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Volumn 121, Issue 5, 2011, Pages 1810-1821

Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

Author keywords

[No Author keywords available]

Indexed keywords

SERINE PROTEINASE; THYMUS SPECIFIC SERINE PROTEASE; UNCLASSIFIED DRUG;

EID: 79955495219     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI43314     Document Type: Article
Times cited : (32)

References (51)
  • 1
    • 0032701409 scopus 로고
    • The role of CD4 vs. CD8 T cells in IDDM
    • Wong FS, Janeway CA Jr. The role of CD4 vs. CD8 T cells in IDDM. J Autoimmun. 1993;13(3):290-295.
    • (1993) J Autoimmun , vol.13 , Issue.3 , pp. 290-295
    • Wong, F.S.1    Janeway Jr., C.A.2
  • 2
    • 0033662436 scopus 로고    scopus 로고
    • Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice
    • Latek RR, et al. Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. Immunity. 2000;12(6):699-710.
    • (2000) Immunity , vol.12 , Issue.6 , pp. 699-710
    • Latek, R.R.1
  • 3
    • 0034664250 scopus 로고    scopus 로고
    • The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder
    • Stratmann T, et al. The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder. J Immunol. 2000;165(6):3214-3225.
    • (2000) J Immunol , vol.165 , Issue.6 , pp. 3214-3225
    • Stratmann, T.1
  • 4
    • 0030067815 scopus 로고    scopus 로고
    • The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders
    • Carrasco-Marin E, Shimizu J, Kanagawa O, Unanue ER. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol. 1996;156(2):450-458.
    • (1996) J Immunol , vol.156 , Issue.2 , pp. 450-458
    • Carrasco-Marin, E.1    Shimizu, J.2    Kanagawa, O.3    Unanue, E.R.4
  • 7
    • 67349233519 scopus 로고    scopus 로고
    • Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex
    • Viken MK, et al. Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex. Genes Immun. 2009;10(4):323-333.
    • (2009) Genes Immun , vol.10 , Issue.4 , pp. 323-333
    • Viken, M.K.1
  • 8
    • 0032729099 scopus 로고    scopus 로고
    • Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus
    • DOI 10.1006/cimm.1999.1543
    • Bowlus CL, Ahn J, Chu T, Gruen JR. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. Cell Immunol. 1999;196(2):80-86. (Pubitemid 29496456)
    • (1999) Cellular Immunology , vol.196 , Issue.2 , pp. 80-86
    • Bowlus, C.L.1    Ahn, J.2    Chu, T.3    Gruen, J.R.4
  • 9
    • 0032785117 scopus 로고    scopus 로고
    • Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: Definition of a set of genes potentially involved in thymocyte maturation
    • Carrier A, et al. Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Immunogenetics. 1999; 50(5-6):255-270.
    • (1999) Immunogenetics , vol.50 , Issue.5-6 , pp. 255-270
    • Carrier, A.1
  • 11
    • 65449189283 scopus 로고    scopus 로고
    • Thymus-specific serine protease regulates positive selection of a subset of CD4(+) thymocytes
    • Gommeaux J, et al. Thymus-specific serine protease regulates positive selection of a subset of CD4(+) thymocytes. Eur J Immunol. 2009;39(4):956-964.
    • (2009) Eur J Immunol , vol.39 , Issue.4 , pp. 956-964
    • Gommeaux, J.1
  • 13
    • 0035175577 scopus 로고    scopus 로고
    • A defect in central tolerance in NOD mice
    • DOI 10.1038/ni726
    • Kishimoto H, Sprent J. A defect in central tolerance in NOD mice. Nat Immunol. 2001;2(11):1025-1031. (Pubitemid 33069497)
    • (2001) Nature Immunology , vol.2 , Issue.11 , pp. 1025-1031
    • Kishimoto, H.1    Sprent, J.2
  • 15
    • 15244338878 scopus 로고    scopus 로고
    • Defective central tolerance induction in NOD mice: Genomics and genetics
    • DOI 10.1016/j.immuni.2005.01.015
    • Zucchelli S, Holler P, Yamagata T, Roy M, Benoist C, Mathis D. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity. 2005;22(3):385-396. (Pubitemid 40387479)
