Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 45, 2006, Pages 16924-16929

  Bansal, Dimple ^a   Scholl, Claudia ^a   Fröhling, Stefan ^a   McDowell, Elizabeth ^a   Lee, Benjamin H ^a   Döhner, Konstanze ^b   Ernst, Patricia ^c   Davidson, Alan J ^d   Daley, George Q ^d   Zon, Leonard I ^d,e   Gilliland, D Gary ^a,e,f   Huntly, Brian J P ^g  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Hox regulation; Leukemogenesis; Self renewal; Transcriptional regulation

Indexed keywords

HOMEODOMAIN PROTEIN; METHYLCELLULOSE; PROTEIN MEIS1A; PROTEIN PBX; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR CDX4; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL GROWTH; CELL RENEWAL; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HOX GENE; HUMAN; HUMAN CELL; LEUKEMOGENESIS; LIQUID CULTURE; MALIGNANT TRANSFORMATION; MOUSE; MULTIGENE FAMILY; NONHUMAN; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RETROVIRUS; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ADULT; ANIMALS; BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, HOMEOBOX; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MICE; NEOPLASM PROTEINS; TRANS-ACTIVATION (GENETICS);

MURINAE;

EID: 33750951686     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604579103     Document Type: Article

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