Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes

Life Sciences

Volumn 81, Issue 19-20, 2007, Pages 1436-1445

  Hanioka, Nobumitsu ^a   Yamamoto, Maki ^a   Iwabu, Hiroyuki ^a   Jinno, Hideto ^b   Tanaka Kagawa, Toshiko ^b   Naito, Shinsaku ^c   Shimizu, Takefumi ^d   Masuda, Kazufumi ^a   Katsu, Takashi ^a   Narimatsu, Shizuo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^d N   (Japan)

Author keywords

4 Nitrophenol 2 hydroxylation; Chlorzoxazone 6 hydroxylation; Cynomolgus monkey; CYP2E1; Cytochrome P450 (CYP); Human; Primates

Indexed keywords

4 NITROPHENOL; 6 HYDROXYCHLORZOXAZONE; COMPLEMENTARY DNA; CYTOCHROME P450 2E1; XENOBIOTIC AGENT;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; HYDROXYLATION; LIVER MICROSOME; MOLECULAR CLONING; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; TOXICITY TESTING; YEAST CELL;

AGED; AMINO ACID SEQUENCE; ANIMALS; APOENZYMES; BASE SEQUENCE; CYTOCHROME P-450 CYP2E1; FEMALE; HOLOENZYMES; HUMANS; IMMUNOBLOTTING; KINETICS; MACACA FASCICULARIS; MALE; MICROSOMES, LIVER; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

MACACA FASCICULARIS; PRIMATES;

EID: 35548975119     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.09.002     Document Type: Article

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