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Volumn 19, Issue 3, 2010, Pages 232-239

Mechanotransduction in aging and osteoporosis;Mechanotransduktion im alter und bei osteoporose

Author keywords

Aging; Mechanosensitivity; Mechanotransduction; Osteoporosis; Primary cilium

Indexed keywords

BONE CELL; BONE MASS; BONE STRUCTURE; CELL AGING; CHEMICAL STRUCTURE; CYTOSKELETON; FRAGILITY FRACTURE; GENE CONTROL; MECHANICAL STRESS; MECHANOTRANSDUCTION; OSTEOBLAST; OSTEOCYTE; OSTEOPOROSIS; REVIEW; RISK FACTOR; SHEAR STRESS; SIGNAL TRANSDUCTION;

EID: 79955518465     PISSN: 10191291     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1619947     Document Type: Review
Times cited : (6)

References (96)
  • 1
    • 0033884110 scopus 로고    scopus 로고
    • Osteoporosis and bone functional adaptation: Mechanobiological regulation of bone architecture in growing and adult bone, a review
    • Mosley JR. Osteoporosis and bone functional adaptation: mechanobiological regulation of bone architecture in growing and adult bone, a review. J Rehabil Res Dev 2000; 37 (2): 189-199. (Pubitemid 30641247)
    • (2000) Journal of Rehabilitation Research and Development , vol.37 , Issue.2 , pp. 189-199
    • Mosley, J.R.1
  • 2
    • 34547911065 scopus 로고    scopus 로고
    • What is new in neuro-muscuskeletal interactions: Mechanotransduction, microdamage and repair?
    • Rittweger J. What is new in neuro-musculoskeletal interactions: mechanotransduction, microdamage and repair? J Musculoskelet Neuronal Interact 2007; 7 (2): 191-193. (Pubitemid 47249010)
    • (2007) Journal of Musculoskeletal Neuronal Interactions , vol.7 , Issue.2 , pp. 191-193
    • Rittweger, J.1
  • 3
    • 33744992495 scopus 로고    scopus 로고
    • Osteoporosis
    • DOI 10.1016/S0140-6736(06)68891-0, PII S0140673606688910
    • Sambrook P, Cooper C. Osteoporosis. Lancet 2006; 367 (9527): 2010-2018. (Pubitemid 43867702)
    • (2006) Lancet , vol.367 , Issue.9527 , pp. 2010-2018
    • Sambrook, P.1    Cooper, C.2
  • 4
    • 0035003317 scopus 로고    scopus 로고
    • Idiopathic osteoporosis: An evolutionary dys-adaptation?
    • DOI 10.1136/ard.60.6.554
    • Alexander C. Idiopathic osteoporosis: an evolutionary dys-adaptation? Ann Rheum Dis 2001; 60 (6): 554-558. (Pubitemid 32493980)
    • (2001) Annals of the Rheumatic Diseases , vol.60 , Issue.6 , pp. 554-558
    • Alexander, C.1
  • 5
    • 72149087688 scopus 로고    scopus 로고
    • Exogenous and endogenous force regulation of endothelial cell behavior
    • Califano JP, Reinhart-King CA. Exogenous and endogenous force regulation of endothelial cell behavior. J Biomech 2010; 43 (1): 79-86.
    • (2010) J Biomech , vol.43 , Issue.1 , pp. 79-86
    • Califano, J.P.1    Reinhart-King, C.A.2
  • 6
    • 73049085663 scopus 로고    scopus 로고
    • Sensing pressure in the cardiovascular system: Gqcoupled mechanoreceptors and TRP channels
    • Sharif-Naeini R, Folgering JH, Bichet D et al. Sensing pressure in the cardiovascular system: Gqcoupled mechanoreceptors and TRP channels. J Mol Cell Cardiol 2010; 48 (1): 83-89.
    • (2010) J Mol Cell Cardiol , vol.48 , Issue.1 , pp. 83-89
    • Sharif-Naeini, R.1    Folgering, J.H.2    Bichet, D.3
  • 7
    • 78649831457 scopus 로고    scopus 로고
    • Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress
    • Mar [Epub ahead of print]
    • Liu L, Yuan W, Wang J. Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress. Biomech Model Mechanobiol 2010; Mar 23. [Epub ahead of print]
    • (2010) Biomech Model Mechanobiol , pp. 23
    • Liu, L.1    Yuan, W.2    Wang, J.3
  • 8
    • 72149125600 scopus 로고    scopus 로고
    • Boning up on Wolff 's Law: Mechanical regulation of the cells that make and maintain bone
    • Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff 's Law: mechanical regulation of the cells that make and maintain bone. J Biomech 2010; 43 (1): 108-118.
