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Volumn 21, Issue 5, 2011, Pages 681-698

Novel calcium sensing receptor ligands: A patent survey

Author keywords

Calcilytics; calcimimetics; calcium sensing receptor; hyperparathyroidism; osteoporosis; parathyroid hormone

Indexed keywords

2 CHLORO 6 [3 [1,1 DIMETHYL 2 (2 NAPHTHYL)ETHYLAMINO] 2 HYDROXYPROPOXY]BENZONITRILE; 3,4 DIMETHOXYPHENYL DERIVATIVE; ALPHA METHYLBENZYLAMINE; CALCILYTIC; CALCIMIMETIC AGENT; CALCIUM SENSING RECEPTOR; CINACALCET; FENDILINE; FOSTEO; NPSR 2143; NPSR 467; NPSR 568; PARATHYROID HORMONE[1-34]; PYRAZOLOPYRIMIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; RONACALERET; UNCLASSIFIED DRUG;

EID: 79955077012     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.2011.568479     Document Type: Review
Times cited : (13)

References (110)
  • 1
    • 0035138842 scopus 로고    scopus 로고
    • Extracellular calcium sensing and extracellular calcium signaling
    • Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 2001;81:239-97 (Pubitemid 32096177)
    • (2001) Physiological Reviews , vol.81 , Issue.1 , pp. 239-297
    • Brown, E.M.1    Macleod, R.J.2
  • 2
    • 0038662595 scopus 로고    scopus 로고
    • Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
    • DOI 10.1016/S0163-7258(03)00038-X
    • Pin JP, Galvez T, Prezeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther 2003;98:325-54 (Pubitemid 36638547)
    • (2003) Pharmacology and Therapeutics , vol.98 , Issue.3 , pp. 325-354
    • Pin, J.-P.1    Galvez, T.2    Prezeau, L.3
  • 3
    • 0037707398 scopus 로고    scopus 로고
    • Structure of the metabotropic glutamate receptor
    • DOI 10.1016/S0959-4388(03)00067-9
    • Jingami H, Nakanishi S, Morikawa K. Structure of the metabotropic glutamate receptor. Curr Opin Neurobiol 2003;13:271-8 (Pubitemid 36792238)
    • (2003) Current Opinion in Neurobiology , vol.13 , Issue.3 , pp. 271-278
    • Jingami, H.1    Nakanishi, S.2    Morikawa, K.3
  • 4
    • 0037707398 scopus 로고    scopus 로고
    • Structure of the metabotropic glutamate receptor
    • DOI 10.1016/S0959-4388(03)00067-9
    • Jingami H, Nakanishi S, Morikawa K. Structure of the metabotropic glutamate receptor. Curr Opin Neurobiol 2003;13:271-8 (Pubitemid 36792238)
    • (2003) Current Opinion in Neurobiology , vol.13 , Issue.3 , pp. 271-278
    • Jingami, H.1    Nakanishi, S.2    Morikawa, K.3
  • 7
    • 1442301549 scopus 로고    scopus 로고
    • 2+ -sensing receptors - An overview
    • DOI 10.1016/j.ceca.2003.10.012, Calcium-Sending Receptor: Physiology, Pathology and Pharmacological Modulation
    • 2+ sensing receptors: an overview. Cell Calcium 2004;35:183-96 (Pubitemid 38292362)
    • (2004) Cell Calcium , vol.35 , Issue.3 , pp. 183-196
    • Chang, W.1    Shoback, D.2
  • 8
    • 0028924833 scopus 로고
    • Cloning and functional expression of a rat kidney extracellular calcium polyvalent cation-sensing receptor
    • USA
    • Riccardi D, Park J, Lee WS, et al. Cloning and functional expression of a rat kidney extracellular calcium/ polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 1995;92:131-5
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 131-135
    • Riccardi, D.1    Park, J.2    Lee, W.S.3
  • 9
    • 0028955536 scopus 로고
    • Calcium sensing receptor: Molecular cloning in rat and localization to nerve terminals
    • USA
    • Ruat M, Molliver ME, Snowman AM, et al. Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc Natl Acad Sci USA 1995;92:3161-5
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 3161-3165
    • Ruat, M.1    Molliver, M.E.2    Snowman, A.M.3
  • 10
