-
1
-
-
77649277719
-
Cancer as a metabolic disease
-
doi:10.1186/1743-7075-7-7
-
Seyfried, T.N.; Shelton, L.M. Cancer as a metabolic disease. Nutr. Metab. (Lond.), 2010, 7:7. doi:10.1186/1743-7075-7-7. http://www.nutritionandmetabolism.com/content/7/1/7.
-
(2010)
Nutr. Metab. (Lond.)
, vol.7
, pp. 7
-
-
Seyfried, T.N.1
Shelton, L.M.2
-
2
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. On the origin of cancer cells. Science, 1956, 123(3191), 309-14.
-
(1956)
Science
, vol.123
, Issue.3191
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
0000459772
-
Ueber den Stoffwechsel der Tumoren
-
Warburg, O.; Posener, K.; Negelein, E. Ueber den Stoffwechsel der Tumoren. Biochem. Z., 1924, 152, 319-44.
-
(1924)
Biochem. Z.
, vol.152
, pp. 319-344
-
-
Warburg, O.1
Posener, K.2
Negelein, E.3
-
4
-
-
48349138947
-
Expression analysis of facilitative glucose transporter(GLUTs) in human thyroid carcinoma cell lines and primary tumors
-
Ciampi, R.; Vivaldi, A.; Romei, C.; Del Guerra, A.; Salvadori, P.; Cosci, B.; Pinchera, A.;Elisei, R. Expression analysis of facilitative glucose transporter(GLUTs) in human thyroid carcinoma cell lines and primary tumors. Mol. Cell. Endocrinol., 2008, 291(1-2), 57-62.
-
(2008)
Mol. Cell. Endocrinol.
, vol.291
, Issue.1-2
, pp. 57-62
-
-
Ciampi, R.1
Vivaldi, A.2
Romei, C.3
Del Guerra, A.4
Salvadori, P.5
Cosci, B.6
Pinchera, A.7
Elisei, R.8
-
5
-
-
78149264310
-
GLUT-1 and Bcl-xl in relation to erythropoietin in human colorectal adenocarcinoma
-
Wincewicz, A.; Baltaziak, M.; Kanczuga-Koda, L.; Sulkowska, U.; Sulkowski S. GLUT-1 and Bcl-xl in relation to erythropoietin in human colorectal adenocarcinoma. Hepatogastroenterology, 2010, 57(101), 741-45.
-
(2010)
Hepatogastroenterology
, vol.57
, Issue.101
, pp. 741-745
-
-
Wincewicz, A.1
Baltaziak, M.2
Kanczuga-Koda, L.3
Sulkowska, U.4
Sulkowski, S.5
-
6
-
-
79952097013
-
FDG uptake in primary squamous cell carcinoma of the head and neck. The relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis
-
Deron, P.; Vangestel, C.; Goethals. I.; De Potter, A.; Peeters, M.; Vermeersch, H.; Van de Wiele, C. FDG uptake in primary squamous cell carcinoma of the head and neck. The relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis. Nuklearmedizin, 2010, 50(1), 15-21.
-
(2010)
Nuklearmedizin
, vol.50
, Issue.1
, pp. 15-21
-
-
Deron, P.1
Vangestel, C.2
Goethals, I.3
de Potter, A.4
Peeters, M.5
Vermeersch, H.6
van de Wiele, C.7
-
7
-
-
79952470343
-
Warburg phenotype in renal cell carcinoma: High expression of glucosetransporter 1 (GLUT-1) correlates with low CD8 (+) T-cell infiltration in the tumor
-
[Online early access] DOI: 10.1002/ijc.25543.Published Online: July 6, (accessed Dec 19, 2010)
-
Singer, K.; Kastenberger, M.; Gottfried, E.; Hammerschmied, C.G.; Büttner, M.; Aigner, M.; Seliger, B.; Walter, B.; Schlösser, H.; Hartmann, A.; Andreesen, R.; Mackensen, A.; Kreutz, M. Warburg phenotype in renal cell carcinoma: High expression of glucosetransporter 1 (GLUT-1) correlates with low CD8 (+) T-cell infiltration in the tumor. Int. J. Cancer. [Online early access] DOI: 10.1002/ijc.25543.Published Online: July 6 2010. http://onlinelibrary.wiley.com (accessed Dec 19, 2010).