    • (2010) J Biomech , vol.43 , Issue.1 , pp. 108-118
    • Chen, J.H.1    Liu, C.2    You, L.3    Simmons, C.A.4
  • 11
    • 0036122913 scopus 로고    scopus 로고
    • Mechanosensation and fluid transport in living bone
    • Cowin SC. Mechanosensation and fluid transport in living bone. J Musculoskelet Neuronal Interact 2002; 2 (3): 256-260. (Pubitemid 34223816)
    • (2002) Journal of Musculoskeletal Neuronal Interactions , vol.2 , Issue.3 , pp. 256-260
    • Cowin, S.C.1
  • 12
    • 56649114147 scopus 로고    scopus 로고
    • Osteocytes in the pathogenesis of osteoporosis
    • Ikeda K. Osteocytes in the pathogenesis of osteoporosis. Geriatr Gerontol Int 2008; 8 (4): 213-217.
    • (2008) Geriatr Gerontol Int , vol.8 , Issue.4 , pp. 213-217
    • Ikeda, K.1
  • 13
    • 77952008742 scopus 로고    scopus 로고
    • Tensile strain as a regulator of mesenchymal stem cell osteogenesis
    • Kearney EM, Farrell E, Prendergast PJ, Campbell VA. Tensile strain as a regulator of mesenchymal stem cell osteogenesis. Ann Biomed Eng 2010; 38 (5): 1767-1779.
    • (2010) Ann Biomed Eng , vol.38 , Issue.5 , pp. 1767-1779
    • Kearney, E.M.1    Farrell, E.2    Prendergast, P.J.3    Campbell, V.A.4
  • 14
    • 77949299962 scopus 로고    scopus 로고
    • Cytoskeletal disassembly and cell rounding promotes adipogenesis from ES cells
    • Feng T, Szabo E, Dziak E, Opas M. Cytoskeletal disassembly and cell rounding promotes adipogenesis from ES cells. Stem Cell Rev 2010; 6 (1): 74-85.
    • (2010) Stem Cell Rev , vol.6 , Issue.1 , pp. 74-85
    • Feng, T.1    Szabo, E.2    Dziak, E.3    Opas, M.4
  • 15
    • 77549083345 scopus 로고    scopus 로고
    • Directing bone marrowderived stromal cell function with mechanics
    • Potier E, Noailly J, Ito K. Directing bone marrowderived stromal cell function with mechanics. J Biomech 2010; 43 (5): 807-817.
    • (2010) J Biomech , vol.43 , Issue.5 , pp. 807-817
    • Potier, E.1    Noailly, J.2    Ito, K.3
  • 16
    • 75149150013 scopus 로고    scopus 로고
    • Mechanical signals as anabolic agents in bone
    • Ozcivici E, Luu YK, Adler B et al. Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol 2010; 6 (1): 50-59.
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.1 , pp. 50-59
    • Ozcivici, E.1    Luu, Y.K.2    Adler, B.3
  • 17
    • 72149101586 scopus 로고    scopus 로고
    • Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage
    • Huang AH, Farrell MJ, Mauck RL. Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage. J Biomech 2010; 43 (1): 128-136.
    • (2010) J Biomech , vol.43 , Issue.1 , pp. 128-136
    • Huang, A.H.1    Farrell, M.J.2    Mauck, R.L.3
  • 18
    • 77950519110 scopus 로고    scopus 로고
    • Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells
    • Liedert A, Wagner L, Seefried L et al. Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells. Biochem Biophys Res Commun 2010; 394 (3): 755-759.
    • (2010) Biochem Biophys Res Commun , vol.394 , Issue.3 , pp. 755-759
    • Liedert, A.1    Wagner, L.2    Seefried, L.3
  • 20
    • 77950648327 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?
    • Guilak F, Leddy HA, Liedtke W. Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Ann N Y Acad Sci 2010; 1192 (1): 404-409.
    • (2010) Ann N Y Acad Sci , vol.1192 , Issue.1 , pp. 404-409
    • Guilak, F.1    Leddy, H.A.2    Liedtke, W.3
  • 21
    • 77957603127 scopus 로고    scopus 로고
    • Effect of stress on mRNA expression of H+-ATPase in osteoclasts
    • Jun [Epub ahead of print]
    • Hong ZQ, Tao LM, Li L. Effect of stress on mRNA expression of H+-ATPase in osteoclasts. Mol Cell Biochem 2010; Jun 12. [Epub ahead of print].
