The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 6, 2009, Pages

  Yao, Ping ^a,b   Hao, Liping ^b,c   Nussler, Natascha ^a   Lehmann, Antje ^a   Song, Fangfang ^b   Zhao, Jing ^b   Neuhaus, Peter ^a   Liu, Liegang ^b   Nussler, Andreas ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Carbon monoxide; CYP 2E1; Heme oxygenase 1; Quercetin

Indexed keywords

ALCOHOL; BILIRUBIN; CARBON MONOXIDE; CYTOCHROME P450 2E1; HEME OXYGENASE 1; HEMOGLOBIN; IRON; PROTOPORPHYRIN ZINC; QUERCETIN; UNCLASSIFIED DRUG; ZINC PROTOPORPHYRIN 9;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL DAMAGE; LIVER TOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALLYL COMPOUNDS; BILIRUBIN; CARBON MONOXIDE; CYTOCHROME P-450 CYP2E1; DEFEROXAMINE; DISULFIDES; ENZYME INHIBITORS; ETHANOL; FERROUS COMPOUNDS; GLUTATHIONE; HEME OXYGENASE-1; HEMOGLOBINS; HEPATOCYTES; HUMANS; IRON; L-LACTATE DEHYDROGENASE; LIVER DISEASES, ALCOHOLIC; MALONDIALDEHYDE; ORGANOMETALLIC COMPOUNDS; PROTOPORPHYRINS; QUERCETIN; TRANSAMINASES;

EID: 67049145006     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00555.2007     Document Type: Article

References (41)

