Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro

Experimental and Molecular Pathology

Volumn 90, Issue 3, 2011, Pages 295-299

  Oliva, Joan ^a   Bardag Gorce, Fawzia ^a   Tillman, Brittany ^a   French, Samuel W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Betaine; Oxidative stress; Quercetin

Indexed keywords

4 HYDROXYNONENAL; ALCOHOL; ARACHIDONIC ACID; BETAINE; CATECHIN; CELL PROTEIN; CYTOCHROME P450 2E1; EPIGALLOCATECHIN GALLATE; HEAT SHOCK PROTEIN 40; IRON; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROTEIN GADD45B; QUERCETIN; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PROTEIN EXPRESSION; UPREGULATION;

ALDEHYDES; ANTI-INFECTIVE AGENTS, LOCAL; ANTIOXIDANTS; BETAINE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CATECHIN; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; ETHANOL; GASTROINTESTINAL AGENTS; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MALONDIALDEHYDE; OXIDATIVE STRESS; QUERCETIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79953264495     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2011.02.006     Document Type: Article

References (46)

1. Arteel G.E., et al. Green tea extract protects against early alcohol-induced liver injury in rats. Biol. Chem. 2002, 383:663-670.
2. Barak A.J., et al. Betaine effects on hepatic methionine metabolism elicited by short-term ethanol feeding. Alcohol 1996, 13:483-486.
3. Barak A.J., et al. Ethanol, the choline requirement, methylation and liver injury. Life Sci. 1985, 37:789-791.
4. Bardag-Gorce F., et al. Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared. Exp. Mol. Pathol. 2006, 80:241-251.
5. Bardag-Gorce F., et al. Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels. Exp. Mol. Pathol. 2007, 82:197-202.
6. Bardag-Gorce F., et al. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Exp. Mol. Pathol. 2006, 81:191-201.
7. Bardag-Gorce F., et al. Chronic ethanol feeding alters hepatocyte memory which is not altered by acute feeding. Alcohol. Clin. Exp. Res. 2009, 33:684-692.
8. Caro A.A., Cederbaum A.I. Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1. Mol. Pharmacol. 2001, 60:742-752.
9. Cederbaum A.I. Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World J. Gastroenterol. 2011, 16:1366-1376.
10. Chen X., et al. Pharmacokinetics and modeling of quercetin and metabolites. Pharm. Res. 2005, 22:892-901.
11. Comporti M., et al. Ethanol-induced oxidative stress: basic knowledge. Genes Nutr. 2011, 5:101-109.
12. Dong J., et al. Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells. PLoS ONE 2011, 6:e16845.
13. Ferry D.R., et al. Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin. Cancer Res. 1996, 2:659-668.
14. Gonzalez O., et al. The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology 2009, 50:1756-1764.
15. Harwood M., et al. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol. 2007, 45:2179-2205.
16. Jimenez-Lopez J.M., Cederbaum A.I. Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells. J. Pharmacol. Exp. Ther. 2005, 312:998-1006.
17. Kensler T.W., et al. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 2007, 47:89-116.
18. Kharbanda K.K. Alcoholic liver disease and methionine metabolism. Semin. Liver Dis. 2009, 29:155-165.
19. Kharbanda K.K., et al. A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes. J. Nutr. 2005, 135:519-524.
20. Kharbanda K.K., et al. Betaine administration corrects ethanol-induced defective VLDL secretion. Mol. Cell. Biochem. 2009, 327:75-78.
21. Khavari D.A., et al. DNA methylation and epigenetic control of cellular differentiation. Cell Cycle 2010, 9:3880-3883.
22. Kim S.J., et al. Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementation. Biochem. Biophys. Res. Commun. 2008, 368:893-898.
23. Lee M.J., et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol. Biomark. Prev. 2002, 11:1025-1032.
24. Levine R.L., et al. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 1994, 233:346-357.
25. Li J., et al. Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changes. Genes Nutr. 2009.
26. Li J., et al. The effects of betaine treatment on rats fed an acute bolus of ethanol at 3 and 12 h post bolus: microarray analysis. Gen Nutr. 2010, 5:321-329.
27. Liang H., et al. Gpx4 protects mitochondrial ATP generation against oxidative damage. Biochem. Biophys. Res. Commun. 2007, 356:893-898.
28. Liu S., et al. Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes. Toxicol. In Vitro 2010, 24:516-522.
29. Mazzanti G., et al. Hepatotoxicity from green tea: a review of the literature and two unpublished cases. Eur. J. Clin. Pharmacol. 2009, 65:331-341.
30. McMahon M., et al. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem. 2003, 278:21592-21600.
31. Miyamoto N., et al. Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest. Ophthalmol. Vis. Sci. 2010.
32. Molina M.F., et al. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol. Pharm. Bull. 2003, 26:1398-1402.
33. Murakami C., et al. Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells. Biosci. Biotechnol. Biochem. 2002, 66:1559-1562.
34. Murakami C., et al. Effects of epigallocatechin 3-O-gallate on cellular antioxidative system in HepG2 cells. J. Nutr. Sci. Vitaminol. (Tokyo) 2002, 48:89-94.
35. Muto S., et al. Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450. Mutat. Res. 2001, 479:197-206.
36. Nguyen T., et al. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 2009, 284:13291-13295.
37. Palakodety R.B., et al. Characterization and identification of a pyrazole-inducible form of cytochrome P-450. J. Biol. Chem. 1988, 263:878-884.
38. Savel J., Leroi E. Comparative experimental study of the hepatoprotector capacity of certain betaine, choline and methionine derivatives. Pathol. Biol. (Paris) 1964, 12:718-722.
39. Tipoe G.L., et al. Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology 2010, 273:45-52.
40. Tournaire C., et al. Antioxidant activity of flavonoids: efficiency of singlet oxygen (1 delta g) quenching. J. Photochem. Photobiol. B 1993, 19:205-215.
41. Vidhya A., Indira M. Protective effect of quercetin in the regression of ethanol-induced hepatotoxicity. Indian J. Pharm. Sci. 2009, 71:527-532.
42. Yao P., et al. The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296:G1318-G1323.
43. Yao P., et al. Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J. Hepatol. 2007, 47:253-261.
44. Yun J.W., et al. Effect of dietary epigallocatechin-3-gallate on cytochrome P450 2E1-dependent alcoholic liver damage: enhancement of fatty acid oxidation. Biosci. Biotechnol. Biochem. 2007, 71:2999-3006.
45. Zhang D.D. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab. Rev. 2006, 38:769-789.
46. Zhong Z., et al. Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats. Free Radic. Biol. Med. 2004, 36:1248-1258.