    • (2005) Immunity , vol.22 , Issue.3 , pp. 385-396
    • Zucchelli, S.1    Holler, P.2    Yamagata, T.3    Roy, M.4    Benoist, C.5    Mathis, D.6
  • 16
    • 0242364727 scopus 로고    scopus 로고
    • A comprehensive guide to antibody and T-cell responses in type 1 diabetes
    • DOI 10.1034/j.1399-0039.2003.00152.x
    • Lieberman SM, DiLorenzo TP. A comprehensive guide to antibody and T-cell responses in type 1 diabetes. Tissue Antigens. 2003;62(5):359-377. (Pubitemid 37338877)
    • (2003) Tissue Antigens , vol.62 , Issue.5 , pp. 359-377
    • Lieberman, S.M.1    DiLorenzo, T.P.2
  • 20
    • 9144271119 scopus 로고    scopus 로고
    • + T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase
    • Lieberman SM, Takaki T, Han B, Santamaria P, Serreze DV, DiLorenzo TP. Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase. J Immunol. 2004;173(11):6727-6734. (Pubitemid 39541058)
    • (2004) Journal of Immunology , vol.173 , Issue.11 , pp. 6727-6734
    • Lieberman, S.M.1    Takaki, T.2    Han, B.3    Santamaria, P.4    Serreze, D.V.5    DiLorenzo, T.P.6
  • 21
    • 17844365884 scopus 로고    scopus 로고
    • + T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: A novel beta cell autoantigen in type 1 diabetes
    • Mukherjee R, Wagar D, Stephens TA, Lee-Chan E, Singh B. Identification of CD4+ T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: a novel beta cell autoantigen in type 1 diabetes. J Immunol. 2005; 174(9):5306-5315. (Pubitemid 40593169)
    • (2005) Journal of Immunology , vol.174 , Issue.9 , pp. 5306-5315
    • Mukherjee, R.1    Wagar, D.2    Stephens, T.A.3    Lee-Chan, E.4    Singh, B.5
  • 22
    • 0042831994 scopus 로고    scopus 로고
    • Analysis of the IDDM candidate gene Prss16 in NOD and NON mice
    • DOI 10.1080/10446670310001593497
    • Cheunsuk S, Hsu T, Gershwin ME, Bowlus CL. Analysis of the IDDM candidate gene Prss16 in NOD and NON mice. Dev Immunol. 2002;9(4):183-186. (Pubitemid 37070083)
    • (2002) Developmental Immunology , vol.9 , Issue.4 , pp. 183-186
    • Cheunsuk, S.1    Hsu, T.2    Gershwin, M.E.3    Bowlus, C.L.4
  • 23
    • 0029826977 scopus 로고    scopus 로고
    • B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: Analysis of a new "speed congenic" stock of NOD.Ig mu null mice
    • Serreze DV, et al. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J Exp Med. 1996;184(5):2049-2053.
    • (1996) J Exp Med , vol.184 , Issue.5 , pp. 2049-2053
    • Serreze, D.V.1
  • 24
    • 0032532294 scopus 로고    scopus 로고
    • B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice
    • Serreze DV, Fleming SA, Chapman HD, Richard SD, Leiter EH, Tisch RM. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol. 1998;161(8):3912-3918. (Pubitemid 28468965)
    • (1998) Journal of Immunology , vol.161 , Issue.8 , pp. 3912-3918
    • Serreze, D.V.1    Fleming, S.A.2    Chapman, H.D.3    Richard, S.D.4    Leiter, E.H.5    Tisch, R.M.6
  • 25
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12(4):431-440.
    • (2000) Immunity , vol.12 , Issue.4 , pp. 431-440
    • Salomon, B.1
  • 26
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • DOI 10.1126/science.1079490
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057-1061. (Pubitemid 36222930)
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 27
    • 0037385330 scopus 로고    scopus 로고
    • + regulatory T cells
    • DOI 10.1038/ni904
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003;4(4):330-336. (Pubitemid 36432314)
    • (2003) Nature Immunology , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 28
    • 0037385314 scopus 로고    scopus 로고
    • + T regulatory cells
    • DOI 10.1038/ni909
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol. 2003;4(4):337-342. (Pubitemid 36432315)
    • (2003) Nature Immunology , vol.4 , Issue.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.-A.3    Ramsdell, F.4
