-
1
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2 (2002) 489-501
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
2
-
-
33644499125
-
Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway
-
Yamaguchi K., Lee S.H., Kim J.S., Wimalasena J., Kitajima S., and Baek S.J. Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. Cancer Res. 66 (2006) 2376-2384
-
(2006)
Cancer Res.
, vol.66
, pp. 2376-2384
-
-
Yamaguchi, K.1
Lee, S.H.2
Kim, J.S.3
Wimalasena, J.4
Kitajima, S.5
Baek, S.J.6
-
3
-
-
18544374589
-
Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells
-
Ramos A.M., Fernandez C., Amran D., Sancho P., de Blas E., and Aller P. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 105 (2005) 4013-4020
-
(2005)
Blood
, vol.105
, pp. 4013-4020
-
-
Ramos, A.M.1
Fernandez, C.2
Amran, D.3
Sancho, P.4
de Blas, E.5
Aller, P.6
-
4
-
-
11144324517
-
Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells
-
Tabellini G., Cappellini A., Tazzari P.L., Fala F., Billi A.M., Manzoli L., Cocco L., and Martelli A.M. Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells. J. Cell. Physiol. 202 (2005) 623-634
-
(2005)
J. Cell. Physiol.
, vol.202
, pp. 623-634
-
-
Tabellini, G.1
Cappellini, A.2
Tazzari, P.L.3
Fala, F.4
Billi, A.M.5
Manzoli, L.6
Cocco, L.7
Martelli, A.M.8
-
5
-
-
39049151617
-
Deregulation of the Akt pathway in human cancer
-
Tokunaga E., Oki E., Egashira A., Sadanaga N., Morita M., Kakeji Y., and Maehara Y. Deregulation of the Akt pathway in human cancer. Curr. Cancer Drug Targets 8 (2008) 27-36
-
(2008)
Curr. Cancer Drug Targets
, vol.8
, pp. 27-36
-
-
Tokunaga, E.1
Oki, E.2
Egashira, A.3
Sadanaga, N.4
Morita, M.5
Kakeji, Y.6
Maehara, Y.7
-
6
-
-
39049094092
-
Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery
-
Cheng G.Z., Park S., Shu S., He L., Kong W., Zhang W., Yuan Z., Wang L.H., and Cheng J.Q. Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery. Curr. Cancer Drug Targets 8 (2008) 2-6
-
(2008)
Curr. Cancer Drug Targets
, vol.8
, pp. 2-6
-
-
Cheng, G.Z.1
Park, S.2
Shu, S.3
He, L.4
Kong, W.5
Zhang, W.6
Yuan, Z.7
Wang, L.H.8
Cheng, J.Q.9
-
7
-
-
22244478639
-
LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway
-
Poh T.W., and Pervaiz S. LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway. Cancer Res. 65 (2005) 6264-6274
-
(2005)
Cancer Res.
, vol.65
, pp. 6264-6274
-
-
Poh, T.W.1
Pervaiz, S.2
-
8
-
-
33846345880
-
Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells
-
Whitley B.R., Beaulieu L.M., Carter J.C., and Church F.C. Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells. Gynecol. Oncol. 104 (2007) 470-479
-
(2007)
Gynecol. Oncol.
, vol.104
, pp. 470-479
-
-
Whitley, B.R.1
Beaulieu, L.M.2
Carter, J.C.3
Church, F.C.4
-
9
-
-
34548272131
-
Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion
-
Shukla S., Maclennan G.T., Hartman D.J., Fu P., Resnick M.I., and Gupta S. Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. Int. J. Cancer 121 (2007) 1424-1432
-
(2007)
Int. J. Cancer
, vol.121
, pp. 1424-1432
-
-
Shukla, S.1
Maclennan, G.T.2
Hartman, D.J.3
Fu, P.4
Resnick, M.I.5
Gupta, S.6
-
10
-
-
33845200847
-
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression
-
Yoon S.O., Shin S., Lee H.J., Chun H.K., and Chung A.S. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol. Cancer Ther. 5 (2006) 2666-2675
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 2666-2675
-
-
Yoon, S.O.1
Shin, S.2
Lee, H.J.3
Chun, H.K.4
Chung, A.S.5
-
11
-
-
13444282673
-
Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein
-
Baek S.J., Kim J.S., Moore S.M., Lee S.H., Martinez J., and Eling T.E. Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol. Pharmacol. 67 (2005) 356-364
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 356-364
-
-
Baek, S.J.1
Kim, J.S.2
Moore, S.M.3
Lee, S.H.4
Martinez, J.5
Eling, T.E.6
-
12
-
-
0034617216
-
The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251
-
Liu C., Yao J., Mercola D., and Adamson E. The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251. J. Biol. Chem. 275 (2000) 20315-20323
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20315-20323
-
-
Liu, C.1
Yao, J.2
Mercola, D.3
Adamson, E.4
-
13
-
-
0028559569
-
Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene
-
Shingu T., and Bornstein P. Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene. J. Biol. Chem. 269 (1994) 32551-32557
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 32551-32557
-
-
Shingu, T.1
Bornstein, P.2
-
14
-
-
33750017080
-
MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration
-
Redondo-Munoz J., Escobar-Diaz E., Samaniego R., Terol M.J., Garcia-Marco J.A., and Garcia-Pardo A. MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood 108 (2006) 3143-3151
-
(2006)
Blood
, vol.108
, pp. 3143-3151
-
-
Redondo-Munoz, J.1
Escobar-Diaz, E.2
Samaniego, R.3
Terol, M.J.4
Garcia-Marco, J.A.5
Garcia-Pardo, A.6
-
15
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
-
Kelly B.D., Hackett S.F., Hirota K., Oshima Y., Cai Z., Berg-Dixon S., Rowan A., Yan Z., Campochiaro P.A., and Semenza G.L. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ. Res. 93 (2003) 1074-1081
-
(2003)
Circ. Res.
