Vascular Endothelial Growth Factor Is a Potent Angiogenic Factor in AIDS-Associated Kaposi's Sarcoma-Derived Spindle Cells

Journal of Immunology

Volumn 158, Issue 10, 1997, Pages 4992-5001

  Nakamura, Shuji ^a   Murakami Mori, Kaoru ^a   Rao, Narsing ^b   Weich, Herbert A ^c   Rajeev, Buddi ^b,d  

^a HUNTINGTON MEMORIAL HOSPITAL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c GBS   (Germany)

^d L V PRASAD EYE INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; LYMPHOKINE; MESSENGER RNA; VASCULAR ENDOTHELIAL GROWTH FACTOR A, HUMAN; VASCULOTROPIN; VASCULOTROPIN A;

ANIMAL; ARTICLE; BIOASSAY; CHICK EMBRYO; CYTOLOGY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KAPOSI SARCOMA; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; RABBIT; VASCULAR ENDOTHELIUM;

ANIMALS; BIOLOGICAL ASSAY; CHICK EMBRYO; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; HIV INFECTIONS; HUMANS; LYMPHOKINES; NEOVASCULARIZATION, PATHOLOGIC; RABBITS; RNA, MESSENGER; SARCOMA, KAPOSI; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0031569950     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Peters, B. S., E. J. Beck, D. G. Coleman, M. J. Wadsworth, O. Mcguinness, J. R. Harris, and A. J. Pinching. 1991. Changing disease patterns in patients with AIDS in a referral centre in the United Kingdom: the changing face of AIDS. Br. Med. J. 302:203.
2. Coleman, D. G., E. J. Beck, B. S. Peters, J. R. Harris, and A. J. Pinching. 1992. Changing disease patterns in AIDS. Br. Med. J. 304:839.
3. McNutt, N. S., V. Fletcher, and M. A. Conant. 1983. Early lesions of Kaposi's sarcoma in homosexual men: an ultrastructural comparison with other vascular proliferations in skin. Am. J. Pathol. 111:62.
4. Meduri, G. U., D. E. Stover, P. L. Myskowski, J. F. Caravelli, and M. B. Zaman. 1986. Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome: clinical, radiographic, and pathologic manifestations. Am. J. Med. 81:11.
5. Purdy, L. J., T. V. Colby, S. A. Yousem, and H. Battifora. 1986. Pulmonary Kaposi's sarcoma: premotem histologic diagnosis. Am. J. Surg. Pathol. 10:301.
6. Ruszczak, Z., A. Mayer da Silva, and C. E. Orfanos. 1987. Angioproliferative changes in clinically noninvolved, perilesional skin in AIDS-associated Kaposi's sarcoma. Dermatologica 175:270.
7. Ruszczak, Z., A. Mayer da Silva, and C. E. Orfanos. 1987. Kaposi's sarcoma in AIDS. Multicentric angioneoplasia in early skin lesions. Am. J. Dermatopathol. 9:388.
8. Kaplan, L. D., P. C. Hopewell, H. Jaffe, P. C. Goodman, K. Bottles, and P. A. Volberding. 1988. Kaposi's sarcoma involving the lung in patients with the acquired immunodeficiency syndrome. J. AIDS 1:23.
9. + T cells. Science 242:426.
10. Salahuddin, S. Z., S. Nakamura, P. Biberfeld, M. H. Kaplan, P. D. Markham, L. Larsson, and R. C. Gallo. 1988. Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro. Science 242:430.
11. Ensoli, B., S. Nakamura, S. Z. Salahuddin, P. Biberfeld, L. Larsson, B. Beaver, F. Wong-Staal, and R. C. Gallo. 1989. AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science 243:223.
12. Weich, H. A., S. Z. Salahuddin, P. Gill, S. Nakamura, R. C. Gallo, and J. Folkmam. 1989. AIDS-associated Kaposi's sarcoma-derived cells in long-term culture express and synthesize smooth muscle alpha-actin. Am. J. Pathol. 139: 1251.
13. Murakami-Mori, K., T. Taga, T. Kishimoto, and S. Nakamura. 1996. Soluble form of IL-6 receptor (sIL-6Rα) is a potent growth factor for AIDS-associated Kaposi's sarcoma (KS) cells: soluble form of gp130 is antagonistic for sIL-6Rα-induced AIDS-KS cell growth. Int. Immunol. 8:595.