-
(2010)
Int. J. Cancer
-
-
Singer, K.1
Kastenberger, M.2
Gottfried, E.3
Hammerschmied, C.G.4
Büttner, M.5
Aigner, M.6
Seliger, B.7
Walter, B.8
Schlösser, H.9
Hartmann, A.10
Andreesen, R.11
McKensen, A.12
Kreutz, M.13
-
8
-
-
56249134557
-
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
-
Wood, T.E.; Dalili, S.; Simpson, C.D.; Hurren, R.; Mao, X.; Saiz, F.S.; Gronda, M.; Eberhard, Y.; Minden, M.D.; Bilan, P.J.; Klip, A.; Batey, R.A.; Schimmer, A.D. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol. Cancer Ther., 2008, 7(11), 3546-3555.
-
(2008)
Mol. Cancer Ther.
, vol.7
, Issue.11
, pp. 3546-3555
-
-
Wood, T.E.1
Dalili, S.2
Simpson, C.D.3
Hurren, R.4
Mao, X.5
Saiz, F.S.6
Gronda, M.7
Eberhard, Y.8
Minden, M.D.9
Bilan, P.J.10
Klip, A.11
Batey, R.A.12
Schimmer, A.D.13
-
9
-
-
0034820481
-
SGLT gene expression in primary lung cancers and their metastatic lesions
-
Ishikawa, N.; Oguri, T.; Isobe, T.; Fujitaka, K.; Kohno, N. SGLT gene expression in primary lung cancers and their metastatic lesions. Jpn. J. Cancer Res., 2001, 92(8), 874-879.
-
(2001)
Jpn. J. Cancer Res.
, vol.92
, Issue.8
, pp. 874-879
-
-
Ishikawa, N.1
Oguri, T.2
Isobe, T.3
Fujitaka, K.4
Kohno, N.5
-
10
-
-
0038714272
-
Isozymes for mammalian hexokinase: Structure, subcellular localization and metabolic function
-
Wilson, J.E. Isozymes for mammalian hexokinase: structure, subcellular localization and metabolic function. J. Exp. Biol., 2003, 206, 2049-2057.
-
(2003)
J. Exp. Biol.
, vol.206
, pp. 2049-2057
-
-
Wilson, J.E.1
-
11
-
-
60249083822
-
Hexokinase-2 bound to mitochondria: Cancer's stygian link to the pivotal target for effective therapy
-
Mathupala, S.P.; Ko Y.H.; Pedersen, P.L. Hexokinase-2 bound to mitochondria: Cancer's stygian link to the pivotal target for effective therapy. Semin. Cancer. Biol., 2009, 19(1), 17-24.
-
(2009)
Semin. Cancer. Biol.
, vol.19
, Issue.1
, pp. 17-24
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
12
-
-
0035829074
-
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase
-
Ko, Y.H.; Pedersen, P.L.; Geschwind, J.F. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer lett., 2001, 173(1), 83-91.
-
(2001)
Cancer lett.
, vol.173
, Issue.1
, pp. 83-91
-
-
Ko, Y.H.1
Pedersen, P.L.2
Geschwind, J.F.3
-
13
-
-
41549113465
-
Synergistic anti pancreatic tumor effect by simultaneously targeting hypoxic tumor cells with HSP90 inhibitor and glycolysis inhibitor
-
Cao, X.; Bloomston, M.; Zhang, T.; Frankel, W.L.; Jia, G.; Wang, B.; Hall, N.C.; Koch, R.M.; Cheng, H.; Knopp, M.V. Synergistic anti pancreatic tumor effect by simultaneously targeting hypoxic tumor cells with HSP90 inhibitor and glycolysis inhibitor. Clin. Cancer Res., 2008, 14(6), 1831-1839.
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.6
, pp. 1831-1839
-
-
Cao, X.1
Bloomston, M.2
Zhang, T.3
Frankel, W.L.4
Jia, G.5
Wang, B.6
Hall, N.C.7
Koch, R.M.8
Cheng, H.9
Knopp, M.V.10
-
14
-
-
34249987354
-
FDG-PET for evaluating the antitumor effect intra-arterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model
-
Park, H.S.; Chung, J.W.; Jae, H.J.; Kim, Y.I.; Sonk, R.; Lee, M.J. FDG-PET for evaluating the antitumor effect intra-arterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model. Korean J. Radiol., 2007, 8(3), 216-24.
-
(2007)
Korean J. Radiol.