    • (2010) Mol Cell Biochem , pp. 12
    • Hong, Z.Q.1    Tao, L.M.2    Li, L.3
  • 23
    • 33846919395 scopus 로고    scopus 로고
    • Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats
    • Jiang SD, Jiang LS, Dai LY. Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats. Osteoporos Int 2007; 18 (3): 339-349.
    • (2007) Osteoporos Int , vol.18 , Issue.3 , pp. 339-349
    • Jiang, S.D.1    Jiang, L.S.2    Dai, L.Y.3
  • 25
    • 77952771209 scopus 로고    scopus 로고
    • Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss
    • Gaudio A, Pennisi P, Bratengeier C et al. Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab 2010; 95 (5): 2248-2253.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.5 , pp. 2248-2253
    • Gaudio, A.1    Pennisi, P.2    Bratengeier, C.3
  • 26
    • 70349934212 scopus 로고    scopus 로고
    • Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    • Lin C, Jiang X, Dai Z et al. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 2009; 24 (10): 1651-1661.
    • (2009) J Bone Miner Res , vol.24 , Issue.10 , pp. 1651-1661
    • Lin, C.1    Jiang, X.2    Dai, Z.3
  • 30
    • 77950473097 scopus 로고    scopus 로고
    • Cystic diseases of the kidney: Molecular biology and genetics
    • Deltas C, Papagregoriou G. Cystic diseases of the kidney: molecular biology and genetics. Arch Pathol Lab Med 2010; 134 (4): 569-582.
    • (2010) Arch Pathol Lab Med , vol.134 , Issue.4 , pp. 569-582
    • Deltas, C.1    Papagregoriou, G.2
  • 31
    • 77950684065 scopus 로고    scopus 로고
    • Osteocyte primary cilium and its role in bone mechanotransduction
    • Temiyasathit S, Jacobs CR. Osteocyte primary cilium and its role in bone mechanotransduction. Ann N Y Acad Sci 2010; 1192 (1): 422-428.
    • (2010) Ann N Y Acad Sci , vol.1192 , Issue.1 , pp. 422-428
    • Temiyasathit, S.1    Jacobs, C.R.2
  • 32
    • 42249090375 scopus 로고    scopus 로고
    • The solitary (primary) cilium - A mechanosensory toggle switch in bone and cartilage cells
    • Whitfield JF. The solitary (primary) cilium - a mechanosensory toggle switch in bone and cartilage cells. Cell Signal 2008; 20 (6): 1019-1024.
    • (2008) Cell Signal , vol.20 , Issue.6 , pp. 1019-1024
    • Whitfield, J.F.1
  • 34
    • 77950673151 scopus 로고    scopus 로고
    • Role of the polycytin-primary cilia complex in bone development and mechanosensing
    • Xiao ZS, Quarles LD. Role of the polycytin-primary cilia complex in bone development and mechanosensing. Ann N Y Acad Sci 2010; 1192 (1): 410-421.
    • (2010) Ann N Y Acad Sci , vol.1192 , Issue.1 , pp. 410-421
    • Xiao, Z.S.1    Quarles, L.D.2
  • 35
    • 67249125789 scopus 로고    scopus 로고
    • Systems biology of autosomal dominant polycystic kidney disease (ADPKD): Computational identification of gene expression pathways and integrated regulatory networks
    • Song X, Di Giovanni V, He N et al. Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks. Hum Mol Genet 2009; 18 (13): 2328-2343.
    • (2009) Hum Mol Genet , vol.18 , Issue.13 , pp. 2328-2343
    • Song, X.1    Di Giovanni, V.2    He, N.3
  • 36
    • 77955449679 scopus 로고    scopus 로고
    • Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia
    • Lee J, Moon S, Cha Y, Chung YD. Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia. PLoS One 2010; 5 (6): e11012.
    • (2010) PLoS One , vol.5 , Issue.6
    • Lee, J.1    Moon, S.2    Cha, Y.3    Chung, Y.D.4
  • 37
    • 70349771967 scopus 로고    scopus 로고
    • Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes
    • Phan MN, Leddy HA, Votta BJ et al. Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum 2009; 60 (10): 3028-3037.