14. Weindel, K., O. Marme, and H. A. Weich. 1992. Kaposi's sarcoma cells in culture express vascular endothelial growth factor. Biochem. Biophys. Res. Commun. 183:1167.
15. Ensoli, B., R. Gendelman, P. Markham, V. Fiorelli, S. Colombini, M. Raffeld, A. Cafaro, H-K. Chang, J. N. Brady, and R. C. Gallo. 1994. Synergy between basic fibroblast growth factor and HIV-1 tat protein in induction of Kaposi's sarcoma. Nature 371:674.
16. Ensoli, B., P. Markham, V. Kao, G. Barillari, V. Fiorelli, R. Gendelman, M. Raffeld, G. Zon, and R. C. Gallo. 1994. Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor: a novel strategy for the therapy of KS. J. Clin. Invest. 94:1736.
17. Leung, D. W., G. Cachianes, W.-J. Kuang, D. V. Goeddel, and N. Farrara. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306.
18. Keek, P. J., S. D. Hauser, G. Krivi, K. Sanzo, T. Warren, J. Feder, and O. T. Connolly. 1989. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246:1309.
19. Nakamura, S., S. Sakurada, S. Z. Salahuddin, Y. Osada, N. G. Tanaka, N. Sakamoto, M. Sekiguchi, and R. C. Gallo. 1992. Inhibition of development of Kaposi's sarcoma-related lesions by a bacterial cell wall complex. Science 255: 1437.
20. Radka, S. F., S. Nakamura, S. Sakurada, and S. Z. Salahuddin. 1993. Correlation of oncostatin M secretion by human retrovirus-infected cells with potent growth stimulation of cultured spindle cells from AIDS-Kaposi's sarcoma. J. Immunol. 150:5195.
21. Murakami-Mori, K., T. Taga, T. Kishimoto, and S. Nakamura. 1995. AIDS-associated Kaposi's sarcoma (KS) cells express oncostatin M (OM)-specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor: complete block of OM-induced KS cell growth and OM binding by anti-gp 130 antibodies. J. Clin. Invest. 96:1319.
22. Vlodavsky, I., J. Folkman, and M. Klagsbrun. 1987. Heparin-binding endothelial cell growth factors are sequestered by the extracellular matrix. In Angiogenesis Mechanisms and Pathobiology. D. B. Rifkin and M. Klagsbrun, eds. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 58.
23. Langer, R., and J. Folkman. 1976. Polymers for the sustained release of proteins and other macromolecules. Nature 263:797.
24. Li, W. W., G. Grayson, J. Folkman, and P. A. D'Amore. 1991. Sustained release endotoxin: a model for inducing corneal neovascularization. Invest. Ophthalmol. Vis. Sci. 32:2906.
25. BenEzra, D., I. Hemo, and G. Maftzir. 1990. In vivo angiogenic activity of interleukins. Arch. Opthalmol. 108:573.
26. Folkman, J., and D. E. Ingber. 1987. Angiostatic steroids: method of discovery and mechanism of action. Ann. Surg. 206:374.
27. Fiebich, B. L., B. Jager, C. Schollmann, K. Weindel, J. Wilting, G. Kochs, D. Marme, H. Hug, and H. A. Weich. 1993. Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells. Eur. J. Biochem. 211:19.
28. Mori, S., K. Goto, F. Goto, K. Murakami, S. Ohkawara, and M. Yoshinaga. 1994. Dynamic changes in mRNA expression of neutrophils during the course of acute inflammation in rabbits. Int. Immunol. 6:149.
29. Pepper, M. S., N. Ferrara, L. Orci, and R. Montesano. 1992. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem. Biophys. Res. Commun. 189:824.
30. Goto, F., K. Goto, K. Weindel, and J. Folkman. 1993. Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab. Invest. 69:508.
31. Shin, Y., J. Folkman, R. Sullivan, C. Butterfield, J. Murry, and M. Klagsbrun. 1984. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 223:1296.
