메뉴 건너뛰기




Volumn 86, Issue 3, 2011, Pages 346-354

Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells

Author keywords

Bladder cancer; Doxorubicin chemotherapy; LY294002; PI3K inhibitor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DOXORUBICIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 79955118584     PISSN: 00421138     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322986     Document Type: Article
Times cited : (14)

References (46)
  • 3
    • 0028095177 scopus 로고
    • Urinary bladder cancer: Mechanisms of development and progression
    • Kroft SH, Oyasu R: Urinary bladder cancer: mechanisms of development and progression. Lab Invest 1994; 71: 158-174. (Pubitemid 24278167)
    • (1994) Laboratory Investigation , vol.71 , Issue.2 , pp. 158-174
    • Kroft, S.H.1    Oyasu, R.2
  • 4
    • 0030853012 scopus 로고    scopus 로고
    • High-risk superficial bladder cancer: Transurethral resection alone in selected patients with T1 tumor
    • Herr HW: High-risk superficial bladder cancer: transurethral resection alone in selected patients with T1 tumor. Semin Urol Oncol 1997; 15: 142-146. (Pubitemid 27360582)
    • (1997) Seminars in Urologic Oncology , vol.15 , Issue.3 , pp. 142-146
    • Herr, H.W.1
  • 5
    • 76649112386 scopus 로고    scopus 로고
    • Emerging targeted therapies for bladder cancer: A disease waiting for a drug
    • Dovedi SJ, Davies BR: Emerging targeted therapies for bladder cancer: a disease waiting for a drug. Cancer Metastasis Rev 2009; 28: 355-367.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 355-367
    • Dovedi, S.J.1    Davies, B.R.2
  • 6
    • 0031712489 scopus 로고    scopus 로고
    • A randomized trial comparing methotrexate and vinblastine (MV) with cisplatin, methotrexate and vinblastine (CMV) in advanced transitional cell carcinoma: Results and a report on prognostic factors in a Medical Research Council study
    • Mead GM, Russell M, Clark P, Harland SJ, Harper PG, Cowan R, Roberts JT, Uscinska BM, Griffiths GO, Parmar MK: A randomized trial comparing methotrexate and vinblastine (MV) with cisplatin, methotrexate and vinblastine (CMV) in advanced transitional cell carcinoma: results and a report on prognostic factors in a Medical Research Council study. MRC Advanced Bladder Cancer Working Party. Br J Cancer 1998; 78: 1067-1075. (Pubitemid 28463984)
    • (1998) British Journal of Cancer , vol.78 , Issue.8 , pp. 1067-1075
    • Mead, G.M.1    Russell, M.2    Clark, P.3    Harland, S.J.4    Harper, P.G.5    Cowan, R.6    Roberts, J.T.7    Uscinska, B.M.8    Griffiths, G.O.9    Parmar, M.K.B.10
  • 7
    • 26944490408 scopus 로고    scopus 로고
    • Prognostic impact of FAS/CD95/APO-1 in urothelial cancers: Decreased expression of Fas is associated with disease progression
    • DOI 10.1038/sj.bjc.6602732, PII 6602732
    • Yamana K, Bilim V, Hara N, Kasahara T, Itoi T, Maruyama R, Nishiyama T, Takahashi K, Tomita Y: Prognostic impact of FAS/CD95/ APO-1 in urothelial cancers: decreased expression of Fas is associated with disease progression. Br J Cancer 2005; 93: 544-551. (Pubitemid 43079997)
    • (2005) British Journal of Cancer , vol.93 , Issue.5 , pp. 544-551
    • Yamana, K.1    Bilim, V.2    Hara, N.3    Kasahara, T.4    Itoi, T.5    Maruyama, R.6    Nishiyama, T.7    Takahashi, K.8    Tomita, Y.9
  • 8
    • 0037374815 scopus 로고    scopus 로고
    • The role of PI3K in immune cells
    • Koyasu S: The role of PI3K in immune cells. Nat Immunol 2003; 4: 313-319.
    • (2003) Nat Immunol , vol.4 , pp. 313-319
    • Koyasu, S.1
  • 9
    • 33846122035 scopus 로고    scopus 로고
    • The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation
    • DOI 10.1016/j.immuni.2006.08.023, PII S1074761306004420
    • Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA: The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 2006; 25: 783-793. (Pubitemid 46107281)
    • (2006) Immunity , vol.25 , Issue.5 , pp. 783-793
    • Gelman, A.E.1    LaRosa, D.F.2    Zhang, J.3    Walsh, P.T.4    Choi, Y.5    Sunyer, J.6    Turka, L.A.7
  • 11
    • 0037019186 scopus 로고    scopus 로고
    • Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells
    • DOI 10.1038/sj.onc.1205555
    • Neve RM, Holbro T, Hynes NE: Distinct roles for phosphoinositide 3-kinase, mitogen- activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells. Oncogene 2002; 21: 4567-4576. (Pubitemid 34785733)
