Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4+ T cells

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1723-1729

  Bajénoff, Marc ^a   Wurtz, Olivier ^a   Guerder, Sylvie ^a  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; IMMUNOSTIMULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL;

EID: 0037083665     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1723     Document Type: Article

References (35)

1. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
2. Antigen-specific T helper cell function: Differential cytokine expression in primary and memory responses
3. Visualization of antigen-specific T cell activation and cytokine expression in vivo
4. The duration of antigenic stimulation determines the fate of naive and effector T cells
5. Helper T cell differentiation is controlled by the cell cycle
6. Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation
7. Cytokines induce the development of functionally heterogeneous T helper cell subsets
8. + T helper cell phenotype development in a T cell receptor-α β-transgenic model
9. + T cells
10. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
11. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
12. A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
13. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
14. A novel transcription factor, T-bet, directs Th1 lineage commitment
15. The molecular basis of T helper 1 and T helper 2 cell differentiation
16. The interplay between the duration of TCR and cytokine signaling determines T cell polarization
17. + T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
18. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
19. + T cells
20. A rapid technique for measuring leukocyte chemotaxis in vivo
21. Determination of lymphocyte division by flow cytometry
22. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon γ production
23. Lessons from immunological, biochemical, and molecular pathways of the activation mediated by IL-2 and IL-4
24. + T cells in vivo by IL-15
25. + memory T cells by opposing cytokines
26. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
27. + T cell survival but not for antigen proliferation
28. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
29. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
30. Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells
31. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
32. The instructive role of innate immunity in the acquired immune response
33. + T cells
34. Visualizing the generation of memory CD4 T cells in the whole body
35. Migration and function of antigen-primed nonpolarized T lymphocytes in vivo