Local bone formation due to combined mechanical loading and intermittent hPTH-(1-34) treatment and its correlation to mechanical signal distributions

Journal of Biomechanics

Volumn 42, Issue 15, 2009, Pages 2431-2438

  Roberts, M D ^a   Santner, T J ^b   Hart, R T ^a  

^a Tulane University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Bone adaptation; Finite element modeling; Mechanical loading; Parathyroid hormone; Rat tibia

Indexed keywords

BONE ADAPTATION; FINITE ELEMENT MODELING; MECHANICAL LOADING; PARATHYROID HORMONE; RAT TIBIA;

ANIMALS; BONE; SIGNAL PROCESSING;

STRESSES;

PARATHYROID HORMONE[1-34];

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BIOSYNTHESIS; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FLUOROCHROME STAINING; MECHANICAL STIMULATION; MECHANICAL STRESS; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TIBIA;

ANIMALS; ANISOTROPY; COMPRESSIVE STRENGTH; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MECHANOTRANSDUCTION, CELLULAR; OSTEOGENESIS; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS AS TOPIC; TENSILE STRENGTH; TERIPARATIDE; TIBIA;

EID: 70350391224     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2009.08.030     Document Type: Article

References (50)

1. Akhter M.P., Raab D.M., Turner C.H., Kimmel D.B., and Recker R.R. Characterization of in vivo strain in the rat tibia during external application of a four-point bending load. Journal of Biomechanics 25 10 (1992) 1241-1246
2. Bober, M.B., 1996. The regulation of gene expression by mechanical stimulation and parathyroid hormone in bone in vivo. Ph.D. Dissertation, Tulane University, New Orleans, Louisiana.
3. Brown T.D., Pedersen D.R., Gray M.L., Brand R.A., and Rubin C.T. Toward an identification of mechanical parameters initiating periosteal remodeling: a combined experimental and analytic approach. Journal of Biomechanics 23 9 (1990) 893-905
4. Carter D.R. Mechanical loading histories and cortical bone remodeling. Calcified Tissue International 36 Suppl 1 (1984) S19-S24
5. Chow J.W., Fox S., Jagger C.J., and Chambers T.J. Role for parathyroid hormone in mechanical responsiveness of rat bone. The American Journal of Physiology 274 1 Pt 1 (1998) E146-E154
6. Cosman F., and Lindsay R. Is parathyroid hormone a therapeutic option for osteoporosis? A review of the clinical evidence. Calcified Tissue International 62 6 (1998) 475-480
7. Deal C., and Gideon J. Recombinant human PTH 1-34 (Forteo): an anabolic drug for osteoporosis. Cleveland Clinic Journal of Medicine 70 7 (2003) 585-594
8. Dempster D.W., Cosman F., Parisien M., Shen V., and Lindsay R. Anabolic actions of parathyroid hormone on bone. Endocrine Reviews 14 6 (1993) 690-709
9. Dobnig H., and Turner R.T. The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats. Endocrinology 138 11 (1997) 4607-4612
10. Ejersted C., Andreassen T.T., Oxlund H., Jørgensen P.H., Bak B., Häggblad J., Tørring O., and Nilsson M.H. Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats. Journal of Bone and Mineral Research 8 9 (1993) 1097-1101
11. Gross T.S., Edwards J.L., McLeod K.J., and Rubin C.T. Strain gradients correlate with sites of periosteal bone formation. Journal of Bone and Mineral Research 12 6 (1997) 982-988
12. Gross T.S., Srinivasan S., Liu C.C., Clemens T.L., and Bain S.D. Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction. Journal of Bone and Mineral Research 17 3 (2002) 493-501
13. Gunness M., and Hock J.M. Anabolic effect of parathyroid hormone on cancellous and cortical bone histology. Bone 14 3 (1993) 277-281
14. Hagino H., Okano T., Akhter M.P., Enokida M., and Teshima R. Effect of parathyroid hormone on cortical bone response to in vivo external loading of the rat tibia. Journal of Bone and Mineral Metabolism 19 4 (2001) 244-250
15. Hart R.T. Bone modeling and remodeling: theories and computation. In: Cowin S.C. (Ed). Bone Mechanics Handbook (2001), CRC Press, Boca Raton, FL 31: 31-40
16. Hart R.T., Hennebel V.V., Thongpreda N., Van Buskirk W.C., and Anderson R.C. Modeling the biomechanics of the mandible: a three-dimensional finite element study. Journal of Biomechanics 25 3 (1992) 261-286
17. Kim C.H., Takai E., Zhou H., von Stechow D., Muller R., Dempster D.W., and Guo X.E. Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironment. Journal of Bone and Mineral Research 18 12 (2003) 2116-2125
18. Kimmel D.B., Bozzato R.P., Kronis K.A., Coble T., Sindrey D., Kwong P., and Recker R.R. The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats. Endocrinology 132 4 (1993) 1577-1584
19. Kohles S.S., Bowers J.R., Vailas A.C., and Vanderby R. Ultrasonic wave velocity measurement in small polymeric and cortical bone specimens. Journal of Biomechanical Engineering 119 3 (1997) 232-236
20. Lanyon L.E., and Rubin C.T. Static vs. dynamic loads as an influence on bone remodelling. Journal of Biomechanics 17 12 (1984) 897-905
21. Li J., Duncan R.L., Burr D.B., Gattone V.H., and Turner C.H. Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels. Endocrinology 144 4 (2003) 1226-1233
