Chronic central leptin infusion differently modulates brain and liver insulin signaling

Molecular and Cellular Endocrinology

Volumn 337, Issue 1-2, 2011, Pages 89-95

  Berthou, Flavien ^a   Rouch, Claude ^b   Gertler, Arieh ^c   Gerozissis, Kyriaki ^a   Taouis, Mohammed ^a  

^a CNRS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Hypothalamus; Insulin sensitivity; Insulin resistance; Leptin; Liver; PTP1B; Signaling pathways

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LEPTIN; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; SERINE; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; HYPOTHALAMUS; INSULIN SENSITIVITY; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD GLUCOSE; BRAIN; EATING; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; LEPTIN; LIVER; MALE; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; WEIGHT GAIN;

EID: 79953311639     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2011.02.005     Document Type: Article

References (38)

1. Bence K.K., Delibegovic M., Xue B., Gorgun C.Z., Hotamisligil G.S., Neel B.G., Kahn B.B. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat. Med. 2006, 12:917-924.
2. Benomar Y., Roy A.F., Aubourg A., Djiane J., Taouis M. Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line. Biochem. J. 2005, 388:929-939.
3. Benomar Y., Wetzler S., Larue-Achagiotis C., Djiane J., Tomé D., Taouis M. In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. Mol. Cell. Endocrinol. 2005, 242:59-66.
4. Benomar Y., Berthou F., Vacher C.M., Bailleux V., Gertler A., Djiane J., Taouis M. Leptin but not ciliary neurotrophic factor (CNTF) induces phosphotyrosine phosphatase-1B expression in human neuronal cells (SH-SY5Y): putative explanation of CNTF efficacy in leptin-resistant state. Endocrinology 2009, 150:1182-1191.
5. Carvalheira J.B., Siloto R.M., Ignacchitti I., Brenelli S.L., Carvalho C.R., Leite A., Velloso L.A., Gontijo J.A., Saad M.J. Insulin modulates leptin-induced STAT-3 activation in rat hypothalamus. FEBS Lett. 2001, 500:119-124.
6. Carvalheira J.B., Ribeiro E.B., Folli F., Velloso L.A., Saad M.J. Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol. Chem. 2003, 384:151-159.
7. Carvalheira J.B., Torsoni M.A., Ueno M., Amaral M.E., Araújo E.P., Velloso L.A., Gontijo J.A., Saad M.J. Cross-talk between the insulinand leptin signaling systems in rat hypothalamus. Obes. Res. 2005, 13:48-57.
8. Cusin I., Zakrzewska K.E., Boss O., Muzzin P., Giacobino J.P., Ricquier D., Jeanrenaud B., Rohner-Jeanrenaud F. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes 1998, 47:1014-1019.
9. Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Loy A.L., Normandin D., Cheng A., Himms-Hagen J., Chan C.C., Ramachandran C., Gresser M.J., Tremblay M.L., Kennedy B.P. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999, 283:1544-1548.
10. Emilsson V., Liu Y.L., Cawthorne M.A., Morton N.M., Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997, 46:313-316.
11. Fehmann H.C., Peiser C., Bode H.P., Stamm M., Staats P., Hedetoft C., Lang R.E., Göke B. Leptin: a potent inhibitor of insulin secretion. Peptides 1997, 18:1267-1273.
12. German J., Kim F., Schwartz G.J., Havel P.J., Rhodes C.J., Schwartz M.W., Morton G.J. Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology 2009, 150:4502-4511.
13. Harris R.B. Acute and chronic effects of leptin on glucose utilization in lean mice. Biochem. Biophys. Res. Commun. 1998, 245:502-509.
14. Ishida K., Murakami T., Mizuno A., Iida M., Kuwajima M., Shima K. Leptin suppresses basal insulin secretion from rat pancreatic islets. Regul. Pept. 1997, 70:179-182.
15. Kalra S.P. Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides 2009, 30:1957-1963.
16. Kieffer T.J., Heller R.S., Leech C.A., Holz G.G., Habener J.F. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 1997, 46:1087-1093.