1. Akamatsu Y, Haga M, Tyagi S, Yamashita K, Graça-Souza AV, Ollinger R, Czismadia E, May GA, Ifedigbo E, Otterbein LE, Bach FH, Soares MP. Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury. FASEB J 18: 771-772, 2004.
2. Albano E. Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 65: 278-290, 2006.
3. Calabrese V, Butterfield DA, Stella AM. Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J Biochem 52: 177-181, 2003.
4. Cederbaum AI. CYP2E1 - biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med 73: 657-672, 2006.
5. Chow JM, Shen SC, Huan SK, Lin HY, Chen YC. Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via antioxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol 69: 1839-1851.
6. Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology 43: S63-S74, 2006.
7. Dicker E, McHugh T, Cederbaum AI. Increased oxidation of p-nitrophenol and aniline by intact hepatocytes isolated from pyrazole-treated rats. Biochim Biophys Acta 1035: 249-256, 1990.
8. Dore S. Decreased activity of the antioxidant heme oxygenase enzyme: implication in ischemia and in Alzheimer's disease. Free Radic Biol Med 32: 1276-1282, 2002.
9. Doré S. Unique properties of polyphenol stilbenes in the brain: more than direct antioxidant actions: gene/protein regulatory activity. Neurosignals 14: 61-70, 2005.
10. Drechsler Y, Dolganiuc A, Norkina O, Romics L, Li W, Kodys K, Bach FH, Mandrekar P, Szabo G. Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes. J Immunol 177: 2592-2600, 2006.
11. Erario MA, Gonzales S, Noriega GO, Tomaro ML. Bilirubin and ferritin as protectors against hemin-induced oxidative stress in rat liver. Cell Mol Biol (Noisy-le-grand) 48: 877-884, 2002.
12. Farombi EO, Surh YJ. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol 39: 479-491, 2006.
13. Galbraith RA, Hodgdon I, Grimm MS, Vizzard MA. Prolonged retention of the anorectic cobalt protoporphyrin in the hypothalamus and the resulting expression of Fos. Am J Physiol Regul Integr Comp Physiol 287: R465-R471, 2004.
14. Gong P, Cederbaum AI, Nieto N. Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Free Radic Biol Med 36: 307-318, 2004.
15. Helmer KS, Suliburk JW, Mercer DW. Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1. Dig Dis Sci 51: 1571-1581, 2006.
16. Huang Y, Wu L, Xu C, Yang B, Wang R. Increased HO-1 expression and decreased iNOS expression in the hippocampus from adult spontaneously hypertensive rats. Cell Biochem Biophys 46: 35-42, 2006.
17. Kirkby KA, Adin CA. Products of heme oxygenase and their potential therapeutic applications. Am J Physiol Renal Physiol 290: F563-F571, 2006.
18. Koizumi S. Human heme oxygenase-1 deficiency: a lesson on serendipity in the discovery of the novel disease. Pediatr Int 49: 125-132, 2007.
19. Ku BM, Joo Y, Mun J, Roh GS, Kang SS, Cho GJ, Choi WS, Kim HJ. Heme oxygenase protects hippocampal neurons from ethanol-induced neurotoxicity. Neurosci Lett 405: 168-171, 2006.
20. Kumar S, Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol Lett 157: 175-188, 2005.
21. Lin HC, Cheng TH, Chen YC, Juan SH. Mechanism of heme oxygenase- 1 gene induction by quercetin in rat aortic smooth muscle cells. Pharmacology 71: 107-112, 2004.
22. Mancuso C, Perluigi M, Cini C, De Marco C, Giuffrida Stella AM, Calabrese V. Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay. J Neurosci Res 84: 1385-1391, 2006.
23. Mense SM, Zhang L. Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases. Cell Res 16: 681-692, 2006.
24. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione-s-transferase activities in rat lung and liver. Biochim Biophys Acta 582: 67-78, 1979.
25. Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol 27: 8-16, 2002.
26. Nussler AK, Liu ZZ, Di Silvio M, Sweetland MA, Geller DA, Lancaster JR Jr, Billiar TR, Freeswick PD, Lowenstein CL, Simmons RL. Hepatocyte inducible nitric oxide synthesis is influenced in vitro by cell density. Am J Physiol Cell Physiol 267: C394-C401, 1994.
27. Pamplona A, Ferreira A, Balla J, Jeney V, Balla G, Epiphanio S, Chora A, Rodrigues CD, Gregoire IP, Cunha-Rodrigues M, Portugal S, Soares MP, Mota MM. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med 13: 703-710, 2007.
28. Pittock ST, Norby SM, Grande JP, Croatt AJ, Bren GD, Badley AD, Caplice NM, Griffin MD, Nath KA. MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: pathophysiologic correlates. Kidney Int 68: 611-622, 2005.
29. Room R, Babor T, Rehm J. Alcohol and public health. Lancet 365: 519-530, 2005.
30. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86: 583-650, 2006.
31. Sassa S. Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide? Antioxid Redox Signal 6: 819-824, 2004.
32. Srisook K, Kim C, Cha YN. Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the "one-two" punch. Antioxid Redox Signal 7: 1674-1687, 2005.
33. Taille C, El-Benna J, Lanone S, Boczkowski J, Motterlini R. Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. J Biol Chem 280: 25350-25360, 2005.
34. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 61: 748-755, 1968.
35. Tuzuner E, Liu L, Shimada M, Yilmaz E, Glanemann Settmacher U, Langrehr JM, Jonas S, Neuhaus P, Nussler AK. Heme oxygenase-1 protects human hepatocytes in vitro against warm and cold hypoxia. J Hepatol 41: 764-772, 2004.
36. Vítek L, Schwertner HA. The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv Clin Chem 43: 1-57, 2007.
37. Wagener FA, Volk HD, Willis D, Abraham NG, Soares MP, Adema GJ, Figdor CG. Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev 55: 551-571, 2003.
38. Wright JR, Colby HD, Miles PR. Cytosolic factors which affect microsomal lipid peroxidation in lung and liver. Arch Biochem Biophys 206: 296-304, 1981.
39. Yao P, Li K, Jin Y, Song F, Zhou S, Sun X, Nussler AK, Liu L. Oxidative damage after chronic ethanol intake in rat tissues: prophylaxis of Ginkgo biloba extract. Food Chem 99: 305-314, 2006.
40. Yao P, Nussler A, Liu L, Hao L, Song F, Schirmeier A, Nussler N. Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J Hepatol 47: 253-261, 2007.
41. Yao P, Li K, Song F, Zhou S, Sun X, Zhang X, Nussler AK, Liu L. Heme oxygenase-1 upregulated by Ginkgo biloba extract: potential protection against ethanol-induced oxidative liver damage. Food Chem Toxicol 45: 1333-1342, 2007.