Generation of therapeutic dendritic cells and regulatory T cells for preventing allogeneic cardiac graft rejection

Clinical Immunology

Volumn 127, Issue 3, 2008, Pages 313-321

  Zhang, Xusheng ^a   Li, Mu ^a   Lian, Dameng ^a   Zheng, Xiufen ^a   Zhang, Zhu Xu ^a   Ichim, Thomas E ^a,b   Xia, Xiaoping ^a   Huang, Xuyan ^a   Vladau, Costin ^a   Suzuki, Motohiko ^a   Garcia, Bertha ^a,c   Jevnikar, Anthony M ^a,c,d   Min, Wei Ping ^a,c,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MediStem Laboratories Inc   (United States)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

^d LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Dendritic cells; Immune modulation; T regulatory cells; Transplant tolerance

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOMODULATING AGENT; INTERLEUKIN 2 RECEPTOR ALPHA; LF 15 0195; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CARDIAC GRAFT REJECTION; CELL COUNT; CONTROLLED STUDY; DENDRITIC CELL; EX VIVO STUDY; FEEDBACK SYSTEM; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOREGULATION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TRANSPLANTATION TOLERANCE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD40; ANTIGENS, CD86; DENDRITIC CELLS; GRAFT REJECTION; GRAFT SURVIVAL; GUANIDINES; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE;

EID: 45249109971     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2008.01.013     Document Type: Article

References (37)

