Ubiquitous hazardous metal lead induces TNF-α in human phagocytic THP-1 cells: Primary role of ERK 1/2

Journal of Hazardous Materials

Volumn 189, Issue 1-2, 2011, Pages 255-264

  Khan, Mohd Imran ^a   Islam, Najmul ^b   Sahasrabuddhe, Amogh A ^c   Mahdi, Abbas Ali ^d   Siddiqui, Huma ^a   Ashquin, Mohd ^a   Ahmad, Iqbal ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b ALIGARH MUSLIM UNIVERSITY   (India)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

^d KING GEORGE'S MEDICAL UNIVERSITY   (India)

Author keywords

Immunotoxicity; MAPKs; Pb; THP 1; TNF

Indexed keywords

ENVIRONMENTAL CONTAMINANT; HALF LIVES; HAZARDOUS METALS; IMMUNOTOXICITY; MAPKS; MECHANISTIC ASPECTS; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR MECHANISM; PB; POST-TRANSCRIPTIONAL REGULATIONS; PROINFLAMMATORY; PROTEIN SECRETION; SPECIFIC INHIBITORS; THP-1; TUMOR NECROSIS FACTORS;

RNA; STABILITY;

NUCLEIC ACIDS;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEAD; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

CELL ORGANELLE; ENZYME ACTIVITY; GENETIC ANALYSIS; HAZARDOUS WASTE; IMMUNE RESPONSE; INHIBITION; INHIBITOR; LEAD; MOLECULAR ANALYSIS; OBSERVATIONAL METHOD; PROTEIN; TOXICITY; TUMOR;

ARTICLE; CELL VIABILITY; CYTOKINE PRODUCTION; DANGEROUS GOODS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MONOCYTE; PHAGOCYTE; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN STABILITY; TRANSCRIPTION REGULATION; UPREGULATION;

CELL LINE; HAZARDOUS SUBSTANCES; HUMANS; LEAD; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHAGOCYTES; RNA STABILITY; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79953794338     PISSN: 03043894     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2011.02.027     Document Type: Article

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