, vol.8
, Issue.3
, pp. 216-224
-
-
Park, H.S.1
Chung, J.W.2
Jae, H.J.3
Kim, Y.I.4
Sonk, R.5
Lee, M.J.6
-
15
-
-
21844468220
-
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
-
Dombrauckas, J.D.; Santasiero, B.D.; Mesecar, A.D. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry, 2005, 44(21), 9417-9429.
-
(2005)
Biochemistry
, vol.44
, Issue.21
, pp. 9417-9429
-
-
Dombrauckas, J.D.1
Santasiero, B.D.2
Mesecar, A.D.3
-
16
-
-
77249154640
-
Evaluation of substituted N, N'-di aryl sulphonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
-
Boxer, M.B.; Jiang, J.K.; Vande Heiden, M. G.; Shen, M.; Skoumbourdis, A.P.; Southall, N.; Veith, H.; Leister, W.; Austin, C.P.; Park, H.W.; Inglese, J.; Cantley, L. C.; Auld, D.S.; & Thomas, C.J. Evaluation of substituted N, N'-di aryl sulphonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J. Med. Chem., 2010, 53(3), 1048-55.
-
(2010)
J. Med. Chem.
, vol.53
, Issue.3
, pp. 1048-1055
-
-
Boxer, M.B.1
Jiang, J.K.2
vande Heiden, M.G.3
Shen, M.4
Skoumbourdis, A.P.5
Southall, N.6
Veith, H.7
Leister, W.8
Austin, C.P.9
Park, H.W.10
Inglese, J.11
Cantley, L.C.12
Auld, D.S.13
Thomas, C.J.14
-
17
-
-
78650722178
-
Anticancer drug that target metabolism: Is dichloroacetate the new paradigm?
-
Papandreou, I.; Goliasova, T.; Denko, N.C. Anticancer drug that target metabolism: Is dichloroacetate the new paradigm? Int. J. Cancer., 2011, 128, 1001-8.
-
(2011)
Int. J. Cancer.
, vol.128
, pp. 1001-1008
-
-
Papandreou, I.1
Goliasova, T.2
Denko, N.C.3
-
18
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet, S.; Archer, S.L.; Allalunis-Turner, J.; Haromy, A.; Beaulieu, C.; Thompson, R.; Lee, C.T.; Lopaschuk, G.D.; Puttagunta, L.; Bonnet, S.; Harry, G.; Hashimoto, K; Porter, C. J.; Andrade, M.A.; Thebaud, B.; Michelakis, E.D. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell, 2007, 11(1), 37-51.
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
Lee, C.T.7
Lopaschuk, G.D.8
Puttagunta, L.9
Bonnet, S.10
Harry, G.11
Hashimoto, K.12
Porter, C.J.13
Andrade, M.A.14
Thebaud, B.15
Michelakis, E.D.16
-
19
-
-
77952995998
-
Metabolic modulation of glioblastoma with dichloroacetate
-
Michelakis, E.D.; Sutendra, G.; Dromparis, P.; Webster, L.; Haromy, A.; Niven, E.; Maguire, C.; Gammer, T. L.; Mackey, J.R.; Fulton, D.; Abdulkarim, B.; McMurtry, M. S.; Petruk, K. C. Metabolic modulation of glioblastoma with dichloroacetate. Sci. Transl. Med., 2010, 2(31), 31ra34.
-
(2010)
Sci. Transl. Med.
, vol.2
, Issue.31
-
-
Michelakis, E.D.1
Sutendra, G.2
Dromparis, P.3
Webster, L.4
Haromy, A.5
Niven, E.6
Maguire, C.7
Gammer, T.L.8
McKey, J.R.9
Fulton, D.10
Abdulkarim, B.11
McMurtry, M.S.12
Petruk, K.C.13
-
20
-
-
44449147036
-
Tumor cell metabolism: Cancer's Achilles' heel
-
Kroemer, G.; Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell, 2008, 13(6), 472-82.
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
21
-
-
79953126723
-
Metabolic micromilieu in tumours
-
Mueller-Klieser, W. Metabolic micromilieu in tumours. Nuklearmedizin, 2010, 49(Suppl1):S16-S20.
-
(2010)
Nuklearmedizin
, vol.49
, Issue.SUPPL1
-
-
Mueller-Klieser, W.1
-
22
-
-
34247352844
-
Inhibitory effect of tumor cell-derived lactic acid on human T cells
-
Fischer, K.; Hoffmann, P.; Voelkl, S.; Meidenbauer, N.; Ammer J.; Edinger, M.; Gottfried, E.; Schwarz, S.; Rothe, G.; Hoves, S.; Renner, K.; Timischl, B.; Mackensen, A.; Kunz-Schughart, L.; Andreesen, R.; Krause, S. W.; Kreutz, M. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood, 2007, 109(9), 3812-3819.