    • (2009) Arthritis Rheum , vol.60 , Issue.10 , pp. 3028-3037
    • Phan, M.N.1    Leddy, H.A.2    Votta, B.J.3
  • 38
    • 55449120240 scopus 로고    scopus 로고
    • TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan
    • Lee BH, Ashrafi K. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. PLoS Genet 2008; 4 (10): e1000213.
    • (2008) PLoS Genet , vol.4 , Issue.10
    • Lee, B.H.1    Ashrafi, K.A.2
  • 39
    • 0033990260 scopus 로고    scopus 로고
    • Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes
    • Stanford CM, Welsch F, Kastner N et al. Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes. J Biomech 2000; 33 (1): 63-71.
    • (2000) J Biomech , vol.33 , Issue.1 , pp. 63-71
    • Stanford, C.M.1    Welsch, F.2    Kastner, N.3
  • 41
    • 58149326842 scopus 로고    scopus 로고
    • Ciliary dysfunction in developmental abnormalities and diseases
    • Sharma N, Berbari NF, Yoder BK. Ciliary dysfunction in developmental abnormalities and diseases. Curr Top Dev Biol 2008; 85: 371-427.
    • (2008) Curr Top Dev Biol , vol.85 , pp. 371-427
    • Sharma, N.1    Berbari, N.F.2    Yoder, B.K.3
  • 42
    • 84934439457 scopus 로고    scopus 로고
    • Assessment of the in vivo adaptive response to mechanical loading
    • Saxon LK, Lanyon LE. Assessment of the in vivo adaptive response to mechanical loading. Methods Mol Biol 2008; 455: 307-322.
    • (2008) Methods Mol Biol , vol.455 , pp. 307-322
    • Saxon, L.K.1    Lanyon, L.E.2
  • 45
    • 4444222474 scopus 로고    scopus 로고
    • Is estrogen receptor alpha key to controlling bones' resistance to fracture?
    • DOI 10.1677/joe.0.1820183
    • Lanyon L, Armstrong V, Ong D et al. Is estrogen receptor alpha key to controlling bones' resistance to fracture? J Endocrinol 2004; 182 (2): 183-191. (Pubitemid 39199002)
    • (2004) Journal of Endocrinology , vol.182 , Issue.2 , pp. 183-191
    • Lanyon, L.1    Armstrong, V.2    Ong, D.3    Zaman, G.4    Price, J.5
  • 48
    • 4444314796 scopus 로고    scopus 로고
    • The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta
    • DOI 10.1677/joe.0.1820193
    • Lee KC, Jessop H, Suswillo R et al. The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta. J Endocrinol 2004; 182 (2): 193-201. (Pubitemid 39199003)
    • (2004) Journal of Endocrinology , vol.182 , Issue.2 , pp. 193-201
    • Lee, K.C.L.1    Jessop, H.2    Suswillo, R.3    Zaman, G.4    Lanyon, L.E.5
  • 50
    • 33645334941 scopus 로고    scopus 로고
    • Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss
    • Aguirre JI, Plotkin LI, Stewart SA et al. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res 2006; 21 (4): 605-615.
    • (2006) J Bone Miner Res , vol.21 , Issue.4 , pp. 605-615
    • Aguirre, J.I.1    Plotkin, L.I.2    Stewart, S.A.3
  • 51
    • 58249118689 scopus 로고    scopus 로고
    • Recovery of muscle atrophy and bone loss from 90 days bed rest: Results from a one-year follow-up
    • Rittweger J, Felsenberg D. Recovery of muscle atrophy and bone loss from 90 days bed rest: results from a one-year follow-up. Bone 2009; 44 (2): 214-224.
    • (2009) Bone , vol.44 , Issue.2 , pp. 214-224
    • Rittweger, J.1    Felsenberg, D.2
  • 52
    • 2342482496 scopus 로고    scopus 로고
    • Relationship between the duration of paralysis and bone structure: A pQCT study of spinal cord injured individuals
    • DOI 10.1016/j.bone.2004.01.001, PII S8756328204000146
    • Eser P, Frotzler A, Zehnder Y et al. Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals. Bone 2004; 34 (5): 869-880. (Pubitemid 38581133)
    • (2004) Bone , vol.34 , Issue.5 , pp. 869-880
    • Eser, P.1    Frotzler, A.2    Zehnder, Y.3    Wick, L.4    Knecht, H.5    Denoth, J.6    Schiessl, H.7
  • 53
    • 70350221000 scopus 로고    scopus 로고
    • Collaborative meta-analysis: Associations of 150 candidate genes with osteoporosis and osteoporotic fracture
    • Richards JB, Kavvoura FK, Rivadeneira F et al. Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med 2009; 151 (8): 528-537.
