Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway

British Journal of Haematology

Volumn 129, Issue 5, 2005, Pages 677-686

  Bortul, Roberta ^a   Tazzari, Pier Luigi ^b   Billi, Anna Maria ^c   Tabellini, Giovanna ^d   Mantovani, Irina ^c   Cappellini, Alessandra ^c   Grafone, Tiziana ^c   Martinelli, Giovanni ^c   Conte, Roberto ^b   Martelli, Alberto M ^c,e  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

^e CNR   (Italy)

Author keywords

Apoptosis; CD34+ cells; Cell signalling; Drug resistance; Leukaemia

Indexed keywords

CYTARABINE; DEGUELIN; ERYTHROPOIETIN; ETOPOSIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; WORTMANNIN;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL ISOLATION; CELL SURVIVAL; CHEMOSENSITIVITY; CLINICAL PATHWAY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACUTE DISEASE; ANTIGENS, CD34; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELLS, CULTURED; CYTARABINE; DRUG RESISTANCE, NEOPLASM; ERYTHROPOIETIN; ETOPOSIDE; HL-60 CELLS; HUMANS; LEUKEMIA; LEUKEMIA, MYELOID; ROTENONE; SIGNAL TRANSDUCTION; STEM CELL FACTOR; STEM CELLS;

EID: 20444484563     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05504.x     Document Type: Article

References (30)