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 3812-3819
-
-
Fischer, K.1
Hoffmann, P.2
Voelkl, S.3
Meidenbauer, N.4
Ammer, J.5
Edinger, M.6
Gottfried, E.7
Schwarz, S.8
Rothe, G.9
Hoves, S.10
Renner, K.11
Timischl, B.12
McKensen, A.13
Kunz-Schughart, L.14
Andreesen, R.15
Krause, S.W.16
Kreutz, M.17
-
23
-
-
69949124867
-
Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
-
Feron, O. Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother. Oncol., 2009, 92(3), 329-333.
-
(2009)
Radiother. Oncol.
, vol.92
, Issue.3
, pp. 329-333
-
-
Feron, O.1
-
24
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
Sonveaux, P.; Végran, F.; Schroeder, T; Wergin, M. C; Verrax, J; Rabbani, Z. N; De Saedeleer, C. J; Kennedy, K. M; Diepart, C; Jordan, B.F.; Kelley, M. J; Gallez, B; Wahl, M.L.; Feron, O.; Dewhirst, M.W. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Invest., 2008, 118(12), 3930-3942.
-
(2008)
J. Clin. Invest.
, vol.118
, Issue.12
, pp. 3930-3942
-
-
Sonveaux, P.1
Végran, F.2
Schroeder, T.3
Wergin, M.C.4
Verrax, J.5
Rabbani, Z.N.6
de Saedeleer, C.J.7
Kennedy, K.M.8
Diepart, C.9
Jordan, B.F.10
Kelley, M.J.11
Gallez, B.12
Wahl, M.L.13
Feron, O.14
Dewhirst, M.W.15
-
25
-
-
34547121206
-
Hypoxia in cancer: Significance and impact on clinical outcome
-
Vaupel P.; Mayer, A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev., 2007, 26(2), 225-39.
-
(2007)
Cancer Metastasis Rev.
, vol.26
, Issue.2
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
26
-
-
33751091519
-
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): A potential therapeutic target for high-risk neuroblastoma
-
Fang, J.; Quinonees, Q.J.; Holman, T.L.; Morowitz, M.J.; Wang, Q.; Zhao, H.; Sivo, F.; Maris, J.M.; Wahl, M.L. The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol. Pharmacol., 2006, 70(6), 2108-15.
-
(2006)
Mol. Pharmacol.
, vol.70
, Issue.6
, pp. 2108-2115
-
-
Fang, J.1
Quinonees, Q.J.2
Holman, T.L.3
Morowitz, M.J.4
Wang, Q.5
Zhao, H.6
Sivo, F.7
Maris, J.M.8
Wahl, M.L.9
-
27
-
-
0035953105
-
Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues
-
Froberg, M.K.; Gerhart, D.Z.; Enerson, B.E.; Manivel, C.; Guzman-Paz M.; Seacotte, N.; Drewes, L.R. Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues. Neuroreport., 2001, 12(4), 761-65.
-
(2001)
Neuroreport.
, vol.12
, Issue.4
, pp. 761-765
-
-
Froberg, M.K.1
Gerhart, D.Z.2
Enerson, B.E.3
Manivel, C.4
Guzman-Paz, M.5
Seacotte, N.6
Drewes, L.R.7
-
28
-
-
39149130681
-
Increased expression of monocarboxylate transporters 1,2 and 4 in colorectal carcinoma
-
Pinheiro, C.; Longatto-Filho, A.; Scapulatempo, C.; Ferreira, L.; Martins, S.; Pellerin, L.; Rodrigues, M.; Alves, V. A.; Schmitt, F.; Baltazar, F. Increased expression of monocarboxylate transporters 1,2 and 4 in colorectal carcinoma. Virchows. Arch., 2008, 452(2), 139-146.
-
(2008)
Virchows. Arch.
, vol.452
, Issue.2
, pp. 139-146
-
-
Pinheiro, C.1
Longatto-Filho, A.2
Scapulatempo, C.3
Ferreira, L.4
Martins, S.5
Pellerin, L.6
Rodrigues, M.7
Alves, V.A.8
Schmitt, F.9
Baltazar, F.10
-
29
-
-
33746291023
-
Increased Lipogenesis in cancer cells: New players, novel targets
-
Swinnen, J.V.; Brusselmans, K.; Verhoeven, G. Increased Lipogenesis in cancer cells: new players, novel targets. Curr. Opin. Nutr. Metab. Care, 2006, 9(4), 358-365.