    • (2009) Ann Intern Med , vol.151 , Issue.8 , pp. 528-537
    • Richards, J.B.1    Kavvoura, F.K.2    Rivadeneira, F.3
  • 54
    • 17644378354 scopus 로고    scopus 로고
    • Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men - The MINOS study
    • DOI 10.1359/JBMR.041230
    • Szulc P, Beck TJ, Marchand F, Delmas PD. Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men--the MINOS study. J Bone Miner Res 2005; 20 (5): 721-729. (Pubitemid 40571628)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.5 , pp. 721-729
    • Szulc, P.1    Beck, T.J.2    Marchand, F.3    Delmas, P.D.4
  • 55
    • 70350246274 scopus 로고    scopus 로고
    • Muscle forces or gravity: What predominates mechanical loading on bone?
    • Kohrt WM, Barry DW, Schwartz RS. Muscle forces or gravity: what predominates mechanical loading on bone? Med Sci Sports Exerc 2009; 41 (11): 2050-2055.
    • (2009) Med Sci Sports Exerc , vol.41 , Issue.11 , pp. 2050-2055
    • Kohrt, W.M.1    Barry, D.W.2    Schwartz, R.S.3
  • 56
    • 77951258321 scopus 로고    scopus 로고
    • Evidence for pleiotropic factors in genetics of the musculoskeletal system
    • Karasik D, Kiel DP. Evidence for pleiotropic factors in genetics of the musculoskeletal system. Bone 2010; 46 (5): 1226-1237.
    • (2010) Bone , vol.46 , Issue.5 , pp. 1226-1237
    • Karasik, D.1    Kiel, D.P.2
  • 57
    • 77955804234 scopus 로고    scopus 로고
    • Hypoestrogenism in young women and its influence on bone mass density
    • Meczekalski B, Podfigurna-Stopa A, Genazzani AR. Hypoestrogenism in young women and its influence on bone mass density. Gynecol Endocrinol 2010; 26 (9): 652-657.
    • (2010) Gynecol Endocrinol , vol.26 , Issue.9 , pp. 652-657
    • Meczekalski, B.1    Podfigurna-Stopa, A.2    Genazzani, A.R.3
  • 58
    • 0031973389 scopus 로고    scopus 로고
    • Estrogen and bone-muscle strength and mass relationships
    • DOI 10.1016/S8756-3282(97)00223-8, PII S8756328297002238
    • Schiessl H, Frost HM, Jee WS. Estrogen and bonemuscle strength and mass relationships. Bone 1998; 22 (1): 1-6. (Pubitemid 28033646)
    • (1998) Bone , vol.22 , Issue.1 , pp. 1-6
    • Schiessl, H.1    Frost, H.M.2    Jee, W.S.S.3
  • 59
    • 33947664444 scopus 로고    scopus 로고
    • Longterm four-year exercise has a positive effect on menopausal risk factors: The Erlangen Fitness Osteoporosis Prevention Study
    • Kemmler W, Engelke K, von Stengel S et al. Longterm four-year exercise has a positive effect on menopausal risk factors: the Erlangen Fitness Osteoporosis Prevention Study. J Strength Cond Res 2007; 21 (1): 232-239.
    • (2007) J Strength Cond Res , vol.21 , Issue.1 , pp. 232-239
    • Kemmler, W.1    Engelke, K.2    Von Stengel, S.3
  • 60
    • 29144439749 scopus 로고    scopus 로고
    • Exercise maintains bone density at spine and hip EFOPS: A 3-year longitudinal study in early postmenopausal women
    • DOI 10.1007/s00198-005-1938-9
    • Engelke K, Kemmler W, Lauber D et al. Exercise maintains bone density at spine and hip EFOPS: a 3-year longitudinal study in early postmenopausal women. Osteoporos Int 2006; 17 (1): 133-142. (Pubitemid 41798038)
    • (2006) Osteoporosis International , vol.17 , Issue.1 , pp. 133-142
    • Engelke, K.1    Kemmler, W.2    Lauber, D.3    Beeskow, C.4    Pintag, R.5    Kalender, W.A.6
  • 61
    • 84856072870 scopus 로고    scopus 로고
    • Sexualsteroide in der Homöostase des Knochens (Sex steroids in bone homeostasis)
    • Jakob F, Benisch P, Klotz B et al. Sexualsteroide in der Homöostase des Knochens (Sex steroids in bone homeostasis). Osteologie 2010; 19 (2): 105-110.