  • 29
    • 33750833099 scopus 로고    scopus 로고
    • + regulatory T cells
    • Brode S, Raine T, Zaccone P, Cooke A. Cyclophosphamide-induced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cells. J Immunol. 2006;177(10):6603-6612. (Pubitemid 44715023)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6603-6612
    • Brode, S.1    Raine, T.2    Zaccqne, P.3    Cooke, A.4
  • 30
    • 78651480854 scopus 로고    scopus 로고
    • Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire
    • Viret C, et al. Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire. J Exp Med. 2011;208(1):3-11.
    • (2011) J Exp Med , vol.208 , Issue.1 , pp. 3-11
    • Viret, C.1
  • 31
    • 5444222000 scopus 로고    scopus 로고
    • Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
    • DOI 10.1038/ni1120
    • Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol. 2004; 5(10):1028-1035. (Pubitemid 41057722)
    • (2004) Nature Immunology , vol.5 , Issue.10 , pp. 1028-1035
    • Jaeckel, E.1    Lipes, M.A.2    Von Boehmer, H.3
  • 34
    • 48449094511 scopus 로고    scopus 로고
    • On the pathogenicity of auto-antigen- specific T-cell receptors
    • Burton AR, et al. On the pathogenicity of auto-antigen- specific T-cell receptors. Diabetes. 2008; 57(5):1321-1330.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1321-1330
    • Burton, A.R.1
  • 35
    • 0032768786 scopus 로고    scopus 로고
    • Cellular immune response to phogrin in the NOD mouse: Cloned T-cells cause destruction of islet transplants
    • DOI 10.2337/diabetes.48.8.1529
    • Kelemen K, Crawford ML, Gill RG, Hutton JC, Wegmann D. Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants. Diabetes. 1999;48(8):1529-1534. (Pubitemid 29356859)
    • (1999) Diabetes , vol.48 , Issue.8 , pp. 1529-1534
    • Kelemen, K.1    Crawford, M.L.2    Gill, R.G.3    Hutton, J.C.4    Wegmann, D.5
  • 36
    • 0036849453 scopus 로고    scopus 로고
    • Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice
    • DOI 10.1006/jaut.2002.0611
    • Achenbach P, Kelemen K, Wegmann DR, Hutton JC. Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. J Autoimmun. 2002;19(3):111-116. (Pubitemid 35341861)
    • (2002) Journal of Autoimmunity , vol.19 , Issue.3 , pp. 111-116
    • Achenbach, P.1    Kelemen, K.2    Wegmann, D.R.3    Hutton, J.C.4
  • 37
    • 3042704212 scopus 로고    scopus 로고
    • Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice
    • DOI 10.2337/diabetes.53.7.1684
    • Kubosaki A, et al. Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes. 2004; 53(7):1684-1691. (Pubitemid 38857025)
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1684-1691
    • Kubosaki, A.1    Gross, S.2    Miura, J.3    Saeki, K.4    Zhu, M.5    Nakamura, S.6    Hendriks, W.7    Notkins, A.L.8
  • 38
    • 0030779118 scopus 로고    scopus 로고
    • A mechanism for the major histocompatibility complex-linked resistance to autoimmunity
    • DOI 10.1084/jem.186.7.1059
    • Schmidt D, Verdaguer J, Averill N, Santamaria P. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med. 1997;186(7):1059-1075. (Pubitemid 27441150)
    • (1997) Journal of Experimental Medicine , vol.186 , Issue.7 , pp. 1059-1075
    • Schmidt, D.1    Verdaguer, J.2    Averill, N.3    Santamaria, P.4
  • 40
    • 0023724209 scopus 로고
    • Positive and negative selection of an antigen receptor on T cells in transgenic mice
    • DOI 10.1038/336073a0
    • Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature. 1988;336(6194):73-76. (Pubitemid 18262137)
    • (1988) Nature , vol.336 , Issue.6194 , pp. 73-76
    • Sha, W.C.1    Nelson, C.A.2    Newberry, R.D.3    Kranz, D.M.4    Russell, J.H.5    Loh, D.Y.6
  • 41
    • 0024356811 scopus 로고
    • Phenotypic differences between alphabeta versus beta T-cell receptor transgenic mice undergoing negative selection
    • DOI 10.1038/340559a0
