Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

Arthritis Research and Therapy

Volumn 6, Issue 4, 2004, Pages

  Westra, Johanna ^a   Doornbos van der Meer, Berber ^a   de Boer, Peter ^b   van Leeuwen, Miek A ^a   van Rijswijk, Martin H ^a   Limburg, Pieter C ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b JOHNSON AND JOHNSON   (United States)

Author keywords

COX 2; matrix metalloproteinase; monocyte derived macrophage; p38 MAPK inhibitor; TNF

Indexed keywords

4 [4 (4 FLUOROPHENYL) 1 (3 PHENYLPROPYL) 5 (4 PYRIDINYL) 1H IMIDAZOL 2 YL] 3 BUTYN 1 OL; CYCLOOXYGENASE 2; CYTOKINE; IMIDAZOLE DERIVATIVE; INTERLEUKIN 8; ISOENZYME; MAP KINASE ACTIVATED KINASE 2; MAP-KINASE-ACTIVATED KINASE 2; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN SYNTHASE; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; MACROPHAGE; METABOLISM; MONOCYTE; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CELLS, CULTURED; CYCLOOXYGENASE 2; CYTOKINES; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMIDAZOLES; INTERLEUKIN-8; ISOENZYMES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 7244243748     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar1204     Document Type: Article

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