Heparin-binding epidermal growth factor-like growth factor (HB-EGF) regulates survival of midbrain dopaminergic neurons

Journal of Neural Transmission

Volumn 109, Issue 3, 2002, Pages 267-277

  Farkas, L M ^a   Krieglstein, K ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Dopaminergic neurons; EGF; Neurotrophic factors; Parkinson's disease (PD); TGF

Indexed keywords

HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPIC AGENT; PROTEIN KINASE B;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT;

ANIMALS; ANTIBODIES; ASTROCYTES; CELL SURVIVAL; CELLS, CULTURED; DOPAMINE; EPIDERMAL GROWTH FACTOR; FEMALE; FETUS; MAP KINASE SIGNALING SYSTEM; NEURONS; PARKINSON DISEASE; PREGNANCY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

EID: 0036203225     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020200022     Document Type: Article

References (25)

1. The ontogeny of epidermal growth factor receptors during mouse development
2. Functions of brain-derived neurotrophic factor, insulin-like growth factor-I and basicfibroblast growth factor in the development and maintenance of dopaminergic neurons
3. Neurotrophins in the pathogenesis and potential treatment of Parkinson's disease
4. EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head
5. Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice
6. Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates
7. Epidermal growth factor receptor immunoreactivity in rat brain. Developmental and cellular localization
8. Expression of heparin-binding epidermal growth factor-like growth factor in rat brain
9. Bone morphoge-netic proteins: Neurotrophic roles for midbrain dopaminergic neurons and implications of astroglial cells
10. Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain
11. Multipletrophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system
12. The neurotrophic factor concept: A reexamination
13. + toxicity
14. Glial cell line-derived neurotrophic factor requires transforming growth factor-β for exerting its full neurotrophic potential on peripheral and CNS neurons
15. Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-a mRN in mouse brain by a quantitative nuclease protection assay
16. Etiology and pathogenesis of Parkinson's disease
17. Nigral type I astrocytes release a soluble factor that increases dopaminergic neuron survival through mechanisms distinct from basicfibroblast growth factor
18. Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice
19. Heparin-binding EGF-like growth factor
20. A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor
21. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
22. Etiology of Parkinson's disease
23. Neurotrophic roles of GDNF and related factors
24. Mitogen and substrate differentially affect the lineage restriction of adult rat subventricular zone neural precursor cell populations