In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus

Molecular and Cellular Endocrinology

Volumn 242, Issue 1-2, 2005, Pages 59-66

  Benomar, Yacir ^a   Wetzler, Sandrine ^b   Larue Achagiotis, Christiane ^b   Djiane, Jean ^a   Tomé, Daniel ^b   Taouis, Mohammed ^a  

^a CNRS   (France)

^b INRA Institut National de la Recherche Agronomique   (France)

Author keywords

Hypothalamus; Leptin and insulin resistance; Liver; Signal transduction

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HYPERLEPTINEMIA; HYPOTHALAMUS; IN VIVO STUDY; INFUSION; INSULIN RESISTANCE; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BODY WEIGHT; EATING; HYPOTHALAMUS; INFUSIONS, PARENTERAL; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; LIVER; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; RATS, WISTAR; SHEEP; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 25844471008     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2005.07.003     Document Type: Article

References (24)

1. C. Anderwald, G. Muller, G. Koca, C. Furnsinn, W. Waldhausl, and M. Roden Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate 2 Mol. Endocrinol. 16 2002 1612 1628
2. N. Barzilai, J. Wang, D. Massilon, P. Vuguin, M. Hawkins, and L. Rossetti Leptin selectively decreases visceral adiposity and enhances insulin action J. Clin. Invest. 100 1997 3105 3110
3. J.B.C. Carvalheira, R.M.P. Siloto, I. Ignacchetti, S.L. Brenelli, C.R.O. Carvalho, A. Leite, L.A. Velloso, J.A.R. Gontijo, and M.J.A. Saad Insulin modulates leptin-induced STAT-3 activation in rat hypothalamus FEBS Lett. 500 2001 119 124
4. J.A. Cases, I. Gabriely, X.H. Ma, X.M. Yang, T. Michaeli, N. Fleischer, L. Rossetti, and N. Barzilai Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo Diabetes 50 2001 348 352
5. R.B. Ceddia, H.A. Koistinen, J.R. Zierath, and G. Sweeney Analysis of paradoxical observations on the association between leptin and insulin resistance FASEB J. 16 2002 1163 1176
6. N. Chinookoswong, J.L. Wang, and Z.Q. Shi Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat Diabetes 48 1999 1478 1492
7. B. Cohen, D. Novick, and M. Rubinstein Modulation of insulin activities by leptin Science 274 1996 1185 1188
8. R.V. Considine, M.K. Sinha, M.L. Heiman, A. Kriauciunas, T.W. Stephens, M.R. Nyce, J.P. Ohannesian, C.C. Marco, L.J. McKee, and T.L. Bauer Serum immunoreactiveleptin concentrations in normal-weight and obese humans N. Engl. J. Med. 334 1996 292 295
9. A. Gertler, J. Simmons, and D.H. Keisler Preparation and characterization of recombinant ovine obese protein (leptin) FEBS Lett. 422 1998 137 140
10. Y.B. Kim, S. Uotani, D.D. Pierroz, J.S. Flier, and B.B. Kahn In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin Endocrinology 141 2000 2328 2339
11. L. Liu, G.B. Karkanias, J.C. Morales, M. Hawkins, N. Barzilai, J. Wang, and L. Rossetti Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes J. Biol. Chem. 273 1998 31160 31167
12. G. Muller, J. Ertl, M. Gerl, and G. Preibisch Leptin impairs metabolic actions of insulin in isolated rat adipocytes J. Biol. Chem. 272 1997 10585 10593
13. P. Muzzin, R.C. Eisensmith, K.C. Copeland, and S.L. Woo Correction of obesity and diabetes in genetically obese mice by leptin therapy Proc. Natl. Acad. Sci. U.S.A. 93 1996 14803 14808
14. C. Perez, C. Fernandez-Galaz, T. Fernandez-Agullo, C. Arribas, A. Andres, M. Ros, and J.M. Carrasco Leptin impairs insulin signaling in rat adipocytes Diabetes 53 2004 347 353
15. K.F. Petersen, E.A. Oral, S. Dufour, D. Befroy, C. Ariyan, C. Yu, G.W. Cline, A.M. Depaoli, S.I. Taylor, P. Gorden, and G.I. Shulman Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy J. Clin. Invest. 109 2002 1345 1350
16. L. Rossetti, D. Massilon, N. Barzilai, P. Vuguin, W. Chen, M. Hawkins, J. Wu, and J. Wang Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action J. Biol. Chem. 272 1997 27758 27763
17. M.K. Singh, A.D. Krisan, A.M. Crain, D.E. Collins, and B.B. Yaspelkis High fat diet and leptin treatment alter skeletal muscle insulin-stimulated phosphatidylinositol 3-kinase activity and glucose transport Metabolism 52 2003 1196 1205
18. W.I. Sivitz, S.A. Walsh, D.A. Morgan, M.J. Thomas, and W.G. Haynes Effects of leptin on insulin sensitivity in normal rats Endocrinology 138 1997 3395 3401
19. G. Sweeney, J. Keen, R. Somwar, D. Konrad, R. Garg, and A. Klip High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting Glut4 translocation in L6 rat skeletal muscle cells Endocrinology 142 2001 4806 4812
20. I. Szanto, and C.R. Kahn Selective interaction between leptin and insulin signaling pathways in a hepatic cell line Proc. Natl. Acad. Sci. U.S.A. 97 2000 2355 2360
21. Y. Wang, K.K. Kuropatwinski, D.W. White, T.S. Hawley, R.G. Hawley, L.A. Tartaglia, and H. Baumann Leptin receptor action in hepatic cells J. Biol. Chem. 272 1997 16216 16223
22. S. Wetzler, V. Dumaz, M. Goubern, D. Tome, and C. Larue-Achagiotis Intra-peritoneal leptin modifies macronutrient choice in self-selecting rats Physiol. Behav. 83 2004 65 72
23. P.S. Widdowson, R. Upton, L. Pickavance, R. Buckingham, M. Tadayyon, J. Arch, and G. Williams Acute hyperleptinemia does not modify insulin sensitivity in vivo in rat Horm. Metab. Res. 30 1998 259 262
24. J.R. Zierath, E.U. Frevert, J.W. Ryder, P.O. Berggren, and B.B. Kahn Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes Diabetes 47 1998 1 4