    • (2010) Osteologie , vol.19 , Issue.2 , pp. 105-110
    • Jakob, F.1    Benisch, P.2    Klotz, B.3
  • 63
    • 77955429849 scopus 로고    scopus 로고
    • Sex steroid metabolism in the regulation of bone health in men
    • Epub 2010 Mar 31
    • Vandenput L, Ohlsson C. Sex steroid metabolism in the regulation of bone health in men. J Steroid Biochem Mol Biol 2010; 121 (3-5): 582-588. Epub 2010 Mar 31.
    • (2010) J Steroid Biochem Mol Biol , vol.121 , Issue.3-5 , pp. 582-588
    • Vandenput, L.1    Ohlsson, C.2
  • 64
    • 70449083246 scopus 로고    scopus 로고
    • Anthropometric and skeletal phenotype in men with idiopathic osteoporosis and their sons is consistent with deficient estrogen action during maturation
    • Lapauw B, Taes Y, Goemaere S et al. Anthropometric and skeletal phenotype in men with idiopathic osteoporosis and their sons is consistent with deficient estrogen action during maturation. J Clin Endocrinol Metab 2009; 94 (11): 4300-4308.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.11 , pp. 4300-4308
    • Lapauw, B.1    Taes, Y.2    Goemaere, S.3
  • 65
    • 69949092976 scopus 로고    scopus 로고
    • The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men
    • LeBlanc ES, Nielson CM, Marshall LM et al. The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. J Clin Endocrinol Metab 2009; 94 (9): 3337-3346.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.9 , pp. 3337-3346
    • LeBlanc, E.S.1    Nielson, C.M.2    Marshall, L.M.3
  • 66
    • 33646489631 scopus 로고    scopus 로고
    • Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study
    • Amin S, Zhang Y, Felson DT et al. Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med 2006; 119 (5): 426-433.
    • (2006) Am J Med , vol.119 , Issue.5 , pp. 426-433
    • Amin, S.1    Zhang, Y.2    Felson, D.T.3
  • 67
    • 0041920903 scopus 로고    scopus 로고
    • Ultralow-Dose Micronized 17beta-Estradiol and Bone Density and Bone Metabolism in Older Women: A Randomized Controlled Trial
    • DOI 10.1001/jama.290.8.1042
    • Prestwood KM, Kenny AM, Kleppinger A, Kulldorff M. Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women: a randomized controlled trial. JAMA 2003; 290 (8): 1042-1048. (Pubitemid 37430444)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.8 , pp. 1042-1048
    • Prestwood, K.M.1    Kenny, A.M.2    Kleppinger, A.3    Kulldorff, M.4
  • 68
    • 38449089068 scopus 로고    scopus 로고
    • Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in postmenopausal women
    • DOI 10.1359/jbmr.070707
    • Huang AJ, Ettinger B, Vittinghoff E et al. Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in postmenopausal women. J Bone Miner Res 2007; 22 (11): 1791-1797. (Pubitemid 351235146)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.11 , pp. 1791-1797
    • Huang, A.J.1    Ettinger, B.2    Vittinghoff, E.3    Ensrud, K.E.4    Johnson, K.C.5    Cummings, S.R.6
  • 69
    • 77951624097 scopus 로고    scopus 로고
    • Update in new anabolic therapies for osteoporosis
    • Canalis E. Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab 2010; 95 (4): 1496-1504.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.4 , pp. 1496-1504
    • Canalis, E.1
  • 70
    • 77949441558 scopus 로고    scopus 로고
    • Anabolics in osteoporosis: The emerging therapeutic tool
    • Trivedi R, Mithal A, Chattopadhyay N. Anabolics in osteoporosis: the emerging therapeutic tool. Curr Mol Med 2010; 10 (1): 14-28.
    • (2010) Curr Mol Med , vol.10 , Issue.1 , pp. 14-28
    • Trivedi, R.1    Mithal, A.2    Chattopadhyay, N.3
  • 71
    • 66749151000 scopus 로고    scopus 로고
    • Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells
    • Zhang YL, Frangos JA, Chachisvilis M. Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells. Am J Physiol Cell Physiol 2009; 296 (6): C1391-C1399.