    • 0034025972 scopus 로고    scopus 로고
    • Developmental and adult expression of rat calcium-sensing receptor transcripts in neurons and oligodendrocytes
    • DOI 10.1046/j.1460-9568.2000.00980.x
    • Ferry S, Traiffort E, Stinnakre J, et al. Development and adult expression of rat calcium-sensing receptor transcripts in neurons and oligodendrocytes. Eur J Neurosci 2000;12:872-84 (Pubitemid 30168765)
    • (2000) European Journal of Neuroscience , vol.12 , Issue.3 , pp. 872-884
    • Ferry, S.1    Traiffort, E.2    Stinnakre, J.3    Ruat, M.4
  • 11
  • 12
    • 0029055771 scopus 로고
    • Molecular cloning and functional expression of human parathyroid calcium receptorc DNAs
    • Garrett JE, Capuano IV, Hammerland LG, et al. Molecular cloning and functional expression of human parathyroid calcium receptorc DNAs. J Biol Chem 1995;270:12919-25
    • (1995) J. Biol. Chem. , vol.270 , pp. 12919-12925
    • Garrett, J.E.1    Capuano, I.V.2    Hammerland, L.G.3
  • 15
    • 4644294488 scopus 로고    scopus 로고
    • In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor
    • DOI 10.1016/j.bbrc.2004.08.209, PII S0006291X04020005
    • Coulombe J, Faure H, Robin B, et al. In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor. Biochem. Biophys Res Commun 2004;323:1184-90 (Pubitemid 39296549)
    • (2004) Biochemical and Biophysical Research Communications , vol.323 , Issue.4 , pp. 1184-1190
    • Coulombe, J.1    Faure, H.2    Robin, B.3    Ruat, M.4
  • 16
    • 20744455408 scopus 로고    scopus 로고
    • Calcimimetics and calcilytics - fooling the calcium receptor
    • Steddon SJ, Cunningham J. Calcimimetics and calcilytics - fooling the calcium receptor. The Lancet 2005;365:2237-9
    • (2005) Lancet , vol.365 , pp. 2237-223
    • Steddon, S.J.1    Cunningham, J.2
  • 17
    • 39049088260 scopus 로고    scopus 로고
    • Recent updates on the calcium-sensing receptor as a drug target
    • DOI 10.2174/092986708783330601
    • Trivedi R, Mithal A, Chattopadhyay N. Recent updates on the calcium-sensing receptor as a drug target. Curr Med Chem 2008;15:178-86 (Pubitemid 351234621)
    • (2008) Current Medicinal Chemistry , vol.15 , Issue.2 , pp. 178-186
    • Trivedi, R.1    Mithal, A.2    Chattopadhyay, N.3
  • 18
    • 31144473816 scopus 로고    scopus 로고
    • Pharmacological and clinical properties of calcimimetics: Calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism
    • DOI 10.1016/j.pharmthera.2005.06.019, PII S016372580500152X
    • Nagano N. Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism. Pharmacol Ther 2006;109:339-65 (Pubitemid 43132817)
    • (2006) Pharmacology and Therapeutics , vol.109 , Issue.3 , pp. 339-365
    • Nagano, N.1
  • 19
    • 32944474360 scopus 로고    scopus 로고
    • Therapeutic use of calcimimetics
    • DOI 10.1146/annurev.med.57.121304.131328
    • Hebert SC. Therapeutic use of calcimimetics. Annu Rev Med 2006;57:349-64 (Pubitemid 43261995)
    • (2006) Annual Review of Medicine , vol.57 , pp. 349-364
    • Hebert, S.C.1
  • 20
    • 33748966446 scopus 로고    scopus 로고
    • Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing
    • DOI 10.1016/j.ymgme.2006.07.003, PII S1096719206002502
    • Chattopadhyay N, Brown EM. Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Mol Genet Metab 2006;89:189-202 (Pubitemid 44442994)
    • (2006) Molecular Genetics and Metabolism , vol.89 , Issue.3 , pp. 189-202
    • Chattopadhyay, N.1    Brown, E.M.2
  • 22
    • 12144285037 scopus 로고    scopus 로고
    • The calcium-sensing receptor: A key factor in the pathogenesis of secondary hyperparathyroidism
    • DOI 10.1152/ajprenal.00302.2004