1. Lechler R., Ng W.F., and Steinman R.M. Dendritic cells in transplantation--friend or foe?. Immunity 14 (2001) 357-368
2. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21 (2003) 685-711
3. Mahnke K., Schmitt E., Bonifaz L., Enk A.H., and Jonuleit H. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol. Cell Biol. 80 (2002) 477-483
4. Gilliet M., and Liu Y.J. Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum. Immunol. 63 (2002) 1149-1155
5. Roelen D.L., Schuurhuis D.H., van den Boogaardt D.E., Koekkoek K., van Miert P.P., van Schip J.J., Laban S., Rea D., Melief C.J., Offringa R., Ossendorp F., and Claas F.H. Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation 76 (2003) 1608-1615
6. Hackstein H., Steinschulte C., Fiedel S., Eisele A., Rathke V., Stadlbauer T., Taner T., Thomson A.W., Tillmanns H., Bein G., and Holschermann H. Sanglifehrin a blocks key dendritic cell functions in vivo and promotes long-term allograft survival together with low-dose CsA. Am. J. Transplant. 7 (2007) 789-798
7. Homann D., Jahreis A., Wolfe T., Hughes A., Coon B., van Stipdonk M.J., Prilliman K.R., Schoenberger S.P., and von Herrath M.G. CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity 16 (2002) 403-415
8. Liang X., Lu L., Zhang H., Vickers T., Fung J.J., and Qian S. Phenotype and allostimulatory function of dendritic cells treated with antisense oligodeoxyribonucleotides targeting CD80 or CD86 mRNA. Transplant. Proc. 33 (2001) 235
9. Lagaraine C., and Lebranchu Y. Effects of immunosuppressive drugs on dendritic cells and tolerance induction. Transplantation 75 (2003) 37S-42S
10. Chen C., Qu Q.X., Huang J.A., Zhu Y.B., Ge Y., Wang Q., and Zhang X.G. Expression of programmed-death receptor ligands 1 and 2 may contribute to the poor stimulatory potential of murine immature dendritic cells. Immunobiology 212 (2007) 159-165
11. Zhou D., O'Brien C., Shum J., Garcia B., Min W., Jevnikar A.M., Dutartre P., and Zhong R. LF 15-0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model. Transplantation 76 (2003) 644-650
12. Ducoroy P., Micheau O., Perruche S., Dubrez-Daloz L., de Fornel D., Dutartre P., Saas P., and Solary E. LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level. Blood 101 (2003) 194-201
13. Yang J., Bernier S.M., Ichim T.E., Li M., Xia X., Zhou D., Huang X., Strejan G.H., White D.J., Zhong R., and Min W.P. LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J. Leukoc. Biol. 74 (2003) 438-447
14. Ichim T.E., Zhong R., and Min W.P. Prevention of allograft rejection by in vitro-generated tolerogenic dendritic cells. Transpl. Immunol. 11 (2003) 295-306
15. McHugh R.S., and Shevach E.M. The role of suppressor T cells in regulation of immune responses. J. Allergy Clin. Immunol. 110 (2002) 693-702
16. Wood K.J., and Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat. Rev., Immunol. 3 (2003) 199-210
17. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6 (2005) 345-352
18. Taylor P.A., Lees C.J., and Blazar B.R. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99 (2002) 3493-3499
19. Min W.P., Zhou D., Ichim T.E., Strejan G.H., Xia X., Yang J., Huang X., Garcia B., White D., Dutartre P., Jevnikar A.M., and Zhong R. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J. Immunol. 170 (2003) 1304-1312
20. Parry N., Lazarovits A.I., Wang J., Garcia B., Luke P., Poppema S., and Zhong R. Cyclosporine inhibits long-term survival in cardiac allografts treated with monoclonal antibody against CD45RB. J. Heart Lung Transplant. 18 (1999) 441-447
21. Nouri-Shirazi M., and Guinet E. Direct and indirect cross-tolerance of alloreactive T cells by dendritic cells retained in the immature stage. Transplantation 74 (2002) 1035-1044
22. Min W.P., Zhou D., Ichim T.E., Xia X., Zhang X., Yang J., Huang X., Garcia B., Dutartre P., Jevnikar A.M., Strejan G.H., and Zhong R. Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation 75 (2003) 1160-1165
23. Alpan O., Bachelder E., Isil E., Arnheiter H., and Matzinger P. "Educated" dendritic cells act as messengers from memory to naive T helper cells. Nat. Immunol. 5 (2004) 615-622
24. Bacchetta R., Gregori S., and Roncarolo M.G. CD4+ regulatory T cells: mechanisms of induction and effector function. Autoimmun. Rev. 4 (2005) 491-496
25. Bushell A., and Wood K. GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function. Am. J. Transplant 7 (2007) 759-768
26. Li W., Carper K., Liang Y., Zheng X.X., Kuhr C.S., Reyes J.D., Perkins D.L., Thomson A.W., and Perkins J.D. Anti-CD25 mAb administration prevents spontaneous liver transplant tolerance. Transplant. Proc. 38 (2006) 3207-3208
27. Golshayan D., Jiang S., Tsang J., Garin M.I., Mottet C., and Lechler R.I. In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. Blood 109 (2007) 827-835
28. Xia X., Zhang X., Huang X., Li M., Zhao L., Tian D., Zhong R., and Min W.P. LF 15-0195 generates synergistic tolerance by promoting formation of CD4+CD25+CTLA4+ T cells. J. Immunother. (1997) 28 (2005) 560-563
29. Yates S.F., Paterson A.M., Nolan K.F., Cobbold S.P., Saunders N.J., Waldmann H., and Fairchild P.J. Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation. J. Immunol. 179 (2007) 967-976
30. Turnquist H.R., Raimondi G., Zahorchak A.F., Fischer R.T., Wang Z., and Thomson A.W. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J. Immunol. 178 (2007) 7018-7031
31. Tarbell K.V., Petit L., Zuo X., Toy P., Luo X., Mqadmi A., Yang H., Suthanthiran M., Mojsov S., and Steinman R.M. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J. Exp. Med. 204 (2007) 191-201
32. Volkmann A., Neefjes J., and Stockinger B. A conditionally immortalized dendritic cell line which differentiates in contact with T cells or T cell-derived cytokines. Eur. J. Immunol. 26 (1996) 2565-2572
33. Kitajima T., Caceres-Dittmar G., Tapia F.J., Jester J., Bergstresser P.R., and Takashima A. T cell-mediated terminal maturation of dendritic cells: loss of adhesive and phagocytotic capacities. J. Immunol. 157 (1996) 2340-2347
34. Shreedhar V., Moodycliffe A.M., Ullrich S.E., Bucana C., Kripke M.L., and Flores-Romo L. Dendritic cells require T cells for functional maturation in vivo. Immunity 11 (1999) 625-636
35. Grabbe S., Gallo R.L., Lindgren A., and Granstein R.D. Deficient antigen presentation by Langerhans cells from athymic (nu/nu) mice. Restoration with thymic transplantation or administration of cytokines. J. Immunol. 151 (1993) 3430-3439
36. Tang Q., Adams J.Y., Tooley A.J., Bi M., Fife B.T., Serra P., Santamaria P., Locksley R.M., Krummel M.F., and Bluestone J.A. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7 (2006) 83-92
37. Serra P., Amrani A., Yamanouchi J., Han B., Thiessen S., Utsugi T., Verdaguer J., and Santamaria P. CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. Immunity 19 (2003) 877-889