    • (2009) Am J Physiol Cell Physiol , vol.296 , Issue.6
    • Zhang, Y.L.1    Frangos, J.A.2    Chachisvilis, M.3
  • 72
    • 0033517755 scopus 로고    scopus 로고
    • Synergistic effect of PTH on the mechanical responses of human alveolar osteocytes
    • Sekiya H, Mikuni-Takagaki Y, Kondoh T, Seto K. Synergistic effect of PTH on the mechanical responses of human alveolar osteocytes. Biochem Biophys Res Commun 1999; 264 (3): 719-723.
    • (1999) Biochem Biophys Res Commun , vol.264 , Issue.3 , pp. 719-723
    • Sekiya, H.1    Mikuni-Takagaki, Y.2    Kondoh, T.3    Seto, K.4
  • 73
    • 0032979399 scopus 로고    scopus 로고
    • Mechanical responses and signal transduction pathways in stretched osteocytes
    • DOI 10.1007/s007740050065
    • Mikuni-Takagaki Y. Mechanical responses and signal transduction pathways in stretched osteocytes. J Bone Miner Metab 1999; 17 (1): 57-60. (Pubitemid 29117754)
    • (1999) Journal of Bone and Mineral Metabolism , vol.17 , Issue.1 , pp. 57-60
    • Mikuni-Takagaki, Y.1
  • 75
    • 74249089194 scopus 로고    scopus 로고
    • Nmp4/CIZ: Road block at the intersection of PTH and load
    • Childress P, Robling AG, Bidwell JP. Nmp4/CIZ: road block at the intersection of PTH and load. Bone 2010; 46 (2): 259-266.
    • (2010) Bone , vol.46 , Issue.2 , pp. 259-266
    • Childress, P.1    Robling, A.G.2    Bidwell, J.P.3
  • 77
    • 70350391224 scopus 로고    scopus 로고
    • Local bone formation due to combined mechanical loading and intermittent hPTH-(1-34) treatment and its correlation to mechanical signal distributions
    • Roberts MD, Santner TJ, Hart RT. Local bone formation due to combined mechanical loading and intermittent hPTH-(1-34) treatment and its correlation to mechanical signal distributions. J Biomech 2009; 42 (15): 2431-2438.
    • (2009) J Biomech , vol.42 , Issue.15 , pp. 2431-2438
    • Roberts, M.D.1    Santner, T.J.2    Hart, R.T.3
  • 80
    • 77953388933 scopus 로고    scopus 로고
    • Quantitative computed tomographic assessment of the effects of 24 months of teriparatide treatment on 3D femoral neck bone distribution, geometry, and bone strength: Results from the EUROFORS study
    • Borggrefe J, Graeff C, Nickelsen TN et al. Quantitative computed tomographic assessment of the effects of 24 months of teriparatide treatment on 3D femoral neck bone distribution, geometry, and bone strength: results from the EUROFORS study. J Bone Miner Res 2010; 25 (3): 472-481.
    • (2010) J Bone Miner Res , vol.25 , Issue.3 , pp. 472-481
    • Borggrefe, J.1    Graeff, C.2    Nickelsen, T.N.3
  • 81
    • 70349911489 scopus 로고    scopus 로고
    • Improvements in vertebral body strength under teriparatide treatment assessed in vivo by finite element analysis: Results from the EUROFORS study
    • Graeff C, Chevalier Y, Charlebois M et al. Improvements in vertebral body strength under teriparatide treatment assessed in vivo by finite element analysis: results from the EUROFORS study. J Bone Miner Res 2009; 24 (10): 1672-1680.
    • (2009) J Bone Miner Res , vol.24 , Issue.10 , pp. 1672-1680
    • Graeff, C.1    Chevalier, Y.2    Charlebois, M.3
  • 84
    • 77953233049 scopus 로고    scopus 로고
    • Beta1 integrins mediate mechanosensitive signaling pathways in osteocytes
    • Litzenberger JB, Kim JB, Tummala P, Jacobs CR. Beta1 integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif Tissue Int 2010; 86 (4): 325-332.