17. Klaman L.D., Boss O., Peroni O.D., Kim J.K., Martino J.L., Zabolotony J.M., Moghal N., Lubkin M., Kim Y.B., Sharpe A.H., Stricker-Krongrad A., Shulman G.I., Neel B.G., Kahn B.B. Increased energy expenditure, decreased adiposity and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell Biol. 2000, 20:5479-5489.
18. Lam N.T., Lewis J.T., Cheung A.T., Luk C.T., Tse J., Wang J., Bryer-Ash M., Kolls J.K., Kieffer T.J. Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Mol. Endocrinol. 2004, 18:1333-1345.
19. Lin C.Y., Higginbotham D.A., Judd R.L., White B.D. Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. Am. J. Physiol. Endocrinol. Metab. 2002, 282:E1084-E1091.
20. Morino K., Neschen S., Bilz S., Sono S., Tsirigotis D., Reznick R.M., Moore I., Nagai Y., Samuel V., Sebastian D., White M., Philbrick W., Shulman G.I. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes 2008, 57:2644-2651.
21. Morton G.J., Gelling R.W., Niswender K.D., Morrison C.D., Rhodes C.J., Schwartz M.W. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2005, 2:411-420.
22. Münzberg H., Flier J.S., Bjørbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004, 145:4880-4889.
23. Ookuma M., Ookuma K., York D.A. Effects of leptin on insulin secretion from isolated rat pancreatic islets. Diabetes 1998, 47:219-223.
24. Pallett A.L., Morton N.M., Cawthorne M.A., Emilsson V. Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochem. Biophys. Res. Commun. 1997, 238:267-270.
25. Park S., Hong S.M., Sung S.R., Jung H.K. Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling. Endocrinology 2008, 149:445-454.
26. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995, 269:540-543.
27. Peters J.H., Simasko S.M., Ritter R.C. Leptin analog antagonizes leptin effects on food intake and body weight but mimics leptin-induced vagal afferent activation. Endocrinology 2007, 148:2878-2885.
28. Picardi P.K., Calegari V.C., Prada P.O., Moraes J.C., Araújo E., Marcondes M.C., Ueno M., Carvalheira J.B., Velloso L.A., Saad M.J. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology 2008, 149:3870-3880.
29. Poitout V., Rouault C., Guerre-Millo M., Briaud I., Reach G. Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology 1998, 139:822-826.
30. Roman E.A., Reis D., Romanatto T., Maimoni D., Ferreira E.A., Santos G.A., Torsoni A.S., Velloso L.A., Torsoni M.A. Central leptin action improves skeletal muscle AKT, AMPK, and PGC1alpha activation by hypothalamic PI3K-dependent mechanism. Mol. Cell. Endocrinol. 2009, 314:62-69.
31. Salomon G., Niv-Spector L., Gussakovsky E.E., Gertler A. Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists. Protein Expr. Purif. 2006, 47:128-136.
32. Sivitz W.I., Walsh S.A., Morgan D.A., Thomas M.J., Haynes W.G. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997, 138:3395-3401.
33. Szanto I., Kahn C.R. Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:2355-2360.
34. Werner E.D., Lee J., Hansen L., Yuan M., Shoelson S.E. Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. J. Biol. Chem. 2004, 279:35298-35305.
35. White C.L., Whittington A., Barnes M.J., Wang Z., Bray G.A., Morrison C.D. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependant and independent mechanisms. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E291-E299.
36. Yaspelkis B.B., Ansari L., Ramey E.L., Holland G.J., Loy S.F. Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport. Metabolism 1999, 48:671-676.
37. Yaspelkis B.B., Davis J.R., Saberi M., Smith T.L., Jazayeri R., Singh M., Fernandez V., Trevino B., Chinookoswong N., Wang J., Shi Z.Q., Levin N. Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats. Am. J. Physiol. Endocrinol. Metab. 2001, 280:E130-E142.
38. Yaspelkis B.B., Singh M.K., Krisan A.D., Collins D.E., Kwong C.C., Bernard J.R., Crain A.M. Chronic leptin treatment enhances insulin-stimulated glucose disposal in skeletal muscle of high-fat fed rodents. Life Sci. 2004, 74:1801-1816.