjic D, Crljen V, Curic J, Batinic D, Volinia S, Banfic H. The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells. FEBS Lett 2002; 529: 268-274.
14. Marchisio M, Bertagnolo V, Colamussi ML, Capitani S, Neri LM. Phosphatidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation. Biochem Biophys Res Commun 1998; 253: 346-351.
15. Bertagnolo V, Brugnoli F, Marchisio M, Celeghini C, Carini C, Capitani S. Association of PI 3-K with tyrosine phosphorylated Vav is essential for its activity in neutrophil-like maturation of myeloid cells. Cell Signal 2004; 16: 423-433.
16. Bertagnolo V, Neri LM, Marchisio M, Mischiati C, Capitani S. Phosphoinositide 3-kinase activity is essential for all-trans-retinoic acid-induced granulocytic differentiation of HL-60 cells. Cancer Res 1999; 59: 542-546.
17. Bertolaso L, Gibellini D, Secchiero P, Previati M, Falgione D, Visani G et al. Accumulation of catalytically active PKC-zeta into the nucleus of HL-60 cell line plays a key role in the induction of granulocytic differentiation mediated by all-trans retinoic acid. Br J Haematol 1998; 100: 541-549.
18. 1 expression. Leukemia 2003; 17: 2157-2167.
19. Neri LM, Borgatti P, Tazzari PL, Bortul R, Cappellini A, Tabellini G et al. The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. Mol Cancer Res 2003; 1: 234-246.
20. Martelli AM, Tazzari PL, Tabellini G, Bortul R, Billi AM, Manzoli L et al. A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells. Leukemia 2003; 17: 1794-1805.
21. Tabellini G, Cappellini A, Tazzari PL, Fala F, Billi AM, Manzoli L et al. Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells. J Cell Physiol 2005; 202: 623-634.
22. Visnjic D, Batinic D, Banfic H. Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line. Blood 1997; 89: 81-91.
23. 2/M phase of the cell cycle in HL-60 cells. Biochim Biophys Acta 2003; 1631: 61-71.
24. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996; 15: 6541-6551.
25. Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R et al. Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma. Blood 2005; 105: 827-829.
26. Tabellini G, Tazzari PL, Bortul R, Billi AM, Conte R, Manzoli L et al. Novel 2′-substituted, 3′-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway. Br J Haematol 2004; 126: 574-582.
27. Yen A, Roberson MS, Varvayanis S, Lee AT. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res 1998; 58: 3163-3172.
28. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 1991; 77: 1080-1086.
29. Zhu QS, Robinson LJ, Roginskaya V, Corey SJ. G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses. Blood 2004; 103: 3305-3312.
30. Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M et al. Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 2004; 166: 85-95.
31. Sugatani T, Hruska KA. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem 2005; 280: 3583-3589.
32. Lopez-Carballo G, Moreno L, Masia S, Perez P, Barettino D. Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. J Biol Chem 2002; 277: 25297-25304.
33. Vandromme M, Rochat A, Meier R, Carnac G, Besser D, Hemmings BA et al. Protein kinase B beta/Akt2 plays a specific role in muscle differentiation. J Biol Chem 2001; 276: 8173-8179.
34. Lal L, Li Y, Smith J, Sassano A, Uddin S, Parmar S et al. Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood 2005; 105: 1669-1677.
35. Kambhampati S, Verma A, Li Y, Parmar S, Sassano A, Platanias LC. Signalling pathways activated by all-trans-retinoic acid in acute promyelocytic leukemia cells. Leuk Lymphoma 2004; 45: 2175-2185.
36. Bertagnolo V, Brugnoli F, Mischiati C, Sereni A, Bavelloni A, Carini C et al. Vav promotes differentiation of human tumoral myeloid precursors. Exp Cell Res 2005; 306: 56-63.
37. Hu Y, Qiao L, Wang S, Rong SB, Meuillet EJ, Berggren M et al. 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth. J Med Chem 2000; 43: 3045-3051.
38. Kozikowski AP, Sun H, Brognard J, Dennis PA. Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. J Am Chem Soc 2003; 125: 1144-1145.
39. Secchiero P, Gonelli A, Mirandola P, Melloni E, Zamai L, Celeghini C et al. Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway. Blood 2002; 100: 2421-2429.