1. Boudot, C., Dasse, E., Lambert, E., Kadri, Z., Mayeux, P., Chretien, S., Haye, B., Billat, C & Petitfrere, E. (2003) Involvement of the Src kinase Lyn in phospholipase C-γ 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling. Biochemical and Biophysical Research Communications, 300, 437-442.
2. Brazil, D.P. & Hemmings, B.A. (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends in Biochemical Sciences, 26, 657-664.
3. Brazil, D.P., Yang, Z.Z. & Hemmings, B.A. (2004) Advances in protein kinase B signalling: AKTion on multiple fronts. Trends in Biochemical Sciences, 29, 233-242.
4. Chun, K.H., Kosmeder, J.W. II, Sun, S., Pezzuto, J.M., Lotan, R., Hong, W.K. & Lee, H.Y. (2003) Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. Journal of the National Cancer Institute, 95, 291-302.
5. Clejan, S., Mallia, C, Vinson, D., Dotson, R. & Beckman, B.S. (1996) Erythropoietin stimulates G-protein-coupled phospholipase D in haematopoietic target cells. Biochemical Journal, 314, 853-860.
6. + human marrow cells in vitro. British Journal of Haematology, 127, 451-463.
7. Frelin, C, Imbert, V., Griessinger, E., Peyron, A.C., Rochet, N., Philip, P., Dageville, C., Sirvent, A., Hummelsberger, M., Berard, E., Dreano, M., Sirvent, N. & Peyron, JF. (2005) Targeting NF-κB via pharmacological inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood, 105, 804-811.
8. Fresno Vara, J.A., Casado, E., de Castro, J., Cejas, P., Belda-Iniesta, C. & Gonzalez-Baron, M. (2004) PI3K/Akt signalling pathway and cancer. Cancer Treatment Reviews, 30, 193-204.
9. Gallagher, R.E. (2002) Retinoic acid resistance in acute promyelocytic leukemia. Leukemia, 16, 1940-1958.
10. Gills, J.J. & Dennis, P.A. (2004) The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. Expert Opinion on Investigative Drugs, 13, 787-797.
11. Hanada, M., Feng, J. & Hemmings, B.A. (2004) Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochimica et Biophysica Acta, 1697, 3-16.
12. Kim, D., Dan, H.C., Park, S., Yang, L., Liu, Q., Kaneko, S., Ning, J., He, L., Yang, H., Sun, M., Nicosia, S.V. & Cheng, J.Q. (2005) AKT/PKB signaling mechanisms in cancer and chemoresistance. Frontiers in Bioscience, 10, 975-984.
13. Kozawa, O., Blume-Jensen, P., Heldin, CH. & Ronnstrand, L. (1997) Involvement of phosphatidylinositol 3′ kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release. European Journal of Biochemistry, 248, 149-155.
14. Lewis, J.L., Marley, S.B., Ojo, M. & Gordon, MY. (2004) Opposing effects of PI3 kinase pathway activation on human myeloid and erythroid progenitor cell proliferation and differentiation in vitro. Experimental Hematology, 32, 36-44.
15. Lu, Y., Wang, H. & Mills, G.B. (2003) Targeting PI3K-AKT pathway for cancer therapy. Reviews on Clinical and Experimental Hematology, 7, 205-228.
16. Martelli, A.M., Tazzari, P.L., Tabellini, G., Bortul, R., Billi, A.M., Manzoli, L., Ruggeri, A., Conte, R. & Cocco, L. (2003) A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells. Leukemia, 17, 1794-1805.
17. Mason-Garcia, M. & Beckman, B.S. (1992) Signal transduction by the erythropoietin receptor: evidence for the activation of phospholipases A2 and C. American Journal of Physiology, 262, C1197-C1203.
18. Matsuoka, Y., Nagahara, Y., Ikekita, M. & Shinomiya, T. (2003) A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. British Journal of Pharmacology, 138, 1303-1312.
19. Mitsiades, C.S., Mitsiades, N. & Koutsilieris, M. (2004) The Akt pathway: molecular targets for anti-cancer drug development. Current Cancer Drug Targets, 4, 235-256.
20. Myklebust, J.H., Blomhoff, H.K., Rusten, L.S., Stokke, T. & Smeland, E.B. (2002) Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells. Experimental Hematology, 30, 990-1000.
21. Neri, L.M., Borgatti, P., Tazzari, P.L., Bortul, R., Cappellini, A., Tabellini, G., Bellicosa, A., Capitani, S. & Martelli, A.M. (2003) The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. Molecular Cancer Research, 1, 234-246.
22. Roberts, P.J., Mollapour, E., Watts, M.J. & Linch, D.C. (1999) Primitive myeloid cells express high levels of phospholipase A(2) activity in the absence of leukotriene release: selective regulation by stem cell factor involving the MAP kinase pathway. Blood, 94, 1261-1272.
23. Sui, X., Krantz, S.B. & Zhao, Z.J. (2000) Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways. British Journal of Haematology, 110, 63-70.
24. Tabellini, G., Tazzari, P.L., Bortul, R., Billi, A.M., Conte, R., Manzoli, L., Cocco, L. & Martelli, A.M. (2004) Novel 2′-substituted, 3′-deoxyphosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway. British Journal of Haematology, 126, 574-582.
25. Tazzari, P.L., Cappellini, A., Grafone, T., Mantovani, I., Ricci, F., Billi, A.M., Ottavini, E., Conte, R., Martinelli, G. & Martelli, A.M. (2004) Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry. British Journal of Haematology, 126, 675-681.
26. Udeani, G.O., Zhao, G.M., Shin, Y.G., Kosmeder, J.W. II, Beecher, C.W., Kinghorn, A.D., Moriarty, R.M., Moon, R.C. & Pezzuto, J.M. (2001) Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats. Cancer Chemotherapy and Pharmacology, 47, 263-268.
27. Vermes, I., Haanen, C, Steffens-Nakken, H. & Reutelingsperger, C. (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. Journal of Immunological Methods, 184, 39-51.
28. West, K.A., Castillo, S.S. & Dennis, P.A. (2002) Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resistance Updates, 5, 234-248.
29. Xu, Q., Simpson, S.E., Scialla, T.J., Bagg, A. & Carroll, M. (2003) Survival of acute myeloid leukemia cells requires PB kinase activation. Blood, 102, 972-980.
30. Zhao, S., Konopleva, M., Cabreira-Hansen, M., Xie, Z., Hu, W., Milella, M., Estrov, Z., Mills, G.B. & Andreeff, M. (2004) Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia, 18, 267-275.