Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease

Experimental Cell Research

Volumn 309, Issue 1, 2005, Pages 78-85

  Kasyapa, Chitta S ^a   Kunapuli, Padmaja ^a   Cowell, John K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Leukemia; Mass spectroscopy; RNA maturation; RNA upstream binding factor; TLS; ZNF198 FGFR1

Indexed keywords

HYBRID PROTEIN; ISOPROTEIN;

ARTICLE; CELLULAR DISTRIBUTION; GENE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SPLICEOSOME; WESTERN BLOTTING;

EID: 23944464489     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2005.05.019     Document Type: Article

References (27)

1. S. Xiao, S.R. Nalabolu, J.C. Aster, J. Ma, L. Abruzzo, E.S. Jaffe, R. Stone, S.M. Weissman, T.J. Hudson, and J.A. Fletcher FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome Nat. Genet. 18 1998 84 87
2. I.H. Still, and J.K. Cowell The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13 Blood 92 1998 1456 1458
3. D. Smedley, R. Hamoudi, J. Clark, W. Warren, M. Abdul-Rauf, G. Somers, D. Venter, K. Fagan, C. Cooper, and J. Shipley The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP Hum. Mol. Genet. 7 1998 637 642
4. H. Baumann, P. Kunapuli, E. Tracy, and J.K. Cowell The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors J. Biol. Chem. 278 2003 16198 16208
5. P. Kunapuli, C.S. Kasyapa, J.K. Cowell, ZNF198, a gene rearranged in myeloproliferative disease, localized to the PMI nuclear bodies and interacts with SUMO1 and PML. (Submitted for publication).
6. P. Kunapuli, R. Somerville, I.H. Still, and J.K. Cowell ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins Oncogene 22 2003 3417 3423
7. V. Ollendorff, G. Guasch, D. Isnardon, R. Galindo, D. Birnbaum, and M.J. Pebusque Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation J. Biol. Chem. 274 1999 26922 26930
8. J.G. Patton, E.B. Porro, J. Galceran, P. Tempst, and B. Nadal-Ginard Cloning and characterization of PSF, a novel pre-mRNA splicing factor Genes Dev. 7 1993 393 406
9. O. Gozani, J.G. Patton, and R. Reed A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction EMBO J. 13 1994 3356 3567
10. D.L. Spector Nuclear domains J. Cell Sci. 114 2001 2891 2893
11. S.P. Bell, R.M. Learned, H.M. Jantzen, and R. Tjian Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis Science 241 1988 1192 1197
12. K.M. Hannan, R.D. Hannan, and L.I. Rothblum Transcription by RNA polymerase I Front. Biosci. 3 1998 376 398
13. T.W. Nilsen The spliceosome: the most complex macromolecular machine in the cell? Bioessays 12 2003 1147 1149
14. M.S. Jurica, and M.J. Moore Pre-mRNA splicing: awash in a sea of proteins Mol. Cell 12 2003 5 14
15. T. Misteli The concept of self-organization in cellular architecture J. Cell Biol. 155 2001 181 185
16. B.T. Dye, and J.G. Patton An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles Exp. Cell Res. 263 2001 131 144
17. J.S. Andersen, C.E. Lyon, A.H. Fox, A.K. Leung, Y.W. Lam, H. Steen, M. Mann, and A.I. Lamond Directed proteomic analysis of the human nucleolus Curr. Biol. 8 2002 1 11
18. M. Meissner, T. Dechat, C. Gerner, R. Grimm, R. Foisner, and G. Sauermann Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB J. Cell. Biochem. 76 2002 559 566
19. G. Varani, and K. Nagai RNA recognition by RNP proteins during RNA processing Ann. Rev. Biophys. Biomol. Struct. 27 1998 407 445
20. Z. Zhou, L.J. Licklider, S.P. Gygi, and R. Reed Comprehensive proteomic analysis of the human spliceosome Nature 419 2002 182 185
21. R. Rappsilber, U. Ryder, A.I. Lamond, and M. Mann Large-scale proteomic analysis of the human spliceosome Genome Res. 12 2002 1231 1245
22. G. Dreyfuss, V.N. Kim, and N. Kataoka Messenger-RNA-binding proteins and the messages they carry Nat. Rev., Mol. Cell Biol. 3 2002 195 205
23. C. Calvio, G. Neubauer, M. Mann, and A.I. Lamond Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry RNA 1 1995 724 733
24. H. Zinszner, D. Immanuel, Y. Yin, F.X. Liang, and D. Ron A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited Oncogene 14 1997 451 461
25. L. Yang, L.J. Embree, and D.D. Hickstein TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins Mol. Cell. Biol. 20 2000 3345 3354
26. L. Yang, L.J. Embree, S. Tsai, and D.D. Hickstein Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing J. Biol. Chem. 273 1998 27761 27764
27. C.S. Kasyapa, P. Kunapuli, L. Hawthorn, J.K. Cowell, Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198/FGFR1 fusion kinase, that is involved in atypical myeloproliferative disease. (Submitted for publication).