-
(2006)
Curr. Opin. Nutr. Metab. Care
, vol.9
, Issue.4
, pp. 358-365
-
-
Swinnen, J.V.1
Brusselmans, K.2
Verhoeven, G.3
-
30
-
-
0012249041
-
Metabolism of neoplastic tissue IV: A study of lipid synthesis in neoplastic tissue slices in vitro
-
Medes, G.; Thomas, A.; Weinhouse, S. Metabolism of neoplastic tissue IV: a study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res., 1953, 13(1), 27-29.
-
(1953)
Cancer Res.
, vol.13
, Issue.1
, pp. 27-29
-
-
Medes, G.1
Thomas, A.2
Weinhouse, S.3
-
31
-
-
0021466891
-
Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor
-
Ookhtens, M.; Kannan, R.; Lyon, I.; Baker N. Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am. J. Physiol., 1984, 247(1Pt 2), R146-R153.
-
(1984)
Am. J. Physiol.
, vol.247
, Issue.1 PART 2
-
-
Ookhtens, M.1
Kannan, R.2
Lyon, I.3
Baker, N.4
-
32
-
-
0014076991
-
Control of lipid metabolism in hepatomas: Insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control
-
Sabine J.R.; Abraham, S.; Chaikoff, I.L. Control of lipid metabolism in hepatomas: insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control. Cancer Res., 1967, 27(4), 793-799.
-
(1967)
Cancer Res.
, vol.27
, Issue.4
, pp. 793-799
-
-
Sabine, J.R.1
Abraham, S.2
Chaikoff, I.L.3
-
33
-
-
0026619273
-
Deviant energetic metabolism of glycolytic cancer cells
-
Baggeto, L.G. Deviant energetic metabolism of glycolytic cancer cells. Biochimie., 1992, 74(11), 959-974.
-
(1992)
Biochimie.
, vol.74
, Issue.11
, pp. 959-974
-
-
Baggeto, L.G.1
-
34
-
-
0000089325
-
Observations on the carbohydrate metabolism of tumors
-
Crabtree, H.G. Observations on the carbohydrate metabolism of tumors. Biochem. J., 1929, 23(3), 536-545.
-
(1929)
Biochem. J.
, vol.23
, Issue.3
, pp. 536-545
-
-
Crabtree, H.G.1
-
35
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen, K.E.; Hatzivassiliou, G.; Sachdeva, U.M.; Bui, T.V.; Cross, J.R.; Thompson, C.B. ATP-citrate lyase links cellular metabolism to histone acetylation. Science, 2009, 324(5930), 1076-1080.
-
(2009)
Science
, vol.324
, Issue.5930
, pp. 1076-1080
-
-
Wellen, K.E.1
Hatzivassiliou, G.2
Sachdeva, U.M.3
Bui, T.V.4
Cross, J.R.5
Thompson, C.B.6
-
36
-
-
30544433533
-
ATP-citrate lyase is an important component of cell growth and transformation
-
Bauer, D.E.; Hatzivassiliou, G.; Zhao, F.; Andreadis, C.; Thompson, C.B. ATP-citrate lyase is an important component of cell growth and transformation. Oncogene, 2005, 24(41), 6314-6322.
-
(2005)
Oncogene
, vol.24
, Issue.41
, pp. 6314-6322
-
-
Bauer, D.E.1
Hatzivassiliou, G.2
Zhao, F.3
Andreadis, C.4
Thompson, C.B.5
-
37
-
-
26644441651
-
ATP-citrate lyase inhibition can suppress tumor cell growth
-
Hatzivassiliou, G.; Zhao, F.; Bauer, D. E.; Andreadis, C.; Shaw, A.N.; Dhanak, D.; Hingorani, S.; Tuveson, D.A.; Thompson, C.B. ATP-citrate lyase inhibition can suppress tumor cell growth. Cancer Cell, 2005, 8(4), 311-321.
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 311-321
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
Andreadis, C.4
Shaw, A.N.5
Dhanak, D.6
Hingorani, S.7
Tuveson, D.A.8
Thompson, C.B.9
-
38
-
-
54249161009
-
ATP-citrate lyase: Activation and therapeutic implications in non-small cell lung cancer
-
Migita, T.; Narita, T.; Nomura, K.; Miyagi, E.; Inazuka, F.; Matsuura, M.; Ushijimam, M.; Mashima, T.; Seimiya, H.; Satoh, Y.; Okumura, S.; Nakagawa, K.; Ishikawa, Y. ATP-citrate lyase: activation and therapeutic implications in non-small cell lung cancer. Cancer Res., 2008, 68(20), 8547-54.