    • Rodriguez M, Nemeth E, Martin D. The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism. Am J Physiol-Renal 2005;288:F253-264 (Pubitemid 40105383)
    • (2005) American Journal of Physiology - Renal Physiology , vol.288
    • Rodriguez, M.1    Nemeth, E.2    Martin, D.3
  • 23
    • 0031978982 scopus 로고    scopus 로고
    • The extracellular calcium-sensing receptor: Its role in health and disease
    • DOI 10.1146/annurev.med.49.1.15
    • Brown EM, Pollak M, Hebert SC. The extracellular calcium-sensing receptor: its role in health and disease. Annu Rev Med 1998;49:15-29 (Pubitemid 28197438)
    • (1998) Annual Review of Medicine , vol.49 , pp. 15-29
    • Brown, E.M.1    Pollak, M.2    Hebert, S.C.3
  • 24
    • 0036668566 scopus 로고    scopus 로고
    • The search for calcium receptor antagonists (calcilytics)
    • DOI 10.1677/jme.0.0290015
    • Nemeth EF. The search for calcium receptor antagonists (calcilytics). J Mol Endocrinol 2002;29:15-21 (Pubitemid 34965743)
    • (2002) Journal of Molecular Endocrinology , vol.29 , Issue.1 , pp. 15-21
    • Nemeth, E.F.1
  • 27
    • 0030113479 scopus 로고    scopus 로고
    • PTH: A future role in the management of osteoporosis
    • Reeve J. PTH: a future role in the management of osteoporosis? J Bone Miner Res 1996;11:440-5
    • (1996) J. Bone Miner Res. , vol.11 , pp. 440-445
    • Reeve, J.1
  • 30
  • 33
    • 1342346546 scopus 로고    scopus 로고
    • Homology Modeling of the Transmembrane Domain of the Human Calcium Sensing Receptor and Localization of an Allosteric Binding Site
    • DOI 10.1074/jbc.M307191200
    • Miedlich SU, Gama L, Seuwen K, et al. Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site. J Biol Chem 2004;279:7254-63 (Pubitemid 38248875)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.8 , pp. 7254-7263
    • Miedlich, S.U.1    Gama, L.2    Seuwen, K.3    Wolf, R.M.4    Breitwieser, G.E.5
  • 37
    • 0032808078 scopus 로고    scopus 로고
    • NPS R-568: A type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium
    • Fox J, Lowe SH, Petty BA, et al. NPS R-568: a type 2 calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. J Pharmacol Exp Ther 1999;290:473-9 (Pubitemid 29344536)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.290 , Issue.2 , pp. 473-479
    • Fox, J.1    Lowe, S.H.2    Petty, B.A.3    Nemeth, E.F.4
  • 45
    • 20844432907 scopus 로고    scopus 로고
    • Effects of cinacalcet on bone mineral density in patients with secondary hyperparathyroidism
    • DOI 10.1093/ndt/gfh829
    • Lien YH, Silva AL, Whittman D. Effects of cinacalcet on bone mineral density in patients with secondary hyperparathyroidism. Nephrol Dial Transplant 2005;20:1232-7 (Pubitemid 40862116)
    • (2005) Nephrology Dialysis Transplantation , vol.20 , pp. 1232-1237
    • Lien, Y.-H.H.1    Silva, A.L.2    Whittman, D.3
  • 49
    • 79955082012 scopus 로고    scopus 로고
    • Ortho-McNeil Pharm Inc. US6172091
    • Ortho-McNeil Pharm, Inc. 1,2-Disubstituted cyclopropanes. US6172091; 2001
    • (2001) 1 2-Disubstituted Cyclopropanes
  • 52
    • 0034604847 scopus 로고    scopus 로고
    • 2-(1-aryl)ethyl-3-phenylpropane-1, 2-diamines as novel calcimimetics acting on the calcium sensing receptor
    • DOI 10.1016/S0960-894X(00)00382-6, PII S0960894X00003826
    • Dauban P, Ferry S, Faure H, et al. N1-Arylsulfonyl-N2-(1-aryl)ethyl-3- phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor. Bioorg Med Chem Lett 2000;10:2001-4 (Pubitemid 30663359)
    • (2000) Bioorganic and Medicinal Chemistry Letters , vol.10 , Issue.17 , pp. 2001-2004
    • Dauban, P.1    Ferry, S.2    Faure, H.3    Ruat, M.4    Dodd, R.H.5