    • (2010) Calcif Tissue Int , vol.86 , Issue.4 , pp. 325-332
    • Litzenberger, J.B.1    Kim, J.B.2    Tummala, P.3    Jacobs, C.R.4
  • 85
    • 33748993124 scopus 로고    scopus 로고
    • Molecular bases of progeroid syndromes
    • DOI 10.1093/hmg/ddl214
    • Navarro CL, Cau P, Levy N. Molecular bases of progeroid syndromes. Hum Mol Genet 2006; 15 (Spec No 2): R151-R161. (Pubitemid 44446788)
    • (2006) Human Molecular Genetics , vol.15 , Issue.SUPPL. 2
    • Navarro, C.L.1    Cau, P.2    Levy, N.3
  • 87
    • 77955844454 scopus 로고    scopus 로고
    • Skeletal phenotype of mandibuloacral dysplasia associated with mutations in ZMPSTE24
    • Epub 2010 Jun 13
    • Cunningham VJ, D'Apice MR, Licata N et al. Skeletal phenotype of mandibuloacral dysplasia associated with mutations in ZMPSTE24. Bone 2010; 47 (3): 591-597. Epub 2010 Jun 13.
    • (2010) Bone , vol.47 , Issue.3 , pp. 591-597
    • Cunningham, V.J.1    D'Apice, M.R.2    Licata, N.3
  • 88
    • 69949111789 scopus 로고    scopus 로고
    • Accelerated features of age-related bone loss in zmpste24 metalloproteinase- Deficient mice
    • Rivas D, Li W, Akter R et al. Accelerated features of age-related bone loss in zmpste24 metalloproteinase- deficient mice. J Gerontol A Biol Sci Med Sci 2009; 64 (10): 1015-1024.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , Issue.10 , pp. 1015-1024
    • Rivas, D.1    Li, W.2    Akter, R.3
  • 90
    • 77950273954 scopus 로고    scopus 로고
    • Mechanobiology and the microcirculation: Cellular, nuclear and fluid mechanics
    • Dahl KN, Kalinowski A, Pekkan K. Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics. Microcirculation 2010; 17 (3): 179-191.
    • (2010) Microcirculation , vol.17 , Issue.3 , pp. 179-191
    • Dahl, K.N.1    Kalinowski, A.2    Pekkan, K.3
  • 91
    • 55549113990 scopus 로고    scopus 로고
    • Nuclear mechanotransduction: Response of the lamina to extracellular stress with implications in aging
    • Philip JT, Dahl KN. Nuclear mechanotransduction: response of the lamina to extracellular stress with implications in aging. J Biomech 2008; 41 (15): 3164-3170.
    • (2008) J Biomech , vol.41 , Issue.15 , pp. 3164-3170
    • Philip, J.T.1    Dahl, K.N.2
  • 92
    • 58149087318 scopus 로고    scopus 로고
    • Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis
    • Rauner M, Sipos W, Goettsch C et al. Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis. J Bone Miner Res 2009; 24 (1): 78-86.
    • (2009) J Bone Miner Res , vol.24 , Issue.1 , pp. 78-86
    • Rauner, M.1    Sipos, W.2    Goettsch, C.3
  • 93
    • 58649084328 scopus 로고    scopus 로고
    • Effect of lamin A/C knockdown on osteoblast differentiation and function
    • Akter R, Rivas D, Geneau G et al. Effect of lamin A/C knockdown on osteoblast differentiation and function. J Bone Miner Res 2009; 24 (2): 283-293.
    • (2009) J Bone Miner Res , vol.24 , Issue.2 , pp. 283-293
    • Akter, R.1    Rivas, D.2    Geneau, G.3
  • 94
    • 46849106102 scopus 로고    scopus 로고
    • Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
    • Varela I, Pereira S, Ugalde AP et al. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat Med 2008; 14 (7): 767-772.
    • (2008) Nat Med , vol.14 , Issue.7 , pp. 767-772
    • Varela, I.1    Pereira, S.2    Ugalde, A.P.3
  • 95
    • 67649628226 scopus 로고    scopus 로고
    • Insights into mesenchymal stem cell aging: Involvement of antioxidant defense and actin cytoskeleton
    • Kasper G, Mao L, Geissler S et al. Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton. Stem Cells 2009; 27 (6): 1288-1297.
    • (2009) Stem Cells , vol.27 , Issue.6 , pp. 1288-1297
    • Kasper, G.1    Mao, L.2    Geissler, S.3
  • 96
    • 40849111286 scopus 로고    scopus 로고
    • Influence of age and mechanical stability on bone defect healing: Age reverses mechanical effects
    • Strube P, Sentuerk U, Riha T et al. Influence of age and mechanical stability on bone defect healing: age reverses mechanical effects. Bone 2008; 42 (4): 758-764.
    • (2008) Bone , vol.42 , Issue.4 , pp. 758-764
    • Strube, P.1    Sentuerk, U.2    Riha, T.3


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