-
(2008)
Cancer Res.
, vol.68
, Issue.20
, pp. 8547-8554
-
-
Migita, T.1
Narita, T.2
Nomura, K.3
Miyagi, E.4
Inazuka, F.5
Matsuura, M.6
Ushijimam, M.7
Mashima, T.8
Seimiya, H.9
Satoh, Y.10
Okumura, S.11
Nakagawa, K.12
Ishikawa, Y.13
-
39
-
-
77951880179
-
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-IR pathway
-
Eliasz, S.; Liang, S.; Chen, Y.; DeMarco, M.A.; Machek, O.; Skuch, AS.; Miele, L.; Boccheta, M. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-IR pathway. Oncogene, 2010, 29(17), 2488-2498
-
(2010)
Oncogene
, vol.29
, Issue.17
, pp. 2488-2498
-
-
Eliasz, S.1
Liang, S.2
Chen, Y.3
de Marco, M.A.4
McHek, O.5
Skuch, A.S.6
Miele, L.7
Boccheta, M.8
-
40
-
-
69949124867
-
Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
-
Feron, O. Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother. Oncol., 2009, 92(3), 329-333.
-
(2009)
Radiother. Oncol.
, vol.92
, Issue.3
, pp. 329-333
-
-
Feron, O.1
-
41
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M.G.; Cantley, L.C.; Thomson, C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 2009, 324(5930), 1029-1033.
-
(2009)
Science
, vol.324
, Issue.5930
, pp. 1029-1033
-
-
vander Heiden, M.G.1
Cantley, L.C.2
Thomson, C.B.3
-
42
-
-
65849362115
-
Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3
-
Young, C. D.; Nolte, E. C.; Lewis, A.; Serkova, N.J.; Anderson, S.M. Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3. Breast Cancer Res., 2008, 10(4), R70.
-
(2008)
Breast Cancer Res.
, vol.10
, Issue.4
-
-
Young, C.D.1
Nolte, E.C.2
Lewis, A.3
Serkova, N.J.4
Anderson, S.M.5
-
43
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumor suppression
-
Shackelford, D.B.; Shaw, R.J. The LKB1-AMPK pathway: metabolism and growth control in tumor suppression. Nat. Rev. Cancer, 2009, 9(8), 563-575.
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.8
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
44
-
-
77955430762
-
Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment
-
Garcia-Echeverria, C. Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment. Bioorg. Med. Chem. Lett., 2010, 20(15), 4308-4312.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.15
, pp. 4308-4312
-
-
Garcia-Echeverria, C.1
-
45
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly, K.E.; Rojo, F.; She, Q.B.; Solit, D.; Mills, G.B.; Smith, D.; Lane, H.; Hoffmann, F.; Hicklin, D.J.; Ludwig, D.L.; Baselga, J.; Rosen, N. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res., 2006, 66(3), 1500-1508.
-
(2006)
Cancer Res.
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hoffmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
Rosen, N.12
-
46
-
-
74849131091
-
Targeting mTOR globally in cancer thinking beyond rapamycin
-
Shor, B.; Gibbons J.J.; Abraham, R.T.; Yu, K. Targeting mTOR globally in cancer thinking beyond rapamycin. Cell cycle, 2009, 8(23), 3831-3837.
-
(2009)
Cell cycle
, vol.8
, Issue.23
, pp. 3831-3837
-
-
Shor, B.1
Gibbons, J.J.2
Abraham, R.T.3
Yu, K.4
-
47
-
-
54249162351
-
Targeted poly pharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases
-
Apsel, B.; Blair, J.A.; Gonzalez, B.; Nazif, T.M.; Feldman, M.E.; Aizenstein, B.; Hoffman, R.; Williams, R.L.; Shokat, K.M.; Knight, Z.A. Targeted poly pharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat. Chem. Biol., 2008, 4(11), 691-699.
-
(2008)
Nat. Chem. Biol.
