Different responsiveness to mechanical stress of bone cells from osteoporotic versus osteoarthritic donors

Osteoporosis International

Volumn 17, Issue 6, 2006, Pages 827-833

  Bakker, A D ^a   Klein Nulend, J ^a   Tanck, E ^b   Heyligers, I C ^c   Albers, G H ^d   Lips, P ^c   Burger, E H ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Ziekenhuis Hilversum   (Netherlands)

Author keywords

Bone cell culture; Mechanosensitivity; Osteoarthritis; Osteoporosis; Pulsating fluid flow

Indexed keywords

NITRIC OXIDE; PROSTAGLANDIN E2;

ADULT; AGED; ARTICLE; BONE CELL; BONE MASS; BONE STRENGTH; CELL COMMUNICATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MECHANICAL STRESS; OSTEOARTHRITIS; OSTEOPOROSIS; PRIORITY JOURNAL; SHEAR STRESS;

AGED; AGED, 80 AND OVER; BONE AND BONES; DINOPROSTONE; FEMALE; HUMANS; MIDDLE AGED; NITRIC OXIDE; OSTEOARTHRITIS; OSTEOBLASTS; OSTEOPOROSIS; PULSATILE FLOW; STRESS, MECHANICAL;

EID: 33646863240     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0072-7     Document Type: Article

References (38)

1. Eriksen EF, Hodgson SF, Eastell R, Cedel SL, O'Fallon WM, Riggs L (1990) Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels. J Bone Miner Res 5:311-319
2. Richelson LS, Wahner HW, Melton LJ, III, Riggs BL (1984) Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. N Engl J Med 311:1273-1275
3. Abyad A, Boyer JT (1992) Arthritis and aging. Curr Opin Rheumatol 4:153-159
4. Dequeker J, Mokassa L, Aerssens J (1995) Bone density and osteoarthritis. J Rheumatol 22:98-100
5. Fazzalari NL, Parkinson IH (1998) Femoral trabecular bone of osteoarthritic and normal subjects in an age and sex matched group. Osteoarthr Cartil 6:377-382
6. Fazzalari NL, Forwood MR, Smith K, Manthey BA, Herreen P (1998) Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone 22:381-388
7. Li B, Aspden RM (1997) Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J Bone Miner Res 12:641-651
8. Page WF, Hoaglund FT, Steinbach LS, Heath AC (2003) Primary osteoarthritis of the hip in monozygotic and dizygotic male twins. Twin Res 6:147-151
9. Wheeless CR (2005) Wheeless' Textbook of Orthopaedics. Available at: http://www.wheelessonline.com
10. Parfitt AM (1994) Osteonal and hemi-osteonal remodelling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55:273-286
11. Petrtyl M, Hert J, Fiala P (1996) Spatial organization of the Haversian bone in man. J Biomech 29:161-169
12. Smit TH, Burger EH (2000) Is BMU-coupling a strain-regulated phenomenon? A finite element analysis. J Bone Miner Res 15:301-307
13. Lanyon LE (1987) Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodeling. J Biomech 20:1083-1093
14. Huiskes R, Ruimerman R, Lenthe van GH, Janssen JD (2000) Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature 405:704-706
15. Cowin SC, Moss-Salentijn L, Moss ML (1991) Candidates for the mechanosensory system in bone. J Biomech Eng 113:191-197
16. Lanyon LE (1993) Osteocytes, strain detection, bone modeling and remodeling. Calcif Tissue Int 53:S102-S106
17. Burger EH, Klein-Nulend J (1999) Mechanotransduction in bone - role of the lacuno-canalicular network. FASEB J 13: S101-S112
18. Piekarski K, Munro M (1977) Transport mechanism operating between blood supply and osteocytes in long bones. Nature 269:80-82
19. Cowin SC, Weinbaum S (1998) Strain amplification in the bone mechanosensory system. Am J Med Sci 316:184-188
20. Knothe Tate ML, Knothe U (2000) An ex vivo model to study transport processes and fluid flow in loaded bone. J Biomech 33:247-254
21. Klein-Nulend J, Semeins CM, Ajubi NE, Nijweide PJ, Burger EH (1995) Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts: correlation with prostaglandin upregulation. Biochem Biophys Res Commun 217:640-648
22. Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G, Lanyon LE (1995) Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re) modeling? FASEB J 9:1614-1622
23. McAllister TN, Frangos JA (1999) Steady and transient fluid shear stress stimulate NO release in osteoblasts trough distinct biochemical pathways. J Bone Miner Res 14:930-936
24. Burger Eh, Klein-Nulend J, Smit TH (2003) Strain-derived canalicular fluid flow regulates osteoclastic activity in a remodeling osteon - a proposal. J Biomech 36:1453-1457
25. Forwood MR (1996) Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res 11:1688-1693
26. Turner CH, Takano Y, Owan I, Murrell GA (1996) Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. Am J Physiol 270:E634-E639
27. Bakker AD, Klein-Nulend J, Burger EH (2003) Mechano-transduction in bone cells proceeds via activation of COX-2, but not COX-1. Biochem Biophys Res Commun 305:677-683
28. Sterck JG, Klein-Nulend J, Lips P, Burger EH (1998) Response of normal and osteoporotic human bone cells to mechanical stress in vitro. Am J Physiol 274:E1113-E1120
29. Lowry OH (1955) Micromethods for the assay of enzyme II specific procedure. Alkaline phosphatase. Meth Enzymol 4:371
30. Klein-Nulend J, van der Plas A, Semeins CM, Ajubi NE, Frangos JA, Nijweide PJ, Burger EH (1995) Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J 9:441-445
31. Klein-Nulend J, Helfrich MH, Sterck JG, MacPherson H, Joldersma M, Ralston SH, Semeins CM, Burger EH (1998) Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent. Biochem Biophys Res Commun 250:108-114
32. Bakker AD, Klein Nulend J, Tanck E, Albers GH, Lips P, Burger EH (2004) Additive effects of estrogen and mechanical loading on paracrine signaling by bone cells from osteoporotic donors. Osteoporosis Int 16(8):983-989. 10.1007/s00198-004-1785-0
33. Westbroek I, AjubiNE, Alblas MJ, Semeins CM, Klein-Nulend J, Burger EH, Nijweide PJ (2000) Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow. Biochem Biophys Res Commun 268:414-419
34. Homminga J, Weinans H, Gowin W, Felsenberg D, Huiskes R (2001) Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution. Spine 26:1555-1561
35. Maclntyre I, Zaidi M, Towhidul Alam ASM, Datta HK, Moonga BS, Lidbury P, Hecker M, Vane JR (1991) Osteoclastic inhibition:An action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci USA 88:2936-2940
36. Wimalawansa SL (2000) Nitroglycerin therapy is as efficacious as standard estrogen replacement therapy (premarin) in prevention of oophorectomy-induced bone loss: a human pilot clinical study. J Bone Miner Res 15:2240-2244
37. Ke HZ, Jee WS (1992) Effects of daily administration of prostaglandin E2 and its withdrawal on the lumbar vertebral bodies in male rats. Anat Rec 234:172-182
38. Li J, Burr DB, Turner CH (2002) Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading. Calcif Tissue Int 70:320-329