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Volumn 377, Issue 1, 2008, Pages 187-190

LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway

Author keywords

Egr 1; Invasion; Leukemia; LY294002; PI3K

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EARLY GROWTH RESPONSE FACTOR 1; LY 303511; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 54449097733     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.09.094     Document Type: Article
Times cited : (30)

References (23)
  • 1
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2 (2002) 489-501
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 2
    • 33644499125 scopus 로고    scopus 로고
    • Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway
    • Yamaguchi K., Lee S.H., Kim J.S., Wimalasena J., Kitajima S., and Baek S.J. Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. Cancer Res. 66 (2006) 2376-2384
    • (2006) Cancer Res. , vol.66 , pp. 2376-2384
    • Yamaguchi, K.1    Lee, S.H.2    Kim, J.S.3    Wimalasena, J.4    Kitajima, S.5    Baek, S.J.6
  • 3
    • 18544374589 scopus 로고    scopus 로고
    • Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells
    • Ramos A.M., Fernandez C., Amran D., Sancho P., de Blas E., and Aller P. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 105 (2005) 4013-4020
    • (2005) Blood , vol.105 , pp. 4013-4020
    • Ramos, A.M.1    Fernandez, C.2    Amran, D.3    Sancho, P.4    de Blas, E.5    Aller, P.6
  • 7
    • 22244478639 scopus 로고    scopus 로고
    • LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway
    • Poh T.W., and Pervaiz S. LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway. Cancer Res. 65 (2005) 6264-6274
    • (2005) Cancer Res. , vol.65 , pp. 6264-6274
    • Poh, T.W.1    Pervaiz, S.2
  • 8
    • 33846345880 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells
    • Whitley B.R., Beaulieu L.M., Carter J.C., and Church F.C. Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells. Gynecol. Oncol. 104 (2007) 470-479
    • (2007) Gynecol. Oncol. , vol.104 , pp. 470-479
    • Whitley, B.R.1    Beaulieu, L.M.2    Carter, J.C.3    Church, F.C.4
  • 9
    • 34548272131 scopus 로고    scopus 로고
    • Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion
    • Shukla S., Maclennan G.T., Hartman D.J., Fu P., Resnick M.I., and Gupta S. Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. Int. J. Cancer 121 (2007) 1424-1432
    • (2007) Int. J. Cancer , vol.121 , pp. 1424-1432
    • Shukla, S.1    Maclennan, G.T.2    Hartman, D.J.3    Fu, P.4    Resnick, M.I.5    Gupta, S.6
  • 10
    • 33845200847 scopus 로고    scopus 로고
    • Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression
    • Yoon S.O., Shin S., Lee H.J., Chun H.K., and Chung A.S. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol. Cancer Ther. 5 (2006) 2666-2675
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2666-2675
    • Yoon, S.O.1    Shin, S.2    Lee, H.J.3    Chun, H.K.4    Chung, A.S.5
  • 11
    • 13444282673 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein
    • Baek S.J., Kim J.S., Moore S.M., Lee S.H., Martinez J., and Eling T.E. Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol. Pharmacol. 67 (2005) 356-364
    • (2005) Mol. Pharmacol. , vol.67 , pp. 356-364
    • Baek, S.J.1    Kim, J.S.2    Moore, S.M.3    Lee, S.H.4    Martinez, J.5    Eling, T.E.6
  • 12
    • 0034617216 scopus 로고    scopus 로고
    • The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251
    • Liu C., Yao J., Mercola D., and Adamson E. The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251. J. Biol. Chem. 275 (2000) 20315-20323
    • (2000) J. Biol. Chem. , vol.275 , pp. 20315-20323
    • Liu, C.1    Yao, J.2    Mercola, D.3    Adamson, E.4
  • 13
    • 0028559569 scopus 로고
    • Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene
    • Shingu T., and Bornstein P. Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene. J. Biol. Chem. 269 (1994) 32551-32557