, vol.4
, Issue.11
, pp. 691-699
-
-
Apsel, B.1
Blair, J.A.2
Gonzalez, B.3
Nazif, T.M.4
Feldman, M.E.5
Aizenstein, B.6
Hoffman, R.7
Williams, R.L.8
Shokat, K.M.9
Knight, Z.A.10
-
48
-
-
77954235821
-
Targeting mTOR: Prospects for mTOR complex 2 inhibitors in cancer therapy
-
Sparks, C.A.; Guertin, D.A. Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene, 2010, 29(26), 3733-3744.
-
(2010)
Oncogene
, vol.29
, Issue.26
, pp. 3733-3744
-
-
Sparks, C.A.1
Guertin, D.A.2
-
49
-
-
62349129015
-
Differential requirement of mTOR in post mitotic tissues and tumorigenesis
-
Nardella, C.; Carracedo, A.; Alimonti, A.; Hobbs, R.M.; Closshesy J.G.; Chen Z. Differential requirement of mTOR in post mitotic tissues and tumorigenesis. Sci. Signal, 2009, 2(55), ra2.
-
(2009)
Sci. Signal
, vol.2
, Issue.55
-
-
Nardella, C.1
Carracedo, A.2
Alimonti, A.3
Hobbs, R.M.4
Closshesy, J.G.5
Chen, Z.6
-
50
-
-
70349616273
-
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
-
Balgi, A.D.; Fonseca, B.D.; Donohue, E.; Tsang, T.C.; Lajoie, P.; Proud, C.G.; Nabi, I.R.; Roberge, M. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS. One, 2009, 4(9), e7124.
-
(2009)
PLoS. One
, vol.4
, Issue.9
-
-
Balgi, A.D.1
Fonseca, B.D.2
Donohue, E.3
Tsang, T.C.4
Lajoie, P.5
Proud, C.G.6
Nabi, I.R.7
Roberge, M.8
-
51
-
-
84864371674
-
Metformin and cancer: New applications for an old drug
-
[Online early access]. DOI:10. 1007/s12032-011-9846-7. Published Online: Feb 8, (accessed Feb 27, 2011)
-
Kourelis, T.V.; Seigel, R.D. Metformin and cancer: new applications for an old drug. Med. Oncol.[Online early access]. DOI:10. 1007/s12032-011-9846-7. Published Online: Feb 8, 2010. http://www.springerlink.com/content/v174h0x552641167, (accessed Feb 27, 2011).
-
(2010)
Med. Oncol.
-
-
Kourelis, T.V.1
Seigel, R.D.2
-
52
-
-
77956415337
-
-
Memmot, R.M.; Mercado, J.R.; Maier, C.R.; Kawabata, S.; Fox, S.D.; Dennis, P.A. Cancer Prev. Res(Phila).,2010, 3(9), 1066-1076.
-
(2010)
Cancer Prev. Res(Phila).
, vol.3
, Issue.9
, pp. 1066-1076
-
-
Memmot, R.M.1
Mercado, J.R.2
Maier, C.R.3
Kawabata, S.4
Fox, S.D.5
Dennis, P.A.6
-
53
-
-
34547114031
-
Systematic treatment with the antidiabetic drug Metformin selectively impairs p53-deficient tumor cell growth
-
Buzzai, M.; Jones, R.G.; Amaravadi, R.K.; Lum, J.J.; DeBerardinis, R.J.; Zhao, F.; Viollet, B.; Thompson, C.B. Systematic treatment with the antidiabetic drug Metformin selectively impairs p53-deficient tumor cell growth. Cancer Res., 2007, 67(14), 6745-6752.
-
(2007)
Cancer Res.
, vol.67
, Issue.14
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
de Berardinis, R.J.5
Zhao, F.6
Viollet, B.7
Thompson, C.B.8
-
54
-
-
67650514082
-
Metformin induces unique biological and molecular responses in triple negative breast cancer cells
-
Liu, B.; Fan, Z.; Edgerton, S.M.; Deng, X.S.; Alimova, I.N.; Lind, S.E.; Thor, A.D. Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle, 2009, 8(13), 2031-2040
-
(2009)
Cell Cycle
, vol.8
, Issue.13
, pp. 2031-2040
-
-
Liu, B.1
Fan, Z.2
Edgerton, S.M.3
Deng, X.S.4
Alimova, I.N.5
Lind, S.E.6
Thor, A.D.7
-
55
-
-
33646548305
-
The amino acid sensitive TOR pathway from yeast to mammals
-
Dann, S.G.; Thomas, G. The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett., 2006, 580(12), 2821-2829.
-
(2006)
FEBS Lett.
