Cellular immune response to phogrin in the NOD mouse: Cloned T-cells cause destruction of islet transplants

Diabetes

Volumn 48, Issue 8, 1999, Pages 1529-1534

  Kelemen, Katalin ^a   Crawford, Megan L ^a   Gill, Ronald G ^a   Hutton, John C ^a   Wegmann, Dale ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; FREUND ADJUVANT; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL DEATH; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; HELPER CELL; IMMUNIZATION; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SCID MOUSE; SECRETORY GRANULE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CELL DIVISION; CLONE CELLS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; IMMUNITY, CELLULAR; IMMUNIZATION; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPH NODES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED NOD; MICE, SCID; PHENOTYPE; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, INBRED STRAINS; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS;

EID: 0032768786     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.8.1529     Document Type: Article

References (37)

1. Haskins K, McDuffie M: Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science 249:1433-1436, 1990
2. α donors. Diabetes 42:44-55, 1993
3. Wegmann DR, Norbury-Glaser N, Daniel D: Insulin-specific T-cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 24:1853-1857, 1994
4. Boitard C, Yasunami R, Dardenne M, Bach JF: T-cell mediated inhibition of the transfer of autoimmune diabetes in NOD mice. JExp Med 169:1669-1680, 1989
5. Healey D, Ozegbe P, Arden SD, Chandler P, Hutton JC, Cooke A: In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J Clin Invest 95:2979-2985, 1995
6. Verdaguer J, Schmidt D, Amrani A, Anderson B, Averill N, Santamaria P: Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. JExp Med 186:1663-1676, 1997
7. Haskins K, Wegmann D: Diabetogenic T-cell clones. Diabetes 45:1299-1305, 1996
8. Gelber C, Paborsky L, Singer S, McAteer D, Tisch R, Jolicoeur C, Buelow R, McDevitt H, Fathman CG: Isolation of nonobese diabetic mouse T-cells that recognize novel autoantigens involved in the early events of diabetes. Diabetes 43:33-39, 1994
9. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL: Insulin antibodies in insulin dependent diabetics before insulin treatment. Science 222:1337-1339, 1983
10. Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, DeCamilli P: Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347:151-156, 1990
11. Rabin DU, Pleasic SM, Palmer-Crocker R, Shapiro JA: Cloning and expression of IDDM-specific human autoantigens. Diabetes 41:183-186, 1992
12. Lan MS, Lu J, Goto Y, Notkins AL: Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13:505-514, 1994
13. Solimena M, Dirkx R Jr, Hermel JM, Pleasic-Williams S, Shapiro JA, Caron L, Rabin Du: ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. Embo J 15:2102-2114, 1996
14. Hawkes CJ, Wasmeier C, Christie MR, Hutton JC: Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes 45:1187-1192, 1996
15. Kawasaki E, Eisenbarth GS, Wasmeier C, Hutton JC: Autoantibodies to protein tyrosine phosphatase-like proteins in type I diabetes: overlapping specificities to phogrin and ICA512/IA-2. Diabetes 45:1344-1349, 1996
16. Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS: Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci U S A 93:2307-2311, 1996
17. Wasmeier C, Hutton JC: Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem 271:18161-18170, 1996
18. Payton MA, Hawkes CJ, Christie MR: Relationship of the 37,000-and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 96: 1506-1511, 1995
19. Kawasaki E, Hutton JC, Eisenbarth GS: Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. Biochem Biophys Res Commun 227:440-447, 1996
20. Zhang B, Lan MS, Notkins AL: Autoantibodies to IA-2 in IDDM: location of major antigenic determinants. Diabetes 46:40-43, 1997
21. Kawasaki E, Yu L, Rewers MJ, Hutton JC, Eisenbarth GS: Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. Diabetes 47:733-742, 1998
22. Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rae PM: Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152:3183-3188, 1994
23. Durinovic-Bello I, Hummel M, Ziegler AG: Cellular immune response to diverse islet cell antigens in IDDM. Diabetes 45:795-800, 1996
24. Ellis TM, Schatz DA, Ottendorfer EW, Lan MS, Wasserfall C, Salisbury PJ, She J-X, Notkins AL, Maclaren NK, Atkinson MA: The relationship between humoral and cellular immunity to IA-2 in IDDM. Diabetes 47:566-569, 1998
25. DeSilva MG, Jun HS, Yoon JW, Notkins AL, Lan MS: Autoantibodies to IA-2 not detected in NOD mice or BB rats (Letter). Diabetologia 39:1237-1238, 1996
26. Myers MA, Laks MR, Feeney SJ, Mandel TE, Koulmanda M, Bone A, Barley J, Rowley MJ, Mackay IR: Antibodies to ICA512/IA-2 in rodent models of IDDM. J Autoimmun 11:265-272, 1998
27. Matsuba H, Jitsukawa T, Yamagata N, Uchida S, Watanabe H: Establishment of rat glutamic acid decarboxylase (GAD)-reactive T-cell clones from NOD mice. Immunol Lett 42:101-103, 1994
28. + Th1 cells induce diabetes in NOD/SCID mice. J Clin Invest 101:68-73, 1998
29. Gotoh M, Maki T, Kiyoizumi T, Satomi S, Monaco AP: An improved method for isolation of mouse pancreatic islets. Transplantation 40:437-438, 1985
30. Scharp DW, Kemp CB, Knight MJ, Ballinger WF, Lacy PE: The use of ficoll in the preparation of viable islets of Langerhans from the rat pancreas. Transplantation 16:686-689, 1973
31. Smith DB, Johnson KS: Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31, 1988
32. Gill RG, Rosenberg AS, Lafferty KJ, Singer A: Characterization of primary T cell subsets mediating rejection of pancreatic islet grafts. J Immunol 143:2176-2178, 1989
33. Bieg S, Seissler J, Herberg L, Northemann W, Scherbaum WA: GAD65 is recognized by T-cells, but not by antibodies from NOD-mice. Autoimmunity 17:189-194, 1994
34. Honeyman MC, Stone NL, Harrison LC: T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents. Mol Med 4:231-239, 1998
35. Daniel D, Gill RG, Schloot N, Wegmann D: Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 25:1056-1062, 1995
36. Sadelain MW, Qin HY, Lauzon J, Singh B: Prevention of type I diabetes in NOD mice by adjuvant immunotherapy. Diabetes 39:583-589, 1990
37. Qin HY, Sadelain MW, Hitchon C, Lauzon J, Singh B: Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J Immunol 136:2348-2357, 1986