32. Schweigerer, L., G. Neufeld, A. Mergia, J. A. Abraham, J. C. Fiddes, and D. Gospodarowicz. 1987. Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications tor the proliferation and neovascularization of myoblast-derived tumors. Proc. Natl. Acad. Sci. USA 84:842.
33. Houck, K. A., N. Ferrara, J. Winter, G. Cachianes, B. Li, and D. W. Leung. 1991. The vascular endothelial growth factor: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. 5:1805.
34. Tischer, E., R. Mitchell, T. Hartman, M. Silva, D. Gospodarowicz, J. C. Fiddes, J. A. Abraham. 1991. The human gene for vascular endothelial growth factor: multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266:11947.
35. Finkenzeller, G., D. Marme, H. A. Weich, and H. Hug. 1992. Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C. Cancer Res. 52:4821.
36. Li, J., M. A. Perrella, J.-C. Tsai, S.-F. Yet, C.-M. Hsieh, M. Yoshizumi, C. Patterson, W. O. Endege, F. Zhou, and M.-E. Lee. 1995. Induction of vascular endothelial growth factor gene expression by interleukin-1β in rat aortic smooth muscle cells. J. Biol. Chem. 270:308.
37. Stavi, G. T., I. C. Zachary, P. A. Baskerville, J. F. Martin, and J. D. Erusalimsky. 1995. Basic fibroblast growth factor up-regulates the expression of vascular endothelial growth factor in vascular smooth muscle cells, synergistic interaction with hypoxia. Circulation 92:11.
38. Li, J. J., Y. Q. Huang, D. Moscatelli, A. Nicolaides, W. C. Zhang, and A. Friedman-Kien. 1993. Expression of fibroblast growth factors and their receptors in acquired immunodeficiency syndrome-associated Kaposi's sarcoma tissue and derived cells. Cancer 72:2253.
39. Brown, L. F., K. Tognazzi, H. F. Dvorak, and T. J. Harrist. 1996. Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/ vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. Am. J. Pathol. 148:1065.
40. Ferrara, N., and W. J. Henzel. 1989. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161:851.
41. Senger, D. R., C. A. Perruzi, J. Feder, and H. F. Dvorak. 1986. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 46:5629.
42. Plate, K. H., G. Breier, H. A. Weich, and W. Risau. 1992. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Science 359:845.
43. Weindel, K., J. R. Moringlane, D. Marme, and H. A. Weich. 1994. Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: the key to angiogenesis? Neurosurgery 35: 439.
44. Burger, P. C., F. S. Vogel, S. B. Green, and T. A. Strike. 1985. Glioblastoma multiform and anaplastic astrocytoma: pathologic criteria and prognostic implications. Cancer 56:1106.
45. Challa, V. R., D. M. Moody, R. B. Marshall, and D. L. Kelly. 1980. The vascular component in meningiomas associated with severe cerebral edema. Neurosurgery 7:363.
46. Alvarez, J. A., A. Baird, A. Tatum, J. Daucher, R. Chorsky, A. M. Gonzalez, and E. G. Stopa. 1992. Localization of basic fibroblast growth factor and vascular endothelial growth factor in human glial neoplasms. Mod. Pathol. 5:303.
47. Mignatti, P., T. Morimoto, and D. B. Rifkin. 1992. Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex. J. Cell. Physiol. 151: 81.
48. Samaniego, F., P. D. Markham, R. C. Gallo, and B. Ensoli. 1995. Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice. J. Immunol. 154:3582.
49. Green, L. L., M. C. Hardy, C. E. Marynard-Currie, H. Tsuda, D. M. Louie, M. J. Mendez, H. Abderrahim, M. Noguchi, D. H. Smith, Y. Zeng, N. E. David, H. Sasai, D. Garza, D. G. Brenner, J. F. Hales, R. P. Mcguinness, D. J. Capon, S. Klapholz, and A. Jakobovits. 1994. Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nature Genet. 7:13.