, vol.93
, pp. 1074-1081
-
-
Kelly, B.D.1
Hackett, S.F.2
Hirota, K.3
Oshima, Y.4
Cai, Z.5
Berg-Dixon, S.6
Rowan, A.7
Yan, Z.8
Campochiaro, P.A.9
Semenza, G.L.10
-
16
-
-
36148993944
-
Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells
-
Kim S.O., Kwon J.I., Jeong Y.K., Kim G.Y., Kim N.D., and Choi Y.H. Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells. Biosci. Biotechnol. Biochem. 71 (2007) 2169-2176
-
(2007)
Biosci. Biotechnol. Biochem.
, vol.71
, pp. 2169-2176
-
-
Kim, S.O.1
Kwon, J.I.2
Jeong, Y.K.3
Kim, G.Y.4
Kim, N.D.5
Choi, Y.H.6
-
17
-
-
27644525709
-
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1
-
Moon Y., Bottone Jr. F.G., McEntee M.F., and Eling T.E. Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1. Mol. Cancer Ther. 4 (2005) 1551-1558
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 1551-1558
-
-
Moon, Y.1
Bottone Jr., F.G.2
McEntee, M.F.3
Eling, T.E.4
-
18
-
-
33746119582
-
Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth
-
Lucerna M., Pomyje J., Mechtcheriakova D., Kadl A., Gruber F., Bilban M., Sobanov Y., Schabbauer G., Breuss J., Wagner O., Bischoff M., Clauss M., Binder B.R., and Hofer E. Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth. Cancer Res. 66 (2006) 6708-6713
-
(2006)
Cancer Res.
, vol.66
, pp. 6708-6713
-
-
Lucerna, M.1
Pomyje, J.2
Mechtcheriakova, D.3
Kadl, A.4
Gruber, F.5
Bilban, M.6
Sobanov, Y.7
Schabbauer, G.8
Breuss, J.9
Wagner, O.10
Bischoff, M.11
Clauss, M.12
Binder, B.R.13
Hofer, E.14
-
19
-
-
37849038561
-
Egr-1 abrogates the E2F-1 block in terminal myeloid differentiation and suppresses leukemia
-
Gibbs J.D., Liebermann D.A., and Hoffman B. Egr-1 abrogates the E2F-1 block in terminal myeloid differentiation and suppresses leukemia. Oncogene 27 (2008) 98-106
-
(2008)
Oncogene
, vol.27
, pp. 98-106
-
-
Gibbs, J.D.1
Liebermann, D.A.2
Hoffman, B.3
-
20
-
-
54049092386
-
Leukemia suppressor function of Egr-1 is dependent on transforming oncogene
-
[Epub ahead of print]
-
Gibbs J.D., Liebermann D.A., and Hoffman B. Leukemia suppressor function of Egr-1 is dependent on transforming oncogene. Leukemia (2008) [Epub ahead of print]
-
(2008)
Leukemia
-
-
Gibbs, J.D.1
Liebermann, D.A.2
Hoffman, B.3
-
21
-
-
23044432869
-
Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation
-
Shafarenko M., Liebermann D.A., and Hoffman B. Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation. Blood 106 (2005) 871-878
-
(2005)
Blood
, vol.106
, pp. 871-878
-
-
Shafarenko, M.1
Liebermann, D.A.2
Hoffman, B.3
-
22
-
-
0442323485
-
LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism
-
Choi E.K., Park H.J., Ma J.S., Lee H.C., Kang H.C., Kim B.G., and Kang I.C. LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Lett. 559 (2004) 141-144
-
(2004)
FEBS Lett.
, vol.559
, pp. 141-144
-
-
Choi, E.K.1
Park, H.J.2
Ma, J.S.3
Lee, H.C.4
Kang, H.C.5
Kim, B.G.6
Kang, I.C.7
-
23
-
-
0142057138
-
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition
-
Rahmani M., Yu C., Reese E., Ahmed W., Hirsch K., Dent P., and Grant S. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. Oncogene 22 (2003) 6231-6242
-
(2003)
Oncogene
, vol.22
, pp. 6231-6242
-
-
Rahmani, M.1
Yu, C.2
Reese, E.3
Ahmed, W.4
Hirsch, K.5
Dent, P.6
Grant, S.7
|