Allogeneic apoptotic thymocyte-stimulated dendritic cells expand functional regulatory T cells

Immunology

Volumn 133, Issue 1, 2011, Pages 123-132

  Da Costa, Thaís Boccia ^a   Sardinha, Luiz R ^b   Larocca, Rafael ^a   Peron, Jean P S ^a   Rizzo, Luiz V ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Albert Einstein Jewish Institute for Education and Research   (Brazil)

Author keywords

Apoptosis; Dendritic cells; Foxp3; Peripheral tolerance; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; LIPOPOLYSACCHARIDE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ALLOGENEIC; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CELL CONTACT; CELL COUNT; CELL FUNCTION; CELL INFILTRATION; CELL MATURATION; CELL PROLIFERATION; CELL SELECTION; CELL TRANSFER; COLON; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; LYMPH NODE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPLEEN CELL; STOMACH; T LYMPHOCYTE; THYMOCYTE; UPREGULATION;

ANIMALS; APOPTOSIS; CELL SEPARATION; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY;

EID: 79953313222     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03420.x     Document Type: Article

References (44)

1. Bach FH, Alter BJ, Schendel DJ, Segall M, Bach ML. Genetic and cellular control of in vitro models of allograft reactivity. Birth Defects Orig Artic Ser 1975; 11:467-76.
2. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2:151-61.
3. + regulatory T cells by antigen-processing dendritic cells. J Exp Med 2003; 198:235-47.
4. Zhang X, Li M, Lian D et al. Generation of therapeutic dendritic cells and regulatory T cells for preventing allogeneic cardiac graft rejection. Clin Immunol 2008; 127:313-21.
5. Gallucci S, Lolkema M, Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999; 5:1249-55.
6. Steinman RM, Turley S, Mellman I, Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000; 191:411-6.
7. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 2000; 191:423-34.
8. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005; 6:1142-51.
9. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-61.
10. + regulatory T cells. Nat Immunol 2003; 4:330-6.
11. Lipscomb MW, Taylor JL, Goldbach CJ, Watkins SC, Wesa AK, Storkus WJ. DC expressing transgene Foxp3 are regulatory APC. Eur J Immunol 2010; 40:480-93.
12. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999; 162:5317-26.
13. + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005; 201:723-35.
14. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-64.
15. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I. Immunosuppressive effects of apoptotic cells. Nature 1997; 390:350-1.
16. + T cells by bone marrow-derived dendritic cells. Immunology 2009; 127:50-61.
17. + population without exogenous cytokines. Scand J Immunol 2010; 71:12-9.
18. + regulatory T cells including suppressors of alloreactivity. Immunol Rev 2006; 212:314-29.
19. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10:1969-80.
20. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16:311-23.
21. Peng Y, Martin DA, Kenkel J, Zhang K, Ogden CA, Elkon KB. Innate and adaptive immune response to apoptotic cells. J Autoimmun 2007; 29:303-9.
22. Fransen JH, Hilbrands LB, Ruben J et al. Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17. Arthritis Rheum 2009; 60:2304-13.
23. Trinchieri G, Wysocka M, D'Andrea A et al. Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation. Prog Growth Factor Res 1992; 4:355-68.
24. Leonard JP, Waldburger KE, Schaub RG et al. Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12. Crit Rev Immunol 1997; 17:545-53.
25. Kim S, Elkon KB, Ma X. Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Immunity 2004; 21:643-53.
26. Kushwah R, Oliver JR, Zhang J, Siminovitch KA, Hu J. Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells. J Immunol 2009; 183:7104-18.
27. + Treg. Eur J Immunol 2010; 40:1022-35.
28. Huynh ML, Fadok VA, Henson PM. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 2002; 109:41-50.
29. Chen X, Doffek K, Sugg SL, Shilyansky J. Phosphatidylserine regulates the maturation of human dendritic cells. J Immunol 2004; 173:2985-94.
30. Morelli AE, Larregina AT. Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells. Apoptosis 2010; 15:1083-97.
31. Takahashi M, Kobayashi Y. Cytokine production in association with phagocytosis of apoptotic cells by immature dendritic cells. Cell Immunol 2003; 226:105-15.
32. + immunoregulatory T cells is antigen nonspecific. J Immunol 2000; 164:183-90.
33. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188:287-96.
34. + T cells: a population of T cells with immune regulatory activities in vitro. Eur J Immunol 1998; 28:3435-47.
35. + T cells. J Immunol 2004; 173:5008-20.
36. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190:995-1004.
37. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193:1295-302.
38. + T cells. Proc Natl Acad Sci USA 2002; 99:8832-7.
39. + donors confer complete protection against spontaneous experimental encephalomyelitis (Sp-EAE) in TCR transgenic, RAG-/- mice. J Neurosci Res 2003; 71:89-103.
40. + T cells induce or protect from chronic intestinal inflammation in C.B-17 SCID mice. Int Immunol 1993; 5:1461-71.
41. Powrie F, Leach MW. Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Ther Immunol 1995; 2:115-23.
42. + regulatory cells that control intestinal inflammation. J Exp Med 2000; 192:295-302.
43. Read S, Powrie F. Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells. Curr Protoc Immunol 2001;Chapter 15:Unit 15.13.
44. Inaba K, Inaba M, Romani N et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176:1693-702.