, vol.580
, Issue.12
, pp. 2821-2829
-
-
Dann, S.G.1
Thomas, G.2
-
56
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4EBP1 through a common effector mechanism
-
Hara, K.; Yonezawa, K.; Weng, Q.P.; Kozlowski, M. T.; Belham, C.; Avruch, J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4EBP1 through a common effector mechanism. J. Biol. Chem., 1998, 273(23), 14484-14494.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.23
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
57
-
-
0036365474
-
Signaling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes
-
Krause, U.; Bertrand, L.; Maisin, L.; Rosa, M.; Hue, L. Signaling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes. Eur. J. Biochem., 2002, 269(15), 3742-3750.
-
(2002)
Eur. J. Biochem.
, vol.269
, Issue.15
, pp. 3742-3750
-
-
Krause, U.1
Bertrand, L.2
Maisin, L.3
Rosa, M.4
Hue, L.5
-
58
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirements for proteins and nucleotide synthesis
-
DeBerardinis, R.J.; Mancuso, A.; Daikhin, E.; Nissim, I.; Yudkoff, M.; Wehrli, S.; Thompson, CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirements for proteins and nucleotide synthesis. Proc. Natl. acad. Sci., 2007, 104(49), 19345-19350.
-
(2007)
Proc. Natl. acad. Sci.
, vol.104
, Issue.49
, pp. 19345-19350
-
-
de Berardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
59
-
-
77955281020
-
Glutamine addiction: A new therapeutic target in cancer
-
Wise, D.R.; Thompson, C. B. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci., 2010, 35(8), 427-433.
-
(2010)
Trends Biochem. Sci.
, vol.35
, Issue.8
, pp. 427-433
-
-
Wise, D.R.1
Thompson, C.B.2
-
60
-
-
34347402459
-
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
-
Yuneva, M.; Zamboni, N.; Oefner, P.; Sachidanandam, R.; Lazebnik, Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J. Cell Biol., 2007, 178(1), 93-105.
-
(2007)
J. Cell Biol.
, vol.178
, Issue.1
, pp. 93-105
-
-
Yuneva, M.1
Zamboni, N.2
Oefner, P.3
Sachidanandam, R.4
Lazebnik, Y.5
-
61
-
-
12844262292
-
N gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site
-
Esslinger, C. S.; Cybulski, K. A.; Rhoderick, J. F. N gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site. Bioorganic. Med. Chem., 2005, 13(4), 1111-1118.
-
(2005)
Bioorganic. Med. Chem.
, vol.13
, Issue.4
, pp. 1111-1118
-
-
Esslinger, C.S.1
Cybulski, K.A.2
Rhoderick, J.F.3
-
62
-
-
0021248051
-
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mito chondrial NAD(P)+-dependent malic enzyme
-
Moreadith, R.W.; Lehninger, A.L. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mito chondrial NAD(P)+-dependent malic enzyme. J. Biol. Chem., 1984, 259(10), 6215-6221.
-
(1984)
J. Biol. Chem.
, vol.259
, Issue.10
, pp. 6215-6221
-
-
Moreadith, R.W.1
Lehninger, A.L.2
-
63
-
-
3242689793
-
New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak
-
Grewer, C.; Grabsch, E. New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. J. Physiol., 2004, 557(Pt 3), 747-759.
-
(2004)
J. Physiol.
, vol.557
, Issue.PART 3
, pp. 747-759
-
-
Grewer, C.1
Grabsch, E.2
-
64
-
-
0032529044
-
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076
-
Pearce, N.J.; Yates, J. W.; Berkhout, T.A.; Jackson, B.; Tew, D.; Boyd, H.; Camilleri, P.; Sweeney, P.; Gribble, A.D.; Shaw, A.; Groot, P.H. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem. J., 1998, 334(Pt1).
-
(1998)
Biochem. J.
, vol.334
, Issue.PART 1
-
-
Pearce, N.J.1
Yates, J.W.2
Berkhout, T.A.3
Jackson, B.4
Tew, D.5
Boyd, H.6
Camilleri, P.7
Sweeney, P.8
Gribble, A.D.9
Shaw, A.10
Groot, P.H.11
-
65
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant, D.A.; Durán, R.V.; Gottlieb, E. Targeting metabolic transformation for cancer therapy. Nat. Rev. Cancer, 2010, 10(4) 267-277.
-
(2010)
Nat. Rev. Cancer
, vol.10
, Issue.4
, pp. 267-277
-
-
Tennant, D.A.1
Durán, R.V.2
Gottlieb, E.3
|