  • 53
    • 2442612684 scopus 로고    scopus 로고
    • 1-(1-(1-naphthyl)ethyl)-3-phenylpropane- 1, 2-diamines and conformationally restrained indole analogues: Development of calindol as a new calcimimetic acting at the calcium sensing receptor
    • DOI 10.1016/j.bmcl.2004.03.056, PII S0960894X04004123
    • Kessler A, Faure H, Petrel C, et al. N2-Benzyl-N1(1-(1-naphthyl)ethyl)-3- phenylpropane-1,2-diamines andconformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett 2004;14:3345-9 (Pubitemid 38624621)
    • (2004) Bioorganic and Medicinal Chemistry Letters , vol.14 , Issue.12 , pp. 3345-3349
    • Kessler, A.1    Faure, H.2    Petrel, C.3    Ruat, M.4    Dauban, P.5    Dodd, R.H.6
  • 56
    • 2942519523 scopus 로고    scopus 로고
    • Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor
    • DOI 10.1016/j.gene.2004.03.003, PII S0378111904001490
    • Wellendorph P, Brauner-Osborne H. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 2004;335:37-46 (Pubitemid 38759751)
    • (2004) Gene , vol.335 , Issue.1-2 , pp. 37-46
    • Wellendorph, P.1    Brauner-Osborne, H.2
  • 57
    • 44349102608 scopus 로고    scopus 로고
    • Evidence for the presence of GPRC6A receptors in rat mesenteric arteries
    • Harno E, Edwards G, Geraghty AR, et al. Evidence for the presence of GPRC6A receptors in rat mesenteric arteries. Cell Calcium 2008;421:210-19
    • (2008) Cell. Calcium. , vol.421 , pp. 210-219
    • Harno, E.1    Edwards, G.2    Geraghty, A.R.3
  • 58
    • 70849106449 scopus 로고    scopus 로고
    • Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor
    • Faure H, Gorojankina T, Rice N, et al. Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium 2009;46:323-32
    • (2009) Cell. Calcium , vol.46 , pp. 323-332
    • Faure, H.1    Gorojankina, T.2    Rice, N.3
  • 59
    • 77649116377 scopus 로고    scopus 로고
    • Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals
    • Chen W, Bergsman JB, Wang X, et al. Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals. PloS One 2010;5:e8563
    • (2010) PloS One , vol.5
    • Chen, W.1    Bergsman, J.B.2    Wang, X.3
  • 64
    • 79955099471 scopus 로고    scopus 로고
    • Daiichi Sankyo Co. Ltd. WO2010021351
    • Daiichi Sankyo Co. Ltd. Cycloalkylamine derivative. WO2010021351; 2010
    • (2010) Cycloalkylamine Derivative
  • 73
    • 79955114474 scopus 로고    scopus 로고
    • Smithkline Beecham Corp NPS Pharma Inc WO9845255 and WO2001008673 2001
    • Smithkline Beecham Corp. and NPS Pharma, Inc. Calcilytic compounds. WO9845255; 1998 and WO2001008673; 2001
    • (1998) Calcilytic Compounds
  • 74
    • 0042333459 scopus 로고    scopus 로고
    • Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure
    • DOI 10.1016/S8756-3282(03)00202-3
    • Frolik CA, Black EC, Cain RL, et al. Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure. Bone 2003;33:372-9 (Pubitemid 37103254)
    • (2003) Bone , vol.33 , Issue.3 , pp. 372-379
    • Frolik, C.A.1    Black, E.C.2    Cain, R.L.3    Satterwhite, J.H.4    Brown-Augsburger, P.L.5    Sato, M.6    Hock, J.M.7
  • 75
    • 79955086085 scopus 로고    scopus 로고
    • Smithkline Beecham Corp WO2002038106
    • Smithkline Beecham Corp. Calcilytic compounds. WO2002038106; 2002
    • (2002) Calcilytic Compounds
  • 76
    • 79955083258 scopus 로고    scopus 로고
    • Smithkline Beecham Corp WO2004047751
    • Smithkline Beecham Corp. Calcilytic compounds. WO2004047751; 2004
    • (2004) Calcilytic Compounds
  • 77
    • 79955098433 scopus 로고    scopus 로고
    • Glaxo Group Ltd WO2005030749
    • Glaxo Group Ltd. Calcilytic compounds. WO2005030749; 2005
