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Volumn 14, Issue 12, 2001, Pages 1035-1041

Improved binding of a bivalent single-chain immunotoxin results in increased efficacy for in vivo T-cell depletion

(14) Thompson, Jerry a Stavrou, Scott b Weetall, Marla c Hexham, J Mark c Digan, Mary Ellen c Wang, Zhuri b Woo, Jung Hee b Yu, Yongjun b Mathias, Askale b Liu, Yuan Yi b Ma, Shenglin d Gordienko, Irina b Lake, Philip c Neville Jr , David M b

a 104 Fenske Laboratory (United States)

b NATIONAL INSTITUTE OF MENTAL HEALTH (United States)

c NOVARTIS PHARMA AG (Switzerland)

d UNIVERSITY OF ALABAMA AT BIRMINGHAM (United States)

Author keywords

CD3; Depletion; Divalent; Immunotoxin; T cell; Transplantation

Indexed keywords

A DMDT390 BISFV; A DMDT390 SFV; CD3 ANTIGEN; DIPHTHERIA TOXIN; GENE PRODUCT; HYBRID PROTEIN; IMMUNOTOXIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; MONOCLONAL ANTIBODY UCHT1; UCHT1 CRM9; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONJUGATION; GLYCOSYLATION; HETEROZYGOSITY; HISTOCOMPATIBILITY; IMMUNOLOGICAL TOLERANCE; IMMUNOTOXICITY; LYMPH NODE; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; SPLEEN; STEREOSPECIFICITY; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0035710053 PISSN: 02692139 EISSN: None Source Type: Journal
DOI: 10.1093/protein/14.12.1035 Document Type: Article

Times cited : (56)

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