    • (2002) Oncogene , vol.21 , Issue.29 , pp. 4567-4576
    • Neve, R.M.1    Holbro, T.2    Hynes, N.E.3
  • 14
    • 15544369937 scopus 로고    scopus 로고
    • Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
    • DOI 10.1016/j.ygyno.2004.11.051
    • Lee S, Choi EJ, Jin C, Kim DH: Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecol Oncol 2005; 97: 26-34. (Pubitemid 40403670)
    • (2005) Gynecologic Oncology , vol.97 , Issue.1 , pp. 26-34
    • Lee, S.1    Choi, E.-J.2    Jin, C.3    Kim, D.-H.4
  • 15
    • 55549083197 scopus 로고    scopus 로고
    • Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells
    • Kim S, Lee TJ, Park JW, Kwon TK: Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells. J Cell Biochem 2008; 105: 971-979.
    • (2008) J Cell Biochem , vol.105 , pp. 971-979
    • Kim, S.1    Lee, T.J.2    Park, J.W.3    Kwon, T.K.4
  • 16
    • 54449097733 scopus 로고    scopus 로고
    • LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway
    • Liu P, Xu B, Li J, Lu H: LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway. Biochem Biophys Res Commun 2008; 377: 187-190.
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 187-190
    • Liu, P.1    Xu, B.2    Li, J.3    Lu, H.4
  • 17
    • 51049112961 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and druginduced apoptosis
    • Opel D, Westhoff MA, Bender A, Braun V, Debatin KM, Fulda S: Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and druginduced apoptosis. Cancer Res 2008; 68: 6271-6280.
    • (2008) Cancer Res , vol.68 , pp. 6271-6280
    • Opel, D.1    Westhoff, M.A.2    Bender, A.3    Braun, V.4    Debatin, K.M.5    Fulda, S.6
  • 18
    • 74749094579 scopus 로고    scopus 로고
    • Naphtho[1,2-b]furan- 4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells
    • Su JC, Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR: Naphtho[1,2-b]furan- 4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells. Life Sci 2010; 86: 207-213.
    • (2010) Life Sci , vol.86 , pp. 207-213
    • Su, J.C.1    Lin, K.L.2    Chien, C.M.3    Tseng, C.H.4    Chen, Y.L.5    Chang, L.S.6    Lin, S.R.7
  • 19
    • 34249798185 scopus 로고    scopus 로고
    • FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway
    • DOI 10.1096/fj.06-6545com
    • Thamilselvan V, Craig DH, Basson MD: FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J 2007; 21: 1730-1741. (Pubitemid 46855619)
    • (2007) FASEB Journal , vol.21 , Issue.8 , pp. 1730-1741
    • Thamilselvan, V.1    Craig, D.H.2    Basson, M.D.3
  • 20
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell 2000; 103: 211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 21
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning BD, Cantley LC: AKT/PKB signaling: navigating downstream. Cell 2007; 129: 1261-1274. (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 23
    • 70749115641 scopus 로고    scopus 로고
    • PI3K regulatory subunits lose control in cancer
    • Martin-Berenjeno I, Vanhaesebroeck B: PI3K regulatory subunits lose control in cancer. Cancer Cell 2009; 16: 449-450.
    • (2009) Cancer Cell , vol.16 , pp. 449-450
    • Martin-Berenjeno, I.1    Vanhaesebroeck, B.2
  • 25
    • 0034604067 scopus 로고    scopus 로고
    • Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
    • Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ: Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide- 3-OH kinase/Akt pathway in human ovarian cancer. Oncogene 2000; 19: 2324-2330. (Pubitemid 30307208)
    • (2000) Oncogene , vol.19 , Issue.19 , pp. 2324-2330
    • Zeng, Q.Y.1    Sun, M.2    Feldman, R.I.3    Wang, G.4    Ma, X.-L.5    Jiang, C.6    Coppola, D.7    Nicosia, S.V.8    Cheng, J.Q.9
  • 26
    • 17444402458 scopus 로고    scopus 로고
    • Immunotherapy for superficial bladder cancer
    • DOI 10.1007/s00262-004-0621-x
    • Schenk-Braat EA, Bangma CH: Immunotherapy for superficial bladder cancer. Cancer Immunol Immunother 2005; 54: 414-423. (Pubitemid 40543681)
    • (2005) Cancer Immunology, Immunotherapy , vol.54 , Issue.5 , pp. 414-423
    • Schenk-Braat, E.A.M.1    Bangma, C.H.2
  • 28
    • 0026659951 scopus 로고
    • Intravesical chemotherapy. Treatment selection, techniques, and results
    • Richie JP: Intravesical chemotherapy. Treatment selection, techniques, and results. Urol Clin North Am 1992; 19: 521-527.