    • (2005) Calcilytic Compounds
  • 78
    • 79955098433 scopus 로고    scopus 로고
    • Smithkline Beecham Corp WO2005077892
    • Smithkline Beecham Corp. Calcilytic compounds. WO2005077892; 2005
    • (2005) Calcilytic Compounds
  • 79
    • 79955090121 scopus 로고    scopus 로고
    • Smithkline Beecham Corp WO2008077009
    • Smithkline Beecham Corp. Calcilytic compounds. WO2008077009; 2008
    • (2008) Calcilytic Compounds
  • 81
    • 79955100961 scopus 로고    scopus 로고
    • Japan Tobacco Inc. WO2004094362
    • Japan Tobacco, Inc. CaSR antagonist. WO2004094362; 2004
    • (2004) CaSR Antagonist
  • 82
    • 79955100961 scopus 로고    scopus 로고
    • Japan Tobacco Inc WO2004106280
    • Japan Tobacco, Inc. CaSR antagonist. WO2004106280; 2004
    • (2004) CaSR Antagonist
  • 87
    • 79955103797 scopus 로고    scopus 로고
    • Smithkline Beecham Corp WO2009055631
    • Smithkline Beecham Corp. Calcilytic compounds. WO2009055631; 2009
    • (2009) Calcilytic Compounds
  • 90
    • 4544349506 scopus 로고    scopus 로고
    • 2-(1-(1-naphthyl)ethyl)-1,2- diaminocyclohexanes: A new class of calcilytic agents acting at the calcium-sensing receptor
    • DOI 10.1002/cbic.200400049
    • Kessler A, Faure H, Roussanne MC, et al. N(1)-Arylsulfonyl-N(2)-(1-(1- naphthyl)ethyl)-1,2-diaminocyclohexanes: a new class of calcilytic agents acting at the calcium-sensing receptor. ChemBioChem 2004;5:1131-6 (Pubitemid 39257035)
    • (2004) ChemBioChem , vol.5 , Issue.8 , pp. 1131-1136
    • Kessler, A.1    Faure, H.2    Cecile Roussanne, M.3    Ferry, S.4    Ruat, M.5    Dauban, P.6    Dodd, R.H.7
  • 91
    • 33747473316 scopus 로고    scopus 로고
    • 2-[1-(1-naphthyl)ethy1]-trans-1,2- diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity
    • DOI 10.1021/jm051233+
    • Kessler A, Faure H, Petrel C, et al. N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]- trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J Med Chem 2006;49:5119-28 (Pubitemid 44260208)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.17 , pp. 5119-5128
    • Kessler, A.1    Faure, H.2    Petrel, C.3    Rognan, D.4    Cesario, M.5    Ruat, M.6    Dauban, P.7    Dodd, R.H.8
  • 103
    • 79955080680 scopus 로고    scopus 로고
    • Smithkline Beecham Corp WO2007062370
    • Smithkline Beecham Corp. Calcilytic compounds. WO2007062370; 2007
    • (2007) Calcilytic Compounds
  • 107
    • 0037378029 scopus 로고    scopus 로고
    • Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors
    • DOI 10.1097/01.ASN.0000056188.23717.E5
    • Ogata H, Ritz E, Odoni G, et al. Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors. J Am Soc Nephrol 2003;14:959-67 (Pubitemid 36359277)
    • (2003) Journal of the American Society of Nephrology , vol.14 , Issue.4 , pp. 959-967
    • Ogata, H.1    Ritz, E.2    Odoni, G.3    Amann, K.4    Orth, S.R.5
  • 108
    • 33645459663 scopus 로고    scopus 로고
    • Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
    • Odenwald T, Nakagawa K, Hadtstein C, et al. Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats. J Am Soc Nephrol 2006;17:655-62
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 655-662
    • Odenwald, T.1    Nakagawa, K.2    Hadtstein, C.3
  • 110
    • 57449115320 scopus 로고    scopus 로고
    • Novel role of the calcium-sensing receptor in blood pressure modulation
    • Smajilovic S, Tfelt-Hansen J. Novel role of the calcium-sensing receptor in blood pressure modulation. Hypertension 2008;52:994-1000
    • (2008) Hypertension , vol.52 , pp. 994-1000
    • Smajilovic, S.1    Tfelt-Hansen, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.