    • (1994) J. Biol. Chem. , vol.269 , pp. 32551-32557
    • Shingu, T.1    Bornstein, P.2
  • 14
    • 33750017080 scopus 로고    scopus 로고
    • MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration
    • Redondo-Munoz J., Escobar-Diaz E., Samaniego R., Terol M.J., Garcia-Marco J.A., and Garcia-Pardo A. MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood 108 (2006) 3143-3151
    • (2006) Blood , vol.108 , pp. 3143-3151
    • Redondo-Munoz, J.1    Escobar-Diaz, E.2    Samaniego, R.3    Terol, M.J.4    Garcia-Marco, J.A.5    Garcia-Pardo, A.6
  • 15
    • 0344874751 scopus 로고    scopus 로고
    • Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
    • Kelly B.D., Hackett S.F., Hirota K., Oshima Y., Cai Z., Berg-Dixon S., Rowan A., Yan Z., Campochiaro P.A., and Semenza G.L. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ. Res. 93 (2003) 1074-1081
    • (2003) Circ. Res. , vol.93 , pp. 1074-1081
    • Kelly, B.D.1    Hackett, S.F.2    Hirota, K.3    Oshima, Y.4    Cai, Z.5    Berg-Dixon, S.6    Rowan, A.7    Yan, Z.8    Campochiaro, P.A.9    Semenza, G.L.10
  • 16
    • 36148993944 scopus 로고    scopus 로고
    • Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells
    • Kim S.O., Kwon J.I., Jeong Y.K., Kim G.Y., Kim N.D., and Choi Y.H. Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells. Biosci. Biotechnol. Biochem. 71 (2007) 2169-2176
    • (2007) Biosci. Biotechnol. Biochem. , vol.71 , pp. 2169-2176
    • Kim, S.O.1    Kwon, J.I.2    Jeong, Y.K.3    Kim, G.Y.4    Kim, N.D.5    Choi, Y.H.6
  • 17
    • 27644525709 scopus 로고    scopus 로고
    • Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1
    • Moon Y., Bottone Jr. F.G., McEntee M.F., and Eling T.E. Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1. Mol. Cancer Ther. 4 (2005) 1551-1558
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1551-1558
    • Moon, Y.1    Bottone Jr., F.G.2    McEntee, M.F.3    Eling, T.E.4
  • 19
    • 37849038561 scopus 로고    scopus 로고
    • Egr-1 abrogates the E2F-1 block in terminal myeloid differentiation and suppresses leukemia
    • Gibbs J.D., Liebermann D.A., and Hoffman B. Egr-1 abrogates the E2F-1 block in terminal myeloid differentiation and suppresses leukemia. Oncogene 27 (2008) 98-106
    • (2008) Oncogene , vol.27 , pp. 98-106
    • Gibbs, J.D.1    Liebermann, D.A.2    Hoffman, B.3
  • 20
    • 54049092386 scopus 로고    scopus 로고
    • Leukemia suppressor function of Egr-1 is dependent on transforming oncogene
    • [Epub ahead of print]
    • Gibbs J.D., Liebermann D.A., and Hoffman B. Leukemia suppressor function of Egr-1 is dependent on transforming oncogene. Leukemia (2008) [Epub ahead of print]
    • (2008) Leukemia
    • Gibbs, J.D.1    Liebermann, D.A.2    Hoffman, B.3
  • 21
    • 23044432869 scopus 로고    scopus 로고
    • Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation
    • Shafarenko M., Liebermann D.A., and Hoffman B. Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation. Blood 106 (2005) 871-878
    • (2005) Blood , vol.106 , pp. 871-878
    • Shafarenko, M.1    Liebermann, D.A.2    Hoffman, B.3
  • 22
    • 0442323485 scopus 로고    scopus 로고
    • LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism
    • Choi E.K., Park H.J., Ma J.S., Lee H.C., Kang H.C., Kim B.G., and Kang I.C. LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Lett. 559 (2004) 141-144
    • (2004) FEBS Lett. , vol.559 , pp. 141-144
    • Choi, E.K.1    Park, H.J.2    Ma, J.S.3    Lee, H.C.4    Kang, H.C.5    Kim, B.G.6    Kang, I.C.7
  • 23
    • 0142057138 scopus 로고    scopus 로고
    • Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition
    • Rahmani M., Yu C., Reese E., Ahmed W., Hirsch K., Dent P., and Grant S. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. Oncogene 22 (2003) 6231-6242
    • (2003) Oncogene , vol.22 , pp. 6231-6242
    • Rahmani, M.1    Yu, C.2    Reese, E.3    Ahmed, W.4    Hirsch, K.5    Dent, P.6    Grant, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.