Quantitative computed tomographic assessment of the effects of 24 months of teriparatide treatment on 3D femoral neck bone distribution, geometry, and bone strength: Results from the EUROFORS study

Journal of Bone and Mineral Research

Volumn 25, Issue 3, 2010, Pages 472-481

  Borggrefe, Jan ^a   Graeff, Christian ^a   Nickelsen, Thomas N ^b   Marin, Fernando ^b   Glüer, Claus C ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Bone mineral density; Buckling ratio; Computed tomography; Osteoporosis; Section modulus; Teriparatide

Indexed keywords

PARATHYROID HORMONE[1-34]; BONE DENSITY CONSERVATION AGENT;

ADULT; AGED; ARTICLE; BONE STRENGTH; BONE STRUCTURE; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER PROGRAM; CONTROLLED STUDY; CORTICAL BONE; DISEASE SEVERITY; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; GEOMETRY; HUMAN; IN VIVO STUDY; INFORMATION; MAJOR CLINICAL STUDY; OSTEOPOROSIS; PERIOSTEUM; POSTMENOPAUSE; QUANTITATIVE ANALYSIS; RISK; THERAPY DELAY; TREATMENT RESPONSE; CLINICAL TRIAL; DRUG EFFECTS; EUROPE; LONGITUDINAL STUDY; MECHANICAL STRESS; MULTICENTER STUDY; OSTEOPOROSIS, POSTMENOPAUSAL;

BONE DENSITY CONSERVATION AGENTS; EUROPE; FEMALE; FEMUR NECK; HUMANS; LONGITUDINAL STUDIES; OSTEOPOROSIS, POSTMENOPAUSAL; STRESS, MECHANICAL; TERIPARATIDE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77953388933     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.090820     Document Type: Article

References (37)

