Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1546, Issue 1, 2001, Pages 143-155

  Schulz, Thomas G ^a   Thiel, Renate ^b   Neubert, Diether ^b   Brassil, Patrick J ^c   Schulz Utermoehl, Timothy ^a   Boobis, Alan R ^a   Edwards, Robert J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c Servier Research and Development   (United Kingdom)

Author keywords

(Marmoset monkey); Anti peptide antibody; Cytochrome P450; Cytochrome P450 antibody; P450 activity; P450 induction

Indexed keywords

CLOFIBRIC ACID; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 2D19; CYTOCHROME P450 2E1; CYTOCHROME P450 3A21; CYTOCHROME P450 ISOENZYME; DIOXIN; ENZYME ANTIBODY; PHENOBARBITAL; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SPECIFICITY; IMMUNOBLOTTING; LIVER MICROSOME; MALE; MARMOSET; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CALLITHRIX; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; IMMUNOBLOTTING; ISOENZYMES; MALE; MICROSOMES, LIVER; PEPTIDES; SPECIES SPECIFICITY; TETRACHLORODIBENZODIOXIN;

MARMOSETS;

EID: 0035831315     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(01)00134-0     Document Type: Article

References (43)

1. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
2. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes Memorial Lecture
3. The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects
4. Non-Human Primates - Developmental Biology and Toxicology
5. The effects of phenobarbitone on urinary 6 beta-hydroxycortisol excretion and hepatic enzyme activity in the marmoset monkey (Callithrix jacchus)
6. Metabolism of some phenoxazone ethers in liver microsomes of untreated and phenobarbital-treated marmoset monkeys (Callithrix jacchus)
7. Purification and properties of cytochrome P-450 from liver microsomes of phenobarbital-treated marmoset monkeys (Callithrix jacchus)
8. The effect of 3-methylcholanthrene on urinary 6 beta-hydroxycortisol excretion and hepatic enzyme activity in the marmoset monkey (Callithrix jacchus)
9. Comparison of the induction of cytochrome P450 and ethoxyresorufin O-deethylase by a single subcutaneous administration of TCDD in liver microsomes of marmoset monkeys (Callithrix jacchus) and rats
10. Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus)
11. Identification of CYP2E1 in marmoset monkey
12. Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors
13. Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C-termini of cytochrome P450 enzymes
14. Targeting antipeptide antibodies towards cytochrome P450 enzymes
15. Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans
16. Marmoset liver cytochrome P450s: Study for expression and molecular cloning of their cDNAs
17. Marmoset CYP1A2: Primary structure and constitutive expression in livers
18. Ontogeny of monooxygenase activities in the marmoset monkey (Callithrix jacchus)
19. Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations
20. Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens
21. Affinity and potency of proinhibitory antipeptide antibodies against CYP2D6 is enhanced using cyclic peptides as immunogens
22. Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes
23. Inhibition of human CYP1A2 activity in vitro by methylxanthines: Potent competitive inhibition by 8-phenyltheophylline
24. Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function
25. Identification of the epitope of an anti-peptide antibody which binds to CYP1A2 in many species including man
26. Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP
27. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
28. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
29. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
30. Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues
31. 2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes
32. Monospecific antipeptide antibody to cytochrome P-450 2B6
33. Human drug-metabolizing enzyme polymorphisms: Effects on risk of toxicity and cancer
34. Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes
35. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines
36. Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor
37. Production and purification of antibodies against rat liver P450 enzymes
38. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
39. Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s
40. Comparative studies on coumarin and testosterone metabolism in mouse and human livers. Differential inhibitions by the anti-P450Coh antibody and metyrapone
41. Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse
42. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily