Two brain sites for cannabinoid reward

Journal of Neuroscience

Volumn 26, Issue 18, 2006, Pages 4901-4907

  Zangen, Abraham ^a,b   Solinas, Marcello ^a,c   Ikemoto, Satoshi ^a   Goldberg, Steven R ^a   Wise, Roy A ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c UNIVERSITÉ DE POITIERS   (France)

Author keywords

Locomotion; Nucleus accumbens; Reward; Self administration; THC; Ventral tegmental area

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR ANTAGONIST; TETRAHYDROCANNABINOL; PSYCHOTROPIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; COMPARATIVE STUDY; DRUG EFFECT; INSTRUMENTAL CONDITIONING; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; REWARD; SELF STIMULATION; SPRAGUE DAWLEY RAT; TIME;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CANNABINOIDS; CONDITIONING, OPERANT; MALE; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; PSYCHOTROPIC DRUGS; RATS; RATS, SPRAGUE-DAWLEY; REWARD; SELF STIMULATION; TETRAHYDROCANNABINOL; TIME FACTORS; VENTRAL TEGMENTAL AREA;

EID: 33646929784     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3554-05.2006     Document Type: Article

References (41)

1. Bardo MT, Rowlett JK, Harris MJ (1995) Conditioned place preference using opiate and stimulant drugs: a meta-analysis. Neurosci Biobehav Rev 19:39-51.
2. Bolanos CA, Perrotti LI, Edwards S, Eisch AJ, Barrot M, Olson VG, Russell DS, Neve RL, Nestler EJ (2003) Phospholipase Cγ in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. J Neurosci 23:7569-7576.
3. Bozarth MA, Wise RA (1981) Intracranial self-administration of morphine into the ventral tegmental area in rats. Life Sci 28:551-555.
4. Carlezon Jr WA, Wise RA (1996) Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. J Neurosci 16:3112-3122.
5. Carlezon Jr WA, Haile CN, Coppersmith R, Hayashi Y, Malinow R, Neve RL, Nestler EJ (2000) Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1. J Neurosci 20:RC62.
6. Devine DP, Wise RA (1994) Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats. J Neurosci 14:1978-1984.
7. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278.
8. Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors. Neurosci Lett 226:159-162.
9. Gardner EL, Paredes W, Smith D, Donner A, Milling C, Cohen D, Morrison D (1988) Facilitation of brain stimulation reward by delta 9-tetrahydrocannabinol. Psychopharmacology (Berl) 96:142-144.
10. Giroud C, Menetrey A, Augsburger M, Buclin T, Sanchez-Mazas P, Mangin P (2001) Delta(9)-THC, 11-OH-Delta(9)-THC and Delta(9)-THCCOOH plasma or serum to whole blood concentrations distribution ratios in blood samples taken from living and dead people. Forensic Sci Int 123:159-164.
11. Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11:563-583.
12. Hoebel BG, Monaco AP, Hernandez L, Aulisi EF, Stanley BG, Lenard L (1983) Self-injection of amphetamine directly into the brain. Psychopharmacology (Berl) 81:158-163.
13. Hohmann AG, Herkenham M (2000) Localization of cannabinoid CB(1) receptor mRNA in neuronal subpopulations of rat striatum: a double-label in situ hybridization study. Synapse 37:71-80.
14. Ikemoto S (2003) Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. J Neurosci 23:9305-9511.
15. Ikemoto S, Sharpe LG (2001) A head-attachable device for injecting nanoliter volumes of drug solutions into brain sites of freely moving rats. J Neurosci Methods 110:135-140.
16. Ikemoto S, Wise RA (2002) Rewarding effects of carbachol and neostigmine in the posterior ventral tegmental area. J Neurosci 22:9895-9904.
17. Ikemoto S, Murphy JM, McBride WJ (1997a) Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions. Behav Neurosci 111:369-380.
18. 2 receptors in the nucleus accumbens in mediating reward. J Neurosci 17:8580-8587.
19. Ikemoto S, Murphy JM, McBride WJ (1998) Regional differences within the rat ventral tegmental area for muscimol self-infusions. Pharmacol Biochem Behav 61:87-92.
20. Δ9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys. Psychopharmacology 169:135-140.
21. Laviolette SR, van der Kooy D (2001) GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems. Eur J Neurosci 13:1009-1015.
22. Laviolette SR, van der Kooy D (2003) Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area. Mol Psychiatry 8:50-59.
23. Lepore M, Vorel SR, Lowinson J, Gardner EL (1995) Conditioned place preference induced by delta 9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward. Life Sci 56:2073-2080.
24. Lupica CR, Riegel AC, Hoffman AF (2004) Marijuana and cannabinoid regulation of brain reward circuits. Br J Pharmacol 143(2):227-234.
25. Manzoni OJ, Bockaert J (2001) Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens. Eur J Pharmacol 412:R3-R5.
26. Martin TJ, Kim SA, Lyupina Y, Smith JE (2002) Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of beta-funaltrexamine. Psychopharmacology (Berl) 161:152-159.
27. Ng Cheong Ton JM, Gerhardt GA, Friedemann M, Etgen AM, Rose GM, Sharpless NS, Gardner EL (1988) The effects of delta 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study. Brain Res 451:59-68.
28. Olds ME (1982) Reinforcing effects of morphine in the nucleus accumbens. Brain Res 237:429-440.
29. Parolaro D, Vigano D, Rubino T (2005) Endocannabinoids and drug dependence. Curr Drug Targets CNS Neurol Disord 4:643-655.
30. Paxinos G, Watson, CS (1998) The rat brain in stereotaxic coordinates. San Diego: Academic.
31. Reynolds SM, Berridge KC (2002) Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste "liking"/"disliking" reactions, place preference/avoidance, and fear. J Neurosci 22:7308-7320.
32. Rodd-Henricks ZA, McKinzie DL, Crile RS, Murphy JM, McBride WJ (2000) Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats. Psychopharmacology (Berl) 149:217-224.
33. Rodd ZA, Melendez RI, Bell RL, Kuc KA, Zhang Y, Murphy JM, McBride WJ (2004) Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons. J Neurosci 24:1050-1057.
34. Solinas M, Panlilio LV, Antoniou K, Pappas LA, Goldberg SR (2003) The cannabinoid CB1 antagonist SR-141716A differentially alters the reinforcing effects of heroin under continuous-reinforcement, fixed-ratio and progressive-ratio schedules of drug self-administration in rats. J Pharmacol Exp Ther 306:93-102.
35. 1 opioid receptor mechanism. Science 27:2048-2050.
36. Tanda G, Munzar P, Goldberg SR (2000) Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys. Nat Neurosci 3:1073-1074.
37. Valjent E, Maldonado R (2000) A behavioural model to reveal place preference to delta 9-tetrahydrocannabinol in mice. Psychopharmacology (Berl) 147:436-438.
38. Wise RA (1998) Drug-activation of brain reward pathways. Drug Alcohol Depend 51:13-22.
39. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469-492.
40. Wise RA, Hoffman DC (1992) Localization of drug reward mechanisms by intracranial injections. Synapse 10:247-263.
41. Zangen A, Ikemoto S, Zadina JE, Wise RA (2002) Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbens. J Neurosci 22:7225-7233.