1. Kanis JA, Burlet N, Cooper C, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008;19:399-428.
2. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996;312:1254-1259. (Pubitemid 26147662)
3. Beck TJ, Looker AC, Ruff CB, Sievanen H, Wahner HW. Structural trends in the aging femoral neck and proximal shaft: analysis of the Third National Health and Nutrition Examination Survey dual-energy X-ray absorptiometry data. J Bone Miner Res. 2000;15:2297-2304.
4. Uusi-Rasi K, Semanick LM, Zanchetta JR, et al. Effects of teriparatide [rhPTH(1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone. 2005;36:948-958. (Pubitemid 40797995)
5. Beck TJ, Ruff CB, Warden KE, Scott WW Jr, Rao GU. Predicting femoral neck strength from bone mineral data: a structural approach. Invest Radiol. 1990;25:6-18.
6. Beck TJ, Oreskovic TL, Stone KL, et al. Structural adaptation to changing skeletal load in the progression toward hip fragility: the Study of Osteoporotic Fractures. J Bone Miner Res. 2001;16:1108-1119.
7. Bolotin HH. DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodeling. Bone. 2007;41:138-154.
8. Bouxsein ML, Karasik D. Bone geometry and skeletal fragility. Curr Osteoporos Rep. 2006;4:49-56.
9. Bauer JS, Kohlmann S, Eckstein F, Mueller D, Lochmuller EM, Link TM. Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro. Calcif Tissue Int. 2006;78:78-89.
10. Duchemin L, Bousson V, Raossanaly C, et al. Prediction of mechanical properties of cortical bone by quantitative computed tomography. Med Eng Phys. 2008;30:321-328. (Pubitemid 351318291)
11. Graeff C, Timm W, Nickelsen TN, et al. Monitoring teriparatide-associated changes in vertebral microstructure by high-resolution CT in vivo: results from the EUROFORS Study. J Bone Miner Res. 2007;22:1426-1433. (Pubitemid 351339687)
12. Obermayer-Pietsch BM, Marin F, McCloskey EV, et al. Effects of two years of daily teriparatide treatment on BMD in postmenopausal women with severe osteoporosis with and without prior antiresorptive treatment. J Bone Miner Res. 2008;23:1591-1600. (Pubitemid 351398563)
13. Young W. Elastic stability formulas for stress and strain. In: Crawford HTS, ed. Roark's Formulas for Stress and Strain. 6th ed. New York: McGraw-Hill, 1989;688.
14. Zebaze RM, Jones A, Welsh F, Knackstedt M, Seeman E. Femoral neck shape and the spatial distribution of its mineral mass varies with its size: clinical and biomechanical implications. Bone. 2005;37:243-252. (Pubitemid 40962433)
15. Crabtree N, Loveridge N, Parker M, et al. Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. J Bone Miner Res. 2001;16:1318-1328. (Pubitemid 32574661)
16. Crabtree N, Lunt M, Holt G, et al. Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS Study. Bone. 2000;27:151-159. (Pubitemid 30365091)
17. Kuiper JW, Van Kuijk C, Grashuis JL. Distribution of trabecular and cortical bone related to geometry: a quantitative computed tomography study of the femoral neck. Invest Radiol. 1997;32:83-89. (Pubitemid 27082075)
18. McClung MR, San Martin J, Miller PD, et al. Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch Intern Med. 2005;165:1762-1768. (Pubitemid 41138965)
19. Boonen S, Marin F, Obermayer-Pietsch B, et al. Effects of previous antiresorptive therapy on the bone mineral density response to two years of teriparatide treatment in postmenopausal women with osteoporosis. J Clin Endocrinol Metab. 2008;93:852-860. (Pubitemid 351398563)
20. Burr DB. Does early PTH treatment compromise bone strength? The balance between remodeling, porosity, bone mineral, and bone size. Curr Osteoporos Rep. 2005;3:19-24.
21. Lindsay R, Zhou H, Cosman F, Nieves J, Dempster DW, Hodsman AB. Effects of a one-month treatment with PTH(1-34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium. J Bone Miner Res. 2007;22:495-502.
22. Jilka RL, O'Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC. Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts. Bone. 2009;44:275-286.
23. Zanchetta JR, Bogado CE, Ferretti JL, et al. Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res. 2003;18:539-543.
24. Kaptoge S, Dalzell N, Jakes RW, et al. Hip section modulus, a measure of bending resistance, is more strongly related to reported physical activity than BMD. Osteoporos Int. 2003;14:941-949. (Pubitemid 38009535)
25. Kaptoge S, Dalzell N, Loveridge N, Beck TJ, Khaw KT, Reeve J. Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone. 2003;32:561-570. (Pubitemid 39665716)
26. Kaptoge S, Jakes RW, Dalzell N, et al. Effects of physical activity on evolution of proximal femur structure in a younger elderly population. Bone. 2007;40:506-515. (Pubitemid 46054561)
27. Szulc P, Delmas PD. Bone loss in elderly men: increased endosteal bone loss and stable periosteal apposition. The prospective MINOS study. Osteoporos Int. 2007;18:495-503.
28. Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J. Osteoclastic cortical erosion as a determinant of subperiosteal osteoblastic bone formation in the femoral neck's response to BMU imbalance: effects of stance-related loading and hip fracture. Osteoporos Int. 2005;16:1049-1056. (Pubitemid 41225091)
29. Power J, Loveridge N, Rushton N, Parker M, Reeve J. Evidence for bone formation on the external "periosteal" surface of the femoral neck: a comparison of intracapsular hip fracture cases and controls. Osteoporos Int. 2003;14:141-145.
30. Burr DB, Hirano T, Turner CH, Hotchkiss C, Brommage R, Hock JM. Intermittently administered human parathyroid hormone (1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys. J Bone Miner Res. 2001;16:157-165.
31. Sato M, Westmore M, Ma YL, et al. Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity. J Bone Miner Res. 2004;19:623-629. (Pubitemid 41071223)
32. Mayhew PM, Thomas CD, Clement JG, et al. Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet. 2005;366:129-135. (Pubitemid 40991213)
33. Frost HM, Bone "mass" and the "mechanostat": a proposal. Anat Rec. 1987;219:1-9.
34. Frost HM. The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and non-mechanical agents. Bone Miner. 1987;2:73-85.
35. Ettinger B, San Martin J, Crans G, Pavo I. Differential effects of teriparatide on BMD after treatment with raloxifene or alendronate. J Bone Miner Res. 2004;19:745-751. (Pubitemid 41094385)
36. Rivadeneira F, Zillikens MC, De Laet CE, et al. Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study. J Bone Miner Res. 2007;22:1781-1790. (Pubitemid 351235145)
37. Lotz JC, Hayes WC. The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. J Bone Joint Surg Am. 1990;72:689-700.