    • (1992) Urol Clin North Am , vol.19 , pp. 521-527
    • Richie, J.P.1
  • 30
    • 0030979119 scopus 로고    scopus 로고
    • Clinical significance of multi-drug resistance associated protein and P-glycoprotein in patients with bladder cancer
    • discussion 1264-1265
    • Nakagawa M, Emoto A, Nasu N, Hanada T, Kuwano M, Cole SP, Nomura Y: Clinical significance of multi-drug resistance associated protein and P-glycoprotein in patients with bladder cancer. J Urol 1997; 157: 1260-1264, discussion 1264-1265.
    • (1997) J Urol , vol.157 , pp. 1260-1264
    • Nakagawa, M.1    Emoto, A.2    Nasu, N.3    Hanada, T.4    Kuwano, M.5    Cole, S.P.6    Nomura, Y.7
  • 33
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P, Cheng H, Roberts TM, Zhao JJ: Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 2009; 8: 627-644.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 34
    • 33644685228 scopus 로고    scopus 로고
    • The phosphatidylinositol- 3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts
    • Ihle NT, Paine-Murrieta G, Berggren MI, Baker A, Tate WR, Wipf P, Abraham RT, Kirkpatrick DL, Powis G: The phosphatidylinositol- 3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther 2005; 4: 1349-1357.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1349-1357
    • Ihle, N.T.1    Paine-Murrieta, G.2    Berggren, M.I.3    Baker, A.4    Tate, W.R.5    Wipf, P.6    Abraham, R.T.7    Kirkpatrick, D.L.8    Powis, G.9
  • 36
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
    • LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA: Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 2008; 11: 32-50.
    • (2008) Drug Resist Updat , vol.11 , pp. 32-50
    • Lopiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 38
    • 51349100763 scopus 로고    scopus 로고
    • A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform- selective inhibition
    • Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D: A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform- selective inhibition. Biochem J 2008; 415: 97-110.
    • (2008) Biochem J , vol.415 , pp. 97-110
    • Torbett, N.E.1    Luna-Moran, A.2    Knight, Z.A.3    Houk, A.4    Moasser, M.5    Weiss, W.6    Shokat, K.M.7    Stokoe, D.8
  • 40
    • 24044551995 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR pathway as a target for cancer therapy
    • DOI 10.1097/01.cad.0000173476.67239.3b
    • Morgensztern D, McLeod HL: PI3K/Akt/ mTOR pathway as a target for cancer therapy. Anticancer Drugs 2005; 16: 797-803. (Pubitemid 41215743)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.8 , pp. 797-803
    • Morgensztern, D.1    McLeod, H.L.2
  • 41
    • 13944256944 scopus 로고    scopus 로고
    • Inhibition of integrin-linked kinase by QLT0254 inhibits Akt-dependent pathways and is growth inhibitory in orthotopic primary pancreatic cancer xenografts
    • DOI 10.1158/0008-5472.CAN-04-2940
    • Yau CY, Wheeler JJ, Sutton KL, Hedley DW: Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res 2005; 65: 1497-1504. (Pubitemid 40270179)
    • (2005) Cancer Research , vol.65 , Issue.4 , pp. 1497-1504
    • Yau, C.Y.F.1    Wheeler, J.J.2    Sutton, K.L.3    Hedley, D.W.4
  • 42
    • 0034307305 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
    • Ng SSW, Tsao MS, Chow S, Hedley DW: Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res 2000; 60: 5451-5455.
    • (2000) Cancer Res , vol.60 , pp. 5451-5455
    • Ng, S.S.W.1    Tsao, M.S.2    Chow, S.3    Hedley, D.W.4
  • 43
    • 0034792844 scopus 로고    scopus 로고
    • Wortmannin inhibits PKB/Akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
    • Ng SS, Tsao MS, Nicklee T, Hedley DW: Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res 2001; 7: 3269-3275. (Pubitemid 32963853)
    • (2001) Clinical Cancer Research , vol.7 , Issue.10 , pp. 3269-3275
    • Ng, S.S.W.1    Tsao, M.-S.2    Nicklee, T.3    Hedley, D.W.4
  • 45
    • 50149101312 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase inhibitors: Promising drug candidates for cancer therapy
    • Kong D, Yamori T: Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy. Cancer Sci 2008; 99: 1734-1740.
    • (2008) Cancer Sci , vol.99 , pp. 1734-1740
    • Kong, D.1    Yamori, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.