    • Berg LJ, Fazekas de St Groth B, Pullen AM, Davis MM. Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. Nature. 1989;340(6234):559-562. (Pubitemid 19201697)
    • (1989) Nature , vol.340 , Issue.6234 , pp. 559-562
    • Berg, L.J.1    De Fazekas, S.G.B.2    Pullen, A.M.3    Davis, M.M.4
  • 42
    • 0024428184 scopus 로고
    • Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
    • Berg LJ, Pullen AM, Fazekas de St Groth B, Mathis D, Benoist C, Davis MM. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell. 1989; 58(6):1035-1046.
    • (1989) Cell , vol.58 , Issue.6 , pp. 1035-1046
    • Berg, L.J.1    Pullen, A.M.2    Fazekas De St Groth, B.3    Mathis, D.4    Benoist, C.5    Davis, M.M.6
  • 44
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • DOI 10.1084/jem.20041457
    • Gallegos AM, Bevan MJ. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med. 2004;200(8):1039-1049. (Pubitemid 39431128)
    • (2004) Journal of Experimental Medicine , vol.200 , Issue.8 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 45
    • 58149154739 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
    • McCaughtry TM, Baldwin TA, Wilken MS, Hogquist KA. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med. 2008;205(11):2575-2584.
    • (2008) J Exp Med , vol.205 , Issue.11 , pp. 2575-2584
    • McCaughtry, T.M.1    Baldwin, T.A.2    Wilken, M.S.3    Hogquist, K.A.4
  • 46
    • 1942453326 scopus 로고    scopus 로고
    • Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
    • DOI 10.1016/S0092-8674(04)00335-6, PII S0092867404003356
    • King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell. 2004;117(2):265-277. (Pubitemid 38496245)
    • (2004) Cell , vol.117 , Issue.2 , pp. 265-277
    • King, C.1    Ilic, A.2    Koelsch, K.3    Sarvetnick, N.4
  • 47
    • 33748880792 scopus 로고    scopus 로고
    • Regulatory T cells control autoimmunity following syngeneic bone marrow transplantation
    • DOI 10.1002/eji.200636434
    • Benard A, Ceredig R, Rolink AG. Regulatory T cells control autoimmunity following syngeneic bone marrow transplantation. Eur J Immunol. 2006;36(9):2324-2335. (Pubitemid 44420589)
    • (2006) European Journal of Immunology , vol.36 , Issue.9 , pp. 2324-2335
    • Bernard, A.1    Ceredig, R.2    Rolink, A.G.3
  • 48
    • 67650507153 scopus 로고    scopus 로고
    • The thymic medulla: A unique microenvironment for intercellular self-antigen transfer
    • Koble C, Kyewski B. The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. J Exp Med. 2009;206(7):1505-1513.
    • (2009) J Exp Med , vol.206 , Issue.7 , pp. 1505-1513
    • Koble, C.1    Kyewski, B.2
  • 49
    • 0037083665 scopus 로고    scopus 로고
    • + T cells
    • Bajenoff M, Wurtz O, Guerder S. Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4(+) T cells. J Immunol. 2002;168(4):1723-1729. (Pubitemid 34135770)
    • (2002) Journal of Immunology , vol.168 , Issue.4 , pp. 1723-1729
    • Bajenoff, M.1    Wurtz, O.2    Guerder, S.3
  • 50
    • 0034046944 scopus 로고    scopus 로고
    • Plat-E: An efficient and stable system for transient packaging of retroviruses
    • Morita S, Kojima T, Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 2000;7(12):1063-1066. (Pubitemid 30398356)
    • (2000) Gene Therapy , vol.7 , Issue.12 , pp. 1063-1066
    • Morita, S.1    Kojima, T.2    Kitamura, T.3
  • 51
    • 67449138561 scopus 로고    scopus 로고
    • Impaired NFAT transcriptional activity in antigen-stimulated CD8 T cells linked to defective phosphorylation of NFAT transactivation domain
    • Leung-Theung-Long S, et al. Impaired NFAT transcriptional activity in antigen-stimulated CD8 T cells linked to defective phosphorylation of NFAT transactivation domain. J Immunol. 2009; 182(11):6807-6814.
    • (2009) J Immunol , vol.182 , Issue.11 , pp. 6807-6814
    • Leung-Theung-Long, S.1


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