A missense mutation in the seven-transmembrane domain of the human Ca 2+ receptor converts a negative allosteric modulator into a positive allosteric modulator

Journal of Biological Chemistry

Volumn 281, Issue 30, 2006, Pages 21558-21565

  Hu, Jianxin ^a,d   Jiang, Jiankang ^b   Costanzi, Stefano ^b   Thomas, Craig ^b   Yang, Wu ^c   Feyen, Jean H M ^c   Jacobson, Kenneth A ^b   Spiegel, Allen M ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DRUG PRODUCTS; MOLECULAR STRUCTURE; MUTAGENESIS; PROTEINS;

ACIDIC RESIDUE; ALLOSTERIC MODULATOR; G PROTEIN-COUPLED RECEPTORS (GPCRS); TRANSMEMBRANE DOMAIN;

CELL MEMBRANES;

2 AMINO 3 PHENYL 1 PROPANOL; CALCIUM ION; G PROTEIN COUPLED RECEPTOR; JKJ 05; MEMBRANE PROTEIN; PROPANOL; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SELECTION; CELL STRAIN HEK293; DRUG ACTIVITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MISSENSE MUTATION; MODULATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ALLOSTERIC SITE; CALCIUM; CELL LINE; GLUTAMIC ACID; HUMANS; HYDROLYSIS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCIUM-SENSING; TRANSFECTION;

EID: 33746364829     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M603682200     Document Type: Article

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