Cell cycle arrest of human gingival fibroblasts and periodontal ligament cells by Actinobacillus actinomycetemcomitans: Involvement of the cytolethal distending toxin

APMIS

Volumn 112, Issue 10, 2004, Pages 674-85

  Belibasakis, G N ^a   Mattsson, A ^a   Wang, Y ^b   Chen, C ^b   Johansson, A ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Actinobacillus actinomycetemcomitans; Cell cycle arrest; Cytolethal distending toxin; Flow cytometry; Periodontal connective tissue cells

Indexed keywords

CYTOLETHAL DISTENDING TOXIN; PROPIDIUM IODIDE; TOXIN; UNCLASSIFIED DRUG;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PHASE; CONTROLLED STUDY; FIBROBLAST; FLOW CYTOMETRY; GINGIVA; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PERIODONTAL LIGAMENT; PRIORITY JOURNAL; STAINING; WILD TYPE;

EID: 11944254634     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2004.apm1121006.x     Document Type: Article

References (38)

1. Slots J, Ting M. Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontol 2000 1999;20:82-121.
2. Shenker BJ, McKay T, Datar S, Miller M, Chowhan R, Demuth D. Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells. J Immunol 1999;162:4773-80.
3. Sugai M, Kawamoto T, Peres SY, Ueno Y, Komatsuzawa H, Fujiwara T, et al. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin. Infect Immun 1998;66:5008-19.
4. Mayer MP, Bueno LC, Hansen EJ, DiRienzo JM. Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans. Infect Immun 1999;67:1227-37.
5. Yamano R, Ohara M, Nishikubo S, Fujiwara T, Kawamoto T, Ueno Y, et al. Prevalence of cytolethal distending toxin production in periodontopathogenic bacteria. J Clin Microbiol 2003;41:1391-8.
6. Johnson WM, Lior H. A new heat-labile cytolethal distending toxin (CLDT) produced by Escherichia coli isolates from clinical material. Microb Pathog 1988;4:103-13.
7. Johnson WM, Lior H. A new heat-labile cytolethal distending toxin (CLDT) produced by Campylobacter spp. Microb Pathog 1988;4:115-26.
8. Lara-Tejero M, Galan JE. Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions. Trends Microbiol 2002;10:147-52.
9. Dreyfus L. Cytolethal Distending Toxin. In: Burns D, Barbieri J, Iglewski B, Rappuoli R, editors. Bacterial Protein Toxins. Washington, DC, USA: ASM Press; 2003:257-70.
10. Cortes-Bratti X, Frisan T, Thelestam M. The cytolethal distending toxins induce DNA damage and cell cycle arrest. Toxicon 2001;39:1729-36.
11. Cortes-Bratti X, Karlsson C, Lagergard T, Thelestam M, Frisan T. The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways. J Biol Chem 2001;276:5296-302.
12. Belibasakis G, Johansson A, Wang Y, Claesson R, Chen C, Asikainen S, et al. Inhibited proliferation of human periodontal ligament cells and gingival fibroblasts by Actinobacillus actinomycetemcomitans: involvement of the cytolethal distending toxin. Eur J Oral Sci 2002;110:336-73.
13. Hassane DC, Lee RB, Pickett CL. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect Immun 2003;71:541-5.
14. Svensson LA, Tarkowski A, Thelestam M, Lagergard T. The impact of Haemophilus ducreyi cytolethal distending toxin on cells involved in immune response. Microb Pathog 2001;30:157-66.
15. DiRienzo JM, Song M, Wan LS, Ellen RP. Kinetics of KB and HEp-2 cell responses to an invasive, cytolethal distending toxin-producing strain of Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 2002;17:245-51.
16. Hickey TE, McVeigh AL, Scott DA, Michielutti RE, Bixby A, Carroll SA, et al. Campylobacter jejuni cytolethal distending toxin mediates release of interleukin-8 from intestinal epithelial cells. Infect Immun 2000;68:6535-41.
17. Cortes-Bratti X, Chaves-Olarte E, Lagergard T, Thelestam M. The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. J Clin Invest 1999;103:107-15.