22. Ma Y., Jee W.S., Yuan Z., Wei W., Chen H., Pun S., Liang H., and Lin C. Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone. Journal of Bone and Mineral Research 14 3 (1999) 439-448
23. Mi L.Y., and Fritton S.P. Analysis of avian bone response to mechanical loading-part one: distribution of bone fluid shear stress induced by bending and axial loading. Biomechanics and modeling in mechanobiology 4 2-3 (2005) 118-131
24. Mosekilde L., Danielsen C.C., Søgaard C.H., McOsker J.E., and Wronski T.J. The anabolic effects of parathyroid hormone on cortical bone mass, dimensions and strength-assessed in a sexually mature, ovariectomized rat model. Bone 16 2 (1995) 223-230
25. Mosley J.R., and Lanyon L.E. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone 23 4 (1998) 313-318
26. Mosley J.R., March B.M., Lynch J., and Lanyon L.E. Strain magnitude related changes in whole bone architecture in growing rats. Bone 20 3 (1997) 191-198
27. Neer R.M., Arnaud C.D., et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. New England Journal of Medicine 344 19 (2001) 1434-1441
28. O'Connor J.A., Lanyon L.E., and MacFie H. The influence of strain rate on adaptive bone remodelling. Journal of Biomechanics 15 10 (1982) 767-781
29. Qin Y.X., Kaplan T., Saldanha A., and Rubin C. Fluid pressure gradients, arising from oscillations in intramedullary pressure, is correlated with the formation of bone and inhibition of intracortical porosity. Journal of Biomechanics 36 10 (2003) 1427-1437
30. Qin Y.X., McLeod K.J., Guilak F., Chiang F.P., and Rubin C.T. Correlation of bony ingrowth to the distribution of stress and strain parameters surrounding a porous-coated implant. Journal of Orthopaedic Research 14 6 (1996) 862-870
31. Qin Y.X., Rubin C.T., and McLeod K.J. Nonlinear dependence of loading intensity and cycle number in the maintenance of bone mass and morphology. Journal of Orthopaedic Research 16 4 (1998) 482-489
32. Raab-Cullen D.M., Akhter M.P., Kimmel D.B., and Recker R.R. Bone response to alternate-day mechanical loading of the rat tibia. Journal of Bone and Mineral Research 9 2 (1994) 203-211
33. Riond J.L. Modulation of the anabolic effect of synthetic human parathyroid hormone fragment-(I-34) in the bone of growing rats by variations in the dosage regimen. Clinical Science 85 2 (1993) 223-228
34. Robling A.G., Burr D.B., and Turner C.H. Recovery periods restore mechanosensitivity to dynamically loaded bone. The Journal of Experimental Biology 204 Pt 19 (2001) 3389-3399
35. Robling A.G., Hinant F.M., Burr D.B., and Turner C.H. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. Journal of Bone and Mineral Research 17 8 (2002) 1545-1554
36. Rubin C., Turner A.S., Mallinckrodt C., Jerome C., McLeod K., and Bain S. Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone. Bone 30 3 (2002) 445-452
37. Rubin C.T., and Lanyon L.E. Regulation of bone formation by applied dynamic loads. The Journal of Bone and Joint Surgery. American Volume 66 3 (1984) 397-402
38. Rubin C.T., and Lanyon L.E. Regulation of bone mass by mechanical strain magnitude. Calcified Tissue International 37 4 (1985) 411-417
39. Sato M., Zeng G.Q., and Turner C.H. Biosynthetic human parathyroid hormone (1-34) effects on bone quality in aged ovariectomized rats. Endocrinology 138 10 (1997) 4330-4337
40. Srinivasan S., Agans S.C., King K.A., Moy N.Y., Poliachik S.L., and Gross T.S. Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. Bone 33 6 (2003) 946-955
41. Srinivasan S., Weimer D.A., Agans S.C., Bain S.D., and Gross T.S. Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. Journal of Bone and Mineral Research 17 9 (2002) 1613-1620
42. Tanaka S.M., Alam I.M., and Turner C.H. Stochastic resonance in osteogenic response to mechanical loading. FASEB Journal 17 2 (2003) 313-314
43. Torrance A.G., Mosley J.R., Suswillo R.F., and Lanyon L.E. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periosteal pressure. Calcified Tissue International 54 3 (1994) 241-247
44. Turner C.H., Akhter M.P., Raab D.M., Kimmel D.B., and Recker R.R. A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone 12 2 (1991) 73-79
45. Turner C.H., Forwood M.R., and Otter M.W. Mechanotransduction in bone: do bone cells act as sensors of fluid flow?. FASEB Journal 8 11 (1994) 875-878
46. Turner C.H., Forwood M.R., Rho J.Y., and Yoshikawa T. Mechanical loading thresholds for lamellar and woven bone formation. Journal of Bone and Mineral Research 9 1 (1994) 87-97
47. Turner C.H., Owan I., and Takano Y. Mechanotransduction in bone: role of strain rate. American Journal of Physiology 269 3 Pt 1 (1995) E438-E442
48. Waarsing J.H., Day J.S., van der Linden J.C., Ederveen A.G., Spanjers C., De Clerck N., Sasov A., Verhaar J.A., and Weinans H. Detecting and tracking local changes in the tibiae of individual rats: a novel method to analyse longitudinal in vivo micro-CT data. Bone 34 1 (2004) 163-169
49. Warden S.J., and Turner C.H. Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5-10 Hz. Bone 34 2 (2004) 261-270
50. Wolff J. The Law of Bone Remodeling (1892), Springer-Verlag, Berlin