18. Sato T, Koseki T, Yamato K, Saiki K, Konishi K, Yoshikawa M, et al. p53-independent expression of p21 (CIP1/WAF1) in plasmacytic cells during G(2) cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect Immun 2002;70:528-34.
19. Nalbant A, Chen C, Wang Y, Zadeh HH. Induction of T-cell apoptosis by Actinobacillus actinomycetemcomitans mutants with deletion of ltxA and cdtABC genes: possible activity of GroEL-like molecule. Oral Microbiol Immunol 2003;18:339-49.
20. Lara-Tejero M, Galan JE. A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science 2000;290:354-7.
21. Bartold PM, Walsh LJ, Narayanan AS. Molecular and cell biology of the gingiva. Periodontol 2000 2000;24:28-55.
22. McCulloch CA, Lekic P, McKee MD. Role of physical forces in regulating the form and function of the periodontal ligament. Periodontol 2000 2000;24:56-72.
23. McCulloch CA, Bordin S. Role of fibroblast sub-populations in periodontal physiology and pathology. J Periodontal Res 1991;26:144-54.
24. Ivanovski S, Li H, Haase HR, Bartold PM. Expression of bone associated macromolecules by gingival and periodontal ligament fibroblasts. J Periodontal Res 2001;36:131-41.
25. Christersson LA, Wikesjo UM, Albini B, Zambon JJ, Genco RJ. Tissue localization of Actinobacillus actinomycetemcomitans in human periodontitis. II. Correlation between immunofluorescence and culture techniques. J Periodontol 1987;58:540-5.
26. Christersson LA, Albini B, Zambon JJ, Wikesjo UM, Genco RJ. Tissue localization of Actinobacillus actinomycetemcomitans in human periodontitis. I. Light, immunofluorescence and electron microscopic studies. J Periodontol 1987;58:529-39.
27. Wang Y, Goodman SD, Redfield RJ, Chen C. Natural transformation and DNA uptake signal sequences in Actinobacillus actinomycetemcomitans. J Bacteriol 2002;184:3442-9.
28. Johansson A, Claesson R, Hanstrom L, Kalfas S. Serum-mediated release of leukotoxin from the cell surface of the periodontal pathogen Actinobacillus actinomycetemcomitans. Eur J Oral Sci 2003;111:209-15.
29. Wising C, Svensson LA, Ahmed HJ, Sundaeus V, Ahlman K, Jonsson IM, et al. Toxicity and immunogenicity of purified Haemophilus ducreyi cytolethal distending toxin in a rabbit model. Microb Pathog 2002;33:49-62.
30. Gitig DM, Koff A. Cdk pathway: cyclin-dependent kinases and cyclin-dependent kinase inhibitors. Mol Biotechnol 2001;19:179-88.
31. Larsen JK. "Washless" procedures for nuclear antigen detection. Methods Cell Biol 1994;41:377-88.
32. Alby F, Mazars R, de Rycke J, Guillou E, Baldin V, Darbon JM, et al. Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase. FEBS Lett 2001;491:261-5.
33. Sert V, Cans C, Tasca C, Bret-Bennis L, Oswald E, Ducommun B, et al. The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks. Oncogene 1999;18:6296-304.
34. Li L, Sharipo A, Chaves-Olarte E, Masucci MG, Levitsky V, Thelestam M, et al. The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells. Cell Microbiol 2002;4:87-99.
35. De Rycke J, Oswald E. Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation? FEMS Microbiol Lett 2001;203:141-8.
36. Frisan T, Cortes-Bratti X, Chaves-Olarte E, Stenerlow B, Thelestam M. The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA. Cell Microbiol 2003;5:695-707.
37. Fabris AS, DiRienzo JM, Wikstrom M, Mayer MP. Detection of cytolethal distending toxin activity and cdt genes in Actinobacillus actinomycetemcomitans isolates from geographically diverse populations. Oral Microbiol Immunol 2002;17:231-8.
38. Tan KS, Song KP, Ong G. Cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Occurrence and association with periodontal disease. J